Article
Immunology
Abi G. Yates, Trisha Jogia, Ellen R. Gillespie, Yvonne Couch, Marc J. Ruitenberg, Daniel C. Anthony
Summary: The study found that exogenous administration of IL-1RA can attenuate the acute phase response (APR) in traumatic spinal cord injury, reducing immune cell infiltration at the spinal cord lesion site.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Multidisciplinary Sciences
Igor Kolotilin
Summary: Plant-based production of recombinant human proteins is feasible and offers scalable, cost-effective, and eco-friendly manufacturing method for therapeutic proteins. The produced plantakines show biological functionality and can modulate pro-inflammatory cytokine secretion.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Bevin C. C. English, Hannah P. P. Savage, Scott P. P. Mahan, Vladimir E. E. Diaz-Ochoa, Briana M. M. Young, Basel H. H. Abuaita, Gautam Sule, Jason S. S. Knight, Mary X. X. O'Riordan, Andreas J. J. Baeumler, Renee M. Tsolis
Summary: IRE1 alpha and its downstream transcription factor XBP1 enhance glycolysis in macrophages in response to bacterial infection. Different inflammatory stimuli activate IRE1 alpha through distinct mechanisms, and the activation of this pathway is not sufficient to increase glycolysis in macrophages. This study provides new insights into the regulation of macrophage metabolism and the role of IRE1 alpha and XBP1 in innate immunity.
Article
Multidisciplinary Sciences
Timur Oljuskin, Nazli Azodi, Greta Volpedo, Parna Bhattacharya, Hannah L. Markle, Shinjiro Hamano, Greg Matlashewski, Abhay R. Satoskar, Sreenivas Gannavaram, Hira L. Nakhasi
Summary: Leishmaniasis remains a prevalent parasitic disease worldwide, with efforts to develop a licensed human vaccine ongoing. A live attenuated vaccine using gene deletion mutant strains shows promise in inducing strong protective immune responses, with metabolomic analysis revealing modulation of host cell metabolism and promotion of pro-inflammatory responses as key mechanisms of protection.
Article
Oncology
Janani Panneerselvam, Venkateshwar Madka, Rajani Rai, Katherine T. Morris, Courtney W. Houchen, Parthasarathy Chandrakesan, Chinthalapally V. Rao
Summary: The Western-style diet high in fat is a major cause of obesity and increased risk of colon cancer, with inflammatory molecules playing a key role in the connection between obesity and colon tumorigenesis. IL-23 is significant in the impact of a Western-style diet on obesity, gut microbiome, and colon tumorigenesis, suggesting it as a potential target for prevention and treatment. Pro-inflammatory eicosanoids and gut bacterial toxins facilitate IL-23 production, which is crucial in the progression of obesity-associated colon tumors.
Article
Biochemistry & Molecular Biology
Suisui Wang, Jingxiu Bi, Chengjun Li, Bin Li
Summary: This study reveals that the GBL domain of TcLph can recognize pathogens and trigger immune defense responses. The GBL domain is highly conserved and can bind to different types of molecules. Moreover, TcLph is significantly upregulated after infection and its silencing worsens bacterial infection and larval mortality. Therefore, TcLph may play an important role in insect defense against invasive microbes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Oncology
Ryo Fukaura, Masashi Akiyama
Summary: IL-36 cytokines are involved in innate and acquired immunity, playing significant roles in host defense and the pathogenesis of various skin diseases. They are mainly expressed by keratinocytes in the epidermis and participate in the first-line defense of the skin. Numerous studies have shown the importance of IL-36 cytokines in the pathogenesis of various skin diseases.
Article
Allergy
M. Cecilia Berin, Daniel Lozano-Ojalvo, Charuta Agashe, Mary Grace Baker, J. Andrew Bird, Anna Nowak-Wegrzyn
Summary: The study found that FPIES challenges led to significant elevation of inflammatory mediators and cytokines, unique IL-17 signature, and activation of innate lymphocytes.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Immunology
Hiroyuki Oshiumi
Summary: Vaccination is the best way to prevent infectious diseases, but vaccine efficacy and adverse reactions vary among individuals. miRNAs in serum EVs can regulate immune responses and vaccine efficacy, such as miR-192 and miR-21. EV miRNAs can be used as tools to improve vaccine efficacy and predict immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Siri Tahtinen, Ann-Jay Tong, Patricia Himmels, Jaehak Oh, Andres Paler-Martinez, Leesun Kim, Sara Wichner, Yoko Oei, Mark J. McCarron, Emily C. Freund, Zhainib Adel Amir, Cecile C. de la Cruz, Benjamin Haley, Craig Blanchette, Jill M. Schartner, Weilan Ye, Mahesh Yadav, Ugur Sahin, Lelia Delamarre, Ira Mellman
Summary: Lipid-formulated RNA vaccines can cause systemic inflammatory responses in humans, which were not predicted in preclinical studies. The IL-1 pathway plays a key role in triggering vaccine-induced inflammation, but this effect is dampened in mice.
Article
Pharmacology & Pharmacy
Shumei He, Hongyan Fan, Bin Sun, Meipan Yang, Hongxu Liu, Jianwei Yang, Jianxin Liu, Sizhu Luo, Zihan Chen, Jing Zhou, Lu Xia, Shulin Zhang, Bo Yan
Summary: This study demonstrates the bacteriostatic effect of Salidroside (SAL) from Tibetan medicine Rhodiola rosea on tuberculosis using an in vivo zebrafish model. It also shows increased immune cell recruitment and improved survival rates with SAL treatment, suggesting a potential novel strategy for TB treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Fisheries
Xueshu Zhang, Song Xu, Weiqun Lu
Summary: The critical receptor IL-1RI in the IL-1 pathway is widely expressed in olive flounder and plays an important role in immune responses. Overexpression of PoIL-1RI significantly enhances the antibacterial ability of immune cells and activates the NF-kappa B signaling pathway.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Andrea Olmos-Ortiz, Mayra Hernandez-Perez, Pilar Flores-Espinosa, Gabriela Sedano, Addy Cecilia Helguera-Repetto, Oscar Villavicencio-Carrisoza, Maria Yolotzin Valdespino-Vazquez, Arturo Flores-Pliego, Claudine Irles, Bruno Rivas-Santiago, Elsa Romelia Moreno-Verduzco, Lorenza Diaz, Veronica Zaga-Clavellina
Summary: Infectious processes in the uterine cavity can compromise the maternal-fetal unit and increase the risk of preterm birth and premature rupture of membranes. This study aimed to characterize the synthesis, activity, and distribution of antimicrobial peptides (AMPs) produced by fetal membranes in response to a choriodecidual Escherichia coli infection. The results showed a temporal- and tissue-specific pattern of AMP synthesis, but the membranes were unable to contain bacterial growth and migration despite the production of AMPs, increasing the risk of preterm birth and premature rupture of membranes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Diana Boraschi
Summary: Interleukin-1 (IL-1) is a cytokine that plays a significant role in inflammation and immune response, primarily produced by macrophages during defensive reactions. It belongs to a superfamily of structurally similar proteins and acts through binding to specific receptors on the plasma membrane of target cells. IL-1 family cytokines not only have innate immune and inflammatory effects but also appear to be involved in the development of adaptive immunity in vertebrates.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Mariasilvia Colantuoni, Raisa Jofra Hernandez, Emanuela Pettinato, Luca Basso-Ricci, Laura Magnani, Grazia Andolfi, Chiara Rigamonti, Annamaria Finardi, Valentina Romeo, Monica Soldi, Lucia Sergi Sergi, Martina Rocchi, Serena Scala, Hal M. Hoffman, Silvia Gregori, Anna Kajaste-Rudnitski, Francesca Sanvito, Luca Muzio, Luigi Naldini, Alessandro Aiuti, Alessandra Mortellaro
Summary: We developed a gene transfer strategy using transplanted autologous hematopoietic stem/progenitor cells (HSPCs) as a source of IL-1 receptor antagonist (IL-1RA) for systemic delivery to tissues and organs. Our findings demonstrate the potential of HSPC-mediated IL-1RA delivery as a therapeutic modality for suppressing tissue and organ inflammation in diverse immune-related diseases involving IL-1-driven inflammation.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Letter
Pediatrics
Rhea Urs, Benjamin Stoecklin, J. Jane Pillow, Benjamin Hartmann, Graham L. Hall, Shannon J. Simpson
PEDIATRIC RESEARCH
(2022)
Review
Pediatrics
Sarah Marie de Medeiros, Avneet Mangat, Graeme R. Polglase, G. Zeballos Sarrato, Peter G. Davis, Georg M. Schmoelzer
Summary: The study found that using a respiratory function monitor (RFM) in addition to clinical assessment during mask ventilation in newborns did not significantly impact mortality rates, but did significantly reduce any brain injury and intraventricular haemorrhage. Further research is needed to determine the routine use of RFMs in neonatal resuscitation.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2022)
Article
Engineering, Electrical & Electronic
Stefano Robbiani, Francesco Tarantini, Lorenzo Ventura, Chiara Veneroni, Lorenza Draghi, Mar Janna Dahl, J. Jane Pillow, Raffaele L. Dellaca
Summary: Tracheal occlusion (TO) is a fetal treatment option for congenital diaphragmatic hernia, aiming to reduce lung hypoplasia and hypertension. However, the effect of TO on lung pressure was unknown. In this study, an implantable device was developed for real-time wireless monitoring and long-term logging of lung pressure in ovine fetuses. The device showed high accuracy and stability, successfully detecting pressure changes caused by TO.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2022)
Article
Obstetrics & Gynecology
Tatiana Ninkov, Elizabeth A. Nathan, Cathryn N. Belcher, Scott W. White, John P. Newnham
Summary: Serial measurement of cervical length at 16 and 19 weeks improves the ability to predict preterm birth in high-risk women prescribed vaginal progesterone therapy.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)
Article
Pediatrics
Timothy J. R. Panneflek, Kristel L. A. M. Kuypers, Graeme R. Polglase, Stuart B. Hooper, Thomas van den Akker, Arjan B. te Pas
Summary: Clinical chorioamnionitis (CCA) is associated with reduced breathing effort and oxygenation in premature infants at birth.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Article
Anatomy & Morphology
Amanda Vrselja, Jennifer Jane Pillow, Jonathan G. Bensley, Siavash Ahmadi-Noorbakhsh, Peter B. Noble, Mary Jane Black
Summary: Postnatal dexamethasone therapy in preterm lambs had a dose-dependent adverse effect on cardiac maturation and morphology within the first week of life. High-dose treatment resulted in significant differences in gene expression, reduced cardiomyocyte endowment in the right ventricle, and increased inflammatory infiltrates in the left ventricle. Low-dose exposure had minimal effects on the preterm heart.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2023)
Article
Pediatrics
Emanuela Zannin, Benjamin Stoecklin, Jane Y. Y. Choi, Shannon J. J. Simpson, Chiara Veneroni, Raffaele L. L. Dellaca, Jane J. J. Pillow
Summary: This study investigated the effects of bronchopulmonary dysplasia (BPD) on ventilatory response and peripheral oxygen saturation (SpO(2)) stability during a hypoxic challenge in preterm infants. The results showed individual variability in ventilatory response regardless of BPD severity. Some infants reduced ventilation, while others increased minute ventilation during the hypoxic challenge. Periodic breathing, increased SpO(2) variability, and oscillatory patterns in ventilation and SpO(2) were also observed, irrespective of BPD severity.
PEDIATRIC PULMONOLOGY
(2023)
Article
Physiology
Benjamin Stoecklin, Y. Jane Choi, Theodore Dassios, J. Gareth Jones, Geoffrey G. Lockwood, J. Jane Pillow
Summary: In preterm infants, instability of peripheral oxyhemoglobin saturation (SpO(2)) is associated with late disability. This study found that a reduced ventilation to perfusion ratio (V-A/Q) is the main factor leading to SpO(2) instability.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Fernando Perez Rojo, J. Jane Pillow, Parwinder Kaur
Summary: The isoflavonoid derivatives, pterocarpans and coumestans, have potential applications as osteo-regenerative, neuroprotective, and anti-cancer agents. Plant-based systems have limitations for producing these derivatives, but microbial cell factories, such as Saccharomyces cerevisiae, offer an efficient platform. Bioprospecting microbes and enzymes can enhance production and identify biosynthetic pathways. Using a holistic approach, microalgal species can be used as microbial cell factories to produce these compounds. Bioprospecting tools provide a promising field for sustainably producing isoflavonoid derivatives.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Matthew Oyang, Beth R. Piscopo, Valerie Zahra, Atul Malhotra, Amy E. Sutherland, Arvind Sehgal, Stuart B. Hooper, Suzanne L. Miller, Graeme R. Polglase, Beth J. Allison
Summary: Preterm growth-restricted lambs showed longer maintenance of carotid blood flow during perinatal asphyxia and lower requirement for chest compressions during resuscitation compared to control lambs. However, there is a risk of cerebrovascular injury in FGR due to the overshoot of carotid blood flow after ROSC.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Editorial Material
Critical Care Medicine
Indya M. Davies, Graeme R. Polglase
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Fernando Perez Rojo, Paton Vuong, J. Jane Pillow, Parwinder Kaur
Summary: Plants produce secondary metabolites that are beneficial for human health. However, native plant production systems face challenges such as excessive land use, high carbon footprints, and long production times, making plant-based production inefficient. Microbial-based synthetic biology offers an alternative method that addresses these limitations.
BIOFUELS BIOPRODUCTS & BIOREFINING-BIOFPR
(2023)
Article
Pediatrics
Rhea Urs, Rubi Ni Chin, Naomi Hemy, Andrew C. C. Wilson, J. Jane Pillow, Graham L. L. Hall, Shannon J. J. Simpson
Summary: The study found that markers of neutrophilic inflammation and oxidative stress in the airways remain elevated in very premature infants even beyond the first year of life.
Letter
Biochemistry & Molecular Biology
J. Jane Pillow, Erzsebet Bartolak-Suki, Peter B. Noble, Clare A. Berry, Bela Suki
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Pediatrics
Georgia A. Santomartino, Douglas A. Blank, Alissa Heng, Anthony Woodward, Stefan C. Kane, Marta Thio, Graeme R. Polglase, Stuart B. Hooper, Peter G. Davis, Shiraz Badurdeen
Summary: This study aimed to identify characteristics associated with clinical instability in at-risk infants in the delivery room. The findings indicate that factors such as labor without oxytocin administration, medical pregnancy complications, difficult extraction at birth, and unplanned cesarean section in labor are independent risk factors for clinical instability. Decision tree analysis further revealed that infants whose mothers did not receive oxytocin during labor were at the highest risk, while those whose mothers received oxytocin during labor and did not have any medical pregnancy complication were at the lowest risk.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)