Article
Obstetrics & Gynecology
A. La Marca, V Donno, M. Longo, P. Greco, F. Cucinelli, M. T. Varricchio, I Listorti, E. Greco
Summary: This study investigates whether anti-Mullerian hormone (AMH) can predict the number of retrieved oocytes during double stimulation (DuoStim). The results show that serum AMH values can be used as a clinical tool to predict ovarian response in IVF cycles following DuoStim. This is beneficial for patients with poor ovarian response and those undergoing medical fertility preservation.
HUMAN REPRODUCTION
(2023)
Article
Endocrinology & Metabolism
Yong Han, Huiyu Xu, Guoshuang Feng, Haiyan Wang, Kannan Alpadi, Lixue Chen, Mengqian Zhang, Rong Li
Summary: This study established a model for predicting ovarian reserve using AMH level and age, and demonstrated its effectiveness in predicting poor ovarian response based on external validation data.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Benjamin S. Harris, Anne Z. Steiner, Anne Marie Jukic
Summary: This study investigated the association between biomarkers of ovarian reserve and menstrual cycle length, indicating that higher AMH levels are associated with longer menstrual cycles, independent of age.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Benjamin S. Harris, Anne Z. Steiner, Anne Marie Jukic
Summary: This study analyzed data from 632 women aged 30-44 without infertility history who were attempting to conceive for less than 3 months, and found that increasing AMH levels were associated with longer menstrual cycle lengths.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, General & Internal
Dodi Suardi, Wiryawan Permadi, Tono Djuwantono, Yudi Mulyana Hidayat, Hartanto Bayuaji, Gusti Putu Edo Gautama
Summary: This study found a significant correlation between serum AMH levels and endometrioma, with levels being lower in the endometrioma group. There was a negative correlation between serum AMH levels and ovarian volume containing endometrioma, although it was not statistically significant.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Antonio La Marca, Martina Capuzzo, Maria Longo, Maria Giovanna Imbrogno, Giorgio Alfredo Spedicato, Francesco Fiorentino, Francesca Spinella, Pierfrancesco Greco, Maria Giulia Minasi, Ermanno Greco
Summary: Ovarian reserve and female age are the most important predictors of having at least one euploid blastocyst and the total number of euploid blastocysts.
HUMAN REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
Hana Visnova, Enrico Papaleo, Fernando Sanchez Martin, Katarzyna Koziol, Bjarke M. Klein, Bernadette Mannaerts
Summary: Individualized follitropin delta dosing provides an improved efficacy-safety balance in women with high ovarian reserve, reducing the risk of ovarian hyperstimulation syndrome (OHSS) without compromising the chance of pregnancy.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Review
Obstetrics & Gynecology
Richard A. Anderson, David Cameron, Florian Clatot, Isabelle Demeestere, Matteo Lambertini, Scott M. Nelson, Fedro Peccatori
Summary: Female patients undergoing anticancer treatment are at risk of adverse ovarian outcomes, and AMH can be used as a biomarker to assess ovarian reserve and POI. Chemotherapy or radiotherapy consistently led to reduced/undetectable AMH levels, but partial recovery was observed during follow-up. Oligo/amenorrhea was associated with post-treatment AMH decline, suggesting impending POI. Long-term follow-up of pediatric patients showed significantly lower AMH levels compared to control groups. AMH can identify the damaging effect of cancer treatments on ovarian function, but further studies are needed to determine its diagnostic and predictive value.
HUMAN REPRODUCTION UPDATE
(2022)
Article
Oncology
Xiangyun Zong, Yang Yu, Wenhu Chen, Weiwei Zong, Hongjian Yang, Xuan Chen
Summary: This study analyzed the changes in anti-Mullerian hormone (AMH) levels and the factors influencing ovarian function in breast cancer patients before and after chemotherapy. The results showed that age, menarche age, baseline AMH level, and GnRHa application are the most important independent factors for the protection and recovery of ovarian reserve in premenopausal women with breast cancer.
Article
Multidisciplinary Sciences
Jessica Ottolina, Michele Vignali, Enrico Papaleo, Paola Vigano, Edgardo Somigliana, Stefano Ferrari, Valeria Liprandi, Gaia Belloni, Marco Reschini, Massimo Candiani, Paolo Vercellini, Laura Benaglia
Summary: The management of endometriosis-related infertility is a challenging issue, with surgery and IVF being the two main treatment options. This study aims to compare the effectiveness and cost-effectiveness of these two approaches, and potentially influence clinical practice and resource allocation.
Review
Endocrinology & Metabolism
Raoul Orvieto
Summary: Ovarian stimulation is crucial for the success of in vitro fertilization-embryo transfer, and the use of GnRH-ag/GnRH-ant can enhance its effectiveness in challenging cases such as poor responders and patients with elevated progesterone levels. It allows better cycle programming and follicular synchronization, resulting in successful outcomes.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Michael Fanton, Veronica Nutting, Arielle Rothman, Paxton Maeder-York, Eduardo Hariton, Oleksii Barash, Louis Weckstein, Denny Sakkas, Alan B. Copperman, Kevin Loewke
Summary: This study retrospectively analyzed 18,591 autologous IVF cycles from three assisted reproductive technology centers in the USA. The findings suggest that using a machine learning model to select the starting dose of follicle-stimulating hormone (FSH) can achieve better laboratory outcomes while reducing the amount of FSH used.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Oncology
Ya Xie, Haoran Duan, Dong Wang, Huiqing Li, Jia Jia, Jialin Zhang, Linlin Li
Summary: GnRH agonist co-therapy is effective in preserving ovarian function during platinum-based chemotherapy in patients with ovarian malignancy, reducing the risk of low AMH levels post-chemotherapy and improving menstrual resumption and quality of life. It provides a therapeutic reference for gynecologists, especially in economically and medically underdeveloped areas.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Casper P. Hagen, Margit Bistrup Fischer, Christine Wohlfahrt-Veje, Maria Assens, Alexander S. Busch, Anette Tonnes Pedersen, Anders Juul, Katharina M. Main
Summary: This study indicates that ovarian activity in healthy girls remains remarkably stable from small growing follicles, suggesting that AMH concentrations in early life can serve as a useful clinical tool to predict future ovarian activity.
Article
Multidisciplinary Sciences
Kun-Jing Hong, Jun-Jie Lin, Liang-Hua Lin, Tsung-Hsuan Lai
Summary: This study investigates the relationship between follicular cytokine concentrations and oocyte maturity in IVF patients with different ovarian reserves. The concentration of leptin in follicular fluid was found to be closely related to oocyte maturity and may serve as a biomarker to predict it. This finding has important implications for the development potential of embryos and pregnancy outcomes in IVF.
SCIENTIFIC REPORTS
(2022)
Letter
Obstetrics & Gynecology
Johnny S. Younis, Ido Izhaki, Scott M. Nelson
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Alastair G. Sutcliffe, Mitana Purkayastha, Daniel R. Brison, Scott M. Nelson, Stephen A. Roberts, Deborah A. Lawlor
Summary: This study examined the effects of assisted reproductive technology on hospital admissions in children. It found that children born after assisted reproductive technology had a higher risk of hospitalization compared to naturally conceived children, but no significant difference was observed when compared to their naturally conceived siblings.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Editorial Material
Anesthesiology
R. J. Kearns, M. Shaw, S. M. Nelson
Article
Obstetrics & Gynecology
Ernesto Bosch, Elena Labarta, Jose Zuzuarregui, Stamatina Iliodromiti, Scott M. Nelson
Summary: The capability of serum AMH measured with the Elecsys AMH immunoassay to determine ovarian response after fertility treatment was evaluated in a retrospective cohort study. AMH concentration showed a strong positive correlation with oocyte yield, and the accuracy of predicting ovarian response using AMH was high. A single determination of serum AMH before stimulation can be used to predict ovarian response and oocyte yield with high accuracy.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Medicine, General & Internal
Abiodun Adanikin, Deborah A. Lawlor, Jill P. Pell, Scott M. Nelson, Gordon C. S. Smith, Stamatina Iliodromiti
Summary: This population-based cohort study investigated the association between birthweight centiles and early childhood developmental concerns among infants born from 37 weeks of gestation. The study found that birthweight below the 25th centile was associated with higher risks of developmental concerns, and this association was apparent at higher centiles above the conventional threshold defining small for gestational age. Mild to moderate small for gestational age may be an important contributor to the prevalence of developmental concerns.
Article
Medicine, General & Internal
Yi-Xin Wang, Jennifer J. Stuart, Janet W. Rich-Edwards, Stacey A. Missmer, Kathryn M. Rexrode, Leslie Farland, Kenneth J. Mukamal, Scott M. Nelson, Caren G. Solomon, Abigail Fraser, Jorge E. Chavarro
Summary: In this cohort study, both irregular and long menstrual cycles were associated with increased rates of CVD, which persisted even after accounting for subsequently established CVD risk factors.
Article
Cardiac & Cardiovascular Systems
Ahmed Elhakeem, Amy E. Taylor, Hazel M. Inskip, Jonathan Y. Huang, Toby Mansell, Carina Rodrigues, Federica Asta, Sophia M. Blaauwendraad, Siri E. Haberg, Jane Halliday, Margreet W. Harskamp-van Ginkel, Jian-Rong He, Vincent W. V. Jaddoe, Sharon Lewis, Gillian M. Maher, Yannis Manios, Fergus P. McCarthy, Irwin K. M. Reiss, Franca Rusconi, Theodosia Salika, Muriel Tafflet, Xiu Qiu, Bjorn O. Asvold, David Burgner, Jerry K. Y. Chan, Luigi Gagliardi, Romy Gaillard, Barbara Heude, Maria C. Magnus, George Moschonis, Deirdre Murray, Scott M. Nelson, Daniela Porta, Richard Saffery, Henrique Barros, Johan G. Eriksson, Tanja G. M. Vrijkotte, Deborah A. Lawlor
Summary: This study aimed to examine the associations of assisted reproductive technology (ART) conception with offspring cardiometabolic health outcomes and whether these associations differ with age. The researchers found small and statistically non-significant differences in offspring cardiometabolic outcomes between ART-conceived and naturally conceived offspring. The study concluded that these findings should reassure individuals receiving ART, but longer-term follow-up is needed to investigate changes in the risks of hypertension, dyslipidaemia, and cardiovascular disease over adulthood.
EUROPEAN HEART JOURNAL
(2023)
Review
Obstetrics & Gynecology
Scott M. Nelson, Susan R. Davis, Sophia Kalantaridou, Mary Ann Lumsden, Nick Panay, Richard A. Anderson
Summary: This systematic review aimed to determine the usefulness of serum anti-Mullerian hormone (AMH) in diagnosing menopause, predicting menopause, or predicting/diagnosing premature ovarian insufficiency (POI). The review found that lower age-specific AMH concentrations were associated with earlier menopause, but AMH alone could not accurately predict the age at menopause. However, undetectable or extremely low AMH levels may assist in the early diagnosis of POI in young women.
HUMAN REPRODUCTION UPDATE
(2023)
Article
Obstetrics & Gynecology
Scott M. Nelson, Benjamin J. Ewing, Piotr S. Gromski, Sharon F. Briggs
Summary: This study aimed to compare the effects of different contraceptive methods on the levels of anti-Müllerian hormone (AMH) in reproductive-age women. The study found that different contraceptive methods have varying effects on AMH, with the greatest impact occurring at lower percentiles. However, these differences in contraceptive methods are small compared to the biological variability in ovarian reserve.
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
Rafael Venson, Abha Maheshwari, Scott M. M. Nelson, Kathleen A. A. Boyd
Summary: The aim of this study was to calculate the average cost of IVF and ICSI cycles for NHS-funded treatment in Scotland. The study found that there is no standardised NHS tariff for these treatments in Scotland, and there is variation amongst different centres providing NHS services. The average cost of fresh IVF and ICSI cycles was found to be 3247 pounds and 3473 pounds, respectively, while frozen cycles averaged 938 pounds.
Article
Medicine, General & Internal
Moritz Oberndorfer, Paul M. Henery, Ruth Dundas, Alastair H. Leyland, Shantini Paranjothy, Sarah Jane Stock, Rachael Wood, Scott M. Nelson, Rachel Kearns, Anna Pearce
Summary: This study aims to analyze the impact of the COVID-19 pandemic on pregnancy and birth outcomes in Scotland. The data from before and during the pandemic will be compared to examine changes in maternal behavior, pregnancy and birth outcomes, and service use. The study also aims to assess the inequalities in the effects of mitigation measures on outcomes, considering various factors such as ethnicity, area deprivation, and social position.
Editorial Material
Medicine, General & Internal
Rachel J. Kearns, Scott M. Nelson
Review
Endocrinology & Metabolism
Stefano Palomba, Flavia Costanzi, Scott M. Nelson, Donatella Caserta, Peter Humaidan
Summary: This study reviewed and analyzed different interventions for preventing and reducing OHSS in IVF patients. The most effective interventions were found to be GnRH-ant co-treatment and GnRH agonist triggering, with moderate evidence. Mild ovarian stimulation and dopaminergic agonists were also effective and safe interventions.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Piotr S. Gromski, Rajendra Sadashiv Patil, Shruti Mahesh Chougule, Deepali Atul Bhomkar, Padma Rekha Jirge, Scott M. Nelson
Summary: The study found that healthy Indian women have significantly lower levels of anti-Mullerian hormone (AMH) compared to European women, and this difference increases with age. Furthermore, different causes of infertility have varying effects on AMH levels in infertile Indian women compared to healthy controls.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Osamu Ishihara, Scott M. Nelson, Joan-Carles Arce
Summary: Individualized follitropin delta dosing provides similar serum FSH concentrations and similar oocyte yield in Japanese and White IVF/ICSI patients, but the oestradiol response is higher in Japanese women.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Alice Newman-Sanders, Jackson C. Kirkman-Brown, Meurig T. Gallagher
Summary: This study revealed a significant lack of awareness among young adults in the UK regarding the potential impacts of gym lifestyles and supplementation on male infertility. Men were found to have a concerning lack of concern for their own fertility, with differences in awareness levels between men and women. It was also observed that men were more likely to consider making changes to their behavior if it had a long-term impact on their fertility compared to short-term effects.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Shachar Reuvenny, Michal Youngster, Almog Luz, Rohi Hourvitz, Ettie Maman, Micha Baum, Ariel Hourvitz
Summary: Using a machine-learning model to determine the optimal trigger days can improve the outcomes of antagonist protocol cycles in freeze-all or fresh transfer cycles, for all age groups. Implementing these models can more accurately predict the number of retrieved oocytes, optimizing physicians' decisions, balancing workloads, and creating more standardized yet patient-specific protocols.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Chao Chen, Qi Wen, Feng Deng, Rong Li, Ying Wang, Xiumei Zhen, Jing Hang
Summary: This study investigates the proteomic and phosphoproteomic differences in the endometrium of women with recurrent pregnancy loss (RPL) compared to healthy control women during different phases of the menstrual cycle. The results identify differentially expressed proteins and phosphorylated proteins, and highlight the insulin/cyclic nucleotide signalling pathway and AMPK/mTOR signalling pathway as major contributors to the abnormality of RPL endometrium. The findings provide insights into potential proteins associated with the pathogenesis of RPL and contribute to the identification of potential targets for RPL treatment.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Jaime Guerrero, Juan Carlos Castillo, Jorge Ten, Jose Antonio Ortiz, Belen Lledo, Domingo Orozco, Francisco Quereda, Andrea Bernabeu, Rafael Bernabeu
Summary: The study found no significant differences in clinical outcomes between using oocytes obtained from random-start protocols and those from conventional ovarian stimulation in oocyte donation treatments. Luteal-phase stimulation required longer stimulation and higher FSH consumption.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
