Article
Medicine, General & Internal
Einat Shmueli, Yulia Gendler, Patrick Stafler, Hagit Levine, Guy Steuer, Ophir Bar-On, Hannah Blau, Dario Prais, Meir Mei-Zahav
Summary: The study aims to evaluate if dynamic hyperinflation (DH) can predict pulmonary deterioration in cystic fibrosis (CF) patients and explore its association with peak VO2. The results showed a significant decline in lung function (FEV1%) trend in the DH group, and the DH group had a higher frequency of intravenous antibiotic treatment in the 4 years after CPETs. Peak VO2 was also correlated with lung function deterioration and intravenous antibiotic treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pediatrics
Li Yun Teng, Sen Wei Tsai, Chun Yuan Hsiao, Wei Hung Sung, Ko Long Lin
Summary: The study found no significant differences in exercise capacity among patients with pulmonary valve stenosis treated with BPV, those under follow-up care, and healthy controls. Pulmonary function also did not significantly differ between the groups. Pulmonary artery pulse wave velocity significantly decreased after catheterization, but not after follow-up care, while pulmonary valve area significantly improved in the group that received BPV treatment.
FRONTIERS IN PEDIATRICS
(2022)
Article
Rehabilitation
Aline Marsico, Simone Dal Corso, Etiene F. De Carvalho, Vivian Arakelian, Shane Phillips, Roberto Stirbulov, Igor Polonio, Flavia Navarro, Fernanda Consolim-Colombo, Lawrence P. Cahalin, Luciana M. Malosa Sampaio
Summary: This study compared physiological responses among three field walk tests and cardiopulmonary exercise testing in patients with pulmonary hypertension. The incremental shuttle walk test (ISWT) achieved the highest physiological response, making it the most effective test for assessing functional capacity of PH patients.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2021)
Article
Respiratory System
Josuel Ora, Emanuela Prendi, Beatrice Ludovica Ritondo, Xhesika Pata, Florian Spada, Paola Rogliani
Summary: Pulmonary rehabilitation improves exercise tolerance in NCFB patients, with a modest impact on respiratory function.
Article
Medicine, Research & Experimental
Yan Gao, Zhaoyun Yang, Kang He, Zeyu Wang, Tingyu Zhang, Jiang Yi, Lijing Zhao
Summary: This study found that exercise has anti-inflammatory and antioxidant effects on pulmonary fibrosis induced by paraquat, reducing the infiltration of inflammatory cells and fibrotic lesions. Furthermore, exercise also increased the expression of antioxidative distress proteins, improved the degree of epithelial-mesenchymal transition in alveolar epithelial cells, and ultimately alleviated paraquat-induced pulmonary fibrosis.
Article
Respiratory System
Sabina Anna Guler, Seo Am Hur, Michael K. Stickland, Patrick Brun, Luc Bovet, Anne E. Holland, Janet Bondarenko, Nathan Hambly, Joshua Wald, Nima Makhdami, Michael Kreuter, Rainer Gloeckl, Inga Jarosch, Benjamin Tan, Kerri A. Johannson, S. Ainslie McBride, Kaissa De Boer, Jacqueline S. Sandoz, Kelly Sun, Deborah Assayag, Surya P. Bhatt, Julie Morisset, Vincent Ferraro, Chris Garvey, Pat G. Camp, Christopher J. Ryerson
Summary: Improvement in physical performance during pulmonary rehabilitation is associated with better survival in patients with fibrotic ILD. Participation in at least 80% of planned outpatient PR sessions is linked to a 33% lower risk of death.
Article
Critical Care Medicine
Thorsten Derlin, Benedikt Jaeger, Danny Jonigk, Rosa M. Apel, Julia Freise, Hoen-Oh Shin, Desiree Weiberg, Gregor Warnecke, Tobias L. Ross, Hans-Jurgen Wester, Benjamin Seeliger, Tobias Welte, Frank M. Bengel, Antje Prasse
Summary: Quantitative molecular imaging of pulmonary CXCR4 expression may predict response to pirfenidone treatment and prognosis in patients with IPF. This method could potentially serve as a future biomarker for personalized guidance of antifibrotic treatment.
Article
Pediatrics
Lisa M. Wilson, Matthew J. Ellis, Rebecca L. Lane, John W. Wilson, Dominic T. Keating, Shapour Jaberzadeh, Brenda M. Button
Summary: The study developed a new incremental maximal step test (A-STEP) to assess exercise capacity in pwCF, avoiding floor or ceiling effects, while addressing space restrictions and infection prevention requirements.
PEDIATRIC PULMONOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tim J. M. Wallis, Magdalena Minnion, Anna Freeman, Andrew Bates, James M. Otto, Stephen A. Wootton, Sophie V. Fletcher, Michael P. W. Grocott, Martin Feelisch, Mark G. Jones, Sandy Jack
Summary: A study found that individualized aerobic interval training can improve exercise capacity and redox status in idiopathic pulmonary fibrosis (IPF) patients. After an 8-week training program, patients showed significant improvements in exercise capacity and redox status.
Article
Respiratory System
Gabriella Tikellis, Allison Tong, Joanna Y. T. Lee, Tamera J. Corte, Alison J. Hey-Cunningham, Michael Bartlett, Tonia Crawford, Ian Glaspole, John Price, Jamie Maloney, Anne E. Holland
Summary: The top 10 research priorities for pulmonary fibrosis include medications to reverse scarring in the lungs, improving lung function, alleviating symptoms, prevention of PF, and the best exercise programme for PF. Interventions for preserving lung health and alleviation of symptom burden were identified as the top research priorities for PF stakeholders.
Article
Medicine, General & Internal
Michele Vitacca, Mara Paneroni, Beatrice Salvi, Antonio Spanevello, Piero Ceriana, Claudio Bruschi, Bruno Balbi, Maria Aliani, Nicolino Ambrosino
Summary: This study suggests that the success rate of pulmonary rehabilitation (PR) is not affected by airflow severity and outcome measures in individuals with severe COPD recovering from exacerbation. In addition to the commonly used outcome measures, Barthel dyspnoea index and Short Physical Performance Battery are also sensitive to PR.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Medicine, General & Internal
Barbara Wagner, Andrej Zdravkovic, Michael Pirchl, Milo A. Puhan, Ralf Harun Zwick, Vincent Grote, Richard Crevenna, Michael J. Fischer
Summary: The study introduced a new method, T2D, for classifying patient performance before and after rehabilitation, which takes into account the patient's current status and changes over time. Results showed that some patients, after reaching the MCID standard in absolute differences, were still classified as below average by T2D, and vice versa.
Article
Critical Care Medicine
Lindsay M. Forbes, Todd M. Bull, Tim Lahm, Barry J. Make, William K. Cornwell III
Summary: Right ventricular dysfunction in pulmonary hypertension has negative implications for exercise capacity, morbidity, and mortality. During exercise, right ventricular afterload may increase disproportionately, impairing right ventricular contractility and limiting cardiac output. Abnormal pulmonary vascular response to exercise can signal early disease and increased mortality. Exercise testing can evaluate pulmonary vascular response and right ventricular contractile reserve. More research is needed to determine the role of exercise stress testing in the management of pulmonary vascular disease.
Review
Medicine, General & Internal
Beatrice Pezzuto, Piergiuseppe Agostoni
Summary: Pulmonary arterial hypertension (PAH) is a progressive disease that has a poor prognosis if not treated. Despite advances in understanding the disease and its treatment, a definitive cure is still lacking. Early diagnosis and treatment have been emphasized to improve the prognosis. Cardiopulmonary exercise testing (CPET) is the standard method for assessing functional capacity and the underlying mechanisms of exercise limitation. It has been shown to be valuable in early detection, differential diagnosis, and prognostic stratification of PAH patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Mathilde Blanquez-Nadal, Nicolas Piliero, Alicia Guillien, Stephane Doutreleau, Muriel Salvat, Frederic Thony, Christophe Pison, Caroline Augier, Helene Bouvaist, Bernard Aguilaniu, Bruno Degano
Summary: Balloon pulmonary angioplasty (BPA) improves ventilatory efficiency and gas exchange during exercise in chronic thromboembolic pulmonary hypertension (CTEPH) patients. Measurement of DLCO may serve as a valuable predictor for the response to BPA treatment in terms of pulmonary gas exchange.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Rehabilitation
Atsuhito Nakazawa, Leona M. Dowman, Narelle S. Cox, Danny J. Brazzale, Christine F. McDonald, Catherine J. Hill, Annemarie Lee, Anne E. Holland
Summary: This study investigates whether walking training prescribed at 80% of the average speed of the 6-minute walk test is suitable for pulmonary rehabilitation (PR) for individuals with interstitial lung disease (ILD). The results show that walking training at this intensity can provide adequate exercise training for PR in ILD patients.
PHYSIOTHERAPY THEORY AND PRACTICE
(2023)
Article
Medicine, General & Internal
Ariel Dahan, Sergio Farina, Natasha E. Holmes, Stefan Kachel, Christine F. McDonald, Jane E. Lewis, Nada Marhoon, Fumitaka Yanase, Natalie Yang, Rinaldo Bellomo
Summary: This study examines the impact of clinical context on anticoagulation and outcomes of subsegmental pulmonary embolism (SSPE). The results suggest that patients with SSPE have a high mortality rate due to coexistent disease processes, regardless of anticoagulation treatment.
INTERNAL MEDICINE JOURNAL
(2023)
Editorial Material
Orthopedics
Janet Bondarenko, Anne E. Holland
JOURNAL OF PHYSIOTHERAPY
(2023)
Article
Medicine, General & Internal
Stuart F. Quan, Matthew D. Weaver, Mark E. Czeisler, Laura K. Barger, Lauren A. Booker, Mark E. Howard, Melinda L. Jackson, Rashon I. Lane, Christine F. McDonald, Anna Ridgers, Rebecca Robbins, Prerna Varma, Joshua F. Wiley, Shantha M. W. Rajaratnam, Charles A. Czeisler
Summary: Based on a cross-sectional survey of 19,926 US adults, the study found that poor sleep quality and extremely long or short sleep durations were associated with an increased risk of COVID-19 infection. Poor sleep quality was also associated with an increased need for hospitalization due to severe COVID-19 illness.
AMERICAN JOURNAL OF MEDICINE
(2023)
Article
Health Care Sciences & Services
Adnan Ansar, Virginia Lewis, Christine Faye McDonald, Chaojie Liu, Muhammad Aziz Rahman
Summary: This study investigated the factors associated with timeliness of care in the healthcare seeking pathway among lung cancer patients in Bangladesh. Data was collected from 418 patients through face-to-face interviews using a structured questionnaire. The results showed that higher education and income levels were associated with shorter intervals, while consulting informal healthcare providers and multiple providers were associated with longer intervals.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Respiratory System
Yet H. Khor, Vincent Cottin, Anne E. Holland, Yoshikazu Inoue, Vanessa M. McDonald, Justin Oldham, Elisabetta A. Renzoni, Anne Marie Russell, Mary E. Strek, Christopher J. Ryerson
Summary: Interstitial lung disease (ILD) is a diverse group of lung conditions that cause inflammation and fibrosis, resulting in significant morbidity and mortality. Beyond the lungs, various factors influence symptoms, quality of life, disease progression, and survival in ILD patients. This article explores the potential application of the treatable traits approach in ILD, which focuses on individualized assessment and targeted interventions for specific traits. The authors propose a framework of treatable traits in ILD and suggest key research directions for advancing patient care and health outcomes.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Pediatrics
Fernanda C. Lanza, Jenifer Santos, Jessyca P. Selman, Ariane O. Crispim, Karina S. Nascimento, Giovanna M. Souza, Danila V. B. Cano, Anne E. Holland, Dirceu Sole, Simone Dal Corso
Summary: The study developed a new test for assessing functional performance in children and adolescents with asthma (PAY test) and found it to be a valid and reproducible tool.
JORNAL DE PEDIATRIA
(2023)
Article
Respiratory System
Anne B. Chang, Scott C. Bell, Catherine A. Byrnes, Paul Dawkins, Anne E. Holland, Emma Kennedy, Paul T. King, Pamela Laird, Sarah Mooney, Lucy Morgan, Marianne Parsons, Betty Poot, Maree Toombs, Paul J. Torzillo, Keith Grimwood
Summary: This position statement provides updated guidelines for the management of chronic suppurative lung disease (CSLD) and bronchiectasis in Australian and New Zealand children/adolescents and adults. The guidelines emphasize early diagnosis, using chest computed-tomography scans, and a baseline panel of investigations to assess severity and develop individualized management plans. Intensive treatment is recommended to improve symptom control and lung function, while individualized airway clearance techniques, regular exercise, and proper nutrition are also important. Exacerbations should be treated with appropriate antibiotics, and ongoing care and monitoring are crucial, especially for under-served populations.
Article
Rehabilitation
Luis H. G. Neves, Carla Malaguti, Marissa R. Santos, Laura A. Cabral, Laura B. D. da Silva, Hugo H. de Oliveira, Alessa S. S. Brugiolo, Anderson Jose, Anne E. Holland, Cristino C. Oliveira
Summary: This study evaluated the feasibility, acceptability, implementation, practicality, and adaptation of pulmonary telerehabilitation (PTR) for people with Chronic Obstructive Pulmonary Disease (COPD) in Brazil. The study found that most participants had good acceptability, implementation, and practicality of PTR sessions. Younger age and higher education were associated with greater acceptability of PTR.
INTERNATIONAL JOURNAL OF TELEREHABILITATION
(2023)
Article
Respiratory System
Jennifer M. V. Mann, Anne E. Holland, Nicole S. L. Goh, Yet H. Khor
Summary: Chronic cough is a common and burdensome symptom in patients with interstitial lung disease (ILD). This study aimed to explore the characteristics and impacts of chronic cough in ILD patients. Patients experienced a spectrum of cough severity and characteristics, with physical, social, and emotional impacts contributing to symptom burden. Management strategies included various approaches such as medication, throat lozenges, and relaxation exercises. The findings highlight the need for further information and education on chronic cough in ILD patients.
Letter
Respiratory System
Narelle S. Cox, Angela T. Burge, Anne E. Holland
Editorial Material
Respiratory System
Marlies Wijsenbeek, Claudia Valenzuela, Anne Holland
EUROPEAN RESPIRATORY JOURNAL
(2023)
Review
Respiratory System
Gabriella Tikellis, Mariana Hoffman, Christie Mellerick, Angela T. Burge, Anne E. Holland
Summary: This systematic review identified the barriers to and facilitators of oxygen therapy use in people with interstitial lung disease (ILD), caregivers, and health professionals. The design of the oxygen delivery system, cost, financing, stigmatization, physical environment, and individual needs were found to impact the optimization of oxygen therapy. Strengthening international guidelines, improving funding models, and providing better oxygen delivery systems that meet user needs, along with increased information and support for users, are crucial to optimize the uptake and outcomes of this therapy.
EUROPEAN RESPIRATORY REVIEW
(2023)
Review
Respiratory System
Joanna Y. T. Lee, Gabriella Tikellis, Leona Dowman, Arwel W. Jones, Mariana Hoffman, Christie R. Mellerick, Carla Malaguti, Yet H. Khor, Anne E. Holland
Summary: This review examined the common self-management components, outcome measures, and impact in individuals with pulmonary fibrosis (PF). The results showed that education, symptom management, and psychosocial well-being were common self-management components. These components were predominantly delivered in pulmonary rehabilitation settings and no studies tested PF-specific self-management packages.
EUROPEAN RESPIRATORY REVIEW
(2023)
Review
Respiratory System
Ana Oliveira, Gaia Fabbri, Thomas Gille, Elena Bargagli, Boris Duchemann, Rachel Evans, Hilary Pinnock, Anne E. Holland, Elisabetta Renzoni, Magnus Ekstrom, Steve Jones, Marlies Wijsenbeek, Anh Tuan Dinh-Xuan, Guido Vagheggini
Summary: This article summarizes the main needs of patients with progressive pulmonary fibrosis (PF) and their caregivers and proposes a supportive care approach. Personalized care, education, emotional and psychological support, specialized treatments, and better access to information and resources are necessary. Treatment should start at diagnosis and be tailored to the patient's needs, including individualized pharmacological and non-pharmacological interventions such as oxygen therapy and pulmonary rehabilitation.