期刊
RESEARCH IN VETERINARY SCIENCE
卷 91, 期 3, 页码 E58-E63出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.rvsc.2010.11.014
关键词
Coxiella burnetii; Q fever; Ovine; Aerosols; Vaccination
资金
- INIA [FAU2006-00002-C04-01]
- FEDER
- Department of Environment, Territorial Planning, Agriculture and Fisheries of Basque Government
- 'Instituto de Salud Carlos III' of Spanish Government
Abortion due to Coxiella burnetii was confirmed in the 2007/08 season in two naturally-infected dairy sheep flocks. Proportion of C. burnetii shedders and bacterial loads in vaginal mucus were high among aborted or lambed ewes, as was within-flock seroprevalence. Before the next reproductive season (2008/09) 75% of ewes and 50% of replacement lambs were vaccinated (Coxevac, CEVA Sante Animale) keeping the remaining as untreated controls. Compared with the previous year results when abortion outbreak started, a great reduction in the percentage of abortions, in the number of shedders and in the bacterial burden excreted by the ewes was found in both flocks. However, seroconversion in non-vaccinated yearlings from both flocks and the presence of C burnetii DNA in bioaerosols taken at sheep premises at lambing indicated that infection was still active. No differences were observed between vaccinated and control groups in terms of proportion of C. burnetii shedders. These results suggest that optimal results of vaccination in heavily infected flocks may not be obtained in a short-term period. (C) 2010 Elsevier Ltd. All rights reserved.
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