Article
Environmental Sciences
Piuque M. Rodriguez, Paola M. Ondarza, Karina S. B. Miglioranza, Critina L. Ramirez, Berta Vera, Celeste Muntaner, Natalia L. Guinazu
Summary: The aim of this study was to determine concentrations of organochlorine pesticides (OCPs) and selected current use pesticides in the placentas of pregnant women from Argentina. The results showed that all pregnant women are highly exposed to complex pesticide mixtures, including banned OCPs and the widely used chlorpyrifos. Intrauterine environment is the first chemical exposure scenario in life, through transplacental transfer.
Article
Multidisciplinary Sciences
Heidi Kaprio, Arafat Siddiqui, Lotta Saustila, Vanina D. Heuser, Maria Gardberg
Summary: The EWSR1::CREM fusion gene, caused by a chromosomal translocation t(10;22)(p11;q12), has been found in various types of cancers with different malignancy levels. The fusion gene leads to production of a chimeric protein, EWSR1::CREM. However, the molecular mechanisms of EWSR1::CREM protein's oncogenic properties have not been systematically characterized. This study used siRNA mediated knockdown to investigate the effects of depletion of EWSR1::CREM protein on gene expression in a melanoma cell line, identified altered pathways and demonstrated the functional differences. The findings contribute to understanding the pathogenesis of tumors with EWSR1::CREM fusion gene and may aid in the development of novel therapeutic strategies.
SCIENTIFIC REPORTS
(2023)
Editorial Material
Dermatology
Kira Allmeroth, Martin S. Denzel
Summary: Polyamines play a critical role in keratinocyte differentiation, with AMD1 mediating the shift in polyamine ratios. Targeting polyamine availability may be beneficial in treating hyperproliferative skin disorders.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Chemistry, Analytical
Yuze Li, Lixia Jiang, Zhenpeng Wang, Yiran Wang, Xiaohua Cao, Lingwei Meng, Jinghan Fan, Caiqiao Xiong, Zongxiu Nie
Summary: A noninvasive profiling method for bladder cancer diagnosis based on carbonyl metabolic fingerprints using a DSI-MS platform with DMED as a labeling reagent has been developed. This method achieves a high accuracy in distinguishing bladder cancer patients from controls. It may pave the way for patient-friendly point-of-care diagnosis of bladder cancer.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Yue Sun, Zhi Zhou, Bing Xie, Zhonghua Wang, Zeper Abliz
Summary: By establishing an AFADESI-MSI system, the molecular information of zebrafish was fully characterized, providing high-quality visual distribution information for over 1000 functional metabolites and mapping a global metabolic network. This comprehensive and in-depth molecular information facilitates the use of zebrafish models in understanding human diseases and developing zebrafish disease models.
ANALYTICAL CHEMISTRY
(2023)
Article
Microbiology
Cun-Cui Kong, Xin Wei, Guang-Lei Liu, Zhen-Ming Chi, Zhe Chi
Summary: In this study, the strain Aureobasidium melanogenum HN6.2 was genetically engineered to enhance siderophore production, ornithine synthesis, and putrescine production. The overexpression of specific genes successfully increased the yields of ornithine and putrescine, making this strain a promising candidate for industrial applications.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Nanoscience & Nanotechnology
Yunxia Yang, Qian Liu, Yisong Zhao, Jianmin Chen, Bing Chen, Yanling Yan, Faming Gao
Summary: This study explored CuPt alloy nanotubes with an open end, which have a larger electrochemical active surface area and more active sites for enzyme immobilization, thus improving the efficiency and sensitivity of the biosensor.
Article
Biotechnology & Applied Microbiology
Hari Priya Sivakumar, Sathish Sundararajan, Venkatesh Rajendran, Sathishkumar Ramalingam
Summary: This study identified the distribution of plant ODC and revealed the highly conserved regulatory motifs among diverse plant species. ODC plays an important role in plant metabolic pathways and is crucial for the development of ultra-low nicotine content tobacco lines.
Article
Reproductive Biology
Christopher L. J. Lavergne, Yong Tao, Yanping Ren, Nahantara Lafleur, X. Johne Liu
Summary: In mammalian species, the ovaries produce ODC and putrescine during ovulation. Aged mice have reduced levels of periovulatory ODC and putrescine. Supplementation of putrescine improves fertility in aged mice. However, increasing putrescine levels may lead to unwanted side effects. Attempts to increase ovarian putrescine levels through L-ornithine supplementation did not yield desired results.
BIOLOGY OF REPRODUCTION
(2022)
Article
Biology
Surender Rajasekaran, Caleb P. Bupp, Mara Leimanis-Laurens, Ankit Shukla, Christopher Russell, Joseph Junewick, Emily Gleason, Elizabeth A. VanSickle, Yvonne Edgerly, Bryan M. Wittmann, Jeremy W. Prokop, Andre S. Bachmann
Summary: This study highlights the therapeutic strategy of repurposing drugs for the treatment of rare diseases, as evidenced by the successful use of eflornithine to normalize polyamine levels and improve neurological symptoms and cortical architecture in a patient with a rare syndrome caused by ODC gain-of-function variants.
Article
Environmental Sciences
Li Zhang, Jiaxin Ma, Peipei Liu, Anxiang Qi, Haiyan Jin, Renming Jia, Zhenming Zheng, Cheng Yan, Minghong Cai
Summary: With the prohibition of conventional organochlorine pesticides, the use of current-use pesticides such as organic amine pesticides and organophosphate pesticides in agriculture and mariculture activities has become a global concern. A study in the Beibu Gulf, a subtropical agricultural and maricultural zone, found that pesticides were widely present in seawater and sediment, with the most abundant categories being organic amine pesticides and organophosphate pesticides. The spatial distribution of pesticides showed a decrease from coastal areas to the sea, indicating the impact of anthropogenic activities on pesticides pollution.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Chemistry, Physical
Nayana Bhat, Bodee Nutho, Alisa Vangnai, Kaito Takahashi, Thanyada Rungrotmongkol
Summary: This study investigated the binding interactions of three organophosphate pesticides with GpdQ enzyme using computational approaches. The results showed that the pesticides binding could stabilize the enzyme structure in the active conformation, allowing the substrate to be catalyzed into less harmful products. The in silico analysis presented here could be informative for enhancing enzyme stability and activity in the future.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Biology
Martin Weber, Rolf Schreckenberg, Klaus-Dieter Schlueter
Summary: Elevated levels of uric acid can stress cardiomyocytes and may contribute to heart failure.
Article
Food Science & Technology
Zhe Xu, Jiale Chang, Jiamin Zhou, Yixin Shi, Hui Chen, Lingyu Han, Maolin Tu, Tingting Li
Summary: This study found that the ornithine decarboxylase gene (ODC) is involved in putrescine biosynthesis and successfully expressed it in E. coli. Functional analysis confirmed that the ODC protein can catalyze the decarboxylation of ornithine to putrescine. Tea polyphenols were identified as effective inhibitors for controlling putrescine content in pickled fish.
Article
Environmental Sciences
Hongxiu Liu, Anna Maria Campana, Yuyan Wang, Kurunthachalam Kannan, Mengling Liu, Hongkai Zhu, Shilpi Mehta-Lee, Sara G. Brubaker, Linda G. Kahn, Leonardo Trasande, Akhgar Ghassabian
Summary: The study found that pregnant women in NYC had lower levels of OP pesticide metabolites than pregnant populations in Europe, Asia, and other regions in the U.S. Lower pre-pregnancy body mass index, being Asian, employed, and single were associated with higher DAP metabolite concentrations, while fruit and grain intakes were associated with higher Sigma DM, Sigma DE, and Sigma DAP levels.
ENVIRONMENTAL POLLUTION
(2021)
Article
Reproductive Biology
Valeria L. Rivero Osimani, Susana R. Valdez, Natalia Guinazu, Gladis Magnarelli
REPRODUCTIVE TOXICOLOGY
(2016)
Article
Toxicology
Marlon Espinoza, Valeria Rivero Osimani, Victoria Sanchez, Enrique Rosenbaum, Natalia Guinazu
TOXICOLOGY IN VITRO
(2016)
Article
Environmental Sciences
Maria Martha Quintana, Berta Vera, Gladis Magnarelli, Natalia Guinazu, Maria Gabriela Rovedatti
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2017)
Article
Environmental Sciences
Pablo Macchi, Ruth Miriam Loewy, Betsabe Lares, Lorena Latini, Liliana Monza, Natalia Guinazu, Cristina Monica Montagna
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Maria Martha Quintana, Valeria Rivero Osimani, Gladis Magnarelli, Maria Gabriela Rovedatti, Natalia Guinazu
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2018)
Article
Parasitology
M. C. Becerra, N. Guinazu, L. Y. Hergert, A. Pellegrini, M. R. Mazzieri, S. Gea, I. Albesa
EXPERIMENTAL PARASITOLOGY
(2012)
Article
Toxicology
Natalia Guinazu, Viviana Rena, Susana Genti-Raimondi, Virginia Rivero, Gladis Magnarelli
TOXICOLOGY IN VITRO
(2012)
Article
Dentistry, Oral Surgery & Medicine
Rosana Morelatto, Maria-Elina Itoiz, Natalia Guinazu, Daniel Piccini, Susana Gea, Silvia Lopez-de Blanc
MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL
(2014)
Article
Environmental Sciences
Victoria Guadalupe Sanchez, Cesar Argentino Gutierrez, Diego Sebastian Gomez, Miriam Loewy, Natalia Guinazu
REVISTA INTERNACIONAL DE CONTAMINACION AMBIENTAL
(2019)
Article
Entomology
J. Soleno, L. B. Parra-Morales, L. Cichon, S. Garrido, N. Guinazu, C. M. Montagna
BULLETIN OF ENTOMOLOGICAL RESEARCH
(2020)
Article
Pharmacology & Pharmacy
Sebastian Diego Gomez, Pamela Soledad Bustos, Victoria Guadalupe Sanchez, Maria Gabriela Ortega, Natalia Guinazu
Article
Pharmacology & Pharmacy
Pamela Soledad Bustos, Melisa de los Angeles Quinteros, Diego Sebastian Gomez, Maria Gabriela Ortega, Paulina Laura Paez, Natalia Lorena Guinazu
Summary: This study investigated the effects of silver bionanoparticles (AgNPs) on human trophoblasts, revealing changes in cell morphology, reduced cell viability, alterations in redox balance with increased ROS and RNS levels, as well as protein oxidation and genotoxic damage. The cytotoxicity of AgNPs was found to be mediated by nitric oxide and glutathione pathways, highlighting differences in toxicity mechanisms between eukaryotic and prokaryotic cells and emphasizing the importance of toxicity evaluation for the safety of AgNPs with pharmaceutical applications.
Article
Entomology
Liliana Cichon, Jimena Soleno, Silvina A. Garrido, Natalia Guinazu, Cristina M. Montagna, Pierre Franck, Jerome Olivares, Selim Musleh, Marcela A. Rodriguez, Eduardo Fuentes-Contreras
Summary: The apple codling moth in Argentina and Chile shows significant genetic differentiation and distribution is influenced by geographic isolation. The Andes range may act as a barrier for dispersal by flight of codling moths, while quarantine measures may limit the movement of infested fruit between the two countries.
JOURNAL OF APPLIED ENTOMOLOGY
(2021)
Article
Environmental Sciences
Piuque M. Rodriguez, Paola M. Ondarza, Karina S. B. Miglioranza, Critina L. Ramirez, Berta Vera, Celeste Muntaner, Natalia L. Guinazu
Summary: The aim of this study was to determine concentrations of organochlorine pesticides (OCPs) and selected current use pesticides in the placentas of pregnant women from Argentina. The results showed that all pregnant women are highly exposed to complex pesticide mixtures, including banned OCPs and the widely used chlorpyrifos. Intrauterine environment is the first chemical exposure scenario in life, through transplacental transfer.
Article
Reproductive Biology
Lei Gong, Siyi Jiang, Jia Tian, Yong Li, Wansu Yu, Lubo Zhang, Daliao Xiao
Summary: Exposure to gestational diabetes mellitus during pregnancy can lead to the development of a neonatal brain hypoxia/ischemia-sensitive phenotype. The PTEN/AKT/mTOR/autophagy signaling pathway plays a role in this process.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Sudipta Dutta, Kirthiram K. Sivakumar, John W. Erwin, Jone A. Stanley, Joe A. Arosh, Robert J. Taylor, Sakhila K. Banu
Summary: This study found that exposure to hexavalent chromium disrupts follicle development and causes apoptosis by altering epigenetic marks in the ovary.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Yuxin Li, Xianzhi He, Bin Sun, Nannan Hu, Jiamin Li, Ruolan You, Feiyan Tao, Lei Fang, Yuanyuan Li, Qingfeng Zhai
Summary: This study investigated the toxic effects and mechanism of beta-CYP and EMB on the reproductive system of female rats. The results showed that exposure to these pesticides led to changes in hormone and gene expression in the hypothalamic-pituitary-ovarian axis, as well as alterations in oxidative damage indicators. The findings support the evaluation of the adverse effects of pesticide exposure on reproductive health in greenhouse operations.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Ran Lee, Won-Young Lee, Hyun-Jung Park
Summary: This study investigates the toxicity of diuron on fetal mouse testes and finds that diuron has a negative impact on the development of fetal Leydig cells, while not affecting germ cells and Sertoli cells.
REPRODUCTIVE TOXICOLOGY
(2024)
