Article
Multidisciplinary Sciences
Marine Peyneau, Vanessa Granger, Paul-Henri Wicky, Dounia Khelifi-Touhami, Jean-Francois Timsit, Francois-Xavier Lescure, Yazdan Yazdanpanah, Alexy Tran-Dinh, Philippe Montravers, Renato C. Monteiro, Sylvie Chollet-Martin, Margarita Hurtado-Nedelec, Luc de Chaisemartin
Summary: This study investigated the correlation between circulating innate phagocytes and disease severity in COVID-19 patients. The results showed abnormal phenotype of neutrophils and monocytes, elevated concentrations of activation markers in plasma. Critical patients exhibited increased immature and immunosuppressive neutrophils, downregulated HLA-DR monocytes, which were closely associated with disease severity. Additionally, impaired antimicrobial functions in neutrophils and monocytes of critical patients were correlated with organ dysfunction, severe infections, and mortality.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Qianying Lu, Sifan Yu, Xiangyan Meng, Mingyu Shi, Siyu Huang, Junfeng Li, Jianfeng Zhang, Yangfan Liang, Mengjun Ji, Yanmei Zhao, Haojun Fan
Summary: Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is an inflammatory response that destroys lung parenchymal cells and reduces lung function. MicroRNAs play a crucial role in regulating inflammatory and immune responses in ALI/ARDS and may serve as diagnostic indicators and therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Pei-Yao Liu, Chih-Yuan Chen, Yu-Lung Lin, Chien-Ming Lin, Wen-Chiuan Tsai, Yu-Ling Tsai, Gu-Jiun Lin, Yu-Guang Chen, Shih-Yun Wang, Rui-Nong Sun, Yu-Chuan Huang, Hung Chang, Ying-Chuan Chen
Summary: Acute lung injury (ALI) is a severe condition characterized by pulmonary inflammation, barrier disruption, and oedema. This study identifies RNF128 as a negative regulator of ALI by inhibiting neutrophil activation, reducing pro-inflammatory cytokines, and targeting TLR4 for degradation. Overexpression of RNF128 alleviates lung damage and reduces inflammatory cell infiltration, suggesting its potential as a therapeutic candidate for ALI.
CELL DEATH & DISEASE
(2023)
Review
Medicine, Research & Experimental
Chaojin Chen, Yufeng He, Yawei Feng, Weilong Hong, Gangjian Luo, Zhiqiang Ye
Summary: Acute lung inflammatory diseases have a significant impact on patients' recovery and outcomes globally, with long noncoding RNAs (lncRNAs) playing a crucial role in acute inflammatory response. LncRNAs are involved in various cellular processes to limit potential deleterious effects.
Article
Plant Sciences
Qi Feng, Yu Si, Lingling Zhu, Feng Wang, Junqiang Fang, Chun Pan, Xiangdong Gao, Wei Liu
Summary: The polysaccharide SERP 30 extracted from Sarcandra glabra showed potential anti-inflammatory and antioxidant effects, improving lung damage, reducing inflammation, and maintaining integrity of the endothelial glycocalyx. The main anti-inflammatory mechanism is likely through inhibiting NF-kappa B and MAPK signaling pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Pradeesh Sivapalan, Barbara Bonnesen, Jens-Ulrik Jensen
Summary: ARDS is an acute inflammation of the lung caused by damage to the alveolar-capillary membrane, diagnosed using a combination of clinical and physiological variables. Recent research has identified biomarkers associated with ARDS pathophysiology, which may be useful for diagnosis and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Xiaoting Yang, Jing Wang, Wei Liu
Summary: In this study, molecular markers associated with type II alveolar epithelial cell injury in acute lung injury (ALI) were identified using bioinformatics methods. The results provide new insights for the diagnosis and treatment of ALI/ARDS.
SCIENTIFIC REPORTS
(2023)
Review
Pharmacology & Pharmacy
Liu Wang, Yan-Fen Tian, Wen-Qing Deng
Summary: This study conducted a systematic review and meta-analysis to evaluate the effects of metformin on ARDS. The results showed that metformin can inhibit pulmonary inflammation and oxidative stress, and improve lung injury and survival rates. More randomized controlled trials are needed to confirm these findings.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Samantha A. Livingstone, Karin S. Wildi, Heidi J. Dalton, Asad Usman, Katrina K. Ki, Margaret R. Passmore, Gianluigi Li Bassi, Jacky Y. Suen, John F. Fraser
Summary: Acute Respiratory Distress Syndrome (ARDS) is a severe disease with varying incidence rates globally. The interplay between inflammation and coagulation is crucial in understanding the underlying mechanisms of ARDS. A holistic approach to studying both systems is essential for improved patient outcomes and development of diagnostic testing and treatments.
FRONTIERS IN MEDICINE
(2021)
Review
Medicine, General & Internal
Mengdi Qu, Hao Zhang, Zhaoyuan Chen, Xingfeng Sun, Shuainan Zhu, Ke Nan, Wankun Chen, Changhong Miao
Summary: ?Ferroptosis is a newly discovered type of regulated cell death characterized by iron-dependent lipid peroxidation. It is involved in the pathological development of various diseases and recent studies suggest its potential as a therapeutic target for acute lung injury/acute respiratory distress syndrome.
FRONTIERS IN MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Pamela Nithzi Bricher Choque, Rodolfo P. Vieira, Luis Ulloa, Caren Grabulosa, Maria Claudia Irigoyen, Katia De Angelis, Ana Paula Ligeiro De Oliveira, Kevin J. Tracey, Valentin A. Pavlov, Fernanda Marciano Consolim-Colombo
Summary: Acute respiratory distress syndrome (ARDS) is a severe complication with high mortality and lacks effective pharmacological treatments. Recent research highlights the significant role of neural cholinergic signaling in inflammation regulation. Treatment with the clinically approved drug pyridostigmine shows promising results in ameliorating inflammatory responses in mice with endotoxin-induced ARDS, suggesting potential therapeutic strategies for this condition.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
JunMei Wang, Chunxiu Ren, WenHui Bi, Wuliji Batu
Summary: Glycyrrhiza glabra L. is a widely used traditional Chinese medicine with various therapeutic effects. This study found that its active ingredient, glycyrrhizin, has anti-inflammatory effects and can alleviate acute lung injury (ALI) by interfering with the NF-κB/NLRP3 signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Immunology
Jian Xie, Cheng-long Zhu, Xiao-jian Wan, Zhen-zhen Zhao, Yan Meng, Peng Li, Yu Guo, Qiang Liu, Jin-jun Bian, Xiao-ming Deng, Jia-feng Wang
Summary: The cleavage of GSDMD in neutrophils is crucial for NET release during ARDS. Inhibition of GSDMD reduces NET production and attenuates lung injury, while extrinsic NETs may reverse the protective effect of GSDMD inhibition.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Yifu Lu, Hiroko Shimizu, Ryu Nakamura, Yaqiang Li, Risa Sakamoto, Emiko Omori, Toru Takahashi, Hiroshi Morimatsu
Summary: Dexmedetomidine (DEX) can reduce lung injury in a hemorrhagic shock (HS) resuscitation (HSR) model in rats by inhibiting inflammation. This study investigated if the protective effects of DEX are mediated by autophagy activation. Rats were subjected to HS and resuscitated, and lung injury was assessed by histopathology, wet/dry lung weight ratio, and autophagy-related marker proteins.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Thomas S. Metkus, Lori J. Sokoll, Andreas S. Barth, Matthew J. Czarny, Allison G. Hays, Charles J. Lowenstein, Erin D. Michos, Eric P. Nolley, Wendy S. Post, Jon R. Resar, David R. Thiemann, Jeffrey C. Trost, Rani K. Hasan
Summary: The study found that over 50% of intubated patients with severe COVID-19 had myocardial injury, which was associated with a higher mortality rate. Myocardial injury in COVID-19 was closely related to baseline comorbidities, age, and multisystem organ dysfunction. Compared with ARDS patients without COVID-19, COVID-19 patients were older and had poorer cardiac function, but had a lower incidence of myocardial injury.
Article
Allergy
Robert Naclerio, Ignacio J. Ansotegui, Jean Bousquet, G. Walter Canonica, Gennaro D'Amato, Nelson Rosario, Ruby Pawankar, David Peden, Karl-Christian Bergmann, Leonard Bielory, Luis Caraballo, Lorenzo Cecchi, S. Alfonso M. Cepeda, Herberto Jose Chong Neto, Carmen Galan, Sandra N. Gonzalez Diaz, Samar Idriss, Todor Popov, German D. Ramon, Erminia Ridolo, Menachem Rottem, Wisuwat Songnuan, Philip Rouadi
WORLD ALLERGY ORGANIZATION JOURNAL
(2020)
Review
Allergy
Michael Levin, Ignacio J. Ansotegui, Jonathan Bernstein, Yoon-Seok Chang, Manana Chikhladze, Motohiro Ebisawa, Alessandro Fiocchi, Enrico Heffler, Bryan Martin, Mario Morais-Almeida, Nikolaos G. Papadopoulos, David Peden, Gary W. K. Wong
WORLD ALLERGY ORGANIZATION JOURNAL
(2020)
Review
Allergy
Mario Morais-Almeida, Rita Aguiar, Bryan Martin, Ignacio J. Ansotegui, Motohiro Ebisawa, L. Karla Arruda, Marco Caminati, Giorgio Walter Canonica, Tara Carr, Geoffrey Chupp, Jonathan Corren, Ignacio Davila, Hae-Sim Park, Nicola A. Hanania, Lanny Rosenwasser, Mario Sanchez-Borges, J. Christian Virchow, Anahi Yanez, Jonathan A. Bernstein, Luis Caraballo, Yoon-Seok Chang, Manana Chikhladze, Alessandro Fiocchi, Sandra N. Gonzalez-Diaz, Luciana Kase Tanno, Michael Levin, Jose Antonio Ortega-Martell, Giovanni Passalacqua, David B. Peden, Philip W. Rouadi, James L. Sublett, Gary W. K. Wong, Eugene R. Bleecker
WORLD ALLERGY ORGANIZATION JOURNAL
(2020)
Letter
Toxicology
Allison J. Burbank, Michelle L. Hernandez, Carole Robinette, Ting Wang, Haibo Zhou, Neil Alexis, William D. Bennett, David B. Peden
INHALATION TOXICOLOGY
(2020)
Article
Microbiology
Amir Barzin, John L. Schmitz, Samuel Rosin, Rameet Sirpal, Martha Almond, Carole Robinette, Samantha Wells, Michael Hudgens, Andrew Olshan, Stephanie Deen, Patrick Krejci, Eugenia Quackenbush, Kevin Chronowski, Caleb Cornaby, Janette Goins, Linda Butler, Julia Aucoin, Kim Boyer, Janet Faulk, Devena Alston-Johnson, Cristen Page, Yijun Zhou, Lynne Fiscus, Blossom Damania, Dirk P. Dittmer, David B. Peden
Review
Allergy
Philip W. Rouadi, Samar A. Idriss, Robert M. Naclerio, David B. Peden, Ignacio J. Ansotegui, Giorgio Walter Canonica, Sandra Nora Gonzalez-Diaz, Nelson A. Rosario Filho, Juan Carlos Ivancevich, Peter W. Hellings, Margarita Murrieta-Aguttes, Fares H. Zaitoun, Carla Irani, Marilyn R. Karam, Jean Bousquet
WORLD ALLERGY ORGANIZATION JOURNAL
(2020)
Letter
Critical Care Medicine
Michelle L. Hernandez, Sally Ivins, Kelly Chason, Allison J. Burbank, Meghan E. Rebuli, Aaron Kobernick, Stephen A. Schworer, Haibo Zhou, Neil E. Alexis, David B. Peden
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Allergy
Nelson Augusto Rosario Filho, Marilyn Urrutia-Pereira, Gennaro D'Amato, Lorenzo Cecchi, Ignacio J. Ansotegui, Carmen Galan, Anna Pomes, Margarita Murrieta-Aguttes, Luis Caraballo, Philip Rouadi, Isabella Annesi-Maesano, Ruby Pawankar, Herberto J. Chong-Neto, David B. Peden
Summary: Indoor environments significantly contribute to human exposure to air pollutants, especially affecting the health of children and adults. Education, community, and health professional involvement can help reduce household pollutants and promote health.
WORLD ALLERGY ORGANIZATION JOURNAL
(2021)
Article
Allergy
Luciana Kase Tanno, Pascal Demoly, Bryan Martin, Jonathan Berstein, Mario Morais-Almeida, Michael Levin, Alessandro Fiocchi, Mario Sanchez-Borges, Luis R. Caraballo, Gary Wong, Jose Antonio Ortega-Martell, Philip Rouadi, Anahi Yanez, Liang Lu Wang, David B. Peden, Manana Chikhladze, Sandra N. Gonzalez-Diaz, Jean-Francois Fontainet, James Sublett, Yoon-Seok Chang, Giovanni Passalacqua, Ignacio J. Ansotegui, Motohiro Ebisawa, Gianenrico Senna, Marco Caminati
Summary: The COVID-19 outbreak posed unprecedented challenges to the world, prompting the allergy societies to produce guidance documents. An international survey revealed that managing allergic patients during the pandemic does not increase the risk of contracting COVID-19. This data can serve as a starting point for feedback on recommendations and new strategies for healthcare professionals.
WORLD ALLERGY ORGANIZATION JOURNAL
(2021)
Editorial Material
Respiratory System
Isabella Annesi-Maesano, Francesco Forastiere, John Balmes, Erika Garcia, Jack Harkema, Stephen Holgate, Frank Kelly, Haneen Khreis, Barbara Hoffmann, Cara Nichole Maesano, Rob McConnell, David Peden, Kent Pinkerton, Tamara Schikowski, George Thurston, Laura S. Van Winkle, Christopher Carlsten
EUROPEAN RESPIRATORY JOURNAL
(2021)
Editorial Material
Allergy
David B. Peden
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Computer Science, Information Systems
Ridwan Alam, David B. Peden, John C. Lach
Summary: This study explores inferring respiratory parameters from wearable ECG and wrist motion signals and proposes a modular and generalizable classification-regression pipeline to learn context-conditioned inference models, including physical activity. Evaluations on data from 15 subjects highlight the potential of wearable sensors not only in continuous monitoring, but also in designing biomarker-driven preventive measures.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2021)
Article
Biochemistry & Molecular Biology
Qing Jiang, Suji Im, James G. Wagner, Michelle L. Hernandez, David B. Peden
Summary: Studies have shown that gamma T has unique antioxidant and anti-inflammatory activities compared to alpha T, providing superior protection for mitochondrial function.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Health Care Sciences & Services
Karamarie Fecho, Stanley C. Ahalt, Stephen Appold, Saravanan Arunachalam, Emily Pfaff, Lisa Stillwell, Alejandro Valencia, Hao Xu, David B. Peden
Summary: This study demonstrates the use of the open-source ICEES as a tool for exposing and exploring integrated clinical and environmental data. The results show significant associations between factors such as proximity to major roadways or highways, exposure to high levels of particulate matter or ozone, female sex, Caucasian race, low residential density, lack of health insurance, low household income, and asthma exacerbations.
JMIR FORMATIVE RESEARCH
(2022)
Article
Respiratory System
William D. Bennett, Allison Burbank, Martha Almond, Jihong Wu, Agathe Ceppe, Michelle Hernandez, Richard C. Boucher, David B. Peden
Summary: The study showed that inhaling 7% hypertonic saline can acutely enhance mucociliary clearance in asthmatic patients, but this effect is not sustained 4 hours post-treatment. While not supporting maintenance therapy, these findings suggest a benefit for treating acute exacerbations in patients with moderate-severe asthma.