期刊
RESEARCH IN VETERINARY SCIENCE
卷 86, 期 2, 页码 223-229出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.rvsc.2008.06.006
关键词
Cushing's disease; Pituitary-dependent hypercortisolism; Retinoic acid; ACTH diurnal rhythm; Cortisol diurnal rhythm
资金
- UBACyT [V045]
Daytime variations in ACTH and plasma cortisol were studied in healthy dogs and in dogs with pituitary-dependent hypercortisolism (PDH). before and after treatment with retinoic acid. In control dogs ACTH showed a higher concentration at 8.00 AM and between 2.00 and 6.00 PM, with the lowest concentration registered at 10.00 AM (p < 0.05 vs. 8.00 AM and 2.00 PM and p < 0.01 vs. 4.00 PM). Cortisol did not show significant differences. In dogs with PDH, ACTH was lower at 8.00 AM (ACTH: p < 0.01 vs. 2.00 and 4.00 PM; and P < 0.05 vs. 6.00 PM). The lowest cortisol concentration was registered at 8.00 AM and 8.00 PM and the highest at 4.00 PM (p < 0.05 vs. 8.00 AM and p < 0.01 vs. 8.00 PM). After treatment, the lowest ACTH concentration was registered at 10.00 AM (p < 0.01 vs. 2.00 and 4.00 PM). To conclude, the adrenal is desensitized in PDH possibly showing negative in diagnostic tests. (c) 2008 Elsevier Ltd. All rights reserved
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