Article
Immunology
Masaru Takeshita, Katsuya Suzuki, Maho Nakazawa, Hirofumi Kamata, Makoto Ishii, Yoshitaka Oyamada, Hisaji Oshima, Tsutomu Takeuchi
Summary: The study investigated humoral immunity in ILD associated with rheumatoid arthritis, Sjogren's syndrome, and mixed connective tissue disease by analyzing bronchoalveolar fluid and serum samples from 15 patients. The researchers found active autoimmunity in the lungs of these patients, with the presence of disease-related autoantibodies and changes in target modification. This suggests a complex immune response and epitope spreading may occur in lungs of autoimmune disease associated-ILD patients.
JOURNAL OF AUTOIMMUNITY
(2021)
Review
Medicine, General & Internal
Stamatis-Nick C. Liossis, Constantina A. Bounia
Summary: Autoimmune rheumatic diseases can affect vital organs, with lung involvement being severe and difficult to treat. Rituximab is an off-label treatment for CTD-ILD, but studies have shown that it can effectively improve pulmonary function and reduce ILD symptoms.
FRONTIERS IN MEDICINE
(2022)
Review
Immunology
Yinlan Wu, Yanhong Li, Yubin Luo, Yu Zhou, Xiuping Liang, Lu Cheng, Tong Wu, Ji Wen, Chunyu Tan, Yi Liu
Summary: This paper reviews the application of proteomics in different subtypes of connective tissue disease-related interstitial lung disease (CTD-ILD), discussing the role of differentially expressed proteins in the development of pulmonary fibrosis and their potential clinical applications.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Respiratory System
R. P. Oliveira, R. Ribeiro, L. Melo, B. Grima, S. Oliveira, J. D. Alves
Summary: Connective tissue diseases (CTD) are frequently associated with interstitial lung disease (ILD), significantly impacting morbidity and mortality. This study analyzed the experience of an autoimmune specialized unit in treating CTD-ILD and characterized the patient population based on common diseases, imaging patterns, lung function tests results, serology, and treatment. It also assessed mortality and mortality predictors, with pulmonary hypertension identified as the most important predictor. The study highlights the importance of chest physicians in these specialized units.
Article
Medicine, General & Internal
Jiaqi Wang, Xiao Wang, Xiaoyan Qi, Zhijian Sun, Tao Zhang, Yi Cui, Qiang Shu
Summary: The combination treatment of pirfenidone (PFD) with immunosuppressant (IS) has shown significant improvement in prognosis for patients with CTD-ILD, especially those with SSc, IIM, and RA.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Natalia Mena-Vazquez, Francisco Javier Godoy-Navarrete, Jose Manuel Lisbona-Montanez, Rocio Redondo-Rodriguez, Sara Manrique-Arija, Jose Rioja, Arkaitz Mucientes, Patricia Ruiz-Limon, Aimara Garcia-Studer, Fernando Ortiz-Marquez, Begona Oliver-Martos, Laura Cano-Garcia, Antonio Fernandez-Nebro
Summary: This study aimed to identify inflammatory factors and soluble cytokines that act as biomarkers in the diagnosis and prognosis of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). The study found that patients with RA-ILD had higher inflammatory activity and certain cytokines were associated with both diagnosis and poorer prognosis in these patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Aiko Saku, Tomoyuki Fujisawa, Koji Nishimoto, Katsuhiro Yoshimura, Hironao Hozumi, Masato Karayama, Yuzo Suzuki, Kazuki Furuhashi, Noriyuki Enomoto, Yutaro Nakamura, Naoki Inui, Takafumi Suda
Summary: This study retrospectively reviewed medical records of 72 patients with RA-ILD and found that increased peripheral monocyte count was significantly associated with poor prognosis. Patients with high monocyte and neutrophil counts had lower survival rates, suggesting their potential as cellular biomarkers to predict outcomes in RA-ILD patients.
RESPIRATORY MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Yerin Kim, Hyung-In Yang, Kyoung-Soo Kim
Summary: This review summarizes and analyzes the etiology and pathogenesis of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). The incidence of RA-ILD increases with age and is higher in men, and is also associated with lifestyle factors such as smoking and exposure to pollutants. The presence of anti-cyclic citrullinated peptide antibody, high RA disease activity, and rheumatoid factor positivity increase the risk of RA-ILD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Matthew Wells, Sughra Alawi, Kyaing Yi Mon Thin, Harsha Gunawardena, Adrian R. Brown, Anthony Edey, John D. Pauling, Shaney L. Barratt, Huzaifa I. Adamali
Summary: Antisynthetase syndrome is a subtype of idiopathic inflammatory myopathy that is strongly associated with interstitial lung disease. Diagnosis is made by detecting specific antibodies and relevant clinical and radiologic features. A multidisciplinary team, including rheumatologists, respiratory physicians, and radiologists, is needed for accurate diagnosis.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Natalia Mena-Vazquez, Marta Rojas-Gimenez, Carmen Maria Romero-Barco, Sara Manrique-Arija, Ana Hidalgo Conde, Rocio Arnedo Diez de los Rios, Eva Cabrera Cesar, Rafaela Ortega-Castro, Francisco Espildora, Maria Carmen Aguilar-Hurtado, Isabel Anon-Onate, Lorena Perez-Albaladejo, Manuel Abarca-Costalago, Inmaculada Urena-Garnica, Maria Luisa Velloso-Feijoo, Rocio Redondo-Rodriguez, Antonio Fernandez-Nebro
Summary: The study found that about half of patients with interstitial lung disease associated with systemic autoimmune disease stabilize or improve after a median of 5 years, but over one-third of patients die. Rheumatoid arthritis is associated with higher rates of disease progression and hospitalization in ILD, while usual interstitial pneumonia pattern, FVC%, and smoking are independent predictors for worsening of ILD-SAI.
Article
Medicine, General & Internal
Manuel Silverio-Antonio, Joana Martins-Martinho, Ana Teresa Melo, Francisca Guimaraes, Eduardo Dourado, Daniela Oliveira, Jorge Lopes, Andre Saraiva, Ana Gago, Margarida Correia, Ana L. Fernandes, Sara Dinis, Rafaela Teixeira, Susana P. Silva, Carlos Costa, Tiago Beirao, Carolina Furtado, Pedro Abreu, Carmo Afonso, Nikita Khmelinskii
Summary: This retrospective study aimed to identify predictors of interstitial lung disease (ILD) in patients with mixed connective tissue disease (MCTD). The study found that gastroesophageal involvement and lymphadenopathy at disease onset were associated with ILD. Additionally, it established that lymphadenopathy at disease onset and older age at diagnosis independently predicted ILD in MCTD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Mitsuhiro Akiyama, Yuko Kaneko
Summary: Rheumatoid arthritis is an autoimmune disease that primarily affects the joints but can also lead to interstitial lung disease. Understanding the pathogenesis and clinical features of this condition is crucial for better management and improved prognosis. Currently, there is no established treatment strategy specifically for RA-ILD.
AUTOIMMUNITY REVIEWS
(2022)
Article
Cardiac & Cardiovascular Systems
Adelle S. Jee, Matthew J. S. Parker, Jane F. Bleasel, Lauren K. Troy, Edmund M. Lau, Helen E. Jo, Alan K. Y. Teoh, Susanne Webster, Stephen Adelstein, Tamera J. Corte
Summary: The study evaluated the diagnostic performance of MA-LIA for IIM-ILD and explored models combining clinical variables to improve patient identification. Results showed that combining MA-LIA with age, gender, clinical manifestations and HRCT features can enhance discrimination for IIM-ILD.
RESPIRATORY MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Takuya Kotani, Masaki Ikemoto, Shogo Matsuda, Ryota Masutani, Tohru Takeuchi
Summary: In this study, it was found that the hybrid protein hMIKO-1 can suppress the abnormal activation of macrophages, reduce lung fibrosis in mice, and decrease the expression of related inflammation factors, indicating its potential as a therapeutic candidate for ILD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Alesandra Florescu, Florin Liviu Gherghina, Anca Emanuela Musetescu, Vlad Padureanu, Anca Rosu, Mirela Marinela Florescu, Cristina Criveanu, Lucian-Mihai Florescu, Anca Bobirca
Summary: This review discusses interstitial lung disease (ILD) in patients with rheumatoid arthritis (RA), including its patterns, molecular mechanisms, and therapeutic challenges. Biomarkers have been found to be useful in identifying high-risk patients and guiding personalized treatment.
Article
Critical Care Medicine
Hironao Hozumi, Masato Kono, Hirotsugu Hasegawa, Hideki Yasui, Yuzo Suzuki, Masato Karayama, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Naoki Inui, Yutaro Nakamura, Koshi Yokomura, Hidenori Nakamura, Takafumi Suda
Summary: This study found that MPA-ILD represents a distinct phenotype with poor prognosis. A lower %FVC was identified as an independent prognostic factor, associated with increased mortality and risk of developing AE in MPA-ILD patients. Specific management strategies for MPA-ILD and AE should be established in the future.
Article
Oncology
Masato Karayama, Naoki Inui, Yusuke Inoue, Katsuhiro Yoshimura, Kazutaka Mori, Hironao Hozumi, Yuzo Suzuki, Kazuki Furuhashi, Tomoyuki Fujisawa, Noriyuki Enomoto, Yutaro Nakamura, Kazuhiro Asada, Tomohiro Uto, Masato Fujii, Takashi Matsui, Shun Matsuura, Dai Hashimoto, Mikio Toyoshima, Hideki Kusagaya, Hiroyuki Matsuda, Nao Inami, Yusuke Kaida, Mitsuru Niwa, Yasuhiro Ito, Takafumi Suda
Summary: Increased serum cholesterol and long-chain fatty acid levels were associated with prolonged survival in non-small cell lung cancer patients treated with nivolumab, suggesting that serum lipid levels may be predictive of the efficacy of immune checkpoint inhibitor therapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Respiratory System
Noriyuki Enomoto, Sakae Homma, Naohiko Inase, Yasuhiro Kondoh, Takeshi Saraya, Hajime Takizawa, Yoshikazu Inoue, Hiroshi Ishii, Yoshio Taguchi, Shinyu Izumi, Yasuhiko Yamano, Yoshinori Tanino, Yasuhiko Nishioka, Mikio Toyoshima, Koshi Yokomura, Shiro Imokawa, Naoki Koshimizu, Takehisa Sano, Taisuke Akamatsu, Hiroshi Mukae, Motoyasu Kato, Naoki Hamada, Hirofumi Chiba, Shinobu Akagawa, Shigeo Muro, Hironori Uruga, Hiroyuki Matsuda, Yusuke Kaida, Miho Kanai, Kazutaka Mori, Masafumi Masuda, Hironao Hozumi, Tomoyuki Fujisawa, Yutaro Nakamura, Noriyoshi Ogawa, Takafumi Suda
Summary: This nationwide multicentre study prospectively evaluated 376 patients with IIP, finding that 18.6% of them met the IPAF criteria. Patients with IPAF were more likely to develop systemic autoimmune diseases, had fewer acute exacerbations of IIP, and showed better survival outcomes. Cluster analysis identified a subgroup with more autoimmune features, predominantly female, and with a better prognosis.
Article
Cell Biology
Yuzo Suzuki, Yuya Aono, Norimichi Akiyama, Yasuoki Horiike, Hyogo Naoi, Ryo Horiguchi, Kiyoshi Shibata, Hironao Hozumi, Masato Karayama, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Naoki Inui, Takafumi Suda
Summary: Obesity is a common comorbidity in patients with asthma and obese asthma patients present the most refractory phenotype among patients with severe asthma. This study found that autophagy contributes to the exacerbation of eosinophilic inflammation in obese asthma, and modulation of autophagy may be a therapeutic target in obesity-associated asthma.
Article
Medicine, General & Internal
Yasutaka Mochizuka, Masato Kono, Mineo Katsumata, Ryutaro Hirama, Masayuki Watanuki, Yuiko Oshima, Kenichiro Takeda, Akari Tsutsumi, Hideki Miwa, Yoshihiro Miki, Dai Hashimoto, Noriyuki Enomoto, Yutaro Nakamura, Takafumi Suda, Hidenori Nakamura
Summary: This article reports a case of silicosis-associated sarcoid-like granulomatous lung disease, rather than sarcoidosis, in a patient with long-term exposure to silica. The patient's pulmonary manifestations improved after discontinuation of silica exposure and combination therapy.
Article
Oncology
Masato Karayama, Yusuke Inoue, Katsuhiro Yoshimura, Hironao Hozumi, Yuzo Suzuki, Kazuki Furuhashi, Tomoyuki Fujisawa, Noriyuki Enomoto, Yutaro Nakamura, Naoki Inui, Takafumi Suda
Summary: The nutritional status may affect the efficacy of nivolumab in NSCLC patients. A post hoc analysis of 158 NSCLC patients receiving nivolumab showed that low Geriatric Nutritional Risk Index (GNRI) was associated with shorter progression-free survival and overall survival. GNRI can predict the efficacy of immune checkpoint inhibitor therapy.
JOURNAL OF IMMUNOTHERAPY
(2022)
Article
Respiratory System
Kazuo Tsuchiya, Tomoyuki Fujisawa, Yasutaka Mochizuka, Sho Takuma, Kyohei Oishi, Yoshinari Endo, Yuko Tanaka, Atsuki Fukada, Hirofumi Watanabe, Mineo Katsumata, Yoichiro Aoshima, Yusuke Inoue, Yuzo Suzuki, Masato Karayama, Hironao Hozumi, Kazuki Furuhashi, Noriyuki Enomoto, Yutaro Nakamura, Naoki Inui, Takafumi Suda
Summary: This study retrospectively analyzed the changes in white blood cell counts in 12 COVID-19 patients who received combination therapy. It was found that the white blood cell count significantly decreased after the start of treatment and then significantly increased 48 hours later.
RESPIRATORY INVESTIGATION
(2022)
Article
Respiratory System
Hirofumi Watanabe, Masato Karayama, Yusuke Inoue, Hironao Hozumi, Yuzo Suzuki, Kazuki Furuhashi, Tomoyuki Fujisawa, Noriyuki Enomoto, Yutaro Nakamura, Naoki Inui, Takafumi Suda
Summary: A 72-year-old male patient with advanced lung adenocarcinoma and a BRAF mutation developed multiple organ infarction, including a massive thrombus in the descending aorta, after treatment with a BRAF inhibitor and a MEK inhibitor was discontinued.
RESPIRATORY MEDICINE CASE REPORTS
(2022)
Article
Respiratory System
Hyogo Naoi, Yuzo Suzuki, Kazutaka Mori, Yuya Aono, Masato Kono, Hirotsugu Hasegawa, Koshi Yokomura, Yusuke Inoue, Hironao Hozumi, Masato Karayama, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Naoki Inui, Hidenori Nakamura, Takafumi Suda
Summary: Antifibrotic therapy may reduce the risk of lung cancer development in patients with idiopathic pulmonary fibrosis (IPF) and potentially prolong their survival.
Article
Respiratory System
Mineo Katsumata, Tomoyuki Fujisawa, Yosuke Kamiya, Yuko Tanaka, Chiaki Kamiya, Yusuke Inoue, Hironao Hozumi, Masato Karayama, Yuzo Suzuki, Kazuki Furuhashi, Noriyuki Enomoto, Yutaro Nakamura, Naoki Inui, Masato Maekawa, Mitsutoshi Setou, Hiroshi Watanabe, Koji Ikegami, Takafumi Suda
Summary: Long-acting muscarinic antagonists (LAMAs) have a direct enhancing effect on airway ciliary functions and may improve impaired mucociliary clearance in asthma and COPD.
BMC PULMONARY MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Noriyuki Enomoto
Summary: This review discusses the life-threatening rapidly progressive interstitial lung diseases and provides an overview of the clinical characteristics, diagnostic methods, and treatment strategies for each disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Respiratory System
Yuko Tanaka, Yuzo Suzuki, Hirotsugu Hasegawa, Koshi Yokomura, Atsuki Fukada, Yusuke Inoue, Hironao Hozumi, Masato Karayama, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Naoki Inui, Takafumi Suda
Summary: This study developed a method for assessing pulmonary physiology using standardized 3D-CT-derived lung volumes, and validated its predictive value for mortality in patients with IPF and IPF acute exacerbation.
RESPIRATORY RESEARCH
(2022)
Article
Respiratory System
Takafumi Koyauchi, Yuzo Suzuki, Kazuki Sato, Hironao Hozumi, Masato Karayama, Kazuki Furuhashi, Tomoyuki Fujisawa, Noriyuki Enomoto, Yutaro Nakamura, Naoki Inui, Koshi Yokomura, Shiro Imokawa, Hidenori Nakamura, Tatsuya Morita, Takafumi Suda
Summary: This multicenter study investigated the impact of end-of-life respiratory modalities on quality of dying and death (QODD) and symptom relief among patients dying with interstitial lung disease (ILD). The results showed that high-flow nasal cannula (HFNC) was associated with higher QODD and symptom relief ratings from bereaved families, suggesting it may improve outcomes for patients dying in a hospital setting with end-stage ILD.
RESPIRATORY RESEARCH
(2022)
Article
Respiratory System
Yasutaka Mochizuka, Tomoyuki Fujisawa, Yusuke Inoue, Hironao Hozumi, Yuzo Suzuki, Masato Karayama, Kazuki Furuhashi, Noriyuki Enomoto, Yutaro Nakamura, Naoki Inui, Takafumi Suda
Summary: We report a case of eosinophilic pneumonia induced by trimethoprim-sulfamethoxazole (TMP-SMX) in a 27-year-old woman. Radiological examination showed bilateral nonsegmental airspace consolidation resembling cryptogenic organizing pneumonia. Eosinophil infiltration was observed in lung specimens and there was marked eosinophilia in the peripheral blood and bronchoalveolar lavage fluid. Discontinuation of TMP-SMX improved eosinophilia and radiological abnormality, confirming the association between TMP-SMX use and onset of eosinophilic pneumonia. TMP-SMX induced eosinophilic pneumonia is rare, but clinicians should be aware of the possibility during TMP-SMX administration.
RESPIRATORY MEDICINE CASE REPORTS
(2022)
Article
Respiratory System
Hironao Hozumi, Masato Kono, Hirotsugu Hasegawa, Shinpei Kato, Yusuke Inoue, Yuzo Suzuki, Masato Karayama, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Naoki Inui, Yutaro Nakamura, Koshi Yokomura, Hidenori Nakamura, Takafumi Suda
Summary: This study found that post-AE mortality was high in patients with AE-RA-ILD, similar to AE-IPF patients. The study also created a predictive model for AE-RA-ILD mortality, which can aid in the management of these patients.
RESPIRATORY RESEARCH
(2022)
