Article
Acoustics
Marco La Verde, Marco Torella, Carlo Ronsini, Gaetano Riemma, Luigi Cobellis, Maria Maddalena Marrapodi, Carlo Capristo, Agnese Maria Chiara Rapisarda, Maddalena Morlando, Pasquale De Franciscis
Summary: This study investigated the relationship between uterine artery blood volume flow (QUtA) and fetal Doppler indices. It found a significant association between QUtA and the umbilical artery pulsatility index (PI) and the uterine artery mean PI, demonstrating an inverse correlation. It also showed a weak correlation between QUtA and newborn weight, with an increase in QUtA associated with higher newborn weight.
ULTRASCHALL IN DER MEDIZIN
(2023)
Article
Medicine, General & Internal
Piotr Kaszczewski, Michal Elwertowski, Jerzy Leszczynski, Tomasz Ostrowski, Joanna Kaszczewska, Zbigniew Galazka
Summary: This study explores the changes in blood flow volume in carotid artery occlusion (CAO) patients and finds that volumetric flow compensation may play an important predictive role in these patients.
Review
Medicine, General & Internal
Serena Resta, Gaia Scandella, Ilenia Mappa, Maria Elena Pietrolucci, Pavjola Maqina, Giuseppe Rizzo
Summary: The number of pregnancies achieved through IVF is increasing globally, with improved chances of success due to technological advances. However, pregnancies conceived through IVF have a higher risk of adverse maternal and perinatal outcomes, mainly related to hypertensive diseases, pre-eclampsia, and fetal growth restriction. Advances in ultrasound technology allow for the evaluation of placental volume and hemodynamics, with differences observed between fresh and frozen-thawed embryos.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Veterinary Sciences
Salvador Ruiz, Juan Carlos Gardon, Ivan Hernandez-Caravaca, Chiara Luongo, Francisco Alberto Garcia-Vazquez
Summary: This study aimed to determine uterine blood flow indices in sows using transabdominal Doppler ultrasound. The results showed significant differences in certain indices between estrus and early diestrus, while the type of seminal dose did not affect uterine vascularity.
VETERINARY SCIENCES
(2022)
Article
Obstetrics & Gynecology
Y. Tang, J. Zhang, F. Dai, N. S. Razali, S. Tagore, B. S. M. Chern, K. H. Tan
Summary: This prospective cohort study aimed to investigate the association between sleep disturbances and blood pressure as well as uterine artery Doppler during pregnancy in women without pre-existing hypertension. The results showed that poor sleep quality was significantly associated with higher blood pressure, especially in the first trimester, and higher uterine artery pulsatility index during pregnancy. Overall, shorter sleep duration, poorer sleep efficiency, and poor sleep quality during pregnancy were all found to be related to adverse maternal outcomes.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Acoustics
Jonathan M. Rubin, Sibo Li, J. Brian Fowlkes, Shriram Sethuraman, Oliver D. Kripfgans, William Shi, Marjorie C. Treadwell, James R. Jago, Ronald D. Leichner, Stephen Z. Pinter
Summary: The study compared a new method for estimating blood volume flow with the standard 1-dimensional spectral Doppler method in the umbilical vein, finding significantly less variation in estimates with the new 3-dimensional ultrasound method.
JOURNAL OF ULTRASOUND IN MEDICINE
(2021)
Article
Agriculture, Dairy & Animal Science
T. Minela, J. R. Pursley
Summary: The study aimed to establish timelines for assessing luteolysis via Doppler ultrasonography. Different doses of CLO had varying effects on the corpus luteum, with the full dose treatment resulting in less LBF and LV reduction.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Obstetrics & Gynecology
Piotr Dobrowolski, Przemyslaw Kosinski, Aleksander Prejbisz, Anna Szczepkowska, Anna Klisiewicz, Magdalena Januszewicz, Miroslaw Wielgos, Andrzej Januszewicz, Piotr Hoffman
Summary: This study analyzed data from 60 healthy pregnant women and found that in uncomplicated pregnancy, left atrial volume index increased and correlated with parameters of Doppler ultrasound of fetal circulation and the uterine artery.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Acoustics
C. Russo, S. Camilli, F. G. Martire, A. Di Giovanni, L. Lazzeri, M. Malzoni, E. Zupi, C. Exacoustos
Summary: The study aimed to correlate the ultrasound appearance of highly vascularized uterine myomas with histopathological diagnosis, highlighting the importance of combining lesion characteristics and patient age for differential diagnosis of typical myomas, benign variants, and malignant lesions.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rachael Bok, Damian D. Guerra, Ramon A. Lorca, Sara A. Wennersten, Peter S. Harris, Abhishek K. Rauniyar, Sally P. Stabler, Kenneth N. MacLean, James R. Roede, Laura D. Brown, K. Joseph Hurt
Summary: The study revealed that cystathionine gamma-lyase (CSE) plays a crucial role in maintaining the glutathione (GSH)/glutathione disulfide (GSSG) balance in uterine arteries for nitric oxide signaling, which is necessary for normal estrogen (E-2) stimulation. These findings have implications for pregnancy pathophysiology and the selective hormone responses of specific vascular beds.
Article
Physiology
Pat R. Vehrs, Shay Richards, Chase Blazzard, Hannah Hart, Nicole Kasper, Ryan Lacey, Daniela Lopez, Luke Baker
Summary: The study aimed to validate a handheld Doppler (HHDOP) device for measuring arterial occlusion pressure (AOP) of the brachial and femoral arteries. The results showed no differences in limb circumference or volume in males and females, or between dominant and non-dominant limbs. The differences between HHDOP and gold standard Doppler measurements of AOP were either not significant or had little practical importance. HHDOP can be used by practitioners for safe and effective blood flow restriction.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Acoustics
E. Hwuang, P. H. Wu, A. Rodriguez-Soto, M. Langham, F. W. Wehrli, M. Vidorreta, B. Moon, K. Kochar, S. Parameshwaran, N. Koelper, M. D. Tisdall, J. A. Detre, W. Witschey, N. Schwartz
Summary: This study recruited 87 pregnant women with a singleton pregnancy to measure UtA hemodynamics using 4D flow MRI. The results showed that MRI blood flow rate and pulsatility index were associated with pregnancy outcomes. The potential of MRI-flow and MRI-PI in predicting pre-eclampsia and small-for-gestational-age neonates was highlighted.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Biophysics
Max E. Weston, Alan R. Barker, Owen W. Tomlinson, Jeff S. Coombes, Tom G. Bailey, Bert Bond
Summary: This study aims to quantify the agreement between left and right middle cerebral artery blood velocity (MCAv) responses to incremental and constant work-rate exercise in adults. The results showed similarities between left and right MCAv responses to incremental and constant work-rate exercise in adults on a group-level, but also highlighted individual variation in the agreement between left and right MCAv exercise responses.
PHYSIOLOGICAL MEASUREMENT
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tetsuya Katsumori, Tatsuya Yoshikawa, Yasuteru Sasakura, Toshinori Yasumura, Mitsuhiro Hisano
Summary: This study found no significant differences in outcomes of UAE for leiomyoma when performed during different phases of the menstrual cycle. All patients completed a 4-month follow-up, and there were no significant differences among groups in baseline characteristics, technical and peri-procedural outcomes, and 1-week and 4-month efficacy.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
David Ramirez-Gonzalez, Angel Poto, Begona Peinado, Laura Almela, Sergio Navarro-Serna, Salvador Ruiz
Summary: A detailed study of fetal growth indices and umbilical artery flow rates in Murciano-Granadina goats has been performed using ultrasonography. The measurements were taken from 18 to 125 days post-breeding, and both fetal growth indices and blood flow parameters showed significant changes throughout the pregnancy period.
Review
Obstetrics & Gynecology
Faith A. Miller, Adalina Sacco, Anna L. David, Ashley K. Boyle
Summary: Interventions targeting inflammation show therapeutic potential for infection/inflammation-induced preterm births in animal models. However, the heterogeneity in methodology and lack of standardization remain challenges in preclinical studies.
REPRODUCTIVE SCIENCES
(2023)
Review
Obstetrics & Gynecology
Adalina Sacco, Emily F. Cornish, Neil Marlow, Anna L. David, Dino A. Giussani
Summary: According to a systematic review of human clinical literature, antenatal corticosteroids (ACS) exposure does not have long-term effects on cardiovascular function in human offspring. However, due to the limited number, heterogeneity, and mixed quality of studies, the effects on cardiac structure and other measures of cardiac function remain unclear. Further research is needed to assess central cardiac function in human offspring exposed to ACS.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Genetics & Heredity
Yada Kunpalin, Simen Vergote, Luc Joyeux, Onur Telli, Anna L. David, Michael Belfort, Paolo De Coppi, Jan Deprest
Summary: A study on commercially available patches used in fetal rabbit models for spina bifida repair found that covering the spinal cord with Duragen or Durepair and closing the skin preserves motor neuron density and reduces the inflammatory response.
PRENATAL DIAGNOSIS
(2023)
Article
Engineering, Biomedical
Sophia Bano, Francisco Vasconcelos, Anna L. David, Jan Deprest, Danail Stoyanov
Summary: Fetoscopic video mosaicking can create an expanded field-of-view image of the fetoscopic intraoperative environment to support surgeons during twin-to-twin transfusion syndrome treatment. However, existing methods relying on vessel presence have limitations. We propose a vessel-guided hybrid fetoscopic mosaicking framework that combines placental vessel-based registration and deep learning-based dense matching to improve overall performance. Experimental results demonstrate the robustness of the proposed framework over state-of-the-art methods, even in vessel-free and low-textured fetoscopic views.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING-IMAGING AND VISUALIZATION
(2023)
Letter
Genetics & Heredity
Anna L. David, Rebecca N. Spencer
PRENATAL DIAGNOSIS
(2023)
Article
Acoustics
S. Vergote, J. van der Stock, Y. Kunpalin, E. Bredaki, H. Maes, S. Banh, L. De Catte, R. Devlieger, L. Lewi, S. Devroe, R. Spencer, A. David, P. De Vloo, F. Van Calenbergh, J. A. Deprest
Summary: This prospective single-center audit examined the fetal and maternal adverse events following fetal surgery for spina bifida and assessed the impact of patient engagement in collecting follow-up data. The study found that severe complications could occur in both the fetus and the mother after the surgery, but the nature and rate of these complications were similar to those reported in other studies. Patient empowerment and involvement improved the collection of outcome data.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Cell Biology
Hannah Ee Juen Yong, Katarzyna Maksym, Muhammad Ashraf Bin Yusoff, Esteban Salazar-Petres, Tatiana Nazarenko, Alexey Zaikin, Anna L. David, Sara L. Hillman, Amanda N. Sferruzzi-Perri
Summary: Fetal growth restriction (FGR) is a major cause of perinatal morbidity and mortality. This study explores the relationship between placental structure and function in healthy and FGR pregnancies through predictive modeling. The findings provide new insights into the etiology of FGR.
Review
Endocrinology & Metabolism
Simon N. Waddington, William H. Peranteau, Ahad A. Rahim, Ashley K. Boyle, Manju A. Kurian, Paul Gissen, Jerry K. Y. Chan, Anna L. David
Summary: Fetal gene therapy was proposed in the late 1990s when gene therapy was at its peak of inflated expectations. Over the years, gene therapy matured and became a clinical and market reality. The trajectory of treatment for genetic diseases is now focused on earlier intervention, with increasing ability to diagnose genetic diseases in utero. Recent clinical trials have pointed towards the potential for fetal gene therapy. This review summarizes the history of fetal gene therapy, advancements in fetal surgery and diagnosis, and the scope of preclinical gene therapy for inherited metabolic diseases.
JOURNAL OF INHERITED METABOLIC DISEASE
(2023)
Article
Developmental Biology
Nada Mufti, Joanna Chappell, Patrick O'Brien, George Attilakos, Hassna Irzan, Magda Sokolska, Priya Narayanan, Trevor Gaunt, Paul D. Humphries, Premal Patel, Elspeth Whitby, Eric Jauniaux, J. Ciaran Hutchinson, Neil J. Sebire, David Atkinson, Giles Kendall, Sebastien Ourselin, Tom Vercauteren, Anna L. David, Andrew Melbourne
Summary: The study investigates the use of super-resolution reconstruction (SRR) MRI to improve placental assessment and predict adverse maternal outcomes. The results show that SRR imaging and paired imaging can enhance the detection of pathological MRI markers, aiding in surgical planning.
Review
Genetics & Heredity
Rachel L. Sagar, Lilian Walther-Jallow, Cecilia Gotherstrom, Magnus Westgren, Anna L. David
Summary: The maternal and fetal safety of In utero stem cell transplantation (IUSCT) was investigated. A systematic review found that the acute fetal complication rate of IUSCT was 4.5% per procedure. Maternal adverse events and pregnancy outcomes have been poorly reported.
PRENATAL DIAGNOSIS
(2023)
Article
Medicine, Research & Experimental
Rebecca Spencer, Kasia Maksym, Kurt Hecher, Karel Marsal, Francesc Figueras, Gareth Ambler, Harry Whitwell, Nuno Rocha Nene, Neil J. Sebire, Stefan R. Hansson, Anke Diemert, Jana Brodszki, Eduard Gratacos, Yuval Ginsberg, Tal Weissbach, Donald M. Peebles, Ian Zachary, Neil Marlow, Angela Huertas-Ceballos, Anna L. David
Summary: This study investigates the use of maternal serum protein and ultrasound measurements to predict outcomes in pregnancies affected by severe, early-onset fetal growth restriction (FGR). The results demonstrate that ultrasound measurements and maternal serum PlGF concentration can predict important pregnancy outcomes for patients and clinicians.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Correction
Engineering, Biomedical
Oluwatosin Alabi, Sophia Bano, Francisco Vasconcelos, Anna L. David, Jan Deprest, Danail Stoyanov
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2023)
Meeting Abstract
Developmental Biology
Kimberley Botting-Lawford, Ruth Horler, Anthony White, Sheila Mizani, Gabrielle Crombie, Hakim-Moulay Dehbi, Owen Vaughan, Anna L. David
Article
Engineering, Biomedical
Efthymios Maneas, Andreas Hauptmann, Erwin J. Alles, Wenfeng Xia, Sacha Noimark, Anna L. David, Simon Arridge, Adrien E. Desjardins
Summary: A post-processing framework based on a convolutional neural network (CNN) is proposed to improve the spatial resolution of ultrasonic tracking images. The application of CNNs shows promising potential in enhancing the resolution of tracking images.
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2023)
Letter
Obstetrics & Gynecology
Jenny Carter, Naomi Carlisle, Anna David, Jane Sandall, Paul Seed, Andrew Shennan, Rachel Tribe, Helena Watson
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
