期刊
REPRODUCTIVE SCIENCES
卷 16, 期 5, 页码 509-517出版社
SPRINGER HEIDELBERG
DOI: 10.1177/1933719108327597
关键词
Fetal asphyxia; heart rate variability; RMSSD; autonomic nervous system; vagus; monitoring
资金
- IZKF [TKM B307-04004]
- DFG [LE 2025/1-3]
Fetal heart rate (FHR) monitoring is commonly used to predict asphyxia but clinical and experimental studies have questioned its diagnostic value. We examined the usefulness of fetal heart rate variability (fHRV) measures in detecting early asphyxia using, chronically), instrumented fetal sheep under normoxic (n = 6) mid asphyxic conditions (3 umbilical cord occlusions, n = 6), The occlusions consistently led to pH decreases from 7.35 +/- 0.01 to 7.09 +/- 0.03 (P < .05). FHR showed biphasic deceleration during each occlusion, associated with increasing arterial blood pressure (P <. 05). RMSSD, an index of vagal modulation of fHRV increased consistently during repeated occlusion induced FHR deceleration (P < .05). Under normoxic conditions, RMSSD did not change during FHR decelerations and decreased during FHR accelerations (P < .05). Our results suggest that an increase of RMSSD in association with FHR decelerations reflects initial vagal activation during fetal ashyxia. RMSSd may accurately identify asphyxic fetuses early. Clinical validation is needed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据