☆ 4.4 Article

Differences in serum levels of CB-153 and p,p′-DDE, and reproductive parameters between men living south and north in Norway

REPRODUCTIVE TOXICOLOGY (2011)

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REPRODUCTIVE TOXICOLOGY
卷 32, 期 3, 页码 261-267

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PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2011.06.072

关键词

CB-153; p,p '-DDE; POPs; Sperm characteristics; Reproductive hormones; Male; Geographical difference; Norway

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Reproductive Biology Toxicology

资金

  1. Swedish Research Council [M 2004-6072]
  2. Swedish Government
  3. Crafoord Fund
  4. Ove Tulefjord's Fund
  5. Foundation for Urological Research

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Arctic is contaminated with persistent organochlorine pollutants (POPs), and exposure to these compounds may differ between south and north in Norway. POPs may have negative impact on male reproductive characteristics. We compared serum levels of the CB-153 and p,p'-DDE in men who were born and had lived most of their lifetime south and north (close to or above the Arctic Circle) in Norway. We found no geographical differences in levels of CB-153 (south: 50 ng/g lipid (mean), north: 59 ng/g lipid; p = 0.27) or sperm parameters. However, the levels of AV-ODE were higher in south than in north (81 ng/g lipid (mean) vs. 66 ng/g lipid; p = 0.02), as were the levels of total and free testosterone. The FSH levels were lowest in south. A strong relationship between the CB-153 and the SHBG levels was observed. The regional differences observed for p,p'-DDE, testosterone and FSH were not reflected in the semen quality. (C) 2011 Elsevier Inc. All rights reserved.

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