期刊
JOURNAL OF COSMETIC DERMATOLOGY
卷 14, 期 2, 页码 113-123出版社
WILEY
DOI: 10.1111/jocd.12143
关键词
melasma; hydroquinone; glycolic acid; hyaluronic acid; dermoscope
类别
BackgroundVarious treatments are currently available for melasma. However, results are often disappointing. Objectives1 To assess the efficacy and safety of combinations of hydroquinone, glycolic acid, and hyaluronic acid in the treatment of melasma after topical application. 2 To evaluate the dermoscopy as a tool in diagnosis and follow-up of melasma treatment. Patients and MethodsOne hundred patients with mild, moderate-to-severe melasma were divided into five groups. Group I (twenty patients were treated with cream formula containing 4% hydroquinone), group II (twenty patients were treated with cream formula containing 4% hydroquinone+10% glycolic acid), group III (twenty patients were treated with cream formula containing 4% hydroquinone+0.01% hyaluronic acid), group IV (twenty patients were treated with cream formula containing 4% hydroquinone+10% glycolic acid+0.01% hyaluronic acid), and group V (twenty patients were treated with placebo cream). All patients were subjected to dermoscopic examination and digital photographs before and after treatment. The response and side effects were evaluated. ResultsGroups I, III, and IV showed highly significant changes in modified Melasma Area and Severity Index (mMASI) score after using the treatment. Group II showed significant change in mMASI score after using the treatment. The side effects were more reported in group II, followed by group IV, followed by group I, followed by group III. There was highly significant difference between the dermoscopic color findings before and after treatment. Vascularization was another dermoscopic finding. ConclusionA cream formula containing 4% hydroquinone+10% glycolic acid+0.01% hyaluronic acid was very effective in treatment of melasma with tolerable side effects. Dermoscope is a valuable noninvasive tool in the diagnosis and follow-up of melasma treatment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据