Review
Biochemistry & Molecular Biology
Qingling Yang, Sezcan Mumusoglu, Yingying Qin, Yingpu Sun, Aaron J. Hsueh
Summary: Ovarian infertility and subfertility are major challenges in developed countries due to the trend of delayed childbirth. Through genetic studies, genes related to premature ovarian insufficiency and ovarian senescence have been identified, especially those crucial for DNA repair, meiosis, and mitochondrial functions.
Review
Cell Biology
Seung Joo Chon, Zobia Umair, Mee-Sup Yoon
Summary: Premature ovarian insufficiency (POI) is a condition characterized by the loss of normal ovarian function before the age of 40, affecting a small percentage of women under 40. The condition is biochemically defined by amenorrhea, low estrogen levels, and high gonadotropin levels, potentially leading to infertility. POI has a heterogeneous etiology, including both genetic and non-genetic factors, and current research focuses on genetic basis, non-coding RNA, and animal models to uncover pathogenesis and potential treatment targets. Despite recent advances, understanding gene regulatory networks and exploring therapies remain critical for future research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Xue Jiao, Tingting Meng, Yiwei Zhai, Lijuan Zhao, Wei Luo, Peihao Liu, Yingying Qin
Summary: Ovarian reserve indicators deteriorate with the progression of ovarian insufficiency, with an increase in FSH and LH but a decrease in AMH, inhibin B, AFC, E-2 and T. AMH has the highest predictive value for POI, and the combination of AMH and AFC is promising for early prediction. Significant differences exist in hormone status among women with different etiologies of POI, with genetic POI showing the worst hormone status.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Linlin Liu, Huasong Wang, Guo Liang Xu, Lin Liu
Summary: Tet enzymes, specifically Tet1, are crucial for DNA demethylation and have a significant impact on stem cell differentiation and pluripotency. The deficiency of Tet1 can lead to accelerated reproductive failure due to decreased follicle reserve and other molecular changes in oocytes, indicating a potential link to premature ovarian failure.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
Yuxuan Sun, Ming Li, Zhongkai Cui, Mengqian Zhang, Tingting Zhang, Lu Li, Na Wang, Xiwen Xu, Min Wei, Wenteng Xu
Summary: By analyzing the transcriptomic profiles of pseudomale and male sperm, key genes involved in pseudomale sperm abnormalities were identified, and the FoxO signaling pathway was found to play an important role in spermatogenesis.
Article
Biotechnology & Applied Microbiology
Xinning Li, Xuelan Li, Ling Deng
Summary: Chrysin regulates hormone expression and weight, inhibits inflammation and oxidative stress, improves ovarian function in animals with POF, and inhibits apoptosis of ovarian granulosa cells. Furthermore, Chrysin targets ER beta and activates its expression. This suggests that Chrysin has potential for the treatment of POF.
Article
Endocrinology & Metabolism
Jingyi Wen, Yanzhi Feng, Wei Yan, Suzhen Yuan, Jinjin Zhang, Aiyue Luo, Shixuan Wang
Summary: This study reveals the characteristics of vaginal microbiota in POI patients and their relationship with reduced ovarian reserve, endocrine disruption, and symptoms of perimenopausal syndrome. Differences in vaginal microbiota between POI and POF patients are also identified.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Jiying Chen, Qinger Zhou, Yonggang Zhang, Wenqing Tan, Hanchao Gao, Liying Zhou, Shuixiu Xiao, Jinhua Gao, Jing Li, Zhiying Zhu
Summary: Using serum-based metabolomics, we identified differentially expressed metabolites (DEMs) in patients with PCOS and POF, as well as in healthy individuals. These DEMs showed significant dysregulation in intergroup comparisons and some DEMs exhibited potential clinical significance in patients with PCOS and POF.
Article
Pharmacology & Pharmacy
Mengwen Zhang, Xiaowei Yu, Danjie Li, Ning Ma, Zhentong Wei, Xinxin Ci, Songling Zhang
Summary: This study investigated the protective function of Daphnetin against ovarian aging induced by D-galactose in mice and found that Daphnetin can protect against premature ovarian failure by increasing Nrf2 expression and inhibiting NLRP3 activation.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Endocrinology & Metabolism
Maki Fukami
Summary: Ovarian dysfunction is a common feature in women with Turner syndrome, in which oocyte apoptosis is accelerated and leads to streak gonads formation. The accelerated germ cell loss in 45,X ovaries may be caused by chromosomal pairing failure, impaired coupling between oocytes and granulosa cells, and reduced dosage of certain genes on the X chromosome. Further research on the mechanisms of ovarian dysfunction is necessary to improve reproductive outcomes in women with Turner syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Cell Biology
Narjes Nouri, Olduz Shareghi-Oskoue, Leili Aghebati-Maleki, Shahla Danaii, Javad Ahmadian Heris, Mohammad Sadegh Soltani-Zangbar, Amin Kamrani, Mehdi Yousefi
Summary: Premature ovarian failure is a complex problem with diverse causes and clinical manifestations. Lack of ovarian sex hormones is believed to be a major factor in its occurrence. Despite limited scientific research progress, clinical medicine has made significant strides in optimizing the quality of life and long-term health of women with premature ovarian insufficiency through timely intervention. Recent investigations have focused on the regulating effects of small RNA molecules on various ovarian processes. This literature review discusses the mechanisms of miRNAs in regulating gene expression in the ovary after transcription.
CELL COMMUNICATION AND SIGNALING
(2022)
Review
Cell & Tissue Engineering
Yun-Xing Fu, Jing Ji, Fang Shan, Jialing Li, Rong Hu
Summary: Premature ovarian failure (POF) is a common disorder in women leading to female infertility. This study investigates the types of MSCs available for POF therapy, their biological characteristics, and mechanisms of action, providing a theoretical basis for further research and clinical treatment of POF.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Plant Sciences
Xia Liu, Yufan Song, Fanru Zhou, Chu Zhang, Fan Li, Runan Hu, Wenwen Ma, Kunkun Song, Zhouping Tang, Mingmin Zhang
Summary: Si-Wu-Tang (SWT) has been widely used in traditional medicine for supplementing blood and regulating menstruation. This study aimed to investigate the potential effects and underlying mechanisms of SWT on premature ovarian failure (POF) in mice. The results showed that SWT improved ovarian function in POF mice, possibly through inhibiting the PI3K/Akt signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Endocrinology & Metabolism
Congcong Guo, Yubo Ma, Yanqiu Situ, Li Liu, Guoqun Luo, Huan Li, Wenmin Ma, Li Sun, Wen Wang, Qiuying Weng, Linlin Wu, Dazhi Fan
Summary: This study conducted a systematic review and meta-analysis and found that the transplantation of mesenchymal stem cells (MSCs) may have therapeutic effects on animal models of premature ovarian failure (POF), potentially by improving sexual cycle disorder, modulating serum hormone expressions, and restoring ovarian function.
FRONTIERS IN ENDOCRINOLOGY
(2023)
News Item
Multidisciplinary Sciences
Freda Kreier
Summary: A survey of almost 13,000 individuals from Iceland has identified, for the first time, a genetic variant that influences the tonal quality of a person's voice.
Article
Obstetrics & Gynecology
Alice Newman-Sanders, Jackson C. Kirkman-Brown, Meurig T. Gallagher
Summary: This study revealed a significant lack of awareness among young adults in the UK regarding the potential impacts of gym lifestyles and supplementation on male infertility. Men were found to have a concerning lack of concern for their own fertility, with differences in awareness levels between men and women. It was also observed that men were more likely to consider making changes to their behavior if it had a long-term impact on their fertility compared to short-term effects.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Shachar Reuvenny, Michal Youngster, Almog Luz, Rohi Hourvitz, Ettie Maman, Micha Baum, Ariel Hourvitz
Summary: Using a machine-learning model to determine the optimal trigger days can improve the outcomes of antagonist protocol cycles in freeze-all or fresh transfer cycles, for all age groups. Implementing these models can more accurately predict the number of retrieved oocytes, optimizing physicians' decisions, balancing workloads, and creating more standardized yet patient-specific protocols.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Chao Chen, Qi Wen, Feng Deng, Rong Li, Ying Wang, Xiumei Zhen, Jing Hang
Summary: This study investigates the proteomic and phosphoproteomic differences in the endometrium of women with recurrent pregnancy loss (RPL) compared to healthy control women during different phases of the menstrual cycle. The results identify differentially expressed proteins and phosphorylated proteins, and highlight the insulin/cyclic nucleotide signalling pathway and AMPK/mTOR signalling pathway as major contributors to the abnormality of RPL endometrium. The findings provide insights into potential proteins associated with the pathogenesis of RPL and contribute to the identification of potential targets for RPL treatment.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Jaime Guerrero, Juan Carlos Castillo, Jorge Ten, Jose Antonio Ortiz, Belen Lledo, Domingo Orozco, Francisco Quereda, Andrea Bernabeu, Rafael Bernabeu
Summary: The study found no significant differences in clinical outcomes between using oocytes obtained from random-start protocols and those from conventional ovarian stimulation in oocyte donation treatments. Luteal-phase stimulation required longer stimulation and higher FSH consumption.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)