Review
Obstetrics & Gynecology
Evangelia T. Katsika, Julia K. Bosdou, Dimitrios G. Goulis, Grigoris F. Grimbizis, Efstratios M. Kolibianakis
Summary: This study found that testosterone pretreatment with transdermal gel in poor responders undergoing ovarian stimulation for IVF was associated with increased clinical pregnancy and live birth rates. Additionally, there was an increase in the number of cumulus-oocyte complexes retrieved and improvements in ovarian stimulation parameters and endometrial thickness. However, no significant differences were observed in other key outcomes.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Endocrinology & Metabolism
Fangyuan Li, Ruihui Lu, Cheng Zeng, Xin Li, Qing Xue
Summary: This study developed a predictive model to estimate the individual probability of clinical pregnancy failure for poor ovarian responders (PORs) undergoing IVF/ICSI. The model was constructed based on characteristics associated with pregnancy failure, and showed satisfactory performance in both the training and validation groups.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Jessica Subira, Anna Algaba, Sheila Vazquez, Roser Taroncher Dasi, Guillermo Molla Robles, Susana Monzo Fabuel, Virginia Baydal, Amparo Ruiz Herreros, Nuria Garcia Camunas, Jose Maria Rubio Rubio
Summary: The study indicated that the use of testosterone before IVF did not increase the number of mature oocytes retrieved in poor ovarian response patients.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Medicine, General & Internal
Jingzhe Li, Shiqing Lyu, Shijian Lyu, Minzhi Gao
Summary: The study compared pregnancy outcomes of double stimulation (DouStim) and two consecutive mild stimulations in poor ovarian responders, finding no significant difference in pregnancy outcomes between the two protocols. However, the DouStim group had fewer frozen embryos, especially in elderly patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Xitong Liu, Wen Wen, Tao Wang, Li Tian, Na Li, Ting Sun, Ting Wang, Hanying Zhou, Na Zhang, Pengfei Qu, Ben W. Mol, Wentao Li, Juanzi Shi
Summary: In women with predicted poor response, increased FSH dosing did not improve live birth rates compared to standard dosing. A standard dose of 150 IU/day is recommended at the start of IVF in these women to reduce potential adverse effects and costs.
HUMAN REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
Hakan Cakmak
Summary: Declining oocyte quality and quantity with age are the main factors affecting female reproductive success. Factors such as the female partner's age, ovarian reserve, previous fertility treatment outcomes, and pregnancy success data are used to predict live birth rates in IVF treatment. The chance of success after the age of 45 is extremely low, making IVF cycles with autologous oocytes discouraged. The number of mature eggs retrieved and available embryos for transfer are important predictors of pregnancy and live birth. Patients aged <= 45 should consider their age and expected ovarian response when deciding to attempt IVF. Patients with a poor prognosis should be fully informed about the prognosis, risks, costs, and alternatives before starting an IVF cycle.
FERTILITY AND STERILITY
(2022)
Article
Obstetrics & Gynecology
N. Massin, I Abdennebi, G. Porcu-Buisson, N. Chevalier, E. Descat, C. Pietin-Vialle, S. Goro, M. Brussieux, M. Pinto, M. Pasquier, H. Bry-Gauillard
Summary: This study compares the effectiveness of two treatment protocols in assisting conception for patients with poor ovarian response, and the results show that there is no significant difference in the number of oocytes retrieved between the dual ovarian stimulation in the same cycle and two consecutive antagonist cycles.
HUMAN REPRODUCTION
(2023)
Article
Multidisciplinary Sciences
Konstantinos Sfakianoudis, Petroula Tsioulou, Evangelos Maziotis, Sokratis Grigoriadis, Argyro Glava, Nikolaos Nitsos, Polina Giannelou, Evangelos Makrakis, Agni Pantou, Anna Rapani, Michael Koutsilieris, George Mastorakos, Konstantinos Pantos, Mara Simopoulou
Summary: This study investigated follicular fluid from patients with poor and normal ovarian response during natural assisted reproductive technology cycles. Results showed similarities between the two groups in terms of inflammatory, apoptotic, and growth factors, with normal responders having higher levels of G-CSF.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Obstetrics & Gynecology
R. Moffat, C. Hansali, A. Schoetzau, A. Ahler, U. Gobrecht, S. Beutler, A. Raggi, G. Sartorius, C. De Geyter
Summary: The study showed that the number of retrieved oocytes was similar regardless of the starting dose of GN or the addition of CC during the early follicular phase. Lower starting doses of GN combined with CC resulted in a higher number of blastocysts, but the impact on live birth rate still needs further investigation in randomized trials.
HUMAN REPRODUCTION
(2021)
Article
Endocrinology & Metabolism
Charlotte Mauries, Noemie Ranisavljevic, Caroline Mollevi, Cecile Brunet, Samir Hamamah, Sophie Brouillet, Tal Anahory
Summary: This study compares the number of oocytes obtained using the SAS stimulation protocol with the previous protocol in poor responder patients. The results show that the SAS protocol can yield a higher number of oocytes and usable embryos, suggesting its potential clinical efficacy for poor responders.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Mara Simopoulou, Dionysios Galatis, Evangelos Maziotis, Agni Pantou, Polina Giannelou, Sokratis Grigoriadis, Panagiotis Tzonis, Theodora Griva, Athanasios Zikopoulos, Anastasios Philippou, Michael Koutsilieris, Konstantinos Pantos, Konstantinos Sfakianoudis
Summary: The aim of this study is to develop a prediction model for successful application of Oocyte Retrieval during the Luteal Phase (LuPOR) in poor responders. The model uses predictive factors to define the population benefiting from LuPOR. The results show that the combined characteristics in the prediction model have a high accuracy.
SCIENTIFIC REPORTS
(2022)
Review
Obstetrics & Gynecology
Angelo Tocci, David Barad, Krzysztof Lukaszuk, Raoul Orvieto, Int Do No Harm Grp IVF IDNHG IVF
Summary: Double ovarian stimulation (DuoStim) is progressively used as a routine clinical IVF treatment, but there is a lack of rationale, evidence, and follow-up for this expansion. The authors suggest that DuoStim should only be used in controlled clinical trials with valid clinical indications and appropriate experimental consents.
HUMAN REPRODUCTION
(2023)
Article
Medicine, General & Internal
Qiao-Song Han, Yue Zhou, Jing-Yan Song, Wen Chen, Zhen-Gao Sun
Summary: This study aims to evaluate the efficacy and safety of the traditional Chinese medicine formula Erzhi Tiangui (EZTG) as a complementary treatment for advanced-age women with poor ovarian response undergoing in vitro fertilization and embryo transfer. The study will be conducted at 10 tertiary hospitals and will enroll 480 women who fulfill the 2011 Bologna criteria. The results of this study will provide robust evidence of the efficacy and safety of EZTG formula.
Article
Endocrinology & Metabolism
Jinliang Zhu, Ying Wang, Lixue Chen, Ping Liu, Rong Li, Jie Qiao
Summary: The study revealed that growth hormone adjuvant therapy could increase the quantity and quality of oocytes, improving the live birth rate in expected poor responders.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Begum Mathyk, Adina Schwartz, Alan DeCherney, Baris Ata
Summary: A receptive endometrium is crucial for successful embryo implantation, and ultrasonography-measured endometrial thickness is commonly used as an indicator of endometrial receptivity in assisted reproductive technology cycles. Factors like age, oestradiol concentration, and oocyte number affect both endometrial thickness and probability of live birth. Most studies on the relationship between endometrial thickness and embryo transfer outcomes lack proper addressing of confounding factors and have limitations. Despite numerous meta-analyses and large-scale studies, controversy still exists. This article provides a critical review of studies on endometrial thickness and embryo transfer outcomes, highlighting methodological issues and suggesting improvements for future research. Currently available evidence does not support modifying management solely based on arbitrary thresholds of endometrial thickness.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Obstetrics & Gynecology
Alice Newman-Sanders, Jackson C. Kirkman-Brown, Meurig T. Gallagher
Summary: This study revealed a significant lack of awareness among young adults in the UK regarding the potential impacts of gym lifestyles and supplementation on male infertility. Men were found to have a concerning lack of concern for their own fertility, with differences in awareness levels between men and women. It was also observed that men were more likely to consider making changes to their behavior if it had a long-term impact on their fertility compared to short-term effects.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Shachar Reuvenny, Michal Youngster, Almog Luz, Rohi Hourvitz, Ettie Maman, Micha Baum, Ariel Hourvitz
Summary: Using a machine-learning model to determine the optimal trigger days can improve the outcomes of antagonist protocol cycles in freeze-all or fresh transfer cycles, for all age groups. Implementing these models can more accurately predict the number of retrieved oocytes, optimizing physicians' decisions, balancing workloads, and creating more standardized yet patient-specific protocols.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Chao Chen, Qi Wen, Feng Deng, Rong Li, Ying Wang, Xiumei Zhen, Jing Hang
Summary: This study investigates the proteomic and phosphoproteomic differences in the endometrium of women with recurrent pregnancy loss (RPL) compared to healthy control women during different phases of the menstrual cycle. The results identify differentially expressed proteins and phosphorylated proteins, and highlight the insulin/cyclic nucleotide signalling pathway and AMPK/mTOR signalling pathway as major contributors to the abnormality of RPL endometrium. The findings provide insights into potential proteins associated with the pathogenesis of RPL and contribute to the identification of potential targets for RPL treatment.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Jaime Guerrero, Juan Carlos Castillo, Jorge Ten, Jose Antonio Ortiz, Belen Lledo, Domingo Orozco, Francisco Quereda, Andrea Bernabeu, Rafael Bernabeu
Summary: The study found no significant differences in clinical outcomes between using oocytes obtained from random-start protocols and those from conventional ovarian stimulation in oocyte donation treatments. Luteal-phase stimulation required longer stimulation and higher FSH consumption.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)