Article
Cell Biology
Hongjie Fan, Sudini R. Fernando, Luhan Jiang, Ziyi Wang, Suranga P. Kodithuwakku, Chris K. C. Wong, Ernest H. Y. Ng, William S. B. Yeung, Kai-Fai Lee
Summary: Research has shown that bisphenol compounds can affect human endometrial epithelial cell receptivity through the modulation of steroid hormone receptor function leading to impaired embryo implantation.
Article
Biochemistry & Molecular Biology
Mahsa Kazemi, Vahid Jajarmi, Hamid Nazarian, Marefat Ghaffari Novin, Saghar Salehpour, Abbas Piryaei, Heidar Heidari Khoei, Hamid Choobineh, Mohammad Amin Abdollahifar, Mostafa Haji Molla Hoseini, Mohammad Hasan Heidari
Summary: The study utilized two different culture methods to culture choriocarcinoma spheroids and evaluated their functional characteristics and interactions through assessments such as morphology, cellular density, hormonal secretion, and gene expression. The results showed differences in morphological structure, hormonal secretion, and gene expression between hanging drop culture spheroids and suspension culture spheroids, with suspension culture spheroids performing better in alkaline phosphatase activity and the expression of genes related to attachment, invasion, and migration.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Xiang Xue, Xiaoli Li, Jinmeng Yao, Xue Zhang, Xu Ren, Shan Xu
Summary: This study investigates the relationship between the Wnt signaling pathway and the progression of Asherman's Syndrome (AS). The study finds that the expression of non-phosphorylated beta-catenin, Wnt5a, and Wnt7a is significantly higher in the endometria with adhesion. Both Wnt5a and Wnt7a promote stem cell proliferation, but only Wnt7a preserves stem cell population by stimulating self-renewal. In a rat model, transient activation of the Wnt/beta-catenin signaling pathway promotes angiogenesis and increases the number of glands. The study suggests that transient Wnt/beta-catenin activation may aid tissue regeneration, while prolonged activation may contribute to fibrosis formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Nevertyty M. Mahmoud, Shimaa M. Elshazly, Samar Rezq
Summary: This study found that geraniol has a dose-dependent protective effect against CsA-induced renal damage, and its effects are comparable or superior to the PPAR gamma agonist pioglitazone. Geraniol exerts its renoprotective potential by modulating the Wnt/beta-catenin and PPAR gamma signaling pathways.
Article
Immunology
Safaa A. Faheem, Yasser M. Moustafa, Noha M. Saeed, Reem M. Hazem, Norhan M. El-Sayed
Summary: The aim of this study was to investigate whether pyrvinium pamoate (PP) could protect against cyclosporin A (CsA)-induced hepatotoxicity. The results showed that PP has antioxidant, anti-inflammatory, and antiapoptotic properties, which can reduce CsA-induced liver damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Yuxuan Li, Lutian Yao, Jing Lu
Summary: IL-35 inhibits adipogenesis by regulating the proliferation, cytotoxicity, and differentiation of adipocytes. It suppresses the expression of PPAR gamma and C/EBP alpha, and also influences the Wnt/beta-actin pathway through the regulation of Axin2 expression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Yi Chen, Shasha Song, Yongfang Wang, Jia Zhu, Xinyu Li
Summary: This study investigated the potential mechanism of Baicalin (HQG) in treating psoriasis. The results showed that HQG could improve skin lesions, reduce inflammatory factor levels, and inhibit Th1/Th17 cell differentiation. Transcriptome analysis further demonstrated the potential mechanism involving the Wnt signaling pathway and Th17/IL-17 axis.
PHYTOTHERAPY RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Zhuo Zhang, Yuhua Yang, Xiaomei Lv, Hongyuan Liu
Summary: This study found that the expression levels of IL-17 were significantly increased in pregnant women with preeclampsia (PE), and IL-17 may serve as a sensitive biomarker for PE. Overexpression of IL-17 promoted the viability, migration, and invasion of trophoblast cells, while knockdown of IL-17 inhibited these effects. Furthermore, IL-17 activated the PPAR-gamma/RXR-alpha/Wnt signaling pathway to promote proliferation, migration, and invasion of trophoblast cells.
Article
Cell Biology
Sylvia C. Hewitt, San-Pin Wu, Tianyuan Wang, Steven L. Young, Thomas E. Spencer, Francesco J. DeMayo
Summary: The study demonstrates that uterine cells respond to estrogen and progesterone through their nuclear receptors ESR1 and PGR, with the involvement of chromatin structures. The organoids model provides insights into the regulatory mechanisms of hormone responsiveness.
Article
Reproductive Biology
Sudini R. Fernando, Xian Chen, Kiu-Wai Cheng, Benancy P. C. Wong, Shiwen Qi, Luhan Jiang, Suranga P. Kodithuwakku, Ernest H. Y. Ng, William S. B. Yeung, Kai-Fai Lee
Summary: This study found that ACE1, ACE2, and TMPRSS2 are expressed in human endometrial tissues, with higher ACE2 expression in mid-secretory endometrium. The use of ACE inhibitors does not alter endometrial receptivity for embryo implantation.
REPRODUCTIVE BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Jinhai Luo, Zhiling Yu, Juscelino Tovar, Anne Nilsson, Baojun Xu
Summary: Phytochemicals inhibit adipogenesis and lipid accumulation by activating the Wnt/β-catenin signaling pathway, potentially serving as anti-obesity drugs.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Cell Biology
Ian James Bell, Matthew Sheldon Horn, Terence John Van Raay
Summary: The non-canonical Wnt signaling pathways have different roles in cancer and development, involving calcium and Vangl2. Cells tend to choose non-canonical Wnt signaling over canonical Wnt signaling when presented with a choice, but this occurs rarely in vivo.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Zeliha Guney, Sivge Kurgan, Canan Onder, Mahmure Ayse Tayman, Oemer Gunhan, Alpdogan Kantarci, Muhittin Abdulkadir Serdar, Meral Gunhan
Summary: This study aimed to evaluate the activity of the Wnt/beta-catenin signaling pathway in gingival samples obtained from patients with periodontitis. The results showed that periodontal inflammation disrupts the Wnt/beta-catenin signaling pathway, leading to tissue inflammation and changes in morphology. This finding may shed light on the pathogenesis of periodontal disease.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Biochemistry & Molecular Biology
Eric A. Hanse, Min Pan, Wenzhu Liu, Ying Yang, Mari B. Ishak Gabra, Thai Q. Tran, Xazmin H. Lowman, Bryan Ruiz, Qiong A. Wang, Mei Kong
Summary: B56 alpha, a subunit of the PP2A phosphatase, is specifically induced during adipocyte differentiation and plays a crucial role in blocking Wnt activity by dephosphorylating GSK3 beta. This regulation is essential for the development of gonadal adipose tissue and the fate decision between adipocytes and osteoblasts. B56 alpha expression is driven by the adipocyte transcription factor PPAR gamma, establishing a novel link between PPAR gamma signaling and Wnt blockade.
Editorial Material
Biochemistry & Molecular Biology
Ermanno Malagola, Yoku Hayakawa, Timothy C. Wang
Summary: Recent research has identified distinct roles for Lgr4 and Lgr5 in directing gland reconstitution following H. pylori infection, shedding new light on the complexities of Rspo signaling during gastric regeneration and raising questions about antral stem cell hierarchy.
Article
Agriculture, Dairy & Animal Science
Ishani Dinisri, Sandarenu Kodikara, Madhusha Prasadani, Indunil Pathirana, Chathura Rathnayake, Basil Alexander, Kai-Fai Lee, Suranga Pradeep Kodithuwakku
Summary: Mancozeb negatively impacts caprine oocytes and granulosa cells, potentially impairing fertilization ability and developmental potential of the oocytes, and suppressing ovulation. It suppresses granulosa cells viability, reduces cumulus expansion, and suppresses metaphase plate formation in oocytes, while also inducing progesterone secretion from granulosa cells.
TROPICAL ANIMAL HEALTH AND PRODUCTION
(2021)
Article
Education & Educational Research
Kin Cheung, Jeremy Ng, Hilda Tsang, King Wah Pang
Summary: This study in an Asian context investigated factors predicting academic performance and degree attainment of vertical transfer students in Hong Kong. It found that factors such as gender, GPA, and number of courses were significant predictors of baccalaureate degree attainment, while transfer shock and required credits per year were negative predictors.
STUDIES IN EDUCATIONAL EVALUATION
(2021)
Article
Environmental Sciences
Nirodha Abayalath, Indeepa Malshani, Rajitha Ariyaratne, Shizhen Zhao, Guangcai Zhong, Gan Zhang, Aruna Manipura, Anoma Siribaddana, Parakrama Karunaratne, Suranga P. Kodithuwakku
Summary: Airborne particulate matter (PM), polycyclic aromatic hydrocarbons (PAHs), and heavy metals (HMs) pose significant health risks and were analyzed in the World Heritage City of Kandy in Sri Lanka. The study found that Kandy air contains potential carcinogenic and mutagenic compounds, leading to increased health risks and respiratory tract-related anomalies. Cytotoxicity, DNA damage, and gene expressions were significantly affected by exposure to airborne pollutants, emphasizing the need for air quality management in urban areas.
Article
Green & Sustainable Science & Technology
Kin Cheung, Ceci Sze Wing Ho, Hilda Tsang, Elaine Lau
Summary: Transfer students experience different adjustment challenges and learning approaches compared to direct entrants. This study found that transfer students tend to adopt surface learning approaches more frequently and identified factors influencing both groups' learning approaches. The commitment of education stakeholders is vital for sustainable learning.
Review
Agriculture, Dairy & Animal Science
Kasun Godakumara, Keerthie Dissanayake, Mohammad Mehedi Hasan, Suranga. P. Kodithuwakku, Alireza Fazeli
Summary: Studying the role of extracellular vesicles in mammalian reproduction is of great significance for understanding the reproductive mechanism and improving animal breeding efficiency.
REPRODUCTION IN DOMESTIC ANIMALS
(2022)
Review
Endocrinology & Metabolism
Xintong Li, Suranga P. Kodithuwakku, Rachel W. S. Chan, William S. B. Yeung, Yuanqing Yao, Ernest H. Y. Ng, Philip C. N. Chiu, Cheuk-Lun Lee
Summary: During implantation, the interaction between trophoblast and endometrium is crucial for successful pregnancy, with defective interaction leading to complications. In the past decade, various in vitro culture models have been established, but further research is needed to create a comprehensive model that can replicate the biology of trophoblast-endometrium interaction during early pregnancy.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Reproductive Biology
Sudini R. Fernando, Xian Chen, Kiu-Wai Cheng, Benancy P. C. Wong, Shiwen Qi, Luhan Jiang, Suranga P. Kodithuwakku, Ernest H. Y. Ng, William S. B. Yeung, Kai-Fai Lee
Summary: This study found that ACE1, ACE2, and TMPRSS2 are expressed in human endometrial tissues, with higher ACE2 expression in mid-secretory endometrium. The use of ACE inhibitors does not alter endometrial receptivity for embryo implantation.
REPRODUCTIVE BIOLOGY
(2022)
Article
Biology
Sisi Zhang, Rachel W. S. Chan, Ernest H. Y. Ng, William S. B. Yeung
Summary: Notch signaling plays a key role in maintaining the quiescent state of endometrial mesenchymal stromal/stem cells (eMSC), and is influenced by Notch and Wnt signaling from the microenvironment.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Luhan Jiang, Dandan Cao, William S. B. Yeung, Kai-Fai Lee
Summary: This study used single-cell transcriptomics to uncover the cellular characteristics of mouse endometrial stromal cells (ESCs) and their role in modulating the microenvironment of a receptive endometrium. The results showed that both decidualized and non-decidualized ESCs are involved in extracellular remodeling and play a role in regulating endometrial receptivity and immune tolerance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Obstetrics & Gynecology
Shiwen Qi, Suranga P. Kodithuwakku, Ronald T. K. Pang, Philip C. N. Chiu, Mary H. Y. Tang, Kai-Fai Lee
Summary: The human endometrium and embryo produce miRNAs that are involved in various physiological activities. Aberrant expression of these miRNAs can cause early pregnancy and gestational disorders. miRNAs can be used for clinicopathological tests, but their therapeutic applications in regulating gestational disorders require further investigation.
REPRODUCTIVE AND DEVELOPMENTAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Jiangming Zhong, Jianlin Li, Graham J. Burton, Hannu Koistinen, Ka Wang Cheung, Ernest H. Y. Ng, Yuanqing Yao, William S. B. Yeung, Cheuk-Lun Lee, Philip C. N. Chiu
Summary: This review summarizes recent findings on glycosylation, glycosyltransferases, and glycan-binding receptors at the maternal-fetal interface, and their roles in regulating endometrial receptivity, placentation, and maternal-fetal immunotolerance. Understanding the functions of glycans could enhance the diagnosis and treatment of implantation failure and pregnancy complications, and potentially serve as early predictive markers and therapeutic targets.
HUMAN REPRODUCTION UPDATE
(2023)
Article
Biochemistry & Molecular Biology
Subhashini Muhandiram, Keerthie Dissanayake, Toomos Orro, Kasun Godakumara, Suranga Kodithuwakku, Alireza Fazeli
Summary: Synchronized crosstalk between the embryo and endometrium during the periconception period is important for pregnancy establishment. The exchange of extracellular vesicles (EVs) of embryonic and endometrial origin plays a crucial role in embryo-maternal communication during peri-implantation. This study found that embryonic signals in the form of EVs can modulate the secretome of endometrial epithelial cells, enriching it with proteins that support embryo development, attachment, or implantation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Johanna Piibor, Andres Waldmann, Keerthie Dissanayake, Aneta Andronowska, Marilin Ivask, Madhusha Prasadani, Ants Kavak, Suranga Kodithuwakku, Alireza Fazeli
Summary: This study used quantitative proteomics-based mass spectrometry to investigate the changes in the proteome of extracellular vesicles (EVs) in the uterine fluid (UF) during the bovine estrous cycle. The results showed that the UF-EV proteome is cycle-dependent and differentially enriched proteins play important roles in normal uterine functions and early embryo development. Furthermore, supplementation of UF-EVs during the luteal phase increased embryo production in vitro. These findings highlight the importance of UF-EVs in uterine communications and their potential use in improving embryo production.
MOLECULAR & CELLULAR PROTEOMICS
(2023)
Article
Multidisciplinary Sciences
Yu Zhao, Yihui Zhang, Dongteng Liu, Haiwei Feng, Xiaohui Wang, Jiajun Su, Yuanqing Yao, Ernest H. Y. Ng, William S. B. Yeung, Raymond H. W. Li, Kenny A. Rodriguez-Wallberg, Kui Liu
Summary: In-vitro fertilization is an effective treatment for infertility, but it remains challenging for women with poor ovarian response or premature ovarian insufficiency. This study demonstrates that curcumin can promote the development of mouse ovarian follicles and can potentially be used as a drug to increase the success rate of in-vitro activation of small human follicles.
Article
Education & Educational Research
Kin Cheung, Eric S. W. Chan, Jeremy Ng, Hilda Tsang, Hong-va Leong
Summary: This study compared the academic performances of native and transfer students in an Asian educational context. The results showed that transfer students experienced transfer shock and had heavier study loads but lighter non-academic loads than the native students. Despite this, they achieved higher grade point averages and had lower attrition rates.
HIGHER EDUCATION RESEARCH & DEVELOPMENT
(2022)
Article
Reproductive Biology
Lei Gong, Siyi Jiang, Jia Tian, Yong Li, Wansu Yu, Lubo Zhang, Daliao Xiao
Summary: Exposure to gestational diabetes mellitus during pregnancy can lead to the development of a neonatal brain hypoxia/ischemia-sensitive phenotype. The PTEN/AKT/mTOR/autophagy signaling pathway plays a role in this process.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Sudipta Dutta, Kirthiram K. Sivakumar, John W. Erwin, Jone A. Stanley, Joe A. Arosh, Robert J. Taylor, Sakhila K. Banu
Summary: This study found that exposure to hexavalent chromium disrupts follicle development and causes apoptosis by altering epigenetic marks in the ovary.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Yuxin Li, Xianzhi He, Bin Sun, Nannan Hu, Jiamin Li, Ruolan You, Feiyan Tao, Lei Fang, Yuanyuan Li, Qingfeng Zhai
Summary: This study investigated the toxic effects and mechanism of beta-CYP and EMB on the reproductive system of female rats. The results showed that exposure to these pesticides led to changes in hormone and gene expression in the hypothalamic-pituitary-ovarian axis, as well as alterations in oxidative damage indicators. The findings support the evaluation of the adverse effects of pesticide exposure on reproductive health in greenhouse operations.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Ran Lee, Won-Young Lee, Hyun-Jung Park
Summary: This study investigates the toxicity of diuron on fetal mouse testes and finds that diuron has a negative impact on the development of fetal Leydig cells, while not affecting germ cells and Sertoli cells.
REPRODUCTIVE TOXICOLOGY
(2024)
