Article
Health Care Sciences & Services
Marco Cossio-Bolanos, Ruben Vidal-Espinoza, Luis Felipe Castelli Correia de Campos, Luis Urzua-Alul, Jose Damian Fuentes-Lopez, Jose Sulla-Torres, Cynthia Lee Andruske, Rossana Gomez-Campos
Summary: Differences in MEF were found when compared to other geographical regions, indicating that maturity may be a more effective indicator for analyzing MEF. Reference values were generated using both chronological age and maturity.
Article
Respiratory System
Shane Hanon, Eef Vanderhelst, Walter Vincken, Daniel Schuermans, Sylvia Verbanck
Summary: This study aimed to obtain reproducible measurements of maximal inspiratory flow rates and to construct reference equations for peak in- and expiratory flows. Results indicated that following current standards for measurement can yield reproducible values for inspiratory and expiratory flows for routine clinical use.
Article
Public, Environmental & Occupational Health
Chao Ji, Yang Xia, Huixu Dai, Zhiying Zhao, Tiancong Liu, Shuhui Tong, Xiaohang Zhang, Yuhong Zhao
Summary: This study aimed to determine age- and sex-specific reference values of PEF in the middle-aged and elderly Chinese population. PEF was found to decrease with age and be higher in men than in women. Factors such as height, weight, handgrip strength, and residence in rural areas were positively associated with PEF.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Respiratory System
Klaita Srisingh, Chutima Phuaksaman
Summary: This study aimed to establish a PEFR equation for Thai children aged 6 to 18 in a suburban environment. The results showed that PEFR has a linear relationship with age, weight, height, and BMI, with age being the most significant factor for males and height for females. Height, weight, and age were found to be important determinants of PEFR for each sex in the regression equation.
JOURNAL OF THORACIC DISEASE
(2021)
Article
Forestry
Joseph M. Gray, Jamie L. Schuler, Melissa Thomas-Van Gundy, Sophan Chhin
Summary: This study aimed to develop reference curves for predicting the height growth of red spruce trees in West Virginia to assess the success of restoration efforts. By reconstructing height growth patterns of red spruce seedlings and saplings and comparing them to contemporary growth rates, it was found that height growth of red spruce peaked between 10 and 30 years of age.
Article
Critical Care Medicine
Andrei Malinovschi, Xingwu Zhou, Anders Andersson, Helena Backman, Bjorn Bake, Anders Blomberg, Kenneth Caidahl, Maria J. Eriksson, Jonas Eriksson Strom, Viktor Hamrefors, Ola Hjelmgren, Christer Janson, Reza Karimi, David Kylhammar, Anne Lindberg, Eva Lindberg, Per Liv, Anna-Carin Olin, Adel Shalabi, C. Magnus Skold, Johan Sundstrom, Hanan Tanash, Kjell Toren, Per Wollmer, Suneela Zaigham, Carl Johan Ostgren, Jan E. Engvall
Summary: Using postbronchodilator spirometry reference values can improve the accuracy and prevalence of diagnosing chronic obstructive pulmonary disease, and can identify individuals with mild disease.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Pediatrics
Luanjie Yao, Lingdong Meng, Xin Liu, Xiaowen Li, Fen Liu, Yunxiao Shang, Yong Feng
Summary: The aim of this study was to define the initial angle called beta and assess its diagnostic value in determining poor-quality maneuvers in spirometry testing in children. The results showed that the angle beta and forced expiratory time are important indicators for evaluating the quality of spirometry in children.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Respiratory System
Sofia Erelund, Kjell Karp, Sandra Arvidsson, Bengt Johansson, Nina Sundstroem, Urban Wiklund
Summary: This study evaluated lung function testing results in a group of subjects from Northern Sweden without heart or pulmonary disease, and compared them with two reference materials. The results showed that the reference values from the Global Lung Initiative (GLI) underestimated lung function in the adult Swedish population.
BMC PULMONARY MEDICINE
(2023)
Article
Biology
Marc Dauty, Thomas Georges, Camille Le Blanc, Bastien Louguet, Pierre Menu, Alban Fouasson-Chailloux
Summary: Several studies have shown that spirometric theoretical values may not be accurate for high-level athletes, including professional cyclists. This study aimed to establish predictive spirometric values for high-level cyclists and found that their lung function parameters were significantly higher than general population values. The variation in forced vital capacity (FVC) was explained by body height and weight, while the variation in forced expiratory volume in one second (FEV1) was explained only by body height. These findings are important for diagnosing obstructive lung diseases and testing reversibility with bronchodilator drugs in clinical settings.
Review
Medicine, General & Internal
Cassidy Du Berry, Christopher Nesci, Jeanie L. Y. Cheong, Tara FitzGerald, Rheanna Mainzer, Sarath Ranganathan, Lex W. Doyle, Elianne J. L. E. Vrijlandt, Liam Welsh
Summary: This study aimed to compare maximal expiratory airflow in children and adults born MLP with term-born controls and with expected norms. The results showed that MLP participants had lower expiratory airflow compared to controls.
Article
Cardiac & Cardiovascular Systems
Christian Heiss, Ana Rodriguez-Mateos, Mariam Bapir, Simon S. Skene, Helmut Sies, Malte Kelm
Summary: This study aims to assess Flow-Mediated Dilation (FMD) values in healthy individuals and provides reference values for cardiovascular health measurement. The study found that FMD values are inversely correlated with age, body mass index (BMI), glucose, cholesterol, and blood pressure. Individuals with higher FMD values are younger and have smaller brachial artery diameter, lower blood pressure and cholesterol. Comparisons with coronary artery disease (CAD) patients also showed that FMD values can be used to exclude cardiovascular disease and determine the health status. The meta-analysis results showed that the average FMD in healthy individuals is 6.4%, with a decline trend associated with age.
CARDIOVASCULAR RESEARCH
(2023)
Article
Respiratory System
Magnus Ekstrom, David Mannino
Summary: This study evaluated the impact of race-specific reference values on the prevalence of lung function impairment and its relation to breathlessness and mortality. The findings suggest that using race-specific spirometry references did not improve the prediction of breathlessness and prognosis compared to using a common reference, potentially misclassifying lung function as normal despite worse outcomes in black people.
RESPIRATORY RESEARCH
(2022)
Article
Medicine, General & Internal
Caroline B. Terwee, Leo D. Roorda
Summary: This study calculated and compared Dutch reference values for PROMIS domains with US reference values, and found that Dutch values were close to US values in some domains but not all. The study highlights the importance of obtaining country-specific reference values to facilitate the use of PROMIS worldwide.
ANNALS OF MEDICINE
(2023)
Article
Respiratory System
David Martinez-Briseno, Laura Gochicoa-Rangel, Luis Torre-Bouscoulet, Silvia Cid-Juarez, Rosario Fernandez-Plata, Luisa Martinez-Valdeavellano, Sofia Chapela-Lara, Rodrigo del Rio-Hidalgo, Rogelio Perez-Padilla
Summary: The study compared results fitted with the LMS method to standard multiple linear regression and international Global Lung Function Initiative equations. It found that LMS models had residuals closer to zero and smaller dispersion than linear models, with differences being small and of questionable practical relevance. Average spirometric values for a given height in the Mexican population were higher than those predicted by the GLI study.
ARCHIVOS DE BRONCONEUMOLOGIA
(2021)
Article
Multidisciplinary Sciences
Hye Jin Lee, Hwan Soo Kim, Jong-seo Yoon
Summary: Impulse oscillometry system (IOS) is a simple and less invasive method for assessing airway resistance in children. This study analyzed the correlation between IOS, spirometry, and plethysmographic parameters in the diagnosis of pediatric BO patients. The results showed that R5% and AX% had the strongest correlation with conventional pulmonary function parameters, and R5% and AX% were the most optimal IOS parameters for BO diagnosis. In conclusion, IOS is an easy-to-use and reliable diagnostic method for detecting airway obstruction in pediatric BO patients.
Editorial Material
Pediatrics
Athanasios Kaditis, Evanthia Botsa, Elissavet Georgiadou, Theoni Petropoulou, Adina Sandu, Christina Kanaka-Gantenbein
Article
Radiology, Nuclear Medicine & Medical Imaging
Dimitrios Moutafidis, Maria Gavra, Sotirios Golfinopoulos, Christina Oikonomopoulou, Vasiliki Kitra, Jason C. Woods, Athanasios G. Kaditis
Summary: Diagnosis of bronchiolitis obliterans syndrome (BOS) in children post-HSCT is based on pulmonary function testing and chest CT findings. This study found a relationship between spirometry indices and CT lung volume and density in these patients.
Article
Pediatrics
Hui-Leng Tan, Athanasios G. Kaditis
Summary: It is crucial for clinicians to understand the reasons behind the significant phenotypic variance in pediatric OSAS in order to implement individually tailored treatment approaches. By considering disease severity, comorbidities, genetics, and environmental/lifestyle factors, a multidimensional assessment strategy can be used to determine the timing and nature of therapeutic interventions more effectively.
PEDIATRIC PULMONOLOGY
(2021)
Article
Pediatrics
Athanasios G. Kaditis, Adrienne Ohler, Alex Gileles-Hillel, Shoham Choshen-Hillel, David Gozal, Oliviero Bruni, Secil Aydinoz, Rene Cortese, Leila Kheirandish-Gozal
Summary: During the pandemic, some children had later bedtime and wake time, but more than 40% did not change their sleep duration. High school-aged children were more likely to sleep longer on weekdays compared to preschoolers, while primary school children were more likely to sleep longer on weekends.
PEDIATRIC PULMONOLOGY
(2021)
Editorial Material
Pediatrics
Athanasios G. Kaditis, Emmanouel I. Alexopoulos
PEDIATRIC PULMONOLOGY
(2021)
Article
Clinical Neurology
Anna Maria Mylona, Georgia Rapti, George Vavougios, Vasileios A. Lachanas, Panagiotis Liakos, Charalambos Skoulakis, Athanasios G. Kaditis, Konstantinos Gourgoulianis, Emmanouil Alexopoulos
Summary: Among healthy children with a history of snoring, an SCR score above 8.25 may indicate the presence of moderate-to-severe OSAS. Analysis of the ROC curve showed that this score has a sensitivity of 83% and a specificity of 70%.
SLEEP AND BREATHING
(2022)
Article
Oncology
Nicole Chmielewski-Stivers, Benoit Petit, Jonathan Ollivier, Virginie Monceau, Pelagia Tsoutsou, Ana Quintela Pousa, Xiaomeng Lin, Charles Limoli, Marie-Catherine Vozenin
Summary: This study identified sex- and organ-specific responses to systemic paclitaxel administration and localized radiotherapy, with female mice showing protection against neurotoxicity and cardiotoxicity compared to males. RhoB was revealed as a molecular determinant driving estrogen-dependent cardioprotection in female mice.
Article
Pediatrics
Dimitrios Moutafidis, Maria Gavra, Sotirios Golfinopoulos, Antonios Kattamis, George Chrousos, Christina Kanaka-Gantenbein, Athanasios G. Kaditis
Summary: This study investigated age effects on lung attenuation and low- and high-attenuation thresholds in pediatric quantitative chest CT scans. It found that age was inversely associated with mean lung attenuation, and there were correlations between low- and high-attenuation percentages with age and total lung capacity. The findings suggest that quantitative analysis of chest CT scans in children without lung disease can help define age-specific thresholds for evaluating pediatric lung disease severity.
Article
Oncology
Walter Paul Weber, Jane Shaw, Andrea Pusic, Lynda Wyld, Monica Morrow, Tari King, Zoltan Matrai, Joerg Heil, Florian Fitzal, Shelley Potter, Isabel T. Rubio, Maria-Joao Cardoso, Oreste Davide Gentilini, Viviana Galimberti, Virgilio Sacchini, Emiel J. T. Rutgers, John Benson, Tanir M. Allweis, Martin Haug, Regis R. Paulinelli, Tibor Kovacs, Yves Harder, Bahadir M. Gulluoglu, Eduardo Gonzalez, Andree Faridi, Elisabeth Elder, Peter Dubsky, Jens-Uwe Blohmer, Vesna Bjelic-Radisic, Mitchel Barry, Susanne Dieroff Hay, Kimberly Bowles, James French, Roland Reitsamer, Rupert Koller, Peter Schrenk, Daniela Kauer-Dorner, Jorge Biazus, Fabricio Brenelli, Jaime Letzkus, Ramon Saccilotto, Sarianna Joukainen, Susanna Kauhanen, Ulla Karhunen-Enckell, Juergen Hoffmann, Ulrich Kneser, Thorsten Kuhn, Michalis Kontos, Ekaterini Christina Tampaki, Moshe Carmon, Tal Hadar, Giuseppe Catanuto, Carlos A. Garcia-Etienne, Linetta Koppert, Pedro F. Gouveia, Jakob Lagergren, Tor Svensjoe, Nadia Maggi, Elisabeth A. Kappos, Fabienne D. Schwab, Liliana Castrezana, Daniel Steffens, Janna Krol, Christoph Tausch, Andreas Gunthert, Michael Knauer, Maria C. Katapodi, Susanne Bucher, Nik Hauser, Christian Kurzeder, Rosine Mucklow, Pelagia G. Tsoutsou, Atakan Sezer, Guldeniz Karadeniz Cakmak, Hasan Karanlik, Patricia Fairbrother, Laszlo Romics, Giacomo Montagna, Cicero Urban, Melanie Walker, Silvia C. Formenti, Guenther Gruber, Frank Zimmermann, Daniel Rudolf Zwahlen, Sherko Kuemmel, Mahmoud El-Tamer, Marie Jeanne Vrancken Peeters, Orit Kaidar-Person, Michael Gnant, Philip Poortmans, Jana de Boniface
Summary: The aim of this article is to discuss the demand for nipple-and skin-sparing mastectomy (NSM/SSM) with immediate breast reconstruction (BR) and present clinical practice recommendations in the context of expanded indications for post-mastectomy radiation therapy (PMRT). The panel agrees that surgical technique for NSM/SSM should not be modified when PMRT is planned, with preference for autologous over implant-based BR. However, no specific recommendations are made regarding implant positioning, use of mesh or timing. The use of patient-reported outcomes in clinical practice is endorsed. The article emphasizes the importance of prospective randomized phase III studies and interdisciplinary collaboration for determining optimal sequencing and techniques for PMRT in the context of BR.
Article
Clinical Neurology
Anastasia Polytarchou, Adrienne Ohler, Aggeliki Moudaki, Georgia Koltsida, Christina Kanaka-Gantenbein, Leila Kheirandish-Gozal, David Gozal, Athanasios G. Kaditis
Summary: This study analyzed the effectiveness of nocturnal oximetry in evaluating the severity of obstructive sleep apnea syndrome (OSAS) when polysomnography is not available. The study found that the Oxygen Desaturation (>= 3%) Index (ODI3) was a better predictor of moderate-to-severe OSAS than the McGill Oximetry Score (MOS).
JOURNAL OF SLEEP RESEARCH
(2023)
Editorial Material
Pediatrics
Athanasios Kaditis, David Gozal
Review
Pediatrics
Panagiota Panagiotou, Christina Kanaka-Gantenbein, Athanasios G. Kaditis
Summary: Gene-based treatments do not have a significant positive impact on the ventilatory support requirements for SMA patients who are already on ventilatory support.
Article
Oncology
Adela Ademaj, Paraskevi D. Veltsista, Dietmar Marder, Roger A. Haelg, Emsad Puric, Thomas B. Brunner, Hans Crezee, Dorota Gabrys, Martine Franckena, Cihan Gani, Michael R. Horsman, Robert Krempien, Lars H. Lindner, Sergio Maluta, Markus Notter, Griseldis Petzold, Sultan Abdel-Rahman, Antonella Richetti, Andreas R. Thomsen, Pelagia Tsoutsou, Rainer Fietkau, Oliver J. Ott, Pirus Ghadjar, Oliver Riesterer
Summary: There is significant heterogeneity among European clinical centers in the practice of hyperthermia, including the indications treated and the recording of thermometric parameters. More evidence from clinical studies is needed to standardize hyperthermia practice.
STRAHLENTHERAPIE UND ONKOLOGIE
(2023)
Meeting Abstract
Oncology
A. Ademaj, D. P. Veltsista, D. Marder, R. A. Haelg, E. Puric, T. B. Brunner, H. Crezee, D. Gabrys, M. Franckena, C. Gani, M. R. Horsman, R. Krempien, L. Lindner, S. Maluta, M. Notter, G. Petzold, S. Abdel-Rahman, A. Richetti, A. R. Thomsen, P. Tsoutsou, R. Fietkau, O. Ott, P. Ghadjar, O. Riesterer
STRAHLENTHERAPIE UND ONKOLOGIE
(2022)
Article
Respiratory System
Matthias Griese, Panagiota Panagiotou, Effrosyni D. Manali, Mirjam Stahl, Nicolaus Schwerk, Vanessa Costa, Konstantinos Douros, Maria Kallieri, Ruth Maria Urbantat, Horst von Bernuth, Lykourgos Kolilekas, Lurdes Morais, Ana Ramos, Kerstin Landwehr, Katrin Knoflach, Florian Gothe, Karl Reiter, Vassiliki Papaevangelou, Athanasios G. Kaditis, Christina Kanaka-Gantenbein, Spyros A. Papiris
Summary: This article discusses the cases of four children with autoimmune PAP and describes the presentation and management issues. By considering various treatment options, including inhaled GM-CSF, the most effective and least invasive treatment method can be selected for patients. Establishing an appropriate registry enables the collection of patient cohorts with rare conditions. To expedite the authorization of novel treatments, adolescents should be included in trials in adults.
