Article
Environmental Sciences
Yun Liu, Antonia M. Calafat, Aimin Chen, Bruce P. Lanphear, Nana-Hawa Yayah Jones, Kim M. Cecil, Susan R. Rose, Kimberly Yolton, Jessie P. Buckley, Joseph M. Braun
Summary: This study examined the associations of prenatal and childhood exposure to per- and polyfluoroalkyl substances (PFAS) with pubertal development and reproductive hormones. The results showed that adolescent PFAS concentrations were associated with later pubic hair growth, breast maturation, and age at menarche in females, but there was no pattern for prenatal or other postnatal concentrations. No associations were observed between PFAS concentrations and pubic hair growth or reproductive hormones in males.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Obstetrics & Gynecology
S. S. Tottenborg, K. S. Hougaard, L. Deen, E. B. Pedersen, M. Frederiksen, A. B. B. Kofoed, K. U. Petersen, H. W. Meyer, N. E. Ebbehoj, J. P. E. Bonde
Summary: The study found marginal and inconsistent associations between maternal exposure to PCBs in indoor air and semen quality, testicular size, and reproductive hormones in adult offspring.
HUMAN REPRODUCTION
(2022)
Article
Environmental Sciences
Kristin J. Marks, Penelope P. Howards, Melissa M. Smarr, W. Dana Flanders, Kate Northstone, Johnni H. Daniel, Antonia M. Calafat, Andreas Sjodin, Michele Marcus, Terryl J. Hartman
Summary: The study found that prenatal exposure to mixtures of persistent EDCs is not significantly associated with early menarche in female offspring.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Bora Plaku-Alakbarova, Oleg Sergeyev, Paige L. Williams, Jane S. Burns, Mary M. Lee, Russ Hauser, Susan A. Korrick
Summary: The study found that in a group of 8-9 year old Russian boys, serum dioxins, furans and PCBs clustered by chlorination pattern, with Sigma NDL-PCBs representing 4,4'-chlorinated PCBs most effectively. This may reflect shared persistence, metabolism or source of exposure of these chemicals in the human body.
Article
Obstetrics & Gynecology
Xiang Hua, Huahua Jiang, Na Guo, Yaoyao Du, Xiaoqiong Yuan, Taoran Deng, Xuemei Teng, Yangcheng Yao, Yufeng Li
Summary: Prepubertal exposure to Aroclor-1221 (A-1221) in rats resulted in reproductive impairment, including early puberty onset, extended estrous cycle, decreased hormone levels, and ovarian developmental abnormalities.
REPRODUCTIVE SCIENCES
(2021)
Article
Environmental Sciences
Carmen Freire, Francesca Castiello, Maria-Jose Lopez-Espinosa, Andrea Beneito, Aitana Lertxundi, Alba Jimeno-Romero, Martine Vrijheid, Maribel Casas
Summary: Prenatal exposure to certain phthalates is associated with pubertal development, particularly earlier puberty in boys with normal weight and girls with overweight/obesity.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Can Wang, Ruina Cui, Congying Niu, Xiali Zhong, Qicheng Zhu, Di Ji, Xianjie Li, Hongxia Zhang, Chunqiao Liu, Lina Zhou, Yanli Li, Guowang Xu, Yanhong Wei
Summary: The study reveals that low-dose exposure to PCB126 disrupts cardiac metabolism, affecting lipid metabolism, amino acid metabolism, and the tricarboxylic acid cycle. The hearts exposed to PCB126 showed increased collagen synthesis, cardiac fibrosis, and perturbed expression of genes related to the TGFβ/PPARγ/MMP-2 signaling pathway.
ENVIRONMENTAL POLLUTION
(2021)
Article
Multidisciplinary Sciences
Lili Long, Xinghua Tang
Summary: This study investigated the association between exposure to organochlorine pesticides and hearing loss in adults, finding a positive correlation between exposure to certain organochlorine pesticides and hearing loss.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Tina Kold Jensen, Anna-Maria Andersson, Katharina M. Main, Trine Holm Johannsen, Marianne S. Andersen, Henriette Boye Kyhl, Anders Juul, Hanne Frederiksen
Summary: The study found that maternal exposure to parabens was associated with reproductive hormone levels and anogenital distance in male and female infants, with greater effects observed in girls and inconsistent effects in boys. This suggests potential endocrine-disrupting effects of parabens on human development, particularly in vulnerable periods.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Toxicology
Jens Rengelshausen, Isabella Randerath, Thomas Schettgen, Andre Esser, Andrea Kaifie, Jessica Lang, Thomas Kraus, Patrick Ziegler
Summary: After detecting high PCB exposure in a German recycling company, the HELPcB program was established to investigate potential health effects of PCB exposure through a longitudinal study. More than 300 individuals were enrolled and various assessments were conducted. The program yielded new data on adverse effects of PCB exposure in humans and potential mechanisms. Larger studies are needed to confirm the results and establish causality between PCB exposure and clinical effects in humans.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Environmental Sciences
Nuria Guil-Oumrait, Damaskini Valvi, Raquel Garcia-Esteban, Monica Guxens, Jordi Sunyer, Maties Torrent, Maribel Casas, Martine Vrijheid
Summary: This study found that prenatal exposure to persistent organic pollutants may have lasting effects on child BMI into adolescence, and exposure to certain pollutants during pregnancy may be associated with major risk factors for adult CM syndrome.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Stine A. Holmboe, Louise Scheutz Henriksen, Hanne Frederiksen, Anna-Maria Andersson, Laerke Priskorn, Niels Jorgensen, Anders Juul, Jorma Toppari, Niels E. Skakkebaek, Katharina M. Main
Summary: This study aimed to assess the association between fetal exposure to selected phenols and benzophenones and markers of testicular function in adult men. The results showed that high exposure to BPA and BP-3 was associated with a compensated reduced Leydig cell function but no other changes in markers of reproductive health.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Neurosciences
Madison H. Fung, Elizabeth Heinrichs-Graham, Brittany K. Taylor, Michaela R. Frenzel, Jacob A. Eastman, Yu-Ping Wang, Vince D. Calhoun, Julia M. Stephen, Tony W. Wilson
Summary: Puberty is a period of significant hormonal fluctuations that can influence the structural and functional changes in the developing brain. This study used MEG technology to investigate the impact of pubertal hormones on motor-related oscillations in 69 youths. The findings revealed that pubertal hormones have complex effects on beta event-related desynchronization and highlight the continued development of motor cortical dynamics during puberty.
Article
Endocrinology & Metabolism
Megan M. Herting, Kristina A. Uban, Marybel Robledo Gonzalez, Fiona C. Baker, Eric C. Kan, Wesley K. Thompson, Douglas A. Granger, Matthew D. Albaugh, Andrey P. Anokhin, Kara S. Bagot, Marie T. Banich, Deanna M. Barch, Arielle Baskin-Sommers, Florence J. Breslin, B. J. Casey, Bader Chaarani, Linda Chang, Duncan B. Clark, Christine C. Cloak, R. Todd Constable, Linda B. Cottler, Rada K. Dagher, Mirella Dapretto, Anthony S. Dick, Nico Dosenbach, Gayathri J. Dowling, Julie A. Dumas, Sarah Edwards, Thomas Ernst, Damien A. Fair, Sarah W. Feldstein-Ewing, Edward G. Freedman, Bernard F. Fuemmeler, Hugh Garavan, Dylan G. Gee, Jay N. Giedd, Paul E. A. Glaser, Aimee Goldstone, Kevin M. Gray, Samuel W. Hawes, Andrew C. Heath, Mary M. Heitzeg, John K. Hewitt, Charles J. Heyser, Elizabeth A. Hoffman, Rebekah S. Huber, Marilyn A. Huestis, Luke W. Hyde, M. Alejandra Infante, Masha Y. Ivanova, Joanna Jacobus, Terry L. Jernigan, Nicole R. Karcher, Angela R. Laird, Kimberly H. LeBlanc, Krista Lisdahl, Monica Luciana, Beatriz Luna, Hermine H. Maes, Andrew T. Marshall, Michael J. Mason, Erin C. McGlade, Amanda S. Morris, Bonnie J. Nagel, Gretchen N. Neigh, Clare E. Palmer, Martin P. Paulus, Alexandra S. Potter, Leon I. Puttler, Nishadi Rajapakse, Kristina Rapuano, Gloria Reeves, Perry F. Renshaw, Claudiu Schirda, Kenneth J. Sher, Chandni Sheth, Paul D. Shilling, Lindsay M. Squeglia, Matthew T. Sutherland, Susan F. Tapert, Rachel L. Tomko, Deborah Yurgelun-Todd, Natasha E. Wade, Susan R. B. Weiss, Robert A. Zucker, Elizabeth R. Sowell
Summary: The study found that sociodemographic characteristics were associated with both objective hormone levels and self-reported physical measures of pubertal maturation in a large, diverse sample of 9-10 year-olds. The latent variables of pubertal maturation described a complex interplay between perceived physical changes and hormone levels, with one factor driven by higher hormone levels and another driven by perceived physical maturation. The synchronous and asynchronous relationships between hormones and physical features were revealed in this large young adolescent sample.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Psychology, Biological
Firas Khoubbieh, Cihan Suleyman Erdogan, Tugce Onel, Ecem Yildirim, Engin Sumer, Aylin Yaba, Bayram Yilmaz
Summary: This study investigated the effects of chronic MPH administration on reproductive parameters in children with ADHD and found that it can affect the reproductive functions in both male and female rats. However, these effects are transient.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Public, Environmental & Occupational Health
Iben H. Beck, Niels Bilenberg, Kirstine A. Davidsen, Anne A. Rasmussen, Henriette Boye, Tina K. Jensen
Summary: This study assessed intelligence quotient scores of 7-year-old children in Denmark and investigated potential predictors. The results showed that girls and children of mothers with higher education had higher intelligence quotient scores, while boys and children of mothers with lower education had lower scores. Maternal education and child sex were strong predictors of intelligence quotient scores.
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Psychology, Developmental
Camilla V. B. Palm, Dorte Glintborg, Laura G. Find, Pia Larsen, Cilia M. Dalgaard, Henriette Boye, Tina K. Jensen, Anja F. Dreyer, Marianne S. Andersen, Niels Bilenberg
Summary: Maternal testosterone levels were positively associated with ASD traits in boys, while maternal PCOS was associated with increased ASD traits in offspring. However, the association became non-significant after excluding parental psychiatric diagnosis. Offspring anogenital distance was not linked to ASD traits.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Article
Statistics & Probability
Brice Ozenne, Esben Budtz-Jorgensen, Sebastian Elgaard Ebert
Summary: This article introduces the use of the max-test procedure in latent variable models for multiple testing. The effectiveness of the procedure for Wald and Score tests in LVMs is evaluated through simulation studies. The procedure is then applied to quantify the neuroinflammatory response to mild traumatic brain injury in multiple brain regions.
COMPUTATIONAL STATISTICS
(2023)
Article
Psychiatry
Emily Cantio, Niels Bilenberg, Signe Monrad Norgaard, Iben Have Beck, Soren Moller, Cathriona Cantio, Tina Kold Jensen, Nicoline Bebe Mortensen, Asta Rasmussen, Henrik Boye Thybo Christesen
Summary: This study investigates the association between blood concentrations of serum 25-hydroxyvitamin D at different time points and intelligence quotient score at the age of 7, and explores potential differences in the association based on child sex.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Public, Environmental & Occupational Health
Veronica van Der Schyff, Jiri Kalina, Eva Govarts, Liese Gilles, Greet Schoeters, Argelia Castano, Marta Esteban-Lopez, Jiri Kohoutek, Petr Kukucka, Adrian Covaci, Gudrun Koppen, Lenka Andryskova, Pavel Piler, Jana Klanova, Tina Kold Jensen, Loic Rambaud, Margaux Riou, Marja Lamoree, Marike Kolossa-Gehring, Nina Vogel, Till Weber, Thomas Goen, Catherine Gabriel, Dimosthenis A. Sarigiannis, Amrit Kaur Sakhi, Line Smastuen Haug, Lubica Palkovicova Murinova, Lucia Fabelova, Janja Snoj Tratnik, Darja Mazej, Lisa Melymuk
Summary: This study reports the adverse health effects of various legacy and emerging flame retardants (FRs) on human and environmental health in children from nine European countries. The study detected ten halogenated FRs in blood and four organophosphate FR metabolites in urine samples from 2136 children. The concentrations of FRs were associated with lifestyle factors.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Antje Gerofke, Madlen David, Phillipp Schmidt, Joana Lobo Vicente, Jurgen Buekers, Liese Gilles, Ann Colles, Jos Bessems, Michiel Bastiaensen, Adrian Covaci, Elly Den Hond, Gudrun Koppen, Michelle Laeremans, Veerle J. Verheyen, Milena Cerna, Jana Klanova, Andrea Krskova, Martin Zvonar, Lisbeth E. Knudsen, Holger M. Koch, Tina Kold Jensen, Loic Rambaud, Margaux Riou, Nina Vogel, Catherine Gabriel, Spyros Karakitsios, Nafsika Papaioannou, Denis Sarigiannis, Reka Kakucs, Szilvia Kozepesy, Peter Rudnai, Tamas Szigeti, Fabio Barbone, Valentina Rosolen, Cedric Guignard, Arno C. Gutleb, Amrit Kaur Sakhi, Line Smastuen Haug, Beata Janasik, Danuta Ligocka, Milada Estokova, Lucia Fabelova, Branislav Kolena, Lubica Palkovicova Murinova, Ida Petrovicova, Denisa Richterova, Milena Horvat, Darja Mazej, Janja Snoj Tratnik, Agneta Annika Runkel, Argelia Castano, Marta Esteban-Lopez, Susana Pedraza-Diaz, Agneta Akesson, Sanna Lignell, Jelle Vlaanderen, Jan-Paul Zock, Greet Schoeters, Marike Kolossa-Gehring
Summary: Within the HBM4EU initiative, HBM indicators were developed to address key policy questions and support chemical policies. Result indicators provide information on chemical exposure in different demographic groups and allow comparisons to identify differences and inform policy measures. Impact indicators assess health risks by comparing exposure values to health-based guidance values, helping to identify relevant health issues and support risk management decisions.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Andrology
Laura Smidt Hansen, Laerke Priskorn, Stine A. Holmboe, Tina Kold Jensen, Ann Holm Hansen, Anna-Maria Andersson, Niels Jorgensen
Summary: This study found an association between testicular function and markers of metabolic and cardiovascular health in young men. Reproductive hormone levels and semen quality may serve as early biomarkers of cardiovascular health in healthy men.
Article
Public, Environmental & Occupational Health
Iben Have Beck, Niels Bilenberg, Soeren Moeller, Flemming Nielsen, Philippe Grandjean, Frederik Damsgaard Hojsager, Thorhallur Ingi Halldorsson, Christel Nielsen, Tina Kold Jensen
Summary: The study found that prenatal and early postnatal exposure to perfluoroalkyl substances (PFAS) may affect intelligence quotient (IQ), especially higher concentrations of perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) were associated with lower IQ scores.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Obstetrics & Gynecology
Ann-Kristin Dicke, Jakob Albrethsen, Bradley L. Hoare, Margot J. Wyrwoll, Alexander S. Busch, Daniela Fietz, Adrian Pilatz, Clara Buehlmann, Anders Juul, Sabine Kliesch, Joerg Gromoll, Ross A. D. Bathgate, Frank Tuettelmann, Birgit Stallmeyer
Summary: This study reveals that bi-allelic loss-of-function variants in the INSL3 and RXFP2 genes are associated with bilateral cryptorchidism and male infertility, while heterozygous variant carriers are unaffected phenotypically. These findings have diagnostic value for patients with familial/bilateral cryptorchidism and shed light on the importance of INSL3 and RXFP2 in testicular descent and fertility.
HUMAN REPRODUCTION
(2023)
Article
Public, Environmental & Occupational Health
Matilde Laerkeholm Mueller, Alexander Siegfried Busch, Marie Lindhardt Ljubicic, Emmie N. Upners, Margit B. Fischer, Casper P. Hagen, Jakob Albrethsen, Hanne Frederiksen, Anders Juul, Anna-Maria Andersson
Summary: The concentrations of potentially endocrine disrupting chemicals (EDCs) in the urine of infant boys were found to be associated with their serum reproductive hormone concentrations, suggesting that minipuberty is a critical developmental period highly sensitive to endocrine disruption.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Review
Endocrinology & Metabolism
Anders Juul, Claus H. Gravholt, Michel De Vos, Ekaterina Koledova, Martine Cools
Summary: Diagnosis and management of individuals with differences of sex development (DSD) due to numerical or structural variations of sex chromosomes (NSVSC) is challenging. Girls with Turner syndrome (45X) may have varying phenotypic features. Individuals with 45,X/46,XY chromosomal mosaicism may have Turner syndrome-like features and short stature. Newborn screening for sex chromosome variations could be possible but requires further analysis. Comprehensive healthcare and fertility assessment are important for individuals with NSVSC.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Trine Holm Johannsen, Jakob Albrethsen, Vassos Neocleous, Federico Baronio, Martine Cools, Lise Aksglaede, Niels Jorgensen, Peter Christiansen, Meropi Toumba, Pavlos Fanis, Marie Lindhardt Ljubicic, Anders Juul
Summary: Congenital adrenal hyperplasia (CAH) is a recessive condition that affects the adrenal glands. Adult males with CAH, despite hormone replacement therapy, exhibit reduced levels of Leydig and Sertoli cell-derived hormones, including insulin-like factor 3 (INSL3) and testosterone. This study suggests that circulating INSL3 may serve as a biomarker to monitor Leydig cell function in CAH patients, particularly those with testicular adrenal rest tumors.
ENDOCRINE CONNECTIONS
(2023)
Article
Environmental Sciences
Frederik Damsgaard Hojsager, Annika Sigvaldsen, Marianne Skovsager Andersen, Anders Juul, Flemming Nielsen, Soren Moller, Henrik Boye Thybo Christesen, Anders Grontved, Philippe Grandjean, Tina Kold Jensen
Summary: This study found that prenatal and early postnatal exposure to perfluoroalkyl substances (PFAS) is associated with lower bone mineral density (BMD) at age 7. The association is stronger for exposure at 18 months than prenatal exposure.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Marzanna Marianna Sorensen, Ane Baerent Fisker, Christine Dalgard, Kristoffer Jarlov Jensen, Flemming Nielsen, Christine Stabell Benn, Philippe Grandjean, Amalie Timmermann
Summary: The aim of this study was to identify predictors of infant serum-PFAS concentrations. The study found that the location of residence was the most important determinant of serum-PFAS concentrations among Guinea-Bissau infants, indicating a potential role of diet as affected by the global spread of PFAS, but further research is needed to explore reasons for the regional differences in PFAS exposure.
ENVIRONMENTAL RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jack J. J. Xu, Lars Loenn, Esben Budtz-Jorgensen, Samir Jawad, Peter S. S. Ulriksen, Kristoffer L. L. Hansen
Summary: This study compared the noise, contrast-to-noise ratio (CNR), signal-to-noise ratio (SNR), and image quality of deep-learning image reconstruction (DLIR) vs. adaptive statistical iterative reconstruction (ASIR-V) in gray scale 74 keV virtual monoenergetic (VM) abdominal dual-energy CT (DECT) with different slice thicknesses. The results showed that DLIR significantly reduced image noise, increased CNR and SNR, and improved image quality, especially in 0.625 mm slice images, compared to ASIR-V.
ABDOMINAL RADIOLOGY
(2023)
Article
Reproductive Biology
Lei Gong, Siyi Jiang, Jia Tian, Yong Li, Wansu Yu, Lubo Zhang, Daliao Xiao
Summary: Exposure to gestational diabetes mellitus during pregnancy can lead to the development of a neonatal brain hypoxia/ischemia-sensitive phenotype. The PTEN/AKT/mTOR/autophagy signaling pathway plays a role in this process.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Sudipta Dutta, Kirthiram K. Sivakumar, John W. Erwin, Jone A. Stanley, Joe A. Arosh, Robert J. Taylor, Sakhila K. Banu
Summary: This study found that exposure to hexavalent chromium disrupts follicle development and causes apoptosis by altering epigenetic marks in the ovary.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Yuxin Li, Xianzhi He, Bin Sun, Nannan Hu, Jiamin Li, Ruolan You, Feiyan Tao, Lei Fang, Yuanyuan Li, Qingfeng Zhai
Summary: This study investigated the toxic effects and mechanism of beta-CYP and EMB on the reproductive system of female rats. The results showed that exposure to these pesticides led to changes in hormone and gene expression in the hypothalamic-pituitary-ovarian axis, as well as alterations in oxidative damage indicators. The findings support the evaluation of the adverse effects of pesticide exposure on reproductive health in greenhouse operations.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Ran Lee, Won-Young Lee, Hyun-Jung Park
Summary: This study investigates the toxicity of diuron on fetal mouse testes and finds that diuron has a negative impact on the development of fetal Leydig cells, while not affecting germ cells and Sertoli cells.
REPRODUCTIVE TOXICOLOGY
(2024)
