Article
Biochemistry & Molecular Biology
Ingrid A. Edwards, Sonia T. Henriques, Mark A. T. Blaskovich, Alysha G. Elliott, Matthew A. Cooper
Summary: In this study, the mechanism of action of arenicin-3 and its synthetic analogue AA139 were investigated. The results showed that simple amino acid changes can affect their interaction with membranes, leading to changes in their potency, selectivity, and toxicity. AA139 demonstrated improved antibacterial activity and lower toxicity compared to arenicin-3, possibly due to its specific binding and insertion properties.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2022)
Article
Biotechnology & Applied Microbiology
Zhenlong Wang, Na Yang, Da Teng, Ya Hao, Ting Li, Huihui Han, Ruoyu Mao, Jianhua Wang
Summary: This study identified the resistance mechanisms of E. coli to the antimicrobial peptide N6NH(2) as increased biofilm formation capacity, decreased affinity with lipopolysaccharide (LPS), and changed cell membrane permeability and potential. Additionally, a chimeric peptide called G6 showed stronger inhibition against N6NH(2)-resistant mutants through enhanced biofilm formation inhibition, increased affinity with LPS, and greater membrane permeability and depolarization compared to N6NH(2).
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Physical
Shaohu Huo, Yamei Gao, Lulu Fang, Zitong Jiang, Qianhui Xie, Qingyong Meng, Guanghe Fei, Shenggang Ding
Summary: A new nanocomposite material with synergistic antibacterial effects was introduced, which could effectively kill bacteria, reduce infection risk, and promote wound healing.
APPLIED SURFACE SCIENCE
(2021)
Article
Engineering, Environmental
Bei Ye, Ziye Liu, Xiaoqin Zhu, Hanjing Wu, Zifan Liang, Wenlong Wang, Qianyuan Wu, Hongying Hu, Xinhao Zhang
Summary: Chlorination is a widely used method for water disinfection, and ammonia/chlorine co-exposure can have a synergistic effect on the degradation of atrazine (ATZ), involving the formation of hydroxyl radicals (OH) and reactive chlorine species.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Pharmacology & Pharmacy
Annarita Falanga, Valentina Del Genio, Stefania Galdiero
Summary: The alarming rise in antimicrobial resistance and recent viral pandemics have increased the demand for novel approaches, such as antimicrobial peptides, cell-penetrating peptides, antiviral peptides, and dendrimers, to combat bacteria and viruses effectively. Nanoplatforms constructed with peptides and dendrimers show promising potential for advanced nanosystems with diverse applications.
Article
Energy & Fuels
Mengchang Zhou, Changsong Zhou, Dong Chen, Hao Wu, Zhen Zhang, Hongmin Yang, Wei Ruan, Yaming Zhou, Zengqiang Tan
Summary: Novel manganese decorated UIO-66 catalysts (Mn/UIO-66) were prepared and applied to the vaporized hydrogen peroxide system for toluene removal, achieving an 82% removal efficiency. The catalytic performance was found to be correlated with the yield of hydroxyl radical and the catalyst specific surface area.
Article
Environmental Sciences
Chi Li, Qin Zhou
Summary: A carbon-based sandwich-like electrocatalyst with a hierarchical structure, consisting of carbon sheet (CS)-loaded Ce-doped SnO2 nanoparticles, was prepared successfully using a simple method. This electrocatalyst exhibited high-efficiency electrocatalytic performance for tetracycline decomposition. Specifically, the Sn0.75Ce0.25Oy/CS composite showed superior catalytic activity with more than 95% tetracycline removal in 120 minutes and over 90% mineralization of total organic carbon in 480 minutes. The layered structure of the catalyst was found to improve mass transfer efficiency, and the structural defect caused by Ce doping played a key role in its catalytic performance. The synergistic effect between CS and Sn0.75Ce0.25Oy contributed to the outstanding catalytic performance of this composite.
Article
Biochemistry & Molecular Biology
Martin van Eijk, Albert van Dijk, Cornelis K. van Der Ent, Hubertus G. M. Arets, Eefjan Breukink, Nico van Os, Roy Adrichem, Sven van Der Water, Rita Lino Gomez, Maartje Kristensen, Martin Hessing, Shehrazade Jekhmane, Markus Weingarth, Ruud A. W. Veldhuizen, Edwin J. A. Veldhuizen, Henk P. Haagsman
Summary: PepBiotics, a novel class of antimicrobial peptides, showed promising antibacterial properties against CF-related respiratory pathogens, with CR-163 demonstrating the most potential for treatment. These observations highlight the therapeutic potential of PepBiotics against CF-related bacterial respiratory infections.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2021)
Article
Engineering, Chemical
Wei Cheng, Peizhi Wang, Yuhao Zhang, Haorui Wang, Jun Ma, Tao Zhang
Summary: In this study, the oxidation resistance of fully aromatic (NF90) and semi-aromatic (NF270) polyamide NF membranes to reactive oxidative species including SO4. and HO. was investigated. The results showed that SO4. was more reactive to the N moieties of the NF90 membrane, while HO. reacted unselectively with polyamides. The radicals also affected the permselectivity of the membranes differently. Fully aromatic polyamide membrane exhibited higher resistance to oxidative radicals than semi-aromatic polyamide membrane.
JOURNAL OF MEMBRANE SCIENCE
(2023)
Article
Veterinary Sciences
Chunling Zhu, Yaya Zhao, Xueqin Zhao, Shanqin Liu, Xiaojing Xia, Shouping Zhang, Yimin Wang, Huihui Zhang, Yanzhao Xu, Shijun Chen, Jinqing Jiang, Yundi Wu, Xilong Wu, Gaiping Zhang, Yueyu Bai, Jianhe Hu, Hanna Fotina, Lei Wang, Xueming Zhang
Summary: This study explores the antibacterial activity and mechanism of an antibacterial peptide called MPX extracted from wasp venom against Staphylococcus aureus. MPX exhibits potent bactericidal activity against S. aureus, with a minimum inhibitory concentration of 0.08 mu M. It can destroy the integrity of the bacterial membrane, increase permeability, disrupt membrane potential, and cause leakage of cellular content, resulting in bactericidal effects. In a mouse scratch model, MPX inhibits colonization by S. aureus, reduces wound size, inflammation, and promotes wound healing.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Infectious Diseases
Yi Wang, Yuchi Song, Shaonan Yan, Rina Hiramine, Yuki Ohnishi, Yuki Yokoi, Kiminori Nakamura, Takashi Kikukawa, Tokiyoshi Ayabe, Tomoyasu Aizawa
Summary: This study investigated the antibacterial mechanisms of Cryptdin-4 in different forms (oxidized and reduced states) under different oxygen conditions using Escherichia coli as a model. The results showed that both forms exhibited antimicrobial activity against bacteria under aerobic conditions through rapid membrane depolarization. Under anaerobic conditions, the ability to disrupt bacterial membrane function decreased, but the reduced form still maintained some antimicrobial activity, possibly through DNA binding inhibition of intracellular functions.
Article
Nanoscience & Nanotechnology
Haiyan Cui, Mingsheng Liu, Wenwen Yu, Yufei Cao, Haicun Zhou, Juanjuan Yin, Hongbin Liu, Sheng Que, Jingjing Wang, Congshu Huang, Chenliang Gong, Guanghui Zhao
Summary: This study reports a pH-responsive copper peroxide-loaded wound dressing that can release hydroxyl radicals specifically in bacterial-infected skin wounds, exhibiting good antibacterial properties and promoting wound healing. The strategy presented in this study aims to enhance antibacterial efficacy and reduce toxic side effects by activating the release of hydroxyl radicals through bacterial self-activation.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Applied
Viorica Patrulea, Bee-Ha Gan, Karl Perron, Xingguang Cai, Philippe Abdel-Sayed, Emmanuelle Sublet, Verena Ducret, Natalia Porroche Nerhot, Lee Ann Applegate, Gerrit Borchard, Jean-Louis Reymond, Olivier Jordan
Summary: We report a new chemical platform for coupling chitosan derivatives to antimicrobial peptide dendrimers, which enables synergistic antimicrobial activity and preservation of activity when incorporated into various biopolymer formulations. This platform could be used for the development of new membrane disruptive therapeutics to eradicate pathogens in wounds.
CARBOHYDRATE POLYMERS
(2022)
Article
Environmental Sciences
Yingchao Zhang, Zhitao Bi, Wenxin Tian, Zhenyu Ge, Yang Xu, Rui Xu, Hongqiong Zhang, Shoufeng Tang
Summary: Metal oxides, particularly Fe2O3, play a crucial role in the formation of humic substances. This study investigates the synergistic interactions between Fe2O3 and O2 in the production of humic acid (HA). The results demonstrate that an O2 level of 21% is optimal for HA production in the presence of Fe2O3. O2 promotes the formation of hydroxyl radicals, which in turn enhances HA formation. Additionally, Fe2O3 acts as a catalyst and oxidant, contributing to the darkening process of humification.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Polymer Science
Wenwen Li, Che Zhang, Xuemei Lu, Shuqing Sun, Kai Yang, Bing Yuan
Summary: In this study, a new type of nanocomposite, composed of polymyxin B (PMB) molecules being chemically decorated on the surface of graphene oxide (GO) nanosheets, was designed to improve the antibacterial performance of PMB. The nanocomposite showed potent antibacterial ability by disturbing the bacterial membrane. The results demonstrate the potential of developing advanced antibacterial agents using this physical mechanism.
Article
Biochemistry & Molecular Biology
Giyeol Han, Dong Gun Lee
Summary: This study explored the antimicrobial activity of Indole propionic acid (IPA) against Candida albicans, showing modulation of mitochondrial respiration and induction of Ca2+-mediated apoptosis.
Article
Microbiology
Minji Kim, Dong G. Lee
Summary: Propionic acid disrupts cell homeostasis in Escherichia coli O157, leading to a form of programmed cell death known as apoptosis-like death (ALD), independently of reactive oxygen species (ROS).
JOURNAL OF BASIC MICROBIOLOGY
(2022)
Article
Surgery
Ga-Yeong Shin, Jae Myung Park, Dong-Gun Lee, Yoo-Jin Kim, Hee-Je Kim, Dong-Wook Kim, Myung-Gyu Choi
Summary: This study investigated the development of infectious events after endoscopic procedures in neutropenic patients with hematologic diseases and assessed the risk factors. The results showed that procedural invasiveness and severity of neutropenia did not affect the occurrence of infectious events, whereas poor performance status was the strongest factor for the development of infectious events.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Biology
Issam I. Raad, Ray Hachem, Nigo Masayuki, Tarcila Datoguia, Hiba Dagher, Ying Jiang, Vivek Subbiah, Bilal Siddiqui, Arnaud Bayle, Robert Somer, Ana Fernandez Cruz, Edward Gorak, Arvinder Bhinder, Nobuyoshi Mori, Nelson Hamerschlak, Samuel Shelanski, Tomislav Dragovich, Yee Elise Vong Kiat, Suha Fakhreddine, Abi Hanna Pierre, Roy F. Chemaly, Victor Mulanovich, Javier Adachi, Jovan Borjan, Fareed Khawaja, Bruno Granwehr, Teny John, Eduardo Yepez Yepez, Harrys A. Torres, Natraj Reddy Ammakkanavar, Marcel Yibirin, Cielito C. Reyes-Gibby, Mala Pande, Noman Ali, Raniv Dawey Rojo, Shahnoor M. Ali, Rita E. Deeba, Patrick Chaftari, Takahiro Matsuo, Kazuhiro Ishikawa, Ryo Hasegawa, Ramon Aguado-Noya, Alvaro Garcia Garcia, Cristina Traseira Puchol, Dong Gun Lee, Monica Slavin, Benjamin Teh, Cesar A. Arias, Dimitrios P. Kontoyiannis, Alexandre E. Malek, Anne-Marie Chaftari
Summary: This international multicenter study aimed to identify independent risk factors for increased 30-day mortality in COVID-19 patients with and without cancer. The study analyzed data from 16 international centers and found that cancer itself was not an independent risk factor for increased mortality. Older age and lymphopenia were the main predictors of 30-day mortality in all patients, and remdesivir was the only therapeutic agent associated with decreased mortality.
Article
Immunology
Jihyun Lee, Dong-Gun Lee, Jin Jung, Ji Hyeong Ryu, Soyoung Shin, Sung-Yeon Cho, Raeseok Lee, Eun-Jee Oh
Summary: Comprehensive assessment of SARS-CoV-2 antibodies is crucial for monitoring infection and vaccination. This study found that antibody levels vary depending on antigenic epitopes, vaccine type, and disease severity. Evaluating seroconversion using multiplex-bead assays can contribute to monitoring disease progression and optimizing vaccination strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Physical
Jitendra Bahadur, Jun Ryu, Dong-Gun Lee, Jongin Hong, Shuzi Hayase, Jung Sang Cho, Sang Mun Jeong, Dong-Won Kang
Summary: In this study, small carbon chain molecules were introduced as liquid additives to improve the crystal growth and surface processing of CsPbI2Br perovskite. The additives could passivate surface defects by conducting with halide ions, leading to improved performance and stability of the photovoltaic devices. The addition of diiodo-methane was found to significantly enhance the power conversion efficiency of perovskite solar cells, reaching a record high of 16.42%.
APPLIED SURFACE SCIENCE
(2023)
Article
Medicine, General & Internal
Alberto Papi, Michael G. Ison, Joanne M. Langley, Dong-Gun Lee, Isabel Leroux-Roels, Federico Martinon-Torres, Tino F. Schwarz, Richard N. van Zyl-Smit, Laura Campora, Nancy Dezutter, Nathalie de Schrevel, Laurence Fissette, Marie-Pierre David, Marie Van der Wielen, Lusine Kostanyan, Veronica Hulstrom
Summary: A phase 3 clinical trial showed that a candidate vaccine for respiratory syncytial virus (RSV) infection has a high efficacy in preventing RSV-related respiratory infection and lower respiratory tract disease in older adults. The vaccine was effective against both RSV subtypes and in individuals with underlying conditions.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Chemistry, Analytical
Ae Sol Lee, Su Min Kim, Kyeong Rok Kim, Chulmin Park, Dong-Gun Lee, Hyung Joon Cha, Hye Ryoung Heo, Chang Sup Kim
Summary: To control SARS-CoV-2, early diagnosis of infected individuals is crucial. A colorimetric lateral flow immunoassay (LFIA) was developed in this study, enabling sensitive detection of cultured SARS-CoV-2 in 15 minutes with a detection limit of 5 x 10^4 copies/mL. Clinical evaluation showed that the LFIA accurately detected all positive and negative samples, achieving 100% accuracy.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Virology
Seungwan Chae, Hoon Seok Kim, Sung-Yeon Cho, Dukhee Nho, Raeseok Lee, Dong-Gun Lee, Myungshin Kim, Yonggoo Kim
Summary: This study aimed to identify variants associated with CMV drug resistance in HCT recipients and assess their clinical significance. The study found that 8.1% of patients had resistance variants, and 39.0% of patients had variants of uncertain significance. Patients with resistance variants had higher CMV viral load and higher risks of severe graft-versus-host disease and lower one-year survival rates.
Article
Biophysics
Juhwan Park, Minjun Park, Junbeom Kim, Youhee Heo, Bo Hoon Han, Nakwon Choi, Chulmin Park, Raeseok Lee, Dong-Gun Lee, Seok Chung, Ji Yoon Kang
Summary: Digital enzyme linked immunosorbent assays (ELISA) can detect SARS-CoV-2 antigens with higher sensitivity compared to conventional antigen tests. To improve detection sensitivity, researchers developed an oil-and bead-free single molecule counting assay with rolling circle amplification (RCA) on a substrate. This method showed more than 100-fold improvement in detecting the N protein of SARS-CoV-2 compared to conventional ELISA.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Immunology
Geon Young Ko, Jihyun Lee, Hyunjoo Bae, Ji Hyeong Ryu, Hye-Sun Park, Hyunhye Kang, Jin Jung, Ae-Ran Choi, Raeseok Lee, Dong-Gun Lee, Eun-Jee Oh
Summary: This prospective study evaluated immune responses and breakthrough infections in 235 infection-naive healthcare workers. The study found that both vaccine groups exhibited peak responses one to two months after the second or third dose, followed by gradual declines. The ChAd group showed a gradual increase in ELISPOT results, but their antibody levels declined more rapidly than the BNT group. Six months after the third dose, both groups had substantial cellular responses, with superior humoral responses in the BNT group.
Article
Pediatrics
Jeong Min Kim, Hyun Mi Kang, In Hyuk Yoo, Dong-Gun Lee, Nack-Gyun Chung, Bin Cho
Summary: Gastrointestinal bleeding is a rare adverse event of dasatinib, which can be caused by dasatinib-induced colitis, severe thrombocytopenia, and platelet dysfunction. We report two cases of pediatric patients who developed hematochezia during treatment with dasatinib after hematopoietic stem cell transplantation (HSCT). A colonic tissue biopsy was performed to differentiate the cause of GI bleeding. Both patients were diagnosed with proven cytomegalovirus (CMV) colitis, but only one received ganciclovir treatment. The patient who did not receive antiviral therapy experienced recurrent GI bleeding during dasatinib administration, leading to multiple treatment interruptions. Patients with GI bleeding and confirmed CMV colitis during dasatinib therapy after HSCT may benefit from antiviral therapy to reduce interruptions in dasatinib therapy.
PEDIATRIC GASTROENTEROLOGY HEPATOLOGY & NUTRITION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jongmin Lee, Raeseok Lee, Kyongmin Sarah Beck, Dae Hee Han, Gi June Min, Suyon Chang, Jung Im Jung, Dong-Gun Lee
Summary: This study reported the clinical and radiological characteristics of patients with B-cell lymphoma and COVID-19, showing migratory airspace opacities on serial chest CT. The results showed that these patients exhibited multifocal patchy peripheral ground glass opacities (GGOs) with basal predominance in the baseline CTs, and clearance of previous opacities with the development of new peripheral and peribronchial GGO and consolidation in different locations. All patients demonstrated prolonged COVID-19 symptoms accompanied by positive polymerase chain reaction results throughout the follow-up period.
KOREAN JOURNAL OF RADIOLOGY
(2023)
Article
Infectious Diseases
Jing Chen, Ju-Young Shin, Sumitra Shantakumar, Sungho Bea, Byong Duk Ye, Dong-Gun Lee, Hyungwoo Kim, Won Suk Choi, Iain Kaan
Summary: The incidence rate of herpes zoster (HZ) is higher in individuals with immunocompromised conditions and autoimmune diseases (IC/AID) in the Republic of Korea (ROK), especially in women, those aged 50 years and above, and those who have undergone transplants and hemato-oncology treatment. HZ in IC/AID patients leads to higher medical costs.
INFECTIOUS DISEASES AND THERAPY
(2023)
Review
Infectious Diseases
Hahn Kim, Yunmi Yi, Sung-Yeon Cho, Dong-Gun Lee, Hye-Sun Chun, Chulmin Park, Yoo-Jin Kim, Yeon-Joon Park
Summary: Schizophyllum commune is an uncommon human pathogen that can cause invasive fungal pneumonia, especially in immunocompromised patients. This article presents a case of invasive fungal pneumonia due to S. commune and reviews global research on the topic.
INFECTION AND CHEMOTHERAPY
(2022)
