Article
Environmental Sciences
Ricardo Ivan Montano-Gonzalez, Gabriela Gutierrez-Salmean, Maria Angelica Mojica-Villegas, Jose Melesio Cristobal-Luna, Jorge Briseno-Bugarin, German Chamorro-Cevallos
Summary: Spirulina and phycobiliproteins have been found to alleviate Cd-induced oxidative damage on the male reproductive system, improving sperm quality and protecting testes from oxidative stress.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jicang Wang, Huali Zhu, Shu Lin, Ke Wang, Hongwei Wang, Zongping Liu
Summary: The study found that naringenin can protect testes from cadmium-induced toxicity by improving body weight, relative testis weights, sperm quality, and reducing testicular damage. It also restores antioxidant enzyme activities and levels, suppresses autophagy, and downregulates the expression of related proteins like P62 and LC3 II.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Veterinary Sciences
Brice Menkem, Bertin Narcisse Vemo, Megnimeza Martine Astride Tsambou, Tadiesse Lavoisier Fonou, Nguedia Arius Baulland Dongmo, Judith Laure Boufack, Margaret Mary Momo Chongsi, Augustave Kenfack
Summary: The ethanolic extract of Polygonum limbatum meism showed positive therapeutic effects on the reproductive parameters of male Guinea pigs exposed to cadmium chloride, mitigating the reproductive impairments caused by cadmium-induced oxidative stress.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Medicine, Research & Experimental
Abhishek Kumar, Nikhat J. Siddiqi, Sara T. Alrashood, Haseeb A. Khan, Anchal Dubey, Bechan Sharma
Summary: The study showed that eugenol has a strong protective effect against liver damage induced by cadmium, including reversing oxidative stress and inflammation. In the experiment, eugenol effectively restored the biochemical alterations caused by Cd.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Environmental Sciences
Fanli Sun, Xuying Wang, Pinzheng Zhang, Ziyun Chen, Zhiyi Guo, Xuan Shang
Summary: Exposure to silica nanoparticles (SiNPs) during puberty significantly damages the structure and function of the testis and epididymis by inducing oxidative stress, cell apoptosis, and an inflammatory response. These findings highlight the need for a more careful assessment of SiNPs before their application in juvenile supplies.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Plant Sciences
Xiaolei Zhuang, Huixue Wan, Hongyu Wang, Sijun Qin, Jiali He, Deguo Lyu
Summary: Cadmium accumulation, translocation, and tolerance in apple trees planted in different soils were investigated in this study. Soil types significantly affected Cd bioavailability, plant Cd accumulation, physiological changes, and gene expression patterns. Higher organic matter, clay, silt content, and lower sand content reduced Cd bioavailability and resulted in lower Cd accumulation levels and bio-concentration factors in apple trees. Therefore, soil types play a crucial role in Cd toxicity in apple trees.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Environmental Sciences
Jing-Bo Liu, Kai Chen, Zi-Fa Li, Zhen-Yong Wang, Lin Wang
Summary: Glyphosate (GLY) exposure can lead to male reproductive toxicity by causing gut microbiota dysbiosis, affecting testis structure and sperm quality, and triggering IL-17A signaling pathway activation and testicular oxidative damage.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Multidisciplinary Sciences
Cankiz Mina Ardic, Sinem Ilgin, Merve Baysal, A. Burak Karaduman, Volkan Kilic, Gozde Aydogan-Kilic, Seyda Ucarcan, Ozlem Atli-Eklioglu
Summary: The research revealed that olanzapine had toxic effects on the reproductive system of rats, causing abnormalities in testicular structure, decreased normal sperm morphology, alterations in hormone levels, and oxidative stress in the testis.
SCIENTIFIC REPORTS
(2021)
Article
Veterinary Sciences
Hong Du, Yilei Zheng, Wei Zhang, Huaqiao Tang, Bo Jing, Haohuan Li, Funeng Xu, Juchun Lin, Hualin Fu, Lijen Chang, Gang Shu
Summary: The study found that NSe alleviated Cd-induced hepatic pathological changes, reduced ALT and AST activities as well as MDA content, and increased T-AOC, T-SOD, and GSH activities. Furthermore, NSe significantly increased mRNA expressions of Nrf2 pathway related molecules and showed potential in reducing Cd-induced liver injury by inhibiting oxidative stress and activating the Nrf2 pathway.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Najah M. Al-Baqami, Reham Z. Hamza
Summary: The study showed that cadmium increased liver enzymes while reducing protein levels, and resveratrol played a major role in alleviating histopathological injuries and hepatic oxidative damage. Rs has the ability to minimize the hepatotoxicity induced by Cd in male rats.
Book Review
Biochemistry & Molecular Biology
Graziela P. F. Dantas, Fausto S. Ferraz, Lidia M. Andrade, Guilherme M. J. Costa
Summary: The use of nanoscale materials for biomedical applications has raised concerns about their toxic effects on human health. This systematic review focuses on the reproductive toxicity of different types of inorganic nanoparticles in male rodents. The findings indicate that these nanoparticles can cause structural and functional alterations in testicular cells, leading to oxidative stress, apoptosis, and/or necrosis. However, the lack of standardized protocols in the studies results in highly variable outcomes.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Nanoscience & Nanotechnology
Asmaa M. Shehata, Fatma M. S. Salem, Eiman M. El-Saied, Sahar S. Abd El-Rahman, Mohamed Y. Mahmoud, Peter A. Noshy
Summary: The study showed that exposure to Ag-NPs had adverse effects on the male reproductive system, affecting sperm motility, morphology, and concentration, inducing oxidative stress and lipid peroxidation in testicular tissue, and decreasing serum hormone levels. However, coadministration of Zn-NPs ameliorated most of the toxic effects of Ag-NPs through their antioxidative capacity.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Cell Biology
Puneet Kaur, Umesh Rai, Rajeev Singh
Summary: During modern era, various electronic devices using radiofrequency waves have become essential in our daily lives. The increasing risk of male infertility is a growing concern, as excessive exposure to non-ionizing radiation may cause genetic health effects on the male reproductive system. Studies on the genotoxic effects of radiofrequency (RF) waves have shown contradictory results regarding their impact on humans and animals. This review focuses on the genomic impact of RF-EMF on male infertility, discussing the potential damage to DNA, chromosomal aberrations, micronuclei formation, and oxidative stress caused by RF radiation exposure.
Article
Biochemistry & Molecular Biology
Yukiko Minamiyama, Shigekazu Takemura, Hiroshi Ichikawa
Summary: The exposome represents the lifetime exposure of an individual to external genetic influences and their impact on health. Certain food additives may affect sperm function, induce oxidative stress in the testes and brain, resulting in infertility and short-term memory loss.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Environmental Sciences
Ana Claudia F. Souza, Daniel S. S. Bastos, Felipe Couto-Santos, Luiz Otavio Guimaraes-Ervilha, Larissa S. Araujo, Pedro H. C. A. Souza, John L. P. Coimbra, Leandro L. Oliveira, Simone E. F. Guimaraes, Mariana Machado-Neves
Summary: This study investigated the long-term effects of prenatal arsenic exposure on reproductive parameters of male offspring at peripubertal and adult periods. Results revealed that arsenic exposure affected body and reproductive organ weights, as well as testicular and epididymal morphology in peripubertal animals but recovered in adulthood. Antioxidant gene expression and the endogenous antioxidant system in the testes and epididymides were affected by arsenic exposure in both peripubertal and adult rats. Impairment in daily sperm production and sperm parameters was observed in adult animals. Therefore, prenatal arsenic exposure has a long-term impact on reproductive parameters and may affect fertility potential in adult animals through oxidative stress.
ENVIRONMENTAL TOXICOLOGY
(2023)
Review
Anatomy & Morphology
Amanda Oliveira Ribeiro, Arthur Casulli de Oliveira, Juliana Mara Costa, Pedro Gabriel Nachtigall, Marcos Edgar Herkenhoff, Vinicius Farias Campos, Flavia Karina Delella, Danillo Pinhal
Summary: miRNAs play pivotal roles in gene expression control, potentially involved in the regenerative process by directing regenerative responses through miRNA-to-target interactions. Zebrafish, known for its exceptional regenerative capability, has been a central focus in regenerative research, providing insights into the regeneration of tissues such as fins, heart, retina, and nervous tissue.
DEVELOPMENTAL DYNAMICS
(2022)
Article
Medicine, Research & Experimental
Roberta Carvalho Cesario, Leticia Barbosa Gaiotte, Maira Smaniotto Cucielo, Henrique Spaulonci Silveira, Lucilene Delazari dos Santos, Debora Aparecida Pires de Campos Zuccari, Fabio Rodrigues Ferreira Seiva, Russel J. Reiter, Luiz Gustavo de Almeida Chuffa
Summary: This study investigated the effects of melatonin on human ovarian carcinoma cells and found that melatonin significantly altered the proteome of the cells, particularly proteins associated with immune response and mitochondrial metabolism. The findings also suggested that melatonin may be an effective therapeutic strategy against ovarian cancer.
Article
Biochemistry & Molecular Biology
Aline de Souza Nicoletti, Marilia Berlofa Visacri, Carla Regina da Silva Correa da Ronda, Pedro Eduardo do Nascimento Silva Vasconcelos, Julia Coelho Franca Quintanilha, Rafael Nogueira de Souza, Deise de Souza Ventura, Adriana Eguti, Lilian Ferreira de Souza Silva, Mauricio Wesley Perroud Junior, Rodrigo Ramos Catharino, Leonardo Oliveira Reis, Luiz Augusto dos Santos, Nelson Duran, Wagner Jose Favaro, Marcelo Lancellotti, Jose Luiz da Costa, Patricia Moriel, Eder de Carvalho Pincinato
Summary: This study identified 18 differentially expressed miRNAs between patients with COVID-19 and healthy controls, with some miRNAs significantly involved in multiple signaling pathways. Additionally, 42 miRNAs were differentially expressed between severe/critical patients with COVID-19 and mild patients, with some miRNAs significantly associated with disease severity. If validated in a larger cohort, these miRNAs could potentially serve as biomarkers for COVID-19 diagnosis and severity.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Anatomy & Morphology
Sabrina Karen Reis, Eduardo Augusto Rabelo Socca, Bianca Ribeiro de Souza, Sandra Cristina Genaro, Nelson Duran, Wagner Jose Favaro
Summary: This study evaluated the effects of combined OncoTherad immunotherapy and probiotic supplementation on chemically induced colorectal carcinogenesis in mice. The results showed that this combination therapy could modulate weight loss, stimulate signaling pathways, reduce proliferation mediated by oncogenes, and stimulate the production of immune factors. These findings provide a potential new therapeutic approach for colorectal cancer.
Review
Biotechnology & Applied Microbiology
N. Duran, G. R. Castro, R. W. D. Portela, W. J. Favaro, M. Duran, L. Tasic, G. Nakazato
Summary: Violacein is an important natural antimicrobial pigment with significant antifungal effects against phytopathogenic and human fungi. It has low toxicity and plays an important role in ecological protection and medical fabric dyeing.
LETTERS IN APPLIED MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maira Smaniotto Cucielo, Roberta Carvalho Cesario, Henrique Spaulonci Silveira, Leticia Barbosa Gaiotte, Sergio Alexandre Alcantara Dos Santos, Debora Aparecida Pires de Campos Zuccari, Fabio Rodrigues Ferreira Seiva, Russel J. Reiter, Luiz Gustavo de Almeida Chuffa
Summary: This study found that melatonin can change the energy metabolism and mitochondrial integrity in ovarian cancer cells, thus reducing the survival advantage of the cancer cells, regardless of the activation of MT1 receptor.
Article
Oncology
Ianny Brum Reis, Luiz Henrique Soares Tibo, Bianca Ribeiro de Souza, Nelson Duran, Wagner Jose Favaro
Summary: Bladder cancer is commonly treated with TUR and OncoTherad(R) immunotherapy. Previous studies with mice have shown that OncoTherad(R) can effectively reduce tumor progression in NMIBC by activating the non-canonical pathway of Toll-like receptors. Immunohistochemical results demonstrate that OncoTherad(R) reduces RANK and RANKL immunoreactivities, indicating a favorable prognosis. Immunohistochemical and western blotting analyses confirm the modulation of PD-1/PD-L1 immune checkpoint by OncoTherad(R).
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Surgery
Bruna Maria Manzini, Jose Luis Davila, Bruno Bosch Volpe, Adriana da Silva Santos Duarte, Maria Teresa Ferreira Cortez, Eliana Aparecida de Rezende Duek, Wagner Jose Favaro, Marcos Akira d'Avila, Ricardo Kalaf Mussi, Angela Cristina Malheiros Luzo
Summary: This study aimed to develop a tissue-engineered alternative for the treatment of small TF and evaluate its association with suture filaments enriched with AT-MSCs. Through in vitro and in vivo experiments and tissue analysis, it was concluded that PLLA membranes with attached AT-MSCs have a high potential for extracellular matrix restoration, and their association with suture filaments enriched with AT-MSCs is advantageous.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Anatomy & Morphology
W. J. Favaro, J. C. C. Alonso, B. R. de Souza, I. B. Reis, J. M. Goncalves, A. C. Deckmann, G. Oliveira, Q. C. Dias, N. Duran
Summary: BCG-based intravesical immunotherapy is the gold standard treatment for high-risk non-muscle invasive bladder cancer. However, some high-risk patients experience relapse and do not respond to BCG. Our research group developed OncoTherad (R) nano-immunotherapy, which showed positive outcomes and mechanisms of action in an animal model with NMIBC. OncoTherad (R) nano-immunotherapy was more effective than BCG treatment, reducing the malignancy rate by 70% through modulation of TLR4-mediated interferon and RANK/RANKL signaling pathways.
Article
Biochemistry & Molecular Biology
Fabiano Goncalves Costa, Chayrra Chehade Gomes, Mateus Contar Adolfi, Mayra Costa da Cruz Gallo de Carvalho, Marco Antonio Zanoni, Fabio Rodrigues Ferreira Seiva, Maria Ines Borella
Summary: This study investigated the distribution of various proteins and compounds in the testis of Astyanax lacustris and explored the localization of androgen receptor in this species. The results provide new insights into the biology of the testis and contribute to a better understanding of this organ in A. lacustris.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Ellen Mayara Souza Cruz, Virginia Marcia Concato, Juliana Maria Bitencourt de Morais, Taylon Felipe Silva, Fabricio Seidy Ribeiro Inoue, Milena de Souza Cremer, Danielle Lazarin Bidoia, Rayanne Regina Beltrame Machado, Luiz Gustavo de Almeida Chuffa, Mario Sergio Mantovani, Carolina Panis, Wander Rogerio Pavanelli, Fabio Rodrigues Ferreira Seiva
Summary: This study investigated the antitumor effects of melatonin on hepatocellular carcinoma (HCC) using HuH 7.5 cells. The results showed that melatonin reduced cell motility, caused changes in cell structure, and inhibited the Warburg effect by regulating lactate dehydrogenase activity. These findings suggest that melatonin could be a promising candidate for adjuvant therapy in HCC treatment.
Review
Biochemistry & Molecular Biology
Maria Beatriz Madureira, Virginia Marcia Concato, Ellen Mayara Souza Cruz, Juliana Maria Bitencourt de Morais, Fabricio Seidy Ribeiro Inoue, Natalia Concimo Santos, Manoela Daniele Goncalves, Milena Cremer de Souza, Thalita Basso Scandolara, Mariane Fontana Mezoni, Murilo Galvani, Fabio Rodrigues Ferreira Seiva, Carolina Panis, Milena Menegazzo Miranda-Sapla, Wander Rogerio Pavanelli
Summary: Citrus fruits are important sources of bioactive compounds with antioxidant properties, such as flavonoids. Naringenin and hesperidin are emerging compounds with potential anticancer effects, particularly for breast cancer. This review discusses the mechanisms by which naringenin and hesperidin can serve as therapeutic tools and alternative treatment sources for breast cancer.
Article
Public, Environmental & Occupational Health
Juliana Maria Bitencourt de Morais Valentim, Tatiane Renata Fagundes, Mariane Okamoto Ferreira, Pamela Lonardoni Micheletti, Geise Ellen Broto Oliveira, Milena Cremer Souza, Beatriz Geovana Leite Vacario, Janaina Carla da Silva, Thalita Basso Scandolara, Shaiane Carla Gaboardi, Luciano Zanetti Pessoa Candiotto, Juliana Mara Serpeloni, Fabio Rodrigues Ferreira Seiva, Carolina Panis
Summary: This study investigated the relationship between pesticides, food contamination, and dietary cancer risk. It found that Brazil has permissive legislation regarding pesticide contamination, resulting in pesticide residues exceeding the maximum limits in food samples. The study highlights the violation of human rights in Brazil due to pesticide contamination of food and water.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Chemistry, Multidisciplinary
Nelson Duran, Wagner J. Favaro, Silvana Albores, Thyerre S. Costa, Ljubica Tasic
Summary: Biogenic silver nanoparticles are synthesized through the reduction of silver(I) using biomolecules derived from plant extracts, fungal bioproduction, and bacteria. The exact mechanisms of this oxidation-reduction process are not fully understood, but oxidoreductases, cofactors (NADH, FADH2), and phenolic compounds have been identified as the main species involved in the formation of silver(0) and silver nanoparticles. Biosynthesis leads to stable silver nanoparticle colloids with controlled size, shape, and uniformity, and their synthesis is facilitated by biomolecules that also act as surface capping agents. The specific quantity and types of biomolecules that cap or surround silver nanoparticles are still not well-known, and more research is needed to understand the role of capping proteins in the bioactivity of biogenic silver nanoparticles.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2023)
Article
Oncology
Wesley Ladeira Caputo, Milena Cremer de Souza, Caroline Rodrigues Basso, Valber de Albuquerque Pedrosa, Fabio Rodrigues Ferreira Seiva
Summary: This study provides a comprehensive analysis of differentially expressed genes in hepatocellular carcinoma (HCC), identifying potential therapeutic targets and opportunities for drug repurposing.
Article
Reproductive Biology
Lei Gong, Siyi Jiang, Jia Tian, Yong Li, Wansu Yu, Lubo Zhang, Daliao Xiao
Summary: Exposure to gestational diabetes mellitus during pregnancy can lead to the development of a neonatal brain hypoxia/ischemia-sensitive phenotype. The PTEN/AKT/mTOR/autophagy signaling pathway plays a role in this process.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Sudipta Dutta, Kirthiram K. Sivakumar, John W. Erwin, Jone A. Stanley, Joe A. Arosh, Robert J. Taylor, Sakhila K. Banu
Summary: This study found that exposure to hexavalent chromium disrupts follicle development and causes apoptosis by altering epigenetic marks in the ovary.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Yuxin Li, Xianzhi He, Bin Sun, Nannan Hu, Jiamin Li, Ruolan You, Feiyan Tao, Lei Fang, Yuanyuan Li, Qingfeng Zhai
Summary: This study investigated the toxic effects and mechanism of beta-CYP and EMB on the reproductive system of female rats. The results showed that exposure to these pesticides led to changes in hormone and gene expression in the hypothalamic-pituitary-ovarian axis, as well as alterations in oxidative damage indicators. The findings support the evaluation of the adverse effects of pesticide exposure on reproductive health in greenhouse operations.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Ran Lee, Won-Young Lee, Hyun-Jung Park
Summary: This study investigates the toxicity of diuron on fetal mouse testes and finds that diuron has a negative impact on the development of fetal Leydig cells, while not affecting germ cells and Sertoli cells.
REPRODUCTIVE TOXICOLOGY
(2024)
