Article
Physiology
Olufunke O. Arishe, Jaine McKenzie, Vanessa Dela Justina, Raiana Dos Anjos Moraes, R. Clinton Webb, Fernanda Priviero
Summary: During normal pregnancy, there is a significant increase in uterine arterial blood flow, which is a result of cardiovascular changes that occur to accommodate the increased metabolic needs of the mother and fetus. The exact mechanism for the vasodilation of the uterine artery during pregnancy is not fully understood. This study investigates the role of the mechanosensitive Piezo1 channel in the dilation of the uterine artery.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Rebecca L. Shaw, Charles E. Norton, Steven S. Segal
Summary: Oxidative stress can lead to apoptosis of vascular cells, with smooth muscle cells (SMCs) showing greater susceptibility compared to endothelial cells (ECs). Further research is needed to validate these findings in intact resistance arteries.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Helen Christou, Raouf A. Khalil
Summary: Pulmonary hypertension is a serious disease characterized by vasoconstriction and remodeling of the pulmonary arterioles, leading to increased pulmonary vascular resistance and right ventricular hypertrophy. Current pharmacological therapies focus on pulmonary vasodilation but are not universally successful. Therefore, researchers are exploring novel approaches to reverse pulmonary vascular pathology and structural remodeling.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Reproductive Biology
Leslie A. Lekatz, Praveen Shukla, Stephen T. O'Rourke, Christopher S. Schauer, Megan L. Van Emon, Kasey R. Maddock-Carlin, Kimberly A. Vonnahme
Summary: This study hypothesized that isocaloric diets low in protein would decrease the sensitivity of caruncular and cotyledonary arteries. The results showed that low protein intake increased the sensitivity of cotyledonary arteries to low doses of potassium chloride, while caruncular arteries of ewes on 80% MP diet were more sensitive to bradykinin compared to ewes on 60% and 100% MP diets.
Review
Biochemistry & Molecular Biology
Oguzhan Yildiz, Kemal Gokhan Ulusoy
Summary: This review summarizes the role of taurine in vascular tone and blood pressure modulation. Taurine supplementation prevents hypertension and reduces blood pressure in hypertensive patients. The mechanisms underlying taurine's vascular effects are still largely unknown.
Review
Biochemistry & Molecular Biology
Xiangqun Hu, Lubo Zhang
Summary: During pregnancy, uteroplacental blood flow increases, which is crucial for the well-being of both the mother and the growth/development of the fetus. This hemodynamic change is primarily achieved through uterine vascular adaptation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Developmental Biology
Gregory W. Kirschen, Abdelrahman AlAshqar, Mariko Miyashita-Ishiwata, Lauren Reschke, Malak El Sabeh, Mostafa A. Borahay
Summary: Fibroids are benign tumors caused by the proliferation of myometrial smooth muscle cells in the uterus, potentially linked with the systemic vasculature system. They are associated with essential hypertension, preeclampsia, and atherosclerosis. Factors such as the renin-angiotensin-aldosterone system, estrogen, and endothelial dysfunction likely play a role in fibroid pathogenesis.
Review
Biochemistry & Molecular Biology
Claudia Rodriguez, Mercedes Munoz, Cristina Contreras, Dolores Prieto
Summary: AMPK serves as a crucial cellular energy sensor activated during energy stress, playing a key role in maintaining energy homeostasis. It is involved in various functions such as mitochondrial biogenesis, redox regulation, cell growth, autophagy, and inflammation. Recent studies have highlighted the protective role of AMPK in cardiovascular function and its association with cardiovascular disease pathogenesis.
Review
Pharmacology & Pharmacy
Gabriel Hoi-Huen Chan, Enoch Chan, Carsten Tsun-Ka Kwok, George Pak-Heng Leung, Simon Ming-Yuen Lee, Sai-Wang Seto
Summary: Ageing is a risk factor for degenerative diseases, including cardiovascular diseases. The tumor suppressor gene p53 may play a regulatory role in vascular remodeling, atherosclerosis, and pulmonary hypertension. Further studies are needed to fully understand the effects of p53 in cardiovascular function and its therapeutic potential.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Neurosciences
Osama F. Harraz, Lars Jorn Jensen
Summary: Changes in cellular Ca2+ levels due to vascular ageing can significantly impact vascular function, blood pressure regulation and cardiovascular diseases. Ageing may cause abnormal Ca2+ signalling in SMCs and ECs, leading to dysregulation of vascular tone and blood flow distribution, thereby increasing the risk of cardiovascular diseases. Research on specific ageing-related Ca2+ signalling deficits is crucial to combat accelerated vascular ageing and its associated health risks in an ageing population.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Cell Biology
Teresa Tropea, Maurizio Mandala
Summary: Caloric restriction improves vascular tone and structural properties of resistance arteries in aged rat model, suggesting it as a beneficial dietary approach to prevent age-related vascular diseases.
MECHANISMS OF AGEING AND DEVELOPMENT
(2021)
Article
Biochemistry & Molecular Biology
Alexander Balatskiy, Ilia Ozhimalov, Maria Balatskaya, Alexandra Savina, Julia Filatova, Natalia Kalinina, Vladimir Popov, Vsevolod Tkachuk
Summary: It was found that immature VSMCs expressing CD146 and neuron-glial antigen 2 are present in atherosclerosis-prone regions, but they are not directly involved in the formation of atherosclerotic lesions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Maria Sancho, Jacob Fletcher, Donald G. Welsh
Summary: Cerebral arteries contain two cell types, smooth muscle cells (SMCs) and endothelial cells (ECs), that can sense specific hemodynamic forces to regulate arterial tone and brain perfusion. This review focuses on the Kir2 channels in vascular tissues and their regulation by membrane lipids, phosphatidylinositol 4,5-bisphosphate (PIP2) and cholesterol, as well as their interaction with caveolin-1 (Cav1) and syntrophin to confer hemodynamic sensitivity.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Cagatay Yelkarasi, Nina Recek, Kursat Kazmanli, Janez Kovac, Miran Mozetic, Mustafa Urgen, Ita Junkar
Summary: This study presents a unique process for the preparation of nanopatterned surfaces on cardiovascular stents using magnetron sputtering and anodization. The nanopatterned surfaces were found to stimulate endothelial cell proliferation while reducing the proliferation of smooth muscle cells. Plasma treatment further enhanced the proliferation of endothelial cells and prevented platelet activation on the surfaces.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Sofia R. Bernstein, Caroline Kelleher, Raouf A. Khalil
Summary: Previous research has assumed that male and female biology is similar except for the reproductive system, leading to misconceptions in research interpretations and clinical applications. However, recent research has identified sex differences in various organs and systems, as well as differences in the prevalence and severity of certain disorders between males and females. This highlights the importance of studying gender differences in biology and disease.
BIOCHEMICAL PHARMACOLOGY
(2023)