Article
Biochemistry & Molecular Biology
Supanat Lumbikananda, Thanaporn Sriwantana, Krit Rattanawonsakul, Tipparat Parakaw, Chareerut Phruksaniyom, Kanyawat Rattanasuwan, Pornpun Vivithanaporn, Charoensri Thonabulsombat, Nathawut Sibmooh, Sirada Srihirun
Summary: The study found that nitrite in stimulated saliva is correlated with blood nitrite levels, while nitrite in unstimulated saliva shows no correlation with blood nitrite. Platelet activity in baseline, determined by P-selectin expression, is negatively correlated with nitrite in blood and post-mouthwash stimulated saliva. Additionally, salivary nitrate levels correlate with plasma nitrate levels.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2021)
Article
Nutrition & Dietetics
Barbora Piknova, Ji Won Park, Samantha M. Thomas, Khalid J. Tunau-Spencer, Alan N. Schechter
Summary: Nitric oxide (NO) (co)regulates physiological processes in the body and its availability is affected by aging. Aging leads to changes in nitrate and nitrite contents in tissues, with higher nitrate levels and lower nitrite levels in old rats compared to young rats. However, the nitrate reduction pathway is not affected by aging. Further investigation is needed to understand the changes in NO accessibility during aging.
Article
Medicine, Research & Experimental
Sabina Galiniak, Nataliya Rohovyk, Marta Rachel
Summary: The measurement of biomarkers in exhaled breath condensate (EBC) offers a non-invasive way to assess airway disease and oxidative and nitrosative stress in patients with cystic fibrosis (CF). In this study, markers of nitrosative stress were assessed in EBC and serum samples collected simultaneously from CF patients. Results showed no differences in nitrosative stress markers in EBC between CF patients and healthy controls, while serum markers were significantly higher in CF patients. The EBC values may not be dependent on the levels of circulating markers in stable CF patients.
ADVANCES IN MEDICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Rose I. M. Batista, Renato C. Nogueira, Graziele C. Ferreira, Gustavo H. Oliveira-Paula, Lucas C. Pinheiro, Jose E. Tanus-Santos
Summary: Supplementation with L-arginine has been shown to have beneficial effects in hypertension by increasing nitric oxide formation and enhancing nitrate concentrations, but these effects may be prevented by antiseptic mouthwash. Alteration of the nitrate cycle in the body by mouthwash can impact endothelial dysfunction, antihypertensive effects, and antioxidant effects of L-arginine in hypertensive rats. The findings suggest a new mechanism where antibacterial mouth rinse can affect arterial blood pressure and the development of cardiovascular diseases.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tijana Suboticki, Olivera Mitrovic Ajtic, Dragoslava Djikic, Marijana Kovacic, Juan F. Santibanez, Milica Tosic, Vladan P. Cokic
Summary: In various systems, hydroxyurea has been shown to stimulate the release of nitric oxide or activate nitric oxide synthase. Through inhibiting nitric oxide metabolites, hydroxyurea is able to inhibit the growth of mature erythroid colonies and impact the presence of iNOS immunoreactive CFU-E.
Review
Pharmacology & Pharmacy
Kayleigh Griffiths, Jordan J. Lee, Michael P. Frenneaux, Martin Feelisch, Melanie Madhani
Summary: Nitric oxide plays a crucial role in protecting the heart from ischemia reperfusion injury through the 'canonical' NO-sGC-cGMP pathway. A new nitrate-nitrite-NO pathway has been discovered to improve endothelial dysfunction, protect the myocardium and reduce infarct size. Nitrite itself also provides multi-faceted protection independent of nitric oxide against various pathophysiologies of IRI.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Lulu Yao, Huimin Fu, Lu Bai, Wenwen Deng, Fang Xie, Ying Li, Rong Zhang, Xinjie Xu, Ting Wang, Shenghan Lai, Jun Wang
Summary: This study found that saliva nitrite levels were significantly higher in children with ASD compared to those in the ND group, and there was a positive correlation between saliva NO2 (-) and serum NO3 (-) in ASD children. Male children with ASD had significantly higher levels of NO compared to boys in the ND group, and saliva may serve as a predictor of health status in children with ASD.
Article
Food Science & Technology
Raul Bescos, Mark L. Rollason, Tanisha S. Davies, Patricia Casas-Agustench
Summary: This study analyzed the content of nitrate (NO3-) and nitrite (NO2-) in commercial and self-made beetroot juices (BJs), finding that the levels of NO3- can vary with different seasons and storage conditions. The self-made BJ showed complete degradation of NO3- after 3 days at 20 degrees C, but this degradation was attenuated when stored at lower temperatures or with the addition of lemon juice. Additionally, self-made BJs had higher concentrations of NO2- and a higher pH compared to commercial BJs.
FOOD SCIENCE & NUTRITION
(2023)
Article
Cell Biology
Florentin-Daniel Staicu, Analuce Canha-Gouveia, Cristina Soriano-Ubeda, Juan Carlos Martinez-Soto, Evdochia Adoamnei, Jorge E. Chavarro, Carmen Matas
Summary: The levels of nitrite and nitrate in follicular fluid were found to be related to the yield of MII oocytes, and nitrate levels showed a suggestive inverse correlation with embryos with high potential of implantation. This suggests that nitrite and nitrate concentrations in follicular fluid may be useful in predicting ovarian response and embryo implantation potential.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Clinical Neurology
Yicong Wang, Weiqi Chen, Jian Zhou, Yongjun Wang, Hao Wang, Yilong Wang
Summary: This review aims to describe the relationship between nitrate metabolism and cerebrovascular disease, providing a basis for further advances in laboratory and clinical medicine.
FRONTIERS IN NEUROLOGY
(2022)
Article
Nutrition & Dietetics
Gary D. Miller, Beverly A. Nesbit, Daniel B. Kim-Shapiro, Swati Basu, Michael J. Berry
Summary: This study aimed to investigate the acute response of plasma nitrate and nitrite levels in healthy middle- to older-aged adults to beetroot juice alone and in combination with vitamin C or protein. The results showed no significant differences in plasma nitrate and nitrite levels at 1 h and 3 h after co-ingesting beetroot juice with vitamin C or a whey protein supplement compared to beetroot juice alone.
Article
Physiology
Michaela L. Sundqvist, Jon O. Lundberg, Eddie Weitzberg, Mattias Carlstrom
Summary: The study aimed to investigate potential sex differences in renal nitrate handling during low and high dietary nitrate intake. It was hypothesized that renal clearance and excretion of nitrate are higher in men compared to women. Results showed that women had lower urinary nitrate concentration, amount of nitrate excreted, renal nitrate clearance, and fractional excretion of nitrate compared to men.
Article
Biochemistry & Molecular Biology
Samuel J. Gentle, Khandaker A. Ahmed, Nengjun Yi, Casey D. Morrow, Namasivayam Ambalavanan, Charitharth Lal, Rakesh P. Patel
Summary: The study found that nitrate reductase activity in the oral cavity peaked at 29 weeks' post menstrual age, and infants who developed bronchopulmonary dysplasia (BPD) had significantly lower nitrate reductase activity at this time. The oral microbiota and nitrate reductase activity may play a role in the development of BPD in extremely preterm infants.
Review
Biochemistry & Molecular Biology
Zahra Bahadoran, Parvin Mirmiran, Khosrow Kashfi, Asghar Ghasemi
Summary: The lack of beneficial metabolic effects of inorganic NO3- in patients with T2DM may be attributed to species differences in AA metabolism and abnormal AA metabolism in patients with T2DM. Supplementation of AA may be needed for T2DM patients to attain the benefits of inorganic NO3- therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Physiology
Lauren K. Park, Andrew R. Coggan, Linda R. Peterson
Summary: Despite advances, heart failure with reduced ejection fraction (HFrEF) remains a deadly and disabling disease. Exercise capacity is closely linked to survival in HFrEF patients, and impaired nitric oxide (NO) bioavailability plays a key role in skeletal muscle pathology. Ingestion of inorganic nitrate has shown potential in improving exercise performance for HFrEF patients.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Allergy
Charlotte Heijkenskjold-Rentzhog, Pia Kalm-Stephens, Lennart Nordvall, Andrei Malinovschi, Kjell Alving
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2015)
Article
Allergy
Jon R. Konradsen, Elizabeth Skantz, Bjorn Nordlund, Marika Lidegran, Anna James, Junya Ono, Shoichiro Ohta, Kenji Izuhara, Sven-Erik Dahlen, Kjell Alving, Gunilla Hedlin
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2015)
Article
Multidisciplinary Sciences
Jennifer Johnson, Magnus P. Borres, Lennart Nordvall, Jonas Lidholm, Christer Janson, Kjell Alving, Andrei Malinovschi
Article
Allergy
A. Patelis, M. Gunnbjornsdottir, K. Alving, M. P. Borres, M. Hogman, C. Janson, A. Malinovschi
CLINICAL AND EXPERIMENTAL ALLERGY
(2016)
Article
Cardiac & Cardiovascular Systems
Elisabet Nerpin, Tiago Jacinto, Joao A. Fonseca, Kjell Alving, Christer Janson, Andrei Malinovschi
RESPIRATORY MEDICINE
(2018)
Editorial Material
Allergy
Kjell Alving
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2018)
Article
Physiology
Tiago Jacinto, Rita Amaral, Andrei Malinovschi, Christer Janson, Joao Fonseca, Kjell Alving
JOURNAL OF APPLIED PHYSIOLOGY
(2018)
Article
Multidisciplinary Sciences
Antonios Patelis, Maria Gunnbjornsdottir, Magnus P. Borres, Peter Burney, Thorarinn Gislason, Kjell Toren, Bertil Forsberg, Kjell Alving, Andrei Malinovschi, Christer Janson
Review
Cardiac & Cardiovascular Systems
Leif Bjermer, Kjell Alving, Zuzana Diamant, Helgo Magnussen, Ian Pavord, Giorgio Piacentini, David Price, Nicolas Roche, Joaquin Sastre, Mike Thomas, Omar Usmani
RESPIRATORY MEDICINE
(2014)
Article
Allergy
Maya Salomonsson, Andrei Malinovschi, Pia Kalm-Stephens, Joakim S. Dahlin, Christer Janson, Kjell Alving, Jenny Hallgren
CLINICAL AND EXPERIMENTAL ALLERGY
(2019)
Letter
Allergy
Kjell Alving, Zuzana Diamant, Sarah Lucas, Helgo Magnussen, Ian D. Pavord, Giorgio Piacentini, David Price, Nicolas Roche, Joaquin Sastre, Mike Thomas, Omar Usmani, Leif Bjermer
Letter
Allergy
Blondal Viiu, Janson Christer, Sundbom Fredrik, P. Borres Magnus, Hallgren Jenny, Tsolakis Nikolaos, Alving Kjell, Malinovschi Andrei
Article
Medicine, General & Internal
Rickard Lagedal, Oskar Eriksson, Anna Sorman, Joram B. Huckriede, Bjarne Kristensen, Stephanie Franzen, Anders Larsson, Anders Bergqvist, Kjell Alving, Anders Forslund, Barbro Persson, Kristina N. Ekdahl, Pablo Garcia de Frutos, Bo Nilsson, Gerry A. F. Nicolaes, Miklos Lipcsey, Michael Hultstrom, Robert Frithiof
Summary: The antibody response in critically ill patients with COVID-19 is associated with organ failure, systemic histone release, and increased 30-day mortality.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Allergy
Kjell Alving, William G. Teague
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Biochemical Research Methods
Tiago Jacinto, Andrei Malinovschi, Christer Janson, Joao Fonseca, Kjell Alving
JOURNAL OF BREATH RESEARCH
(2015)