Article
Pediatrics
Leon S. Siriwardhana, Alicia K. Yee, Dwayne L. Mann, Shrinkhala Dawadi, Gillian M. Nixon, Flora Y. Wong, Bradley A. Edwards, Rosemary S. C. Horne
Summary: Periodic breathing in preterm infants is associated with ventilatory control instability, with higher loop gain at 32-36 weeks postmenstrual age being a risk factor for persistent periodic breathing at 6 months corrected age. Early assessment of ventilatory control stability may help identify infants at risk for persistent periodic breathing.
PEDIATRIC RESEARCH
(2022)
Article
Clinical Neurology
Sergio Ghirardo, Alessandro Amaddeo, Lucie Griffon, Sonia Khirani, Brigitte Fauroux
Summary: Central sleep apnea and periodic breathing in children are rare conditions, with Chiari malformation being the most common diagnosis. Treatment options vary and may include watchful waiting or other interventions such as surgery, oxygen therapy, and ventilation. Sleep studies play a crucial role in diagnosis, characterization, and management of these conditions.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Neurosciences
Ana M. Casarrubios, Leonel F. Perez-Atencio, Cristina Martin, Jose M. Ibarz, Eva Manas, David L. Paul, Luis C. Barrio
Summary: Periodic Cheyne-Stokes breathing (CSB) is characterized by alternating cycles of apnea and crescendo-decrescendo hyperpnea, and it is the most common type of central apnea. However, the underlying neural mechanism responsible for this breathing pattern is still unclear. In this study, we used a transgenic mouse model to analyze the interaction between the inspiratory and expiratory oscillators in CSB. We found that the oscillation between apnea and hyperpnea is driven by the cyclical activation and deactivation of the expiratory oscillator, which acts as the master pacemaker of respiration and entrains the inspiratory oscillator to restore ventilation. Additionally, we discovered that supplemental CO2 administration can stabilize the coupling between these two oscillators and regularize respiration. This study provides insights into the neurogenic mechanism of CSB and highlights the potential of CO2 therapy in treating this condition.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Jun Young An, Hyun Joon Shin, Myunghyun Yang, Do-Yang Park, Jisun Yang, Hyun Jun Kim
Summary: This study aimed to detect respiratory events during sleep using infrared optical gas imaging and evaluate its feasibility for diagnosing OSA. Results showed a strong correlation between respiratory parameters obtained from infrared optical gas imaging and PSG sensors. Based on these findings, infrared optical gas imaging can accurately detect respiratory events during sleep, making it a potential screening tool for OSA.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Liza J. Severs, Nicholas E. Bush, Lely A. Quina, Skyler Hidalgo-Andrade, Nicholas J. Burgraff, Tatiana Dashevskiy, Andy Y. Shih, Nathan A. Baertsch, Jan-Marino Ramirez
Summary: Sighs play important roles in lung function, emotional expression and arousal. The preBotzinger complex (preBotC) is involved in the generation of spontaneous and hypoxia-induced sighs. Purinergic signaling is necessary for the generation of sighs and increasing astrocytic calcium levels can enhance sigh frequency.
NATURE COMMUNICATIONS
(2023)
Article
Physiology
Jens Spiesshoefer, Alberto Giannoni, Chiara Borrelli, Paolo Sciarrone, Imke Husstedt, Michele Emdin, Claudio Passino, Florian Kahles, Tye Dawood, Binaya Regmi, Matthew Naughton, Michael Dreher, Matthias Boentert, Vaughan G. Macefield
Summary: This study found that periodic breathing patterns with shorter periods of hyperventilation are associated with increased sympathetic nerve activity and decreased heart rate variability. Simulated periodic breathing with short hyperventilation resulted in a significant increase in sympathetic nerve activity compared to normal breathing. However, there was no change in sympathetic nerve activity during periodic breathing with long hyperventilation.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Pediatrics
Alicia K. Yee, Leon S. Siriwardhana, Gillian M. Nixon, Lisa M. Walter, Flora Y. Wong, Rosemary S. C. Horne
Summary: The study aimed to investigate the frequency and severity of periodic breathing (PB) in clinically stable very preterm infants. The majority of infants exhibited PB when they were off respiratory support, and the time spent in PB varied greatly between infants and was associated with significant hypoxia in some infants. Shorter duration on respiratory support was associated with increased frequency and severity of PB.
PEDIATRIC PULMONOLOGY
(2023)
Review
Clinical Neurology
Karl M. Schottelkotte, Steven A. Crone
Summary: The forebrain is crucial in ensuring that breathing is aligned with current and anticipated behavioral, emotional, and physiological needs. This review provides an overview of the anatomical and functional evidence implicating forebrain regions in the control of breathing, including the cerebral cortex, extended amygdala, hippocampus, hypothalamus, and thalamus. Additional research is needed to better understand the specific roles of these regions.
FRONTIERS IN NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Joseph W. Arthurs, Anna J. Bowen, Richard D. Palmiter, Nathan A. Baertsch
Summary: Breathing is regulated automatically by neural circuits in the medulla, but it is also influenced by behavior and emotion. Researchers identified a subset of neurons in the parabrachial nucleus that control specific breathing patterns in awake mice. These neurons exert conditional control over breathing in the awake state through projections to the ventral intermediate reticular zone of the medulla.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Enric Sanchez, Esther Sapina-Beltran, Ricard Gavalda, Ferran Barbe, Gerard Torres, Ariadna Sauret, Mireia Dalmases, Carolina Lopez-Cano, Liliana Gutierrez-Carrasquilla, Marcelino Bermudez-Lopez, Elvira Fernandez, Francisco Purroy, Eva Castro-Boque, Cristina Farras-Salles, Reinald Pamplona, Didac Mauricio, Cristina Hernandez, Rafael Simo, Albert Lecube, ILERVAS Project Collaborators
Summary: The study found that individuals in the prediabetes stage exhibited higher abnormal sleep breathing parameters compared to those with normal glucose metabolism, with a significant increase in apnea events and hypoxemia.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
Mateus R. Amorim, Xin Wang, O. Aung, Shannon Bevans-Fonti, Frederick Anokye-Danso, Caitlin Ribeiro, Joan Escobar, Carla Freire, Huy Pho, Olga Dergacheva, Luiz G. S. Branco, Rexford S. Ahima, David Mendelowitz, Vsevolod Y. Polotsky
Summary: The mismatch between CO2 production and respiration is responsible for obesity hypoventilation. Leptin stimulates both metabolism and breathing, but the interactions between these functions are not well understood. This study reveals that LEPRb+ neurons in the DMH regulate metabolism and breathing in obesity through serotonergic pathways, preventing obesity-induced hypoventilation.
Review
Obstetrics & Gynecology
Grant Erickson, Nicole R. Dobson, Carl E. Hunt
Summary: Premature infants commonly exhibit immature control of breathing, with severity inversely correlated to gestational age. Common treatment strategies include caffeine and noninvasive respiratory support, but there is variability in effectiveness. Knowledge gaps exist regarding effective strategies for quantifying the severity of clinical manifestations and potential long-term adverse outcomes.
JOURNAL OF PERINATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Paola Faverio, Umberto Zanini, Anna Monzani, Gianfranco Parati, Fabrizio Luppi, Carolina Lombardi, Elisa Perger
Summary: The prevalence and impact of sleep-disordered breathing (SDB) in chronic respiratory infections, such as cystic fibrosis (CF), bronchiectasis, and mycobacterial infections, are reported in this narrative review. The common pathophysiological mechanisms underlying SDB onset in these infections include inflammation, nocturnal cough and pain, mucous plugs, ventilatory impairment, upper airway involvement, and comorbidities. SDB may affect approximately 50% of bronchiectasis patients and significantly impact the quality of life in both children and adults with CF. Routine assessment of SDB should be incorporated into the clinical evaluation of patients with CF from the early stages of the disease to avoid late diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pediatrics
Rosemary S. C. Horne, Ashwini Sakthiakumaran, Ahmad Bassam, Julie Thacker, Lisa M. Walter, Margot J. Davey, Gillian M. Nixon
Summary: Children with Down syndrome experiencing sleep disordered breathing exhibit reduced parasympathetic activity and increased exposure to hypoxia, which may lead to adverse cardiovascular outcomes compared to typically developing children. Early screening and treatment for sleep disordered breathing in children with Down syndrome is recommended.
PEDIATRIC RESEARCH
(2021)
Article
Clinical Neurology
Riccardo A. Stoohs, Morris S. Gold
Summary: This study investigated the association between typical symptoms of obstructive sleep apnea, daytime somatic arousal, and the apnea-hypopnea index. The findings suggest that there is a relationship between sleepiness, fatigue, and somatic arousal in individuals with sleep apnea. The apnea-hypopnea index and the body sensation questionnaire (BSQ) both independently correlate with sleepiness, with the apnea-hypopnea index impacting sleepiness when it exceeds 50/h.
Article
Clinical Neurology
Motoo Yamauchi, Hideaki Nakayama, Satomi Shiota, Yasuyoshi Ohshima, Jiro Terada, Tsuguo Nishijima, Motomichi Kosuga, Takuro Kitamura, Naoko Tachibana, Takuya Oguri, Ryutaro Shirahama, Yasuhiro Aoki, Keiko Ishigaki, Kazuma Sugie, Tomoko Yagi, Hisae Muraki, Yukio Fujita, Tsunenori Takatani, Shigeo Muro
Summary: Pompe disease, an autosomal recessive disorder caused by deficiency of the acid alpha-glucosidase enzyme, leads to progressive glycogen accumulation and weakness of respiratory muscles. The study aims to demonstrate a higher prevalence of late-onset Pompe disease in a sleep lab-based population and identify predictive factors from diagnostic polysomnography and clinical symptoms.
SLEEP AND BREATHING
(2021)
Article
Oncology
Yoshiro Kai, Masayuki Matsuda, Atsuhiko Fukuoka, Shigeto Hontsu, Motoo Yamauchi, Masanori Yoshikawa, Shigeo Muro
Summary: The case of a patient with non-small cell lung carcinoma complicated by IPF treated with nintedanib shows the potential efficacy of the treatment in suppressing lung cancer and relieving IPF. However, further research is needed to identify effective therapy for lung cancer with IPF, as the efficacy of treatment in such patients remains unknown.
Article
Critical Care Medicine
Yukio Fujita, Motoo Yamauchi, Masanori Yoshikawa, Yoshifumi Yamamoto, Kazuhiro Sakaguchi, Nobuhiro Fujioka, Takahiro Ibaraki, Shigeo Muro
Summary: This study found that resting breathing instability during wakefulness is associated with the severity of dyspnea and exacerbation frequency in patients with COPD. Breathing instability may serve as a novel assessment tool that predicts the prognosis and disease severity in COPD patients.
Article
Respiratory System
Yoshiro Kai, Masanori Yoshikawa, Masayuki Matsuda, Atsuhiko Fukuoka, Yukio Fujita, Motoo Yamauchi, Shigeo Muro
Summary: Studies have shown that treatment with Dupilumab can significantly improve symptoms and lung function in patients with severe asthma and chronic rhinosinusitis, as well as improve quality of life.
RESPIROLOGY CASE REPORTS
(2021)
Article
Automation & Control Systems
Chen Liu, Changsong Zhou, Jiang Wang, Chris Fietkiewicz, Kenneth A. Loparo
Summary: This study investigates the impact of delayed feedback control strategies on alleviating motor symptoms of Parkinson's disease, proposing three new control schemes involving the inhibitory external GPe nucleus in the excitatory-inhibitory STN-GPe reciprocal network. Results show that these new strategies improve control performance by expanding oscillatory suppression space and reducing energy expenditure, suggesting their potential effectiveness in applications.
IEEE TRANSACTIONS ON CYBERNETICS
(2021)
Article
Respiratory System
Nobuhiro Fujioka, Masahiro Kitabatake, Noriko Ouji-Sageshima, Takahiro Ibaraki, Makiko Kumamoto, Yukio Fujita, Shigeto Hontsu, Motoo Yamauchi, Masanori Yoshikawa, Shigeo Muro, Toshihiro Ito
Summary: Researches revealed that hADSCs have the potential to ameliorate the pathogenesis of COPD by differentiating into alveolar epithelial cells through mesenchymal-epithelial transition.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2021)
Article
Respiratory System
Tsuneto Akashiba, Yuichi Inoue, Naohisa Uchimura, Motoharu Ohi, Takatoshi Kasai, Fusae Kawana, Shigeru Sakurai, Misa Takegami, Rho Tachikawa, Takeshi Tanigawa, Shintaro Chiba, Kazuo Chin, Satoru Tsuiki, Morio Tonogi, Hiroshi Nakamura, Takeo Nakayama, Koji Narui, Tomoko Yagi, Motoo Yamauchi, Yoshihiro Yamashiro, Masahiro Yoshida, Toru Oga, Yasuhiro Tomita, Satoshi Hamada, Kimihiko Murase, Hiroyuki Mori, Hiroo Wada, Makoto Uchiyama, Hiromasa Ogawa, Kazumichi Sato, Seiichi Nakata, Kazuo Mishima, Shin-Ichi Momomura
Summary: The prevalence of sleep disordered breathing (SDB) is high and the incidence of obstructive sleep apnea (OSA) is higher than previously believed. The number of sleep apnea patients in Japan has increased significantly, leading to the need for updated medical guidelines. This interdisciplinary guideline addresses 36 clinical questions.
RESPIRATORY INVESTIGATION
(2022)
Article
Respiratory System
Takahiro Ibaraki, Koich Tomoda, Nobuhiro Fujioka, Kazuhiro Sakaguchi, Yukio Fujita, Yoshifumi Yamamoto, Shigeto Hontsu, Motoo Yamauchi, Masanori Yoshikawa, Naoya Tanabe, Kazuya Tanimura, Susumu Sato, Keigo Saeki, Shigeo Muro
Summary: The relationship between lung morphometry evaluated using CT images and initiation of long-term oxygen therapy (LTOT) in chronic obstructive pulmonary disease (COPD) patients was studied. The study found that lower diffusing capacity and fractal dimension were independently associated with LTOT initiation.
RESPIRATORY INVESTIGATION
(2022)
Article
Energy & Fuels
Hanieh Agharazi, Marija D. Prica, Kenneth A. Loparo
Summary: This paper proposes a two-level model predictive control-based approach for coordinated control and energy management. The system can simultaneously manage building loads and energy storage to achieve different operational objectives through the design of specific power trajectory tracking performance functionals and energy trim function.
Article
Computer Science, Artificial Intelligence
Shuangming Yang, Jiang Wang, Xinyu Hao, Huiyan Li, Xile Wei, Bin Deng, Kenneth A. Loparo
Summary: The article introduces a biologically-inspired cognitive supercomputing system, BiCoSS, which integrates multiple GRs of SNNs to create a hybrid neuromorphic platform with efficient and scalable architecture and low power consumption. The system has successfully replicated various biological cognitive activities, demonstrating its high performance and potential applications.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2022)
Article
Critical Care Medicine
Anna M. May, Sanjay R. Patel, Motoo Yamauchi, Tilak K. Verma, Terri E. Weaver, Ching Li Chai-Coetzer, J. Daryl Thornton, Gary Ewart, Terrance Showers, Najib T. Ayas, Sairam Parthasarathy, Reena Mehra, Martha E. Billings
Summary: This paper advocates for policy changes to CMS PAP coverage requirements in order to reduce disparities and align with patient-centered goals.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Respiratory System
Yoshiro Kai, Hiroya Ohara, Masayuki Matsuda, Hironori Shimizu, Hun Soo Park, Kaoru Myouchin, Naoya Kikutsuji, Shigeto Hontsu, Motoo Yamauchi, Masanori Yoshikawa, Shigeo Muro
Summary: This case report describes a patient with lung carcinoma who developed Trousseau's syndrome. Treatment with osimertinib resulted in pneumonitis, but was controlled with prednisolone. Endovascular therapy improved the patient's condition related to Trousseau's syndrome-induced cerebral infarction.
RESPIRATORY MEDICINE CASE REPORTS
(2021)
Article
Engineering, Electrical & Electronic
Yinyin Ge, Hongxing Ye, Kenneth A. Loparo
IEEE TRANSACTIONS ON SMART GRID
(2020)
Article
Computer Science, Information Systems
Chen Liu, Ge Zhao, Jiang Wang, Hao Wu, Huiyan Li, Chris Fietkiewicz, Kenneth A. Loparo
Article
Green & Sustainable Science & Technology
Amirhossein Sajadi, Kara Clark, Kenneth A. Loparo
CLEAN TECHNOLOGIES
(2020)
Article
Physiology
Alyssa R. Mickle, Jesus D. Penaloza-Aponte, Richard Coffey, Natale A. Hall, David Baekey, Erica A. Dale
Summary: Closed-loop epidural stimulation (CL-ES) can improve respiratory deficits caused by cervical spinal cord injury, restoring diaphragm activity and enhancing contralateral activity. This treatment has the potential to lead to lasting recovery and device independence.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Shawn Miller Jr, Edgar Juarez Lopez, Jessica M. L. Grittner, Brendan J. Dougherty
Summary: This study tested the impact of CO2 supplementation at different concentrations on ventilatory long-term facilitation (vLTF) in rats and found that 2% CO2 supplementation during and after acute, intermittent hypoxia (AIH) was sufficient to maintain isocapnia and induce significant vLTF.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Behnam Vafadari, Yoshitaka Oku, Charlotte Tacke, Ali Harb, Swen Huelsmann
Summary: The preBo·tzinger Complex (preBo·tC) in the brainstem plays a critical role in generating respiratory rhythm. This study aimed to investigate the activity of inhibitory glycinergic neurons in the preBo·tC of anesthetized mice. Using juxtacellular recordings and optogenetic activation, the researchers were able to identify and characterize the activity pattern of these inhibitory neurons in relation to the breathing rhythm.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Stephen M. Johnson, Maia G. Gumnit, Sarah M. Johnson, Tracy L. Baker, Jyoti J. Watters
Summary: Low-level activation of mu-opioid receptors can increase the amplitude of inspiratory bursts in neonatal rat brainstem-spinal cord preparations. Endomorphin-2, an endogenous ligand for these receptors, was found to have similar effects. Disinhibition of inhibitory synaptic transmission may not be involved in the changes induced by endomorphin-2, and different mechanisms may underlie the increase in burst amplitude and decrease in burst frequency.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Raphael Martins de Abreu, Beatrice Cairo, Patricia Rehder-Santos, Claudio Donisete da Silva, Etore De Favari Signini, Juliana Cristina Milan-Mattos, Camila Akemi Sakaguchi, Aparecida Maria Catai, Alberto Porta
Summary: The purpose of this study was to determine the association between exercise capacity based on peak oxygen uptake (VO2peak) and resting cardiorespiratory coupling (CRC) levels. The results showed that resting CRC values were associated with exercise capacity in athletes but not in non-athletes.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Sarah M. Russel, Raluca E. Gosman, Katherine Gonzalez, Joshua Wright, Dennis O. Frank-Ito
Summary: This study aimed to characterize the response of different nasal morphologies to airflow-related variables during rapid/deep inspiration. The results showed that notched nasal vestibules had higher resistance values and airflow velocities, while standard nasal vestibules had higher mucosal heat flux. Different nasal phenotypes may predispose individuals to exercise-induced rhinitis.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Ivan Poliacek, Lukas Martvon, Michal Simera, Marcel Veternik, Jakub Misek, Lucia Cibulkova, Kimberly E. Iceman, Donald C. Bolser, Teresa Pitts
Summary: An animal model study evaluated the effects of an abdominal incision on cough and swallow, revealing that abdominal wall manipulations can increase pharyngeal muscle activity during swallow without affecting the cough reflex. Swallowing tended to occur more during the inspiratory phase. The results highlight the important role of abdominal wall sensory feedback in regulating swallow motor patterns.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Rui Yu, Tatsuma Okazaki, Yuzhuo Ren, Junko Okuyama, Satoru Ebihara, Shin-Ichi Izumi
Summary: Body postures significantly influence respiratory muscle force, cough pressure, subjective ease of coughing, and pulmonary function. The 60-degree semi-recumbent posture and sitting posture show better results compared to the supine posture.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Suzuna Sato, Koji Ishida, Noriko I. Tanaka, Keisho Katayama
Summary: Respiratory muscle endurance training has beneficial effects on whole-body endurance performance. A novel high-intensity interval (HII) protocol is found to enhance the efficacy of respiratory muscle training programs.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Letter
Physiology
R. Arieli
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Correction
Physiology
Ivan Poliacek, Michal Simera, Marcel Veternik, Zuzana Kotmanova, Teresa Pitts, Jan Hanacek, Jana Plevkova, Peter Machac, Nadezda Visnovcova, Jakub Misek, Jan Jakus
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Dimitrios I. Bourdas, Nickos D. Geladas
Summary: This study examined the effects of breath-hold training on the performance of novice and elite breath-hold divers. The results showed that breath-hold training significantly improved red blood cell concentration, hemoglobin oxygen saturation steady state duration, and breath-hold time in novice divers. Elite divers had better breath-hold performance and higher peak mean arterial pressure compared to novices. The study suggests that breath-hold training can enhance the performance of divers.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
