期刊
RESEARCH IN VETERINARY SCIENCE
卷 86, 期 1, 页码 56-62出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.rvsc.2008.05.007
关键词
Rhipicephalus (Boophilus) microplus; Cattle tick; Hemostasis; Platelet; Coagulation; Hemostatic disorders
资金
- Conselho Nacional de Pesquisa (CNPq)
- Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Programa Nacional de Excelencia (PRONEX)
The tick Rhipicephalus (Boophilus) microplus is a hematophagous ectoparasite that causes considerable economic losses to cattle breeding. Although R. microplus saliva contains several molecules that interfere with the blood coagulation process, so far the systemic alterations in the host hemostatic system have not been described. This study aims to determine if R. microplus infestation induces any disturbance to the host's hemostatic system. To address these questions, six calves were experimentally infested with 20,000 R. microplus larvae and their blood was collected before and 7, 14 and 21 days post-infestation. Collagen and ADP-induced platelet aggregation as well as coagulation (activated partial thromboplastin time and prothrombin time) decreased in infested bovines. Platelet blood count and fibrinogen increased during the course of infestation, probably as a compensatory response. These alterations may play a role in host health status, and show that the host cannot fully counteract the tick anti-hemostatic mechanisms. (c) 2008 Elsevier Ltd. All rights reserved.
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