Review
Engineering, Biomedical
Diana Alves, Tania Grainha, Maria Olivia Pereira, Susana Patricia Lopes
Summary: Ventilator-associated pneumonia (VAP) is a persistent problem in hospitals, resulting in inadequate treatment, high mortality, and prolonged hospital stays. The endotracheal tube (ETT) is the main cause of VAP due to microbial colonization and biofilm formation by various pathogens. Research on antimicrobial ETT surface coating/modification approaches has been conducted to address this issue. This review provides an overview of the relevance of the ETT biofilms in VAP and the technological advancements in antimicrobial ETT materials. Rating: 8/10
ACTA BIOMATERIALIA
(2023)
Review
Chemistry, Physical
Lavinia Marcut, Veronica Manescu (Paltanea), Aurora Antoniac, Gheorghe Paltanea, Alina Robu, Aurel George Mohan, Elena Grosu, Iuliana Corneschi, Alin Danut Bodog
Summary: Ventilator-associated pneumonia is a common hospital infection that has a high mortality rate and prolonged hospitalization time. The endotracheal tube is a major cause of this pneumonia due to its surface being colonized by different pathogens. This paper discusses the definition, economic burdens, and outcomes of ventilator-associated pneumonia, as well as the latest technological solutions for endotracheal tube surfaces. The analysis concludes by identifying research gaps and exploring future possibilities for reducing ventilator-associated pneumonia cases and improving patient comfort.
Review
Nanoscience & Nanotechnology
Xuemeng Chen, Xiaomei Ling, Gaowang Liu, Jinfang Xiao
Summary: Ventilator-associated pneumonia (VAP) is a common and serious nosocomial infection in mechanically ventilated patients. Recent studies have shown that tracheal intubation plays a key role in the pathogenesis of VAP, primarily through rapid colonization of the tracheal intubation surface by microbiota. Antibiotics are ineffective against microbial airway colonization, thus antimicrobial coating materials offer new solutions.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Yue Wang, Bingyue Cai, Dalong Ni, Yu Sun, Gang Wang, Hong Jiang
Summary: This study developed a new coating method for endotracheal tubes, which can achieve both antibacterial and antifouling effects. The experiments demonstrated the inhibitory effect of the coating on various bacteria and its ability to prevent biofilm formation. The results also showed good stain resistance and biocompatibility of the coating.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Pediatrics
Jian Zhou, Jingqian Zhou, Yan Hong, Youcheng Wang, Hailong Lin, Leting Huang
Summary: The study evaluated the diagnostic value of ETT-aspirate sTREM-1 and serum C-reactive protein concentrations in neonatal ventilator-associated pneumonia (NVAP) among preterm and full-term neonates on mechanical ventilators. The results showed that these indicators may be useful for diagnosing NVAP, especially when combined. Changes in these indicators over ventilation days were also observed, providing valuable insights into neonatal recovery processes.
FRONTIERS IN PEDIATRICS
(2021)
Article
Microbiology
Marta Palau, Estela Munoz, Nieves Larrosa, Xavier Gomis, Ester Marquez, Oscar Len, Benito Almirante, Joan Gavalda
Summary: Biofilm-producing microorganisms are medically crucial and cause 80% of human infections. This study evaluated the efficacy of hyperthermia in preventing biofilm formation in vitro and in a rabbit model. The results showed that hyperthermia can effectively prevent biofilm formation under specific temperature and time conditions.
MICROBIOLOGY SPECTRUM
(2023)
Article
Pediatrics
Ajaya Kumar Gahan, Suksham Jain, Supreet Khurana, Deepak Chawla
Summary: This study compared the effect of closed versus open endotracheal tube suction on the occurrence of ventilator-associated pneumonia in mechanically ventilated neonates. The results showed that the choice of suction method did not significantly impact the incidence of ventilator-associated pneumonia in a unit with a low incidence of this condition.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Immunology
Vu Quoc Dat, Lam Minh Yen, Huynh Thi Loan, Vu Dinh Phu, Nguyen Thien Binh, Ronald B. Geskus, Dong Huu Khanh Trinh, Nguyen Thi Hoang Mai, Nguyen Hoan Phu, Nguyen Phu Huong Lan, Tran Phuong Thuy, Nguyen Vu Trung, Nguyen Trung Cap, Dao Tuyet Trinh, Nguyen Thi Hoa, Nguyen Thi Thu Van, Vy Thi Thu Luan, Tran Thi Quynh Nhu, Hoang Bao Long, Nguyen Thi Thanh Ha, Ninh Thi Thanh Van, James Campbell, Ehsan Ahmadnia, Evelyne Kestelyn, Duncan Wyncoll, Guy E. Thwaites, Nguyen Van Hao, Le Thanh Chien, Nguyen Van Kinh, Nguyen Van Vinh Chau, H. Rogier van Doorn, C. Louise Thwaites, Behzad Nadjm
Summary: The study found that continuous cuff pressure control (CPC) using an automated electronic device did not reduce the incidence of ventilator-associated respiratory infection (VARI) in intubated patients compared to intermittent CPC.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Respiratory System
Erika Alejandra Cifuentes, Maria A. Sierra, Andres Felipe Yepes, Ana Margarita Baldion, Jose Antonio Rojas, Carlos Arturo Alvarez-Moreno, Juan Manuel Anzola, Maria Mercedes Zambrano, Monica G. Huertas
Summary: This study investigated the microbiome of the endotracheal tube (ETT) and found that it mainly consists of Proteobacteria, Firmicutes, and Bacteroidetes. The composition of the microbiome was associated with the ICU where the patients were hospitalized, but not with the duration of intubation or the diagnosis of ventilator-associated pneumonia (VAP). These findings suggest that the ICU environment or medical practices may influence the colonization of microbial communities in patients requiring mechanical ventilation.
RESPIRATORY RESEARCH
(2022)
Review
Medicine, General & Internal
Min Gan, Zhuming Bao, Juan Han
Summary: This systematic review evaluates the therapeutic effect of the Venner-PneuX endotracheal tube system (VPXETS) in preventing ventilator-associated pneumonia (VAP), with outcome measures including the incidence and side effects of VAP. The findings will be disseminated through peer-reviewed publication, and ethical approval is not required as only published data is used, ensuring anonymity in the data analysis process.
Article
Multidisciplinary Sciences
Thomas Maldiney, Valentin Pineau, Catherine Neuwirth, Linda Ouzen, Isabelle Eberl, Geraldine Jeudy, Sophie Dalac, Lionel Piroth, Mathieu Blot, Marc Sautour, Frederic Dalle, Caroline Abdulmalak, Romain Ter Schiphorst, Paul-Simon Pugliesi, Thomas Poussant, Agathe Ogier-Desserrey, Isabelle Fournel, Melchior de Giraud D'Agay, Marine Jacquier, Marie Labruyere, Francois Aptel, Jean-Baptiste Roudaut, Thibault Vieille, Pascal Andreu, Sebastien Prin, Pierre-Emmanuel Charles, Mael Hamet, Jean-Pierre Quenot
Summary: Biofilm growth is important in the development of ventilator-associated pneumonia in intensive care units. The study reveals two different morphological aspects of endotracheal tube-deposited biofilm, as well as higher acquired resistance compared to other colonization sites. These findings have significant clinical implications for antimicrobial treatment in critically ill patients.
SCIENTIFIC REPORTS
(2022)
Article
Virology
Olympia E. Anastasiou, Fotis Theodoropoulos, Christian Taube, Melanie Fiedler, Ulf Dittmer
Summary: Data analysis on cases tested with bilateral BAL samples and EA showed that there was no significant improvement in diagnostic efficiency for detecting common viral respiratory pathogens. Discrepant results were observed in a small percentage of cases, indicating comparable diagnostic quality between EA and BAL samples for detecting common viral respiratory infections.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Respiratory System
Nan Wu, Piyush Ranjan, Changyu Tao, Chao Liu, Ence Yang, Bei He, John R. Erb-Downward, Shining Bo, Jiajia Zheng, Chenxia Guo, Beibei Liu, Lina Sun, Wei Yan, Meng Wang, Wenting Wang, Jianing Wen, Ping Yang, Lin Yang, Qiaoshan Tian, Robert P. Dickson, Ning Shen
Summary: This study utilized Nanopore sequencing to quickly detect pathogens in ventilator-associated pneumonia patients, using saponins to remove human genomes and a non-PCR amplification method for library construction. The average sensitivity of metagenomic sequencing was approximately 2.4 times higher than clinical culture, allowing for accurate pathogen identification within 6 hours.
RESPIRATORY RESEARCH
(2021)
Article
Medicine, General & Internal
Ioana Roxana Codru, Mihai Sava, Bogdan Ioan Vintila, Alina Simona Bereanu, Victoria Birlutiu
Summary: Ventilator-associated pneumonia is a severe complication in critically ill patients undergoing mechanical respiratory support, with potential risks of prolonged hospitalization, disability, and death. This study aims to propose a new method using sonication to determine infectious bacteria in patients, which is simple, cost-effective, and readily available.
MEDICINA-LITHUANIA
(2023)
Article
Infectious Diseases
Viviane C. Oliveira, Ana P. Macedo, Luis D. R. Melo, Silvio B. Santos, Paula R. S. Hermann, Claudia H. Silva-Lovato, Helena F. O. Paranhos, Denise Andrade, Evandro Watanabe
Summary: This study evaluated the effectiveness of five bacteriophages in removing and preventing Pseudomonas aeruginosa biofilms on endotracheal tubes, finding a significant reduction in biofilms, especially in multidrug-resistant strains, after phage treatment. Two phages were selected as cocktail components, showing potential in preventing bacterial colonization on tube surfaces in a dynamic biofilm model.
Letter
Anesthesiology
Claude Guerin, Martin Cour, Florian Degivry, Francois Charbon, Bruno Louis, Laurent Argaud, Nicolas Terzi
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
(2022)
Article
Biophysics
Marion Tardieu, Najat Salameh, Line Souris, David Rousseau, Laurene Jourdain, Hanadi Skeif, Francois Prevot, Ludovic de Rochefort, Denis Ducreux, Bruno Louis, Philippe Garteiser, Ralph Sinkus, Luc Darrasse, Marie Poirier-Quinot, Xavier Maitre
Summary: Magnetic resonance elastography is a non-invasive and remote technique to characterize the mechanical properties of living tissues. By guiding pressure waves through the buccal cavity and bypassing the skull, quantitative measurement of mechanical properties in the human brain can be obtained.
NMR IN BIOMEDICINE
(2022)
Editorial Material
Otorhinolaryngology
Margaux Petitjean, Emilie Bequignon, Maxime Fieux, Bruno Louis, Francoise Zerah, Andre Coste, Sophie Bartier
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2022)
Article
Otorhinolaryngology
Pierre Gagnieur, Maxime Fieux, Bruno Louis, Emilie Bequignon, Sophie Bartier, Delphine Vertu-Ciolino
Summary: This study evaluated the potential of four-phase rhinomanometry as a diagnostic test for internal valve collapse in patients with chronic nasal obstruction. The results showed that a specific inspiratory loop area in the rhinomanometry data had high sensitivity and specificity for reproducing clinical diagnoses of internal valve collapse, offering a more reliable basis for treatment indications than subjective physical examinations.
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
(2022)
Article
Critical Care Medicine
Claude Guerin, Martin Cour, Florian Degivry, Laurent Argaud, Bruno Louis
Summary: Work of breathing was marginally higher and positive end-expiratory pressure (PEEP) was marginally lower with high-flow nasal cannula (HFNC) devices compared to the reference device.
Article
Chemistry, Multidisciplinary
Zijun Wang, Fanny Delille, Sophie Bartier, Thomas Pons, Nicolas Lequeux, Bruno Louis, Jongwook Kim, Thierry Gacoin
Summary: Dynamics with orientational freedom are fundamental in biological events. Lanthanide-doped nanocrystals with polarized luminescence provide precise analysis and are more stable than quantum dots. However, the polarization property often deteriorates in complex physiological environments. In this study, we demonstrate a surface functionalization method for lanthanide-doped nanorods using zwitterionic block copolymers. The coated nanorods exhibit high colloidal stability, preserved shear-aligned ability, strongly polarized emission, and good biocompatibility. This study validates the strategy of coupling zwitterions to lanthanide-doped nanocrystals for various bioapplications.
Article
Pediatrics
Claude Danan, Manon Tauzin, Camille Jung, Xavier Durrmeyer, Laurence Caeymaex, Charles Treussart, Fabrice Decobert, Bruno Louis
Summary: The humidity during HFOV was significantly lower than during IPPV, both in vitro and in vivo. The type of heater-humidifier also influenced humidification. More systematic measurements of humidity of inspired gas, especially during HFOV, should be considered to optimize humidification and consequently lung protection in ELBW infants.
PEDIATRIC PULMONOLOGY
(2023)
Article
Critical Care Medicine
Mathieu Delorme, Karl Leroux, Antoine Leotard, Ghilas Boussaid, Helene Prigent, Bruno Louis, Frederic Lofaso
Summary: A study found that current noninvasive ventilation devices have varied responses and scoring of sleep-related respiratory events. Further improvements in algorithms are needed to enable more widespread initiation and follow-up of domiciliary noninvasive ventilation.
Article
Medicine, General & Internal
Martin Cour, Claude Guerin, Florian Degivry, Laurent Argaud, Bruno Louis
Summary: This study compared the work of breathing (WOB) using a tracheal cannula (TC) and a nasal cannula (NC) during high flow oxygen therapy (HFOT), and found that the WOB was lower with the TC than with the NC. However, these differences were very small and may not be clinically relevant.
FRONTIERS IN MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Florent Carsuzaa, Emilie Bequignon, Sophie Bartier, Andre Coste, Xavier Dufour, Matthieu Bainaud, Jean Claude Lecron, Bruno Louis, Stephane Tringali, Laure Favot, Maxime Fieux
Summary: This study investigated the presence of OSM and IL-6, as well as the expression pattern of tight junctions, in CRSwNP patients and controls. The results showed that OSM and IL-6 were overexpressed, and tight junction (ZO-1 and occludin) expression was decreased in nasal polyps compared to control mucosa. In vitro experiments further demonstrated that OSM could significantly reduce tight junction expression, transepithelial electric resistance, and ciliary beating efficiency, while promoting cell repair mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Amene Majidipur, Margot Morin-Dewaele, Jeanne Gaspar Lopes, Francois Berry, Julien Fouchet, Sophie Bartier, Anais Dufros Duval, Pascale Soyeux, Eric Huet, Bruno Louis, Andre Coste, Emilie Bequignon, Carolina Saldana, Philippe Le Corvoisier, Damien Destouches, Jean-Michel Pawlotsky, Alexandre de la Taille, Francis Vacherot, Patrice Bruscella, Virginie Firlej
Summary: In early 2020, the emergence of SARS-CoV-2 in Wuhan, China caused a global health emergency. The virus enters cells through the ACE2 protein and TMPRSS2 facilitates membrane fusion. TMPRSS2 is regulated by AR signaling, and inhibiting it with apalutamide reduces SARS-CoV-2 entry and infection in lung and nasal cells. These findings suggest that apalutamide could be a treatment option for PCa patients at risk for severe COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Critical Care Medicine
Nicolas Terzi, Isabelle Vaugier, Claude Guerin, Helene Prigent, Ghilas Boussaid, Karl Leroux, Mathieu Delorme, Frederic Lofaso, Bruno Louis
Summary: This study compares the measurement of CPF and ECV between 4 MI-E devices under simulated conditions. The results show significant differences in CPF values and ECV values among different devices, suggesting limitations in using only CPF values to determine cough effectiveness.
Article
Medicine, General & Internal
Noemie Bricmont, Romane Bonhiver, Lionel Benchimol, Bruno Louis, Jean-Francois Papon, Justine Monseur, Anne-Francoise Donneau, Catherine Moermans, Florence Schleich, Doriane Calmes, Anne-Lise Poirrier, Renaud Louis, Marie-Christine Seghaye, Celine Kempeneers
Summary: In this study, we evaluated the effects of delay after sampling and the temperature for conservation of respiratory ciliated samples on assessments of ciliary beating. We found that ciliary beating can be evaluated at 37 degrees Celsius up to 9 hours after nasal brushing, but the storage temperature can modify ciliary beating.
Article
Critical Care Medicine
Anne-Fleur Haudebourg, Elsa Moncomble, Arnaud Lesimple, Flora Delamaire, Bruno Louis, Armand Mekontso Dessap, Alain Mercat, Jean-Christophe Richard, Francois Beloncle, Guillaume Carteaux
Summary: This study proposes a novel method for assessing airway opening pressure (AOP) during volume assist control ventilation at a constant-flow rate of 60 L/min. The P-cond method, which compares the airway pressure waveform to detect and measure AOP, was validated and showed good respiratory and hemodynamic tolerance compared to the standard low-flow method.
Article
Pediatrics
Charles Treussart, Fabrice Decobert, Manon Tauzin, Laura Bourgoin, Claude Danan, Gilles Dassieu, Guillaume Carteaux, Armand Mekontso-Dessap, Bruno Louis, Xavier Durrmeyer
Summary: This study compared patient-ventilator synchrony between non-invasive neurally adjusted ventilatory assist and synchronized intermittent positive airway pressure in extremely premature infants. The results showed that compared to synchronized intermittent positive airway pressure, non-invasive neurally adjusted ventilatory assist significantly improved patient-ventilator synchrony.