期刊
RESEARCH IN MICROBIOLOGY
卷 160, 期 9, 页码 645-651出版社
ELSEVIER
DOI: 10.1016/j.resmic.2009.08.021
关键词
Lon protease; Gene expression regulation; Stress response
类别
资金
- Research Foundation - Flanders (FWO)
After their first discovery in Escherichia coli, Lon homologues were found to be widely distributed among prokaryotes to eukaryotes. The ATP-dependent Lon protease belongs to the AAA(+) (ATPases associated with a variety of cellular activities) superfamily, and is involved in both general quality control by degrading abnormal proteins and in the specific control of several regulatory proteins. As such, this enzyme has a pivotal role in quality control and cellular physiology. This review focuses on mechanisms of degradation both from the protease and substrate points of view, and discusses the role of Lon in global regulation, stress response and virulence. (C) 2009 Elsevier Masson SAS. All rights reserved.
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