Article
Biochemistry & Molecular Biology
Elena Yu. Gorbacheva, Konstantin A. A. Toniyan, Yulia A. A. Biriukova, Nadezhda A. A. Lukicheva, Oleg I. I. Orlov, Valery V. V. Boyarintsev, Irina V. V. Ogneva
Summary: The impact of weightlessness on the female reproductive system is not well understood. This study examined the effects of a 5-day dry immersion on the reproductive system of female subjects. Results showed that after immersion, there was an increase in inhibin B and a decrease in luteinizing hormone and progesterone. The size of the uterus and the thickness of the endometrium did not change. However, the average diameters of the antral follicles and the dominant follicle were higher after immersion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Developmental Biology
S. Marla, S. Mortlock, S. Houshdaran, J. Fung, B. McKinnon, S. J. Holdsworth-Carson, J. E. Girling, P. A. W. Rogers, L. C. Giudice, G. W. Montgomery
Summary: The study found that genetic regulation of genes in the ESR1 region is associated with endometriosis risk, with gene expression influenced more significantly by hormone concentrations and receptor expression. Due to limited sample size and cellular heterogeneity, the study also noted that detecting genetic effects on gene expression may be challenging.
MOLECULAR HUMAN REPRODUCTION
(2021)
Review
Endocrinology & Metabolism
Jimena Lopez Dacal, Sebastian Castro, Sofia Suco, Lourdes Correa Brito, Romina P. Grinspon, Rodolfo A. Rey
Summary: This review addresses the approaches to evaluate the hypothalamic-pituitary-testicular axis in newborns, children, and adolescents, focusing on hormonal laboratory and genetic studies, clinical signs, and imaging studies.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Oncology
Susanne Fischer, Ulrike Kuebler, Elvira Abbruzzese, Christian Breymann, Laura Mernone, Ulrike Ehlert
Summary: High levels of estradiol were found to be positively associated with the presence and persistence of HR-HPV, while progesterone was not related to HR-HPV. Regular monitoring of estradiol levels may be useful in identifying women at risk of developing cervical cancer.
Article
Zoology
Beenish Shahid, Muhammad Ijaz Khan
Summary: The study aimed to improve the maturation of in vitro matured oocytes of Nili Ravi buffalo by adding hormones. The addition of E2+rhFSH to the culture media significantly increased the diameter and maturation of oocytes, while reducing the proportion of degenerated oocytes.
PAKISTAN JOURNAL OF ZOOLOGY
(2023)
Article
Food Science & Technology
Kensei Nishida, Daisuke Sawada, Toshiyuki Yasui, Yuki Kuwano, Kazuhito Rokutan
Summary: The study suggests that Lactobacillus gasseri CP2305 can improve premenstrual symptoms in healthy young women, particularly psychological symptoms like depressed mood and anxiety. Compared to the placebo group, the CP2305 group did not show a reduction in water retention-related physical symptoms, but they did show sustained elevated levels of salivary estradiol and progesterone in the luteal phase.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Leonie Dopavogui, Florence Cadoret, Gaspard Loison, Sara El Fouikar, Francois-Xavier Frenois, Frank Giton, Sandrine Ellero-Simatos, Frederic Lasserre, Arnaud Polizzi, Clemence Rives, Nicolas Loiseau, Roger D. Leandri, Nicolas Gatimel, Laurence Gamet-Payrastre
Summary: Female infertility has a multifactorial origin, and exposure to contaminants, including pesticides, is considered to be involved in this reproductive disorder. This study found that exposure to a common pesticide mixture can disrupt folliculogenesis in mice, leading to abnormal ovarian structure and changes in hormone levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Birgit Alsbjerg, Ulrik S. Kesmodel, Helle Elbaek, Rita Laursen, Steen B. Laursen, Dorthe Andreasen, Betina B. Povlsen, Peter Humaidan
Summary: The study did not find a significant reduction in total pregnancy loss or biochemical pregnancy loss with GnRHa supplementation in HRT-FET cycles. However, participants who had a live birth had higher progesterone concentrations. Additionally, there was a trend for higher live birth rates correlated with the highest estradiol concentrations.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Multidisciplinary Sciences
Hui Long, Weina Yu, Sha Yu, Mingru Yin, Ling Wu, Qiuju Chen, Renfei Cai, Lun Suo, Li Wang, Qifeng Lyu, Yanping Kuang
Summary: The study investigated the impact of progesterone on clinical oocyte outcomes and the coordination between progesterone and follicle stimulating hormone (FSH) in regulating follicle growth and oocyte yields. Findings revealed that progesterone inhibited granular cell proliferation and follicle growth through the PI3K/AKT and MAPK signaling pathways, ultimately affecting oocyte outcomes in clinical settings.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Obstetrics & Gynecology
Denny Sakkas, Colin M. Howles, Leslie Atkinson, Andrea Borini, Ernesto A. Bosch, Crystal Bryce, Monica Cattoli, Alan B. Copperman, Astrid Finet de Bantel, Brian French, Jan Gerris, Steve W. Granger, Veronika Grzegorczyk-Martin, Joseph A. Lee, Michael J. Levy, Marla J. Matin, Sara Somers, Eric A. Widra, Michael M. Alper
Summary: This study presented a blind validation of a novel saliva-based oestradiol and progesterone assay in samples collected in independent IVF clinics. The results showed that salivary oestradiol hormone testing correlates well to serum-based assessment, whereas progesterone values, around the time of trigger, are not consistent from patient to patient.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Obstetrics & Gynecology
Xiao Xu, Hao-Ran Shen, Min Yu, Mei-Rong Du, Xue-Lian Li
Summary: The study revealed that let-7i is down-regulated in PCOS granulosa-luteal cells, and overexpression of let-7i inhibits cell proliferation and decreases estradiol production through IMP2-dependent mechanisms. This finding provides a new molecular mechanism for PCOS.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Nathalie Soderhamn Bulow, Sven Olaf Skouby, Agnieszka Katarzyna Warzecha, Hanne Udengaard, Claus Yding Andersen, Marianne Dreyer Holt, Marie Louise Grondahl, Anders Nyboe Andersen, Negjyp Sopa, Anne Lis Englund Mikkelsen, Anja Pinborg, Nicholas Stephen Macklon
Summary: The use of letrozole during ovarian stimulation for IVF did not significantly decrease the proportion of women with premature progesterone levels above 1.5 ng/ml at the time of triggering final oocyte maturation. However, letrozole did significantly increase the proportion of women with mid-luteal progesterone levels above 30 ng/ml.
HUMAN REPRODUCTION
(2022)
Article
Physiology
Juana Monroy, Omar D. Cortes, Roberto Dominguez, Maria Eugenia Mendoza-Garrido, Eloir Gallegos, Mario Cardenas, Andres Aragon, Maria E. Ayala
Summary: This study reveals that administration of 5-hydroxytryptophan (5-HTP) either intraperitoneally or directly into the ovarian bursa enhances the concentrations of 5-HT and its metabolite in the ovary, as well as the serum concentration of estradiol. These findings suggest that 5-HTP has a promoting effect on ovarian function.
EXPERIMENTAL PHYSIOLOGY
(2023)
Article
Endocrinology & Metabolism
Margaret A. Mohr, Tina Keshishian, Brennan A. Falcy, Blake J. Laham, Angela M. Wong, Paul E. Micevych
Summary: The development of oestrogen positive feedback during female puberty is not fully understood. This study investigates the role of astrocytes in the facilitation of neuroP synthesis by oestradiol (E2) and the expression of membrane oestrogen receptor alpha (mER alpha) in pre- and post-pubertal stages. The results suggest that prior to puberty, astrocytes have low levels of mER alpha, which hinders the response of neuroP synthesis to E2. However, after puberty, the expression of mER alpha in astrocytes increases, leading to the facilitation of neuroP synthesis.
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Rong Zhou, Ya-lan Yang, Ying Liu, Jie Chen, Bing Yang, Zhong-lin Tang
Summary: This study investigates the molecular mechanisms underlying high prolificacy in Meishan pigs compared to Yorkshire pigs by analyzing the differences in the ovaries' transcriptome, proteome, and metabolome. The results suggest that lower biosynthesis rates and higher serum levels of reproductive hormones during mid- and late pregnancy contribute to the greater prolificacy of Meishan pigs.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2023)
Article
Cell Biology
E. Katsiani, A. Garas, C. Skentou, A. Tsezou, C. I. Messini, K. Dafopoulos, A. Daponte, I. E. Messinis
CELL AND TISSUE BANKING
(2016)
Review
Obstetrics & Gynecology
Christina I. Messini, Alexandros Daponte, George Anifandis, Tahir Mahmood, Ioannis E. Messinis
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2016)
Review
Obstetrics & Gynecology
Ioannis E. Messinis, Christina I. Messini, Alexandros Daponte, Antonios Garas, Tahir Mahmood
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2016)
Review
Genetics & Heredity
George Anifandis, Christina I. Messini, Konstantinos Dafopoulos, Alexandros Daponte, Ioannis E. Messinis
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2016)
Article
Obstetrics & Gynecology
Theofania Bounartzi, Konstantinos Dafopoulos, George Anifandis, Christina I. Messini, Chrysoula Koutsonikou, Spyros Kouris, Maria Satra, Sotirios Sotiriou, Nicholas Vamvakopoulos, Ioannis E. Messinis
Article
Biochemistry & Molecular Biology
George Anifandis, Ourania Markandona, Konstantinos Dafopoulos, Christina Messini, Aspasia Tsezou, Marina Dimitraki, Panagiotis Georgoulias, Alexandros Daponte, Ioannis Messinis
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Anesthesiology
D. Aretha, F. Fligou, P. Kiekkas, C. Messini, E. Panteli, E. Zintzaras, M. Karanikolas
INTERNATIONAL JOURNAL OF OBSTETRIC ANESTHESIA
(2017)
Article
Environmental Sciences
George Anifandis, Katerina Katsanaki, Georgia Lagodonti, Christina Messini, Mara Simopoulou, Konstantinos Dafopoulos, Alexandros Daponte
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2018)
Article
Obstetrics & Gynecology
Christos Dragamestianos, Christina I. Messini, Pantelis T. Antonakis, Konstantina Zacharouli, Evanthia Kostopoulou, Antonis Makrigiannakis, Panagiotis Georgoulias, George Anifandis, Konstantinos Dafopoulos, Antonios Garas, Alexandros Daponte, Ioannis E. Messinis
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
(2019)
Review
Medicine, General & Internal
Konstantinos Zacharis, Christina I. Messini, George Anifandis, George Koukoulis, Maria Satra, Alexandros Daponte
MEDICINA-LITHUANIA
(2018)
Review
Andrology
George Anifandis, Alexandros Michopoulos, Alexandros Daponte, Katerina Chatzimeletiou, Mara Simopoulou, Christina I. Messini, Nikolas P. Polyzos, Katerina Vassiou, Konstantinos Dafopoulos, Dimitrios G. Goulis
SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE
(2019)
Article
Obstetrics & Gynecology
Serafeim Pousias, Christina Messini, George Anifandis, George Sveronis, Panagiotis Georgoulias, Alexandros Daponte, Ioannis E. Messinis, Konstantinos Dafopoulos
REPRODUCTIVE BIOMEDICINE ONLINE
(2019)
Article
Andrology
Christina I. Messini, Anna Vasilaki, Evangelia Korona, George Anifandis, Panagiotis Georgoulias, Konstantinos Dafopoulos, Antonios Garas, Alexandros Daponte, Ioannis E. Messinis
SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE
(2019)
Article
Environmental Sciences
George Anifandis, George Amiridis, Konstantinos Dafopoulos, Alexandros Daponte, Eleni Dovolou, Eleftherios Gavriil, Vyron Gorgogietas, Elli Kachpani, Zissis Mamuris, Christina I. Messini, Katerina Vassiou, Anna-Maria G. Psarra
Article
Endocrinology & Metabolism
Christina I. Messini, Maria Malandri, George Anifandis, Konstantinos Dafopoulos, Panagiotis Georgoulias, Georgios Sveronis, Antonios Garas, Alexandros Daponte, Ioannis E. Messinis
CLINICAL ENDOCRINOLOGY
(2017)
Article
Obstetrics & Gynecology
Alice Newman-Sanders, Jackson C. Kirkman-Brown, Meurig T. Gallagher
Summary: This study revealed a significant lack of awareness among young adults in the UK regarding the potential impacts of gym lifestyles and supplementation on male infertility. Men were found to have a concerning lack of concern for their own fertility, with differences in awareness levels between men and women. It was also observed that men were more likely to consider making changes to their behavior if it had a long-term impact on their fertility compared to short-term effects.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Shachar Reuvenny, Michal Youngster, Almog Luz, Rohi Hourvitz, Ettie Maman, Micha Baum, Ariel Hourvitz
Summary: Using a machine-learning model to determine the optimal trigger days can improve the outcomes of antagonist protocol cycles in freeze-all or fresh transfer cycles, for all age groups. Implementing these models can more accurately predict the number of retrieved oocytes, optimizing physicians' decisions, balancing workloads, and creating more standardized yet patient-specific protocols.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Chao Chen, Qi Wen, Feng Deng, Rong Li, Ying Wang, Xiumei Zhen, Jing Hang
Summary: This study investigates the proteomic and phosphoproteomic differences in the endometrium of women with recurrent pregnancy loss (RPL) compared to healthy control women during different phases of the menstrual cycle. The results identify differentially expressed proteins and phosphorylated proteins, and highlight the insulin/cyclic nucleotide signalling pathway and AMPK/mTOR signalling pathway as major contributors to the abnormality of RPL endometrium. The findings provide insights into potential proteins associated with the pathogenesis of RPL and contribute to the identification of potential targets for RPL treatment.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Jaime Guerrero, Juan Carlos Castillo, Jorge Ten, Jose Antonio Ortiz, Belen Lledo, Domingo Orozco, Francisco Quereda, Andrea Bernabeu, Rafael Bernabeu
Summary: The study found no significant differences in clinical outcomes between using oocytes obtained from random-start protocols and those from conventional ovarian stimulation in oocyte donation treatments. Luteal-phase stimulation required longer stimulation and higher FSH consumption.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)