期刊
RESEARCH IN VETERINARY SCIENCE
卷 95, 期 3, 页码 908-912出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.rvsc.2013.07.029
关键词
PRRSV; ORF5; Genetic variation; Phylogenetic analysis
资金
- National Nature Science Foundation of China [31172346]
- Henan Province key technology RD program [92102110018]
To investigate the genetic diversity of prevailing porcine reproductive and respiratory syndrome virus (PRRSV) in Henan Province of China, 61 ORF5 gene sequences, originating from Henan Province during 2003-2010, were subjected to amino acid variation and phylogenetic analysis. The analyzed PRRSV ORF5 sequences carried evidence of one unique recombination event. Phylogenetic analysis revealed that all Henan isolates belonged to type 2 genotype and were divided into two subgroups. The dominant isolates had shifted from subgroup 1 to subgroup 2 during 2003-2010. Amino acid variation analysis of the glycoprotein 5 revealed that Henan PRRSV strains tended to accumulate more substitutions within the N-terminus and hypervariable region. Selective pressure analysis revealed evidence that some ORF5 sites have likely evolved in response to immune pressure. (C) 2013 Elsevier Ltd. All rights reserved.
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