期刊
REPRODUCTIVE TOXICOLOGY
卷 50, 期 -, 页码 4-10出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2014.09.013
关键词
Nicotine; Myosin heavy chain; Collagen; Transforming growth factor-beta 1
资金
- Taipei Medical University Hospital [103TMU-TMUH-15]
The aim of this study was to evaluate the effects of maternal nicotine exposure on heart morphology and fibrosis in rat offspring. Nicotine was administered to pregnant Sprague-Dawley rats by using a subcutaneous osmotic mini-pump at a dose of 6 mg/kg/day from Gestational Days 7-21 or Gestational Day 7 to Postnatal Day 14.A control group received an equal volume of saline by the same route as nicotine. Rats born to prenatal nicotine-treated dams exhibited significantly greater cell width of cardiomyocytes, fewer cardiomyocyte nuclei number, higher beta-myosin heavy chain and transforming growth factor (TGF-beta 1) expression, and higher collagen deposition in heart compared with rats born to normal saline-treated dams on Postnatal Days 7 and 21. Postnatal nicotine exposure further enhances these effects. We conclude that TGF-beta 1 may be involved in the pathogenesis of cardiac remodeling induced by maternal nicotine exposure during gestation and lactation in rat offspring. (C) 2014 Elsevier Inc. All rights reserved.
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