Article
Environmental Sciences
Ying Wang, Yi-Tong Du, Nora Fung-Yee Tam
Summary: This study investigated the toxic effects of decabromodiphenyl ether (BDE-209) on the antioxidative and non-antioxidative responses of the mangrove species Kandelia obovata. Results showed that BDE-209 did not negatively affect the growth of K. obovata seedlings, but stimulated the activity of certain enzymes only in weeks 1 and 4. The production of reactive oxygen species was induced only at high concentrations of BDE-209, and BDE-209 was taken up, translocated, and accumulated by the plants. These findings highlight the ability of mangrove plants to accumulate PBDEs and the difficulty in removing BDE-209 from mangrove systems.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Environmental Sciences
Rui Wan, Xiaoxiao Li, Yunyi Zha, Xiong Zheng, Haining Huang, Minghui Li
Summary: This study revealed the influence of decabromodiphenyl ether (BDE-209) on denitrification process for the first time. BDE-209 caused a decrease in denitrification efficiency and the production of harmful substances, and these inhibitory effects were enhanced with increasing exposure duration and concentration. However, BDE-209 had insignificant effects on the global abundance of denitrifying bacteria, mainly due to microbial exchange with the overlying water.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Ping-Chi Hsu, Zheng-Kuan Li, Ching-Shu Lai, Li-Ho Tseng, Chia-Wei Lee, Fu-Jen Cheng, Chao-Yu Chang, Jenq-Renn Chen
Summary: The study revealed that BDE-209, an endocrine disrupting chemical, can impact male reproductive function from F1 to F3 generations, leading to changes in DNA methylation levels and alterations in sperm function.
Article
Environmental Sciences
Xuan Zhou, Lebin Song, Rong Cong, Jiaochen Luan, Xiang Zhou, Yichun Wang, Liangyu Yao, Xu Zhang, Xiaohan Ren, Tongtong Zhang, Mengchi Yu, Ninghong Song
Summary: This study investigated the effect of the brominated flame retardant BDE-209 on erectile function in rats and identified potential underlying mechanisms. The findings suggest that BDE-209 may impair endothelial function and gene expression, leading to erectile dysfunction.
Article
Environmental Sciences
Taifa Zhang, Huan He, Yu Wei, Wenfeng Geng, Jinxia Zhai
Summary: This study investigated the protective effect of vitamin C on meiotic arrest induced by BDE-209 in spermatocytes and its mechanism. The results showed that vitamin C had a protective effect on male reproductive system by reducing testicular damage and abnormal sperm rate. Vitamin C also attenuated the oxidative stress response induced by BDE-209 and restored DNA repair and crossover markers necessary for meiotic division.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Multidisciplinary Sciences
Sobhy M. Yakout, Ahmed M. Isa, Amel A. El-Sayed, Mohamed H. EL-Saeid
Summary: This study presents the temporal changes of decabromodiphenyl ether (decaBDE) in Saudi human breast milk samples for the first time. Through analysis using gas chromatography-mass spectrometry, it was found that the predominant congeners were BDE-209, -28, -138, and -208. BDE-209 was detected in all analyzed samples, indicating recent exposure of mothers to deca-BDE. The study also suggests that eggs may be a source of BDE-28 in the bodies of mothers. Overall, the study highlights the health concerns and the need for further research on the exposure and effects of decaBDE. Rating: 8 out of 10.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Environmental Sciences
Lin Cheng, Qinxiong Rao, Qicai Zhang, Wei Song, Shuhui Guan, Zhilin Jiang, Tian Wu, Zhihui Zhao, Weiguo Song
Summary: The mechanism through which BDE-209 affects the immune system involves damaging and necrotizing lymphocytes, as well as affecting the activities of immune organs. This leads to suppression of immune functions and atrophy of the spleen.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Debarshi Sarkar, Shio Kumar Singh
Summary: The study showed that maternal exposure to BDE-209 during lactation significantly affects male reproductive health in adult offspring, leading to altered testicular histoarchitecture, decreased testosterone production, down-regulation of certain steroidogenic markers, as well as interference with germ cell dynamics and oxidative status in testes.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Yue Zhang, Xiangyang Li, Li Jing, Guiqing Zhou, Yujian Sang, Leqiang Gao, Shuqin Jiang, Zhixiong Shi, Wei Ge, Zhiwei Sun, Xianqing Zhou
Summary: The study revealed that BDE-209 reduced sperm quality and quantity, which was correlated with glycolipid metabolism dysbiosis of testis. Additionally, BDE-209 exposure activated glycolipid metabolism pathways and the mitochondrial apoptotic pathway, leading to spermatogenic cell apoptosis.
Article
Environmental Sciences
Yao Wang, Jinbao Huang, Hong Wang, Lin Lan, Xin Mu, Weiwei Xu, Shanjin Lv, Xinsheng Li
Summary: This study investigated the thermal degradation mechanism of BDE-209 using density functional theory method and found that the primary degradation reactions involved cleaving the ether bond and the C-Br bond. The formation of hexabromobenzene and low-brominated diphenyl ethers were observed as major products. The results obtained in this study provide valuable information for the treatment and reuse of waste plastics containing BDE-209.
Article
Environmental Sciences
Guanghua Mao, Junjie Tang, Taotao Liao, Xiaoxiang Shi, FangYuan Dong, Weiwei Feng, Yao Chen, Ting Zhao, Xiangyang Wu, Liuqing Yang
Summary: This study investigated the effects of BDE-209 on insulin resistance in type 2 diabetes patients. The results showed that BDE-209 could inhibit glucose absorption and disrupt lipid metabolism, leading to cell damage. The IR-BRL cells were found to be more susceptible to the metabolism toxicity induced by BDE-209.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Microbiology
Hao Xu, Qingtao Cai, Qiuying An, Chen Tang, Wanpeng Wang, Guangshun Wang, Wanting You, Dongbei Guo, Ran Zhao
Summary: In this study, a high-efficiency BDE-209 degrading strain, TAW-CT127, was isolated from Tong'an Bay. The strain's growth conditions and degradation performance were investigated, and relevant genes were identified through whole-genome sequencing. This research provides new insights for the bioremediation of BDE-209 pollution.
Article
Environmental Sciences
Lin Cheng, Junhua Yang, Qinxiong Rao, Zehui Liu, Wei Song, Shuhui Guan, Zhihui Zhao, Weiguo Song
Summary: This study found that oral intake of BDE-209 may lead to ruptured and even hyperplastic follicular epithelial cells in the thyroid, and affect gene transcription involved in the neuroactive ligand-receptor interaction pathway and thyroid hormones in the serum.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Environmental Sciences
Debarshi Sarkar, Parul Midha, Shashanka Sekhar Shanti, Shio Kumar Singh
Summary: Polybrominated diphenyl ethers (PBDEs), including decabromodiphenyl ether (BDE-209), are widely used as flame retardants in manufactured products, but the increasing levels of BDE-209 in biological samples has raised concerns about its reproductive toxicity, particularly in males. BDE-209 is structurally similar to thyroid hormone (TH) and can disrupt TH function. Exposure to BDE-209 can lead to male reproductive toxicity through various pathways, including impairment of steroidogenesis and oxidative stress. However, further research is needed to fully understand the adverse effects and mechanisms of BDE-209 on male reproductive health.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Feihua Wang, Yaocheng Fan, Haibin Tang, Yanran Dai, Wei Liang
Summary: The study revealed that BDE-209 negatively affected the growth and development of Lythrum salicaria plants, while promoting ROS accumulation and inducing changes in various reactive substances.
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2021)
Article
Reproductive Biology
Lei Gong, Siyi Jiang, Jia Tian, Yong Li, Wansu Yu, Lubo Zhang, Daliao Xiao
Summary: Exposure to gestational diabetes mellitus during pregnancy can lead to the development of a neonatal brain hypoxia/ischemia-sensitive phenotype. The PTEN/AKT/mTOR/autophagy signaling pathway plays a role in this process.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Sudipta Dutta, Kirthiram K. Sivakumar, John W. Erwin, Jone A. Stanley, Joe A. Arosh, Robert J. Taylor, Sakhila K. Banu
Summary: This study found that exposure to hexavalent chromium disrupts follicle development and causes apoptosis by altering epigenetic marks in the ovary.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Yuxin Li, Xianzhi He, Bin Sun, Nannan Hu, Jiamin Li, Ruolan You, Feiyan Tao, Lei Fang, Yuanyuan Li, Qingfeng Zhai
Summary: This study investigated the toxic effects and mechanism of beta-CYP and EMB on the reproductive system of female rats. The results showed that exposure to these pesticides led to changes in hormone and gene expression in the hypothalamic-pituitary-ovarian axis, as well as alterations in oxidative damage indicators. The findings support the evaluation of the adverse effects of pesticide exposure on reproductive health in greenhouse operations.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Ran Lee, Won-Young Lee, Hyun-Jung Park
Summary: This study investigates the toxicity of diuron on fetal mouse testes and finds that diuron has a negative impact on the development of fetal Leydig cells, while not affecting germ cells and Sertoli cells.
REPRODUCTIVE TOXICOLOGY
(2024)
