Article
Cardiac & Cardiovascular Systems
Maarja A. Mae, Liqun He, Sofia Nordling, Elisa Vazquez-Liebanas, Khayrun Nahar, Bongnam Jung, Xidan Li, Bryan C. Tan, Juat Chin Foo, Amaury Cazenave-Gassiot, Markus R. Wenk, Yvette Zarb, Barbara Lavina, Susan E. Quaggin, Marie Jeansson, Chengua Gu, David L. Silver, Michael Vanlandewijck, Eugene C. Butcher, Annika Keller, Christer Betsholtz
Summary: Through single-cell RNA sequencing and other methods, the study revealed the transcriptional, morphological, and functional changes in brain endothelial cells in response to pericyte deficiency. Endothelial cells without pericyte contact maintain a BBB-specific gene expression profile and acquire a venous-shifted molecular pattern.
CIRCULATION RESEARCH
(2021)
Article
Physiology
Ping Yu, Yanyu Li, Gaoliang Zhong, Wen Li, Bing Chen, Jingjing Zhang
Summary: This study found that loss of membranous Claudin-5 led to hypoxia-induced autophagy in cerebrovascular endothelial cells, partially attenuating endothelial cell apoptosis. Mechanism studies showed that membranous Claudin-5 affected the stimulation of HIF-1a and iNOS under hypoxic conditions, leading to suppressed endothelial autophagy. Loss of Claudin-5 also influenced the generation of ROS and expression of Bnip3, contributing to the inhibition of endothelial autophagy under hypoxia.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Immunology
Nuria Villalba, Yonggang Ma, Sarah A. Gahan, Aurelie Joly-Amado, Sam Spence, Xiaoyuan Yang, Kevin R. Nash, Sarah Y. Yuan
Summary: This study investigated the effects of lung infection on blood-brain barrier disruption and behavioral changes, and found that systemic bacterial infection may contribute to lung-brain axis inflammatory response through cytokine release.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zixuan Lin, Dengrong Jiang, Peiying Liu, Yulin Ge, Abhay Moghekar, Hanzhang Lu
Summary: This study used non-contrast MRI technique to dynamically monitor the effect of caffeine on blood-brain barrier (BBB) permeability to water. The results showed that caffeine ingestion led to decreased cerebral blood flow and venous oxygenation, but did not affect BBB permeability to water. These findings provide important insights into the effects of caffeine on the nervous system.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Haoan Wu, Lei Liu, Ming Ma, Yu Zhang
Summary: This study proposes a novel approach for the treatment of glioblastoma, using targeted delivery of fingolimod to the brain tumor region to modulate the blood-brain tumor barrier (BBTB) and deliver magnetic hyperthermia.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Pharmacology & Pharmacy
Ji He, Riya Biswas, Piyush Bugde, Jiawei Li, Dong-Xu Liu, Yan Li
Summary: CRISPR-Cas9 is widely used in genome editing and provides several advantages for studying the interactions between membrane proteins and drugs. However, there are still challenges and issues to be addressed in CRISPR-Cas9 gene editing.
Article
Neurosciences
Fangfang Zhao, Liyuan Zhong, Yumin Luo
Summary: The blood-brain barrier is a complex neurovascular unit that protects neurons and maintains stability of the central nervous system, with endothelial glycocalyx playing a critical role in its structure and functions. Damage to glycocalyx can lead to dysfunction and neurological diseases, highlighting the importance of research in providing theoretical basis for diagnosis and treatment.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Immunology
Qin Zhang, Juan Tan, Li Wan, Chao Chen, Bin Wu, Xijian Ke, Rongxue Wu, Xiao Ran
Summary: The study demonstrated that high doses of tissue kallikrein (TK) may increase blood-brain barrier permeability, while standard and medium doses of TK have less impact on the integrity of the blood-brain barrier. TK modulates blood-brain barrier permeability through different signaling pathways, serving as a potential adjunctive treatment to enhance the efficacy of neurotherapeutics.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Clinical Neurology
Hongyan Wu, Jie Wang, Teng Teng, Bangmin Yin, Yuqian He, Yuanliang Jiang, Xueer Liu, Ying Yu, Xuemei Li, Xinyu Zhou
Summary: This study aims to explore the differences in plasma levels of intestinal and blood-brain barrier permeability markers in adolescents with major depressive disorder (MDD) compared with healthy controls (HCs). The findings indicate that MDD patients have significantly higher levels of these markers in their plasma compared to HCs. Furthermore, these markers can be used as diagnostic tools for MDD in adolescents.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Heera Yoen, Roh Eul Yoo, Seung Hong Choi, Eunkyung Kim, Byung-Mo Oh, Dongjin Yang, Inpyeong Hwang, Koung Mi Kang, Tae Jin Yun, Ji Hoon Kim, Chul-Ho Sohn
Summary: Using dynamic contrast-enhanced magnetic resonance imaging and automatic whole brain segmentation, this study found increased Ktrans values and decreased vp values in mTBI patients, indicating disruption of the blood-brain barrier.
KOREAN JOURNAL OF RADIOLOGY
(2021)
Article
Cell Biology
Yunfei Li, Yifan Xia, Huixiang Zhu, Eric Luu, Guangyao Huang, Yan Sun, Kevin Sun, Sander Markx, Kam W. Leong, Bin Xu, Bingmei M. Fu
Summary: The integrity of the blood-brain barrier is compromised in patients with 22q11.2 deletion syndrome associated with schizophrenia, leading to increased solute permeability, decreased trans-endothelial electrical resistance, and disruption of tight junction proteins and endothelial glycocalyx.
Article
Radiology, Nuclear Medicine & Medical Imaging
Anthony Tessier, Anthony J. Ruze, Isabelle Varlet, Estelle M. H. Laib, Emilien Royer, Monique Bernard, Angele Viola, Teodora-Adriana Perles-Barbacaru
Summary: This study aims to validate a quantitative time-resolved MRI technique for mapping the kinetics of contrast agent in the brain upon intraperitoneal administration. It was a prospective study using mice as an animal model.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Review
Biochemistry & Molecular Biology
Kamila Wala, Wojciech Szlasa, Jolanta Saczko, Julia Rudno-Rudzinska, Julita Kulbacka
Summary: The blood-brain barrier plays a crucial role in protecting the central nervous system and maintaining homeostasis, but higher permeability may be necessary in treating primary brain tumors. Modulating the BBB permeability via A2AR agonists could potentially increase drug concentration in the CNS and improve cancer therapy outcomes.
Article
Pharmacology & Pharmacy
Sadegh Faramarzi, Marlene T. T. Kim, Donna A. A. Volpe, Kevin P. P. Cross, Suman Chakravarti, Lidiya Stavitskaya
Summary: Two statistical-based quantitative structure-activity relationship (QSAR) models were developed in this study to predict drug permeability across the blood-brain barrier (BBB). By using in vivo data and cross-validation, these models showed good performance in sensitivity and negative predictivity, making them a useful tool to reduce the use of experimental animals.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Anna Stasilowicz-Krzemien, Natalia Rosiak, Anita Plazinska, Wojciech Plazinski, Andrzej Miklaszewski, Ewa Tykarska, Judyta Cielecka-Piontek
Summary: Rosmarinic acid (RA) physicochemical properties were improved through system formation with cyclodextrins (CDs), particularly hydroxypropyl-gamma-CD (HP-gamma-CD), which showed the greatest enhancement. The system formation increased RA solubility and dissolution rate, improved gastrointestinal permeability, and enhanced antioxidant activity. This study suggests that CDs can be effective excipients for improving the properties of RA, with potential applications in food or dietary supplements.
Article
Obstetrics & Gynecology
Elizabeth A. Stewart, Barbara L. Lytle, Laine Thomas, Ganesa R. Wegienka, Vanessa Jacoby, Michael P. Diamond, Wanda K. Nicholson, Raymond M. Anchan, Sateria Venable, Kedra Wallace, Erica E. Marsh, George L. Maxwell, Bijan J. Borah, William H. Catherino, Evan R. Myers
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Jessica L. Faulkner, Nicole L. Plenty, Kedra Wallace, Lorena M. Amaral, Mark W. Cunningham, Sydney Murphy, Babbette LaMarca
PROSTAGLANDINS & OTHER LIPID MEDIATORS
(2018)
Article
Medicine, Research & Experimental
Kedra Wallace, Krystal Chatman, Venessia Johnson, Alexis Brookins, John Rushing, Babbette LaMarca
Editorial Material
Medicine, General & Internal
Denise C. Cornelius, Kedra Wallace
Article
Public, Environmental & Occupational Health
Jaleen Sims, Elizabeth Lutz, Kedra Wallace, Wondwosen Kassahun-Yimer, Chiamaka Ngwudike, James Shwayder
EUROPEAN JOURNAL OF CONTRACEPTION AND REPRODUCTIVE HEALTH CARE
(2020)
Article
Obstetrics & Gynecology
Kedra Wallace, Shuaiqi Zhang, Laine Thomas, Elizabeth A. Stewart, Wanda Kay Nicholson, Ganesa R. Wegienka, Lauren A. Wise, Shannon K. Laughlin-Tommaso, Michael P. Diamond, Erica E. Marsh, Vanessa L. Jacoby, Raymond M. Anchan, Sateria Venable, G. Maxwell Larry, Barbara Lytle, Tracy Wang, Evan R. Myers
FERTILITY AND STERILITY
(2020)
Editorial Material
Medicine, General & Internal
Denise C. Cornelius, Kedra Wallace
Article
Endocrinology & Metabolism
Jamie Szczepanski, Shauna-Kay Spencer, Ashley Griffin, Teylor Bowles, Jan Michael Williams, Patrick B. Kyle, John Polk Dumas, Sarah Araji, Kedra Wallace
BIOLOGY OF SEX DIFFERENCES
(2020)
Article
Medicine, General & Internal
Ramana Vaka, Evangeline Deer, Mark Cunningham, Kristen M. McMaster, Kedra Wallace, Denise C. Cornelius, Lorena M. Amaral, Babbette LaMarca
Summary: Preeclampsia is associated with oxidative stress, placental ischemia, and autoantibodies to angiotensin II type I receptor. This study found that mitochondrial dysfunction plays a role in the pathophysiology of preeclampsia, particularly in affecting placental function. Antioxidants may not be an effective treatment for the oxidative stress in preeclampsia.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Peripheral Vascular Disease
Denise C. Cornelius, Xi Wang, Ashley Griffin, Rachael Morris, Kedra Wallace
Summary: Controlled immune activation and balance are crucial for women's reproductive health and successful pregnancy outcomes. Aberrant activation of inflammasomes, which mediate immune activation, has been found to play a role in the development and progression of women's reproductive health and pregnancy-related disorders. Increased inflammasome activation is associated with various reproductive disorders and pregnancy-associated disorders, including preeclampsia, as well as the COVID-19 disease caused by the SARS-CoV-2 virus. Identifying mechanisms of pathophysiology and potential therapeutic targets for these disorders is of great importance.
CURRENT HYPERTENSION REPORTS
(2022)
Article
Environmental Sciences
Rachael Morris, Ahmed S. Z. Moustafa, Wondwosen Kassahun-Yimer, Sarah Novotny, Brittney Billsby, Amira Abbas, Kedra Wallace
Summary: This study aimed to investigate the impact of COVID-19 infection on the risk of developing preeclampsia in pregnant women. The severity of symptoms in COVID-19 patients was found to be associated with the incidence of preeclampsia, but not with pre-existing diabetes or hypertension. The study also found that women with more severe symptoms were more likely to deliver pre-term with smaller babies. For women with pre-existing diabetes or hypertension, the risk of developing preeclampsia was only increased if they were also diagnosed with COVID-19.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Psychology, Multidisciplinary
Kedra Wallace, Teylor Bowles, Ashley Griffin, Reanna Robinson, Lucia Solis, Teryn Railey, James P. Shaffery, Sarah Araji, Shauna-Kay Spencer
Summary: This study suggests that hypertensive disorders of pregnancy are associated with postpartum depression, anxiety, and learning impairments. Using preclinical rodent models, the researchers found evidence of these mood and cognitive changes in rats with a history of Preeclampsia and HELLP syndrome.
BEHAVIORAL SCIENCES
(2022)
Article
Neurosciences
Cynthia Bean, Shauna-Kay Spencer, Mallikarjuna R. Pabbidi, Jamie Szczepanski, Sarah Araji, Sellena Dixon, Kedra Wallace
Article
Physiology
Jessica L. Faulkner, Lorena M. Amaral, Denise C. Cornelius, Mark W. Cunningham, Tarek Ibrahim, Autumn Heep, Nathan Campbell, Nathan Usry, Kedra Wallace, Florian Herse, Ralf Dechend, Babbette LaMarca
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2017)
Review
Peripheral Vascular Disease
Lorena M. Amaral, Kedra Wallace, Michelle Owens, Babbette LaMarca
CURRENT HYPERTENSION REPORTS
(2017)