Article
Pharmacology & Pharmacy
Shan Liu, Xiao-Bing Lan, Miao-Miao Tian, Chun-Hao Zhu, Lin Ma, Jia-Mei Yang, Juan Du, Ping Zheng, Jian-Qiang Yu, Ning Liu
Summary: Chronic pain poses a significant public health challenge, impacting patients' physical and psychological health as well as their quality of life. Current drug treatments for chronic pain often have limited efficacy and come with numerous side effects. The chemokine system, specifically the CCL2/CCR2 axis, plays a crucial role in the development and maintenance of chronic pain. Targeting this system through various approaches, such as siRNA, blocking antibodies, or small molecule antagonists, holds promise for managing chronic pain.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Ting-Ting Chang, Ching Chen, Jaw-Wen Chen
Summary: Chemokine CC motif ligand 7 (CCL7) is implicated in the development of cardiovascular disease, diabetes mellitus, and kidney disease by attracting macrophages and monocytes to contribute to inflammatory processes. However, the specific pathological signaling pathways of CCL7 need to be further investigated.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Immunology
Ting-Ting Chang, Liang-Yu Lin, Jaw-Wen Chen
Summary: The study showed that inhibiting CCL4 could protect pancreatic islet cells, improve insulin resistance, and slow down the progression of hyperglycemia in different experimental diabetes models. This suggests a critical role of CCL4-related inflammation in the advancement of diabetes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Ching Chen, Ting-Ting Chang, Jaw-Wen Chen
Summary: Chemokines, through modulating inflammation process, have a potential role in the development of cardiovascular disease, diabetes mellitus, and kidney disease. Among them, CXCL5, a chemokine with bidirectional promiscuity, may be involved in various inflammatory diseases, but its specific mechanistic roles in each disease need further investigation. Recent evidence suggests differential effects of CXCL5 in cardiovascular disease, diabetes mellitus, and renal disease, but its potential as a therapeutic target in these diseases requires further validation.
Article
Biochemistry & Molecular Biology
Ting-Ting Chang, Ching Chen, Liang-Yu Lin, Jaw-Wen Chen
Summary: This study found that the increased level of CCL4 in diabetes patients is associated with non-healing wounds. Inhibiting CCL4 can restore cell function and accelerate wound healing in diabetic patients. These findings provide a new therapeutic option for clinical treatment of diabetic wounds.
Article
Biochemistry & Molecular Biology
Hiroyoshi Machida, Sumito Inoue, Akira Igarashi, Shinichi Saitoh, Keiko Yamauchi, Michiko Nishiwaki, Takako Nemoto, Yoichiro Otaki, Masamichi Sato, Kento Sato, Hiroshi Nakano, Sujeong Yang, Kodai Furuyama, Hiroaki Murano, Yu Ishibashi, Takahito Ota, Takashi Nakayama, Yoko Shibata, Masafumi Watanabe
Summary: The production of CCL17 by lung epithelial cells upon cigarette smoke exposure contributes to the accumulation of alveolar macrophages and the development of pulmonary emphysema. CCL17-induced production of CCL2 by macrophages plays a role in macrophage accumulation. These findings provide new insights into the pathogenesis of COPD.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hongguang Ma, Mengchu Li, Piyusha P. Pagare, Huiqun Wang, Nima Nassehi, Edna J. Santos, S. Stevens Negus, Dana E. Selley, Yan Zhang
Summary: This study synthesized a series of bivalent ligands to investigate the functional interactions between opioid and chemokine receptors. Compound 1a showed promising antinociceptive effect and may serve as a novel chemical probe for developing more potent bivalent ligands for chronic pain management.
BIOORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Xinxin Huang, Juncheng Hao, Yan Qin Tan, Tao Zhu, Vijay Pandey, Peter E. Lobie
Summary: Patients with epithelial ovarian cancer are often diagnosed at an advanced stage, leading to poor overall prognosis. This review summarizes the functional significance of CXCL/CXCR chemokines in modulating EOC progression and discusses the current status and prospects of CXCR/CXCL-based theranostic strategies in EOC management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Haiyu Zhang, Shoujing Luan, Xiao Xiao, Lingyu Lin, Xiaowei Zhao, Xueyao Liu
Summary: By regulating miR-222, the action of CXCR4 can be promoted, and the activation of NLRP3 inflammasomes can be inhibited, thereby alleviating the inflammatory response in gestational diabetes mellitus patients.
Review
Biochemistry & Molecular Biology
Ioanna Kokkinopoulou, Andriana Diakoumi, Paraskevi Moutsatsou
Summary: Research shows that stress and depression increase the risk of Type 2 Diabetes by impairing the negative feedback of Glucocorticoid in patients, leading to HPA axis hyperactivity and hypercortisolism. Glucocorticoid Receptor has a key role in regulating glucose homeostasis in peripheral tissues, while impaired signaling in Peripheral Blood Mononuclear Cells of T2D patients is linked to metabolic disturbances. Further investigation into selective modulation of GR signaling in T2D therapy is warranted.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Fei Kong, Huiyuan Bai, Ming Ma, Chen Wang, Haiyan Xu, Ning Gu, Yu Zhang
Summary: The utilization of a composite nanozyme to target and treat acute myeloid leukemia represents a potential therapeutic approach, alleviating the toxic side effects of chemotherapy and improving treatment efficacy.
Article
Biochemistry & Molecular Biology
Wei Gao, Yufen Wang, Jian Bi, Xiuli Chen, Na Li, Yingde Wang, Haiying Tang, Jingwei Mao
Summary: The abnormal crosstalk between gut immune system and liver in nonalcoholic steatohepatitis (NASH) may be related to the changes in the numbers and activity of CD4+ T cells and DC subsets. This imbalance in gut immunity in NASH could be due to impaired gut chemokine receptor 9 (CCR9)/chemokine ligand 25 (CCL25) signaling pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Nagesha Guthalu Kondegowda, Joanna Filipowska, Jeong-su Do, Nancy Leon-Rivera, Rosemary Li, Rollie Hampton, Selassie Ogyaadu, Camilla Levister, Josef M. Penninger, Helena Reijonen, Carol J. Levy, Rupangi C. Vasavada
Summary: Inhibition of the RANKL/RANK pathway promotes beta cell regeneration and survival, offering potential therapeutic benefits for type 1 diabetes. Osteoprotegerin and denosumab provide protection against cytokine-induced beta cell death, and have shown promising results in reversing recent-onset type 1 diabetes in mice and reducing inflammation.
Article
Biochemistry & Molecular Biology
Xin Zhong, Xueying Zhao, Liyuan Zhang, Ning Liu, Sa Shi, Yuwen Wang
Summary: This study found that the donor of hydrogen sulfide, sodium hydrosulfide, can inhibit endothelial cell injury and neutrophil activation in type 1 diabetes mellitus rats through the IL-8/CXCR2/ROS/NF-kappa B axis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Hang Yu, Ying Mei, Yang Dong, Chao Chen, Xianke Lin, Hailong Jin, Jiren Yu, Xiaosun Liu
Summary: The study aimed to investigate the role of CCR9-CCL25 interaction in the pDC-mediated immunosuppressive microenvironment of gastric cancer. The results showed that the expression of CCR9+CCL25 increased in gastric cancer tissue, and more CCR9+ pDCs were found in metastatic lymph nodes and carcinoma tissue, which were associated with advanced T staging and lymph node metastasis and conferred a poor prognosis. Therefore, CCR9-CCL25 interaction may play an important role in guiding pDCs to metastatic lymph nodes and carcinoma tissue, contributing to the formation of tumor immunosuppressive microenvironment and leading to a worse prognosis.
TRANSLATIONAL ONCOLOGY
(2023)
Article
Endocrinology & Metabolism
Fu-peng Liu, Ming-hui Sun, Jun-yu Zhao, Ming Yang, Xiao-jun Zhou, Zhong-wen Zhang, Jian-jun Dong, Lin Liao
HORMONE AND METABOLIC RESEARCH
(2020)
Article
Cardiac & Cardiovascular Systems
Liqun Li, Qiang Liu, Tongyao Shang, Wei Song, Dongmei Xu, Thaddeus D. Allen, Xia Wang, James Jeong, Corrinne G. Lobe, Ju Liu
Summary: The study established a transgenic mouse model with aberrant activation of the Notch1 signaling pathway, revealing that activated Notch1 signaling resulted in decreased VE-cadherin expression, dysfunction of the glomerular filtration barrier, and induction of albuminuria.
CIRCULATION RESEARCH
(2021)
Article
Medicine, Research & Experimental
Ling Guo, Xiaoqing Wen, Yinglong Hou, Rong Sun, Liang Zhang, Fuhong Liu, Ju Liu
Summary: Anti-angiogenesis therapy is a new treatment method for malignant tumors, and dihydroartemisinin (DHA) inhibits endothelial cell (EC) migration through the TGF-beta 1/ALK5/SMAD2 signaling pathway. These findings suggest that DHA may be a novel drug for the treatment of patients with malignant tumors.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Cell Biology
Qian Zhang, Chen Zhao, Lei Zhang, Kai Sun, Linlin Yu, Xianming Wang, Lei Ren, Nan Zhang, Chengyu Chen, Ju Liu, Haimei Wang, Hu Tian
Summary: The study demonstrates that pretreatment with ES can reduce levels of amylase and lipase, decrease inflammatory cytokines, attenuate pancreatic damage, and promote apoptosis in acinar cells. Additionally, ES enhances cell apoptosis by regulating the ERK/STAT3 signaling pathway, suggesting it as a potential therapeutic option for AP treatment.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Cell & Tissue Engineering
Yuanyuan Liu, Chao He, Xin Li, Zewen Zhang, Ju Liu, Congcong Sun, Zeming Li, Caiqing Zhang
Summary: The study demonstrated that IL-27 could inhibit airway remodeling by attenuating bronchial epithelial cell EMT both in vivo and in vitro, suggesting that IL-27 may be a beneficial therapeutic option for targeting asthmatic airway remodeling.
JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING
(2021)
Article
Endocrinology & Metabolism
Qing Yang, Mei Zhang, Peng Sun, Yanying Li, Huichao Xu, Kejun Wang, Hongshan Shen, Bo Ban, Fupeng Liu
Summary: The study found a significant correlation between Cre/CysC and skeletal muscle composition in patients with type 2 diabetes, making it a valuable predictor for SMI and MMA. Patients with higher Cre/CysC may have better postprandial glucose disposal ability and lower risk of macrovascular diseases.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)
Article
Medicine, Research & Experimental
Qi Xie, Tong-yao Shang, Shuo Feng, Ru-cai Zhan, Jing Liang, Meng-ge Fan, Liang Zhang, Ju Liu
Summary: The study found that hypoxia inhibits the proliferation of HDLECs, and CEACAM1 plays a crucial role in this process. Silencing of CEACAM1 inhibited HDLEC proliferation through activation of the JNK pathway, providing insights into the specific response mechanisms of LECs to hypoxia and potential novel therapies for pathological lymphangiogenesis.
CURRENT MEDICAL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Ju Han, Guangyan Xu, Qihao Dong, Guoxian Jing, Qiang Liu, Ju Liu
Summary: The study suggests that CIZ1 may be a novel repressor of neointimal lesion formation by inhibiting proliferation and migration of vascular smooth muscle cells, as shown by decreased p21 expression and MMP9 levels in CIZ1 knockdown cells.
Article
Pharmacology & Pharmacy
Fuhong Liu, Jing Liu, Hongjie Xiang, Zongguo Sun, Yan Li, Xiao Li, Yanjun Liu, Ju Liu
Summary: This study found that DHA can protect BBB permeability during sepsis by reducing permeability, increasing the expression of tight junction protein OCLN, and inhibiting the expression of SNAI1.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Fupeng Liu, Qing Yang, Hongli Zhang, Yanhong Zhang, Guangzhi Yang, Bo Ban, Yanying Li, Mei Zhang
Summary: GLP-1RA treatment leads to significant and similar absolute reductions in VAT and SAT in patients with type 2 diabetes. The reduction in adipose tissues is significantly correlated with the reduction in body weight.
Article
Endocrinology & Metabolism
Guangzhi Yang, Qing Yang, Yanying Li, Yanhong Zhang, Shuxiong Chen, Dongye He, Mei Zhang, Bo Ban, Fupeng Liu
Summary: This study aims to evaluate the association between the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis and muscle density in children and adolescents of short stature. The results showed that a chest CT scan is a credible method of evaluating body composition in these individuals. Peak GH and IGF-1 SDS are independent predictors of muscle density.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cell Biology
Bingxuan Lv, Shengshi Huang, Hong Huang, Na Niu, Ju Liu
Summary: This review summarizes the latest knowledge on glycocalyx and its potential role in SARS-CoV-2 infection. The endothelial glycocalyx is a dynamic grid composed of membrane-bound proteoglycans and glycoproteins, which regulates EC permeability, adhesion, and coagulation. Maintaining the integrity of glycocalyx may provide a novel treatment approach for SARS-CoV-2 infection.
MEDIATORS OF INFLAMMATION
(2023)
Article
Cell Biology
Hui Yang, Wenguang Yuan, Wei Shang, Haoran Wang, Shanglei Ning, Ju Liu
Summary: Gastric cancer stem cells (GCSCs) are important in the initiation and development of gastric cancer (GC). Circular RNAs (circRNAs) have diverse functions in cancer biology, acting as tumor suppressors or oncogenes. This study focused on the expression profile and functional roles of circRNAs in GCSCs. Through enrichment of GCSCs using a spheroid formation assay, it was found that circSLC4A7 was one of the most upregulated circRNAs in GCSCs. Further experiments showed that circSLC4A7 promoted CSC-like properties and cell proliferation, migration, and invasion by interacting with HSP90 and activating the Notch1 signaling pathway in GC.
CELL DEATH & DISEASE
(2023)
Review
Geriatrics & Gerontology
Xia Wang, Maria N. Starodubtseva, Carolyn M. Kapron, Ju Liu
Summary: Vascular aging is characterized by thickening and stiffening of blood vessels, which is caused by endothelial cell dysfunction induced by oxidative stress and inflammation. von Willebrand Factor (vWF) plays a role in coagulation and its plasma levels increase with age. Elevated vWF promotes thrombosis, atherosclerotic plaque formation, inflammation, and proliferation of vascular smooth muscle cells. Cadmium (Cd), an environmental pollutant, is associated with increased cardiovascular disease risk. Low concentrations of Cd activate pro-survival signaling in endothelial cells, but also increase intima-media thickness and atherogenesis. Cd exposure at non-cytotoxic doses increases endothelial vWF expression and secretion. This review summarizes the molecular mechanisms of vWF-promoted vascular aging-associated pathologies and Cd-induced vWF expression and suggests that low-dose Cd exposure is a risk factor for vascular aging through elevated plasma vWF.
Review
Oncology
Tingting Ling, Jing Liu, Liang Dong, Ju Liu
Summary: P-selectin plays an important role in cancer cachexia, and is associated with leukocyte capture, inflammatory processes, muscle atrophy, and hypercoagulation.
