Article
Multidisciplinary Sciences
Jezid Miranda, Cristina Paules, Guillaume Noell, Lina Youssef, Angel Paternina-Caicedo, Francesca Crovetto, Nicolau Canellas, Maria L. Garcia-Martin, Nuria Amigo, Elisenda Eixarch, Rosa Faner, Francesc Figueras, Rui Simos, Fatima Crispi, Eduard Gratacos
Summary: This study used machine learning to conduct cluster analysis of FGR, confirming the existence of two distinct subtypes with different molecular and clinical features. The clusters generated by machine learning outperformed single data subtype analysis in predicting adverse maternal and neonatal outcomes, supporting the current clinical classification.
Article
Multidisciplinary Sciences
Lan-Wan Wang, Hung-Chih Lin, Ming-Luen Tsai, Yu-Tzu Chang, Yu-Chia Chang
Summary: This study investigated the relationship between hypertensive disorders of pregnancy (HDP) and the risk of autism spectrum disorder (ASD) in children. It found that children born to mothers with HDP had higher rates of preterm-birth and small-for-gestational-age, both of which are risk factors for ASD. The study also suggested that HDP may not be a major contributor to ASD, but rather preterm-birth and SGA play a moderating role in increasing ASD risks.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Manjunath Ramanjaneya, Alexandra E. Butler, Mohammed Bashir, Ilham Bettahi, Abu Saleh Md Moin, Lina Ahmed, Mohamed A. Elrayess, Steven C. Hunt, Stephen L. Atkin, Abdul Badi Abou-Samra
Summary: Pregnant women with GDM have lower levels of apoproteins apoA2, apoC1, apoC3, and apoE compared to control women, which may be related to inflammation. ApoA2 correlates with gestational age at delivery and may serve as a biomarker for premature delivery.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)
Article
Endocrinology & Metabolism
Julie M. Petersen, Jennifer A. Hutcheon, Lisa M. Bodnar, Samantha E. Parker, Katherine A. Ahrens, Martha M. Werler
Summary: This study investigated the relationship between gestational weight gain (GWG) and the size of infants at birth, and found that weight maintenance during the second and third trimesters may be associated with better birth weight for gestational age. However, it is unclear how this can be achieved (e.g., through diet and exercise interventions) due to the observational design of the study.
Article
Medicine, General & Internal
Christine Ladd-Acosta, Elizabeth Vang, Emily S. Barrett, Catherine M. Bulka, Nicole R. Bush, Andres Cardenas, Dana Dabelea, Anne L. Dunlop, Rebecca C. Fry, Xingyu Gao, Jaclyn M. Goodrich, Julie Herbstman, Marie-France Hivert, Linda G. Kahn, Margaret R. Karagas, Elizabeth M. Kennedy, Anna K. Knight, Sahra Mohazzab-Hosseinian, Andreanne Morin, Zhongzheng Niu, T. Michael O'Shea, Meredith Palmore, Douglas Ruden, Rebecca J. Schmidt, Alicia K. Smith, Ashley Song, Eliot R. Spindel, Leonardo Trasande, Heather Volk, Daniel J. Weisenberger, Carrie V. Breton
Summary: This US cohort study found that preeclampsia and gestational diabetes delay biological maturity in children, especially in female offspring.
Article
Medicine, General & Internal
Christine Ladd-Acosta, Elizabeth Vang, Emily S. Barrett, Catherine M. Bulka, Nicole R. Bush, Andres Cardenas, Dana Dabelea, Anne L. Dunlop, Rebecca C. Fry, Xingyu Gao, Jaclyn M. Goodrich, Julie Herbstman, Marie-France Hivert, Linda G. Kahn, Margaret R. Karagas, Elizabeth M. Kennedy, Anna K. Knight, Sahra Mohazzab-Hosseinian, Andreanne Morin, Zhongzheng Niu, T. Michael O'Shea, Meredith Palmore, Douglas Ruden, Rebecca J. Schmidt, Alicia K. Smith, Ashley Song, Eliot R. Spindel, Leonardo Trasande, Heather Volk, Daniel J. Weisenberger, Carrie V. Breton
Summary: Preeclampsia and gestational diabetes delay biological maturity in offspring, especially females, according to a US cohort study examining neonatal biological changes related to exposure to maternal pregnancy conditions.
Article
Endocrinology & Metabolism
Daniel R. McKeating, Joshua J. Fisher, Teresa MacDonald, Sue Walker, Stephen Tong, William W. Bennett, Tu'uhevaha J. Kaitu'u-Lino, Anthony Perkins
Summary: In this study, elemental metabolomics was used to predict the risk of preeclampsia and small-for-gestational age babies, revealing significant changes in elemental concentrations, but no clustering of control, preeclampsia, or small-for-gestational age samples was observed. Positive predictive values correctly identified around 60% of small-for-gestational age samples and 70% of preeclampsia samples. Further analysis should consider other biomarkers, metabolic data, or clinical measurements throughout gestation.
Article
Nutrition & Dietetics
Justyna Zamojska, Katarzyna Niewiadomska-Jarosik, Beata Kierzkowska, Marta Gruca, Agnieszka Wosiak, Elzbieta Smolewska
Summary: This study aimed to evaluate the lipid profile in early childhood in SGA children and found that even without overweight or obesity in early childhood, SGA children had abnormal lipid profiles, which may contribute to the development of cardiovascular diseases in adulthood.
Review
Cell Biology
Vicente Barrios, Julie A. Chowen, Alvaro Martin-Rivada, Santiago Guerra-Cantera, Jesus Pozo, Shoshana Yakar, Ron G. Rosenfeld, Luis A. Perez-Jurado, Juan Suarez, Jesus Argente
Summary: The GH/IGF axis is crucial in human growth, with recent research focusing on the role of the PAPP-A2 gene mutations in affecting physiology. Understanding the implications of PAPP-A2 can provide insights for controlling growth processes.
Article
Acoustics
G. P. Guy, K. Leslie, D. Diaz Gomez, K. Forenc, E. Buck, A. Bhide, B. Thilaganathan
Summary: This retrospective cohort study evaluated the impact of a first-trimester combined screening program for pre-eclampsia using the FMF algorithm. The results showed a significant reduction in the rate of term small-for-gestational age (SGA) birth below the 10th percentile, but no effect on SGA birth below the 5th or 3rd percentile.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Developmental Biology
Faith Andres, Georgia P. Wong, Susan P. Walker, Teresa M. MacDonald, Emerson Keenan, Ping Cannon, Tuong-Vi Nguyen, Natalie J. Hannan, Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino
Summary: The circulating ADAM12 levels in the first trimester are reduced in fetal growth restriction and preeclampsia. This study validates ADAM12 as a biomarker for small for gestational age infants near term, but its predictive value for preeclampsia is inconsistent.
Article
Acoustics
R. L. Deter, W. Lee, P. Dicker, E. C. Tully, F. Cody, F. D. Malone, K. M. Flood
Summary: This study found that there are seven growth restriction patterns in small fetuses with delayed growth in the third trimester. 37% of fetuses without evidence of growth restriction had vascular abnormalities. The distribution and types of normal growth and growth restriction patterns in the AGA cohort were different compared to the SGA cohort.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Xiaobo Zhao, Sophia Twum Frempong, Tao Duan
Summary: The study found that elevated serum uric acid in Chinese Han women with gestational hypertension is associated with an increased risk of progression to preeclampsia and delivering small-for-gestational-age infants. ROC analysis showed moderate prediction values for preeclampsia, but relatively low prediction values for small-for-gestational-age infants, with improved accuracy in Han women with early onset gestational hypertension.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Christian Giommi, Marta Lombo, Nina Montik, Michela Paolucci, Valentina Notarstefano, Giovanni Delli Carpini, Andrea Ciavattini, Antonio Ragusa, Francesca Maradonna, Elisabetta Giorgini, Oliana Carnevali
Summary: Gestational diabetes mellitus (GDM) and small-for-gestational-age (SGA) are metabolic-related diseases that can occur during pregnancy. This study investigated the changes in the placental chorionic villi (CVs) of GDM and SGA patients. The results showed higher levels of SOD-1 and CAT in GDM placentae, which may be related to the hyperglycemic environment. Lipid composition and structure of the placenta were altered in both pathologies, with SGA inducing lipid peroxidation and reducing collagen deposition in the CVs. The cannabinoid system does not seem to be involved in these two pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Fatima Crispi, Merida Rodriguez-Lopez, Gabriel Bernardino, Alvaro Sepulveda-Martinez, Susanna Prat-Gonzalez, Carolina Pajuelo, Rosario J. Perea, Maria T. Caralt, Giulia Casu, Kilian Vellve, Francesca Crovetto, Felip Burgos, Mathieu De Craene, Constantine Butakoff, Miguel A. Gonzalez Ballester, Isabel Blanco, Marta Sitges, Bart Bijnens, Eduard Gratacos
Summary: This study evaluated the baseline cardiac function and structure as well as exercise capacity in young adults born small for gestational age (SGA). The results showed that these young adults had markedly reduced exercise capacity, indicating potential association with increased cardiovascular mortality.
Article
Developmental Biology
Julian K. Christians, David Grynspan, Susan L. Greenwood, Mark R. Dilworth
Article
Developmental Biology
Julian K. Christians, David Grynspan
Article
Cell Biology
Julian K. Christians, Neilab Amiri, John D. Schipilow, Steven W. Zhang, Kristyna I. May-Rashke
GROWTH HORMONE & IGF RESEARCH
(2019)
Review
Endocrinology & Metabolism
Julian K. Christians, Kendra I. Lennie, Lisa K. Wild, Raajan Garcha
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2019)
Article
Reproductive Biology
Jennet Baltayeva, Chaini Konwar, Barbara Castellana, Danielle L. Mara, Julian K. Christians, Alexander G. Beristain
BIOLOGY OF REPRODUCTION
(2020)
Article
Multidisciplinary Sciences
Julian K. Christians, Maria F. Huicochea Munoz
Article
Biology
Natasha Virginkar, Julian K. Christians
Review
Endocrinology & Metabolism
Julian K. Christians, Haroop K. Shergill, Arianne Y. K. Albert
Summary: Research suggests that the impact of food and protein restriction during gestation on offspring health in rats does not necessarily vary by sex, although some studies indicate that food restriction may have a greater effect on blood pressure in male rats. However, birth weight reduction seems consistent regardless of sex.
BIOLOGY OF SEX DIFFERENCES
(2021)
Article
Biochemistry & Molecular Biology
Leticia Rubio, Antonio Vargas, Patricia Rivera, Antonio J. Lopez-Gambero, Ruben Tovar, Julian K. Christians, Stella Martin-de-las-Heras, Fernando Rodriguez de Fonseca, Julie A. Chowen, Jesus Argente, Juan Suarez
Summary: Deficiency of PAPP-A2 gene affects bone composition and remodeling in mice, with acute IGF-1 treatment leading to short-term changes in bone composition and local IGF-1 response. The effects of rmIGF-1 treatment depend on sex, providing insights for potential IGF-1 therapy in growth failure and bone loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Monika D. Rogowska, Uriel N. Pena, Nimrat Binning, Julian K. Christians
Summary: Lactation leads to significant maternal bone loss that is recovered after weaning. The recovery of maternal skeleton after lactation is impaired in moderately-aged mice compared with younger mice. The role of insulin-like growth factor 1 (IGF-I) in this recovery process is not clear.
Review
Obstetrics & Gynecology
Julian K. Christians
Summary: Fetal sex impacts pregnancy complications and long-term health effects of prenatal environment, with placenta playing a crucial role. Sexual dimorphism may affect gene expression, responses to nutrient supply, and histopathology, but there is no clear pattern supporting the hypothesis that one sex is more responsive. More robust statistical approaches are needed to test for sex-dependent effects in order to reduce spurious results.
REPRODUCTIVE SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Julian K. Christians, Natalie A. Chow
Summary: The hypothesis that males prioritize growth over placental development in the prenatal stage, making them more susceptible to early-life adversity, was not strongly supported in this study. Despite differences in birthweight, there was no significant variation in the effects of early-life adversity between males and females. Analyzing the sexes separately rather than testing the interaction between sex and adversity may lead to misleading sex-specific effects.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2022)
Review
Endocrinology & Metabolism
Julian K. Christians, Saboura Ahmadzadeh-Seddeighi, Alishba Bilal, Anastasia Bogdanovic, Rebecca Ho, Estee V. Leung, Megan A. MacGregor, Nolan M. Nadasdy, Gabriella M. Principe
Summary: Early life environmental conditions and adversities, such as premature birth and low birthweight, have long-lasting effects on cognitive abilities and behavioral problems in children. However, there is no consistent difference between boys and girls in the effects of prematurity and low birthweight on these outcomes. This study shows that prematurity and low birthweight have similar long-term effects on intelligence and behavior in both boys and girls.
BIOLOGY OF SEX DIFFERENCES
(2023)
Meeting Abstract
Obstetrics & Gynecology
Natasha Virginkar, Alexander G. Beristain, Julian K. Christians
REPRODUCTIVE SCIENCES
(2020)
Meeting Abstract
Obstetrics & Gynecology
Monika D. Rogowska, Uriel N. V. Pena, Julian K. Christians
REPRODUCTIVE SCIENCES
(2020)