Article
Andrology
Marwa Boussada, Imen Hammami, Ridha Ben Ali, Awatef Ben Ammar, Marco Alves, Pedro Fontes Oliveira, Azaiez Ben Akacha, Ines Limam Abdelkarim, Sami Zekri, Michele Veronique El May
Summary: This study aimed to investigate the in vivo effects of doxorubicin (DOX) on the germinal epithelium and the potential benefits of co-administration with a new analog of thioamide called thiocyanoacetamide (TA). The results showed that DOX treatment led to testicular injuries and decreased germ cell count, while co-administration with TA increased germ cell count, reduced apoptotic cells, and restored normal testicular structure. This study provides important insights into the toxic effects of DOX and the development of alternative therapeutic schemes for male patients undergoing chemotherapy.
Article
Obstetrics & Gynecology
Rashid A. Aldahhan, Peter G. Stanton, Helen Ludlow, David M. de Kretser, Mark P. Hedger
Summary: Experimental cryptorchidism in adult rats leads to complete spermatogenic failure, chronic testicular inflammation, edema, and fibrosis, impacting Sertoli and Leydig cell function at the molecular level.
REPRODUCTIVE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Huimin Sun, Bo Lv, Haiqin Zhu, Zhi Zeng, Saeed El-Ashram, Jinjin Li, Yinying Chao, Juan Wang, Zhi Wang
Summary: SeGlu, a novel organic selenium compound, can significantly improve sperm quality and reduce harmful bacterial colonization in rats. It may be used as an effective dietary supplement.
Article
Agriculture, Dairy & Animal Science
Yi Zheng, Qiang Gao, Tianjiao Li, Ruifang Liu, Zechao Cheng, Ming Guo, Jinhong Xiao, De Wu, Wenxian Zeng
Summary: The study systematically investigated the development patterns of Sertoli cells and spermatogonia in pigs from neonate to sexual maturity, shedding light on previously unknown details. The findings not only expand knowledge about spermatogenesis and testicular development in pigs, but also provide a theoretical basis for porcine breeding and rearing.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Review
Endocrinology & Metabolism
Angela K. Lucas-Herald, Rod T. Mitchell
Summary: Sertoli cells play an important role in gonadal development, germ cell survival, and spermatogenesis. The levels of AMH and inhibin B in individuals with DSD are regulated and can impact their gonadal function throughout life.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Wasim Shah, Ranjha Khan, Basit Shah, Asad Khan, Sobia Dil, Wei Liu, Jie Wen, Xiaohua Jiang
Summary: The process of spermatogenesis relies on hormones and growth factors acting through endocrine and paracrine pathways. Sertoli cells are major regulators, while sex hormones play a significant role in determining their proliferation.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Joao C. Ribeiro, Ana D. Martins, Ivana Jarak, Rui A. Carvalho, Marco G. Alves, Pedro F. Oliveira
Summary: The combination therapy of dapagliflozin and exenatide shows promising effects in improving the treatment of type 2 diabetes mellitus, protecting male fertility, inducing weight loss, and improving glucose homeostasis.
Article
Developmental Biology
Yi Jacky Peng, Xinyu Thomas Tang, Hui Sophie Shu, Wenjie Dong, Hongfang Shao, Bo O. Zhou
Summary: The study found that testicular stromal cells, including Sertoli, endothelial, Leydig, smooth muscle, and Tcf21-CreER+ stromal cells, express stem cell factor (SCF), an essential growth factor for spermatogenesis. Undifferentiated and differentiating spermatogonia were associated with SCF-expressing Sertoli cells. Conditional deletion of SCF from Sertoli cells blocked the differentiation of spermatogonia, leading to male infertility. Conditional overexpression of SCF in Sertoli cells significantly increased spermatogenesis.
Review
Endocrinology & Metabolism
Maia Corpuz-Hilsabeck, Martine Culty
Summary: Sertoli cells play crucial roles in male reproduction, and dysregulation of their functions can have lifelong adverse effects on testis development and spermatogenesis. Understanding the impact of endocrine disrupting chemicals and drugs on Sertoli cells is important for comprehending the adverse outcomes on the reproductive system that these compounds may induce.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Junjie Xu, Mengmeng Sang, Jinmei Cheng, Chunhai Luo, Jie Shi, Fei Sun
Summary: In this study, the role of DAAM2 in cytoskeleton and phagocytosis of rat Sertoli cells was investigated through siRNA transfection and intratesticular injection. Knockdown of DAAM2 attenuated marker expression related to cytoskeleton and tight junction, as well as the integrity of Sertoli cell monolayer. Loss of DAAM2 in rats resulted in disarrangement and deformation of sperms, accumulation of apoptotic sperms, and abnormalities in the blood-testis barrier, indicating its involvement in spermatogenesis.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Cell Biology
Kehan Wang, Feifei Kong, Yuexin Qiu, Tao Chen, Jiayi Fu, Xin Jin, Youqiang Su, Yayun Gu, Zhibin Hu, Jing Li
Summary: Sertoli cells provide a nurturing environment for germ cell development and maturation, and the role of phosphatidylinositol 3-kinase (PtdIns3K) in Sertoli cells is unclear. Deleting the Pik3c3 gene specifically in Sertoli cells resulted in infertility, disrupted Sertoli cell polarity, and impaired spermiogenesis. Accumulation of SCIN caused the disorganization of the F-actin cytoskeleton, while accumulated HDAC6 deacetylated SCIN, leading to a disorganized F-actin cytoskeleton.
Article
Cell Biology
Nikol Dibus, Eliska Zobalova, Mario A. M. Monleon, Vladimir Korinek, Dominik Filipp, Jana Petrusova, Radislav Sedlacek, Petr Kasparek, Lukas Cermak
Summary: The ubiquitin ligase SCFFBXO38 regulates centromeric chromatin by promoting the degradation of the ZXDB protein. Loss of FBXO38 leads to growth retardation, pathological changes in the testes, decreased sperm production, and reduced fertility in mice. FBXO38 is specifically expressed in Sertoli cells in the testes, and its absence results in Sertoli cell maturation defect and impaired spermatogonial differentiation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Endocrinology & Metabolism
Victor A. Ruthig, Dolores J. Lamb
Summary: Since their discovery, Sertoli cells have fascinated researchers in the field of testis biology. They play a crucial role in regulating germ cell state through endocrine and paracrine signals. Recent advances in understanding these signals have potential implications for treating male infertility, while Sertoli cell transplantation has emerged as a promising breakthrough.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Anatomy & Morphology
Brendan J. Houston, Liina Nagirnaja, D. Jo Merriner, Anne E. O'Connor, Hidenobu Okuda, Kenan Omurtag, Craig Smith, Kenneth I. Aston, Donald F. Conrad, Moira K. O'Bryan
Summary: This study reveals that Scrn1 is dispensable for male fertility, but identifies SCRN1 as a novel marker of the Sertoli cell cytoplasm.
DEVELOPMENTAL DYNAMICS
(2021)
Article
Endocrinology & Metabolism
Elizabeth Tang, C. Yan Cheng
Summary: Microtubule affinity-regulating kinases (MARKs) play an important role in the Sertoli cell blood-testis barrier, regulating cell polarity, microtubule dynamics, and tight junction permeability. MARK2 and MARK4 have different effects on the blood-testis barrier and MT cytoskeleton, with MARK4 being more severe.
Article
Andrology
R. E. L. Cabral, T. B. Mendes, V. Vendramini, S. M. Miraglia
Article
Andrology
L. N. G. Adami, L. B. Belardin, B. T. Lima, J. T. Jeremias, M. P. Antoniassi, F. K. Okada, R. P. Bertolla
Article
Endocrinology & Metabolism
Flavia Luciana Beltrame, Fabiane de Santi, Vanessa Vendramini, Regina Elizabeth Lourenco Cabral, Sandra Maria Miraglia, Paulo Sergio Cerri, Estela Sasso-Cerri
FRONTIERS IN ENDOCRINOLOGY
(2019)
Article
Cell Biology
Andre da Costa Vaz, Camila Cicconi Paccola, Talita Biude Mendes, Regina Elizabeth Lourenco Cabral, Joana Nogueres Simas, Vanessa Vendramini, Sandra Maria Miraglia
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2020)
Article
Cell Biology
Fatima Kazue Okada, Taiza Stumpp, Sandra Maria Miraglia
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2020)
Article
Andrology
Samara Urban de Oliva, Rafael de Mendonca Engelbrecht, Sandra Maria Miraglia
Article
Andrology
Joana N. Simas, Talita B. Mendes, Leonardo W. Fischer, Vanessa Vendramini, Sandra M. Miraglia
Summary: The study found that resveratrol (RES) can effectively alleviate male reproductive damage caused by type 1 diabetes, improve sperm DNA integrity and reproductive outcomes. RES acts as an adjuvant against hyperglycemia by controlling oxidative stress, thus ameliorating the severe impact of diabetes on male reproductive system.
Article
Andrology
Samara U. Oliva, Rhaiza R. Andretta, Joana N. Simas, Renato B. Tesser, Camila C. Paccola, Sandra M. Miraglia
Summary: In rat offspring from dams treated with CBZ during pregnancy/lactation, there was a delay in Sertoli cell differentiation and abnormal thyroid hormone levels. This indicates a potential dysregulation of thyroid hormone homeostasis and altered testis development in the progenies.
Article
Urology & Nephrology
Jessica Timoteo Jeremias, Larissa Berloffa Belardin, Fatima Kazue Okada, Mariana P. Antoniassi, Renato Fraietta, Ricardo Pimenta Bertolla, Paula Intasqui
Summary: This study found that patients with varicocele have significantly increased levels of sperm DNA fragmentation, particularly in oxidative stress-induced sperm DNA damage.
INTERNATIONAL BRAZ J UROL
(2021)
Article
Pharmacology & Pharmacy
C. C. Paccola, G. S. Souza, I. M. M. Freitas, J. C. Souza, L. L. Martins, V. Vendramini, S. M. Miraglia
Summary: Nicotine exposure during pregnancy and breastfeeding can potentially harm female gametes, affecting reproductive capacity. However, it does not significantly impact the number of oocytes and fertility in adult rats. Nevertheless, morphological alterations in oocytes, mitochondrial changes, embryonic fragmentation, and disruption of fetal development can still occur as a result of nicotine exposure.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Andrology
Talita Biude Mendes, Joana Nogueres Simas, Leonardo Wensing Fischer, Camila Cicconi Paccola, Samara Urban de Oliva, Vanessa Vendramini, Sandra Maria Miraglia
Summary: The study showed that resveratrol has beneficial effects on reproductive damage caused by experimental varicocele, improving oxidative stress, sperm vitality, DNA integrity, and enhancing gestational index and embryonic quality.
Article
Andrology
Camila Monteiro Francisco, Leonardo Wensing Fischer, Vanessa Vendramini, Samara Urban de Oliva, Camila Cicconi Paccola, Sandra Maria Miraglia
Summary: Resveratrol was found to reverse the reproductive damage caused by nicotine in male offspring. Nicotine can cross the blood-placental membrane and is present in the breast milk of smoking mothers. Resveratrol improved the reproductive parameters of adult male offspring exposed to nicotine, possibly through epigenetic modulation.
Article
Andrology
Leonardo Wensing Fischer, Talita Biude Mendes, Joana Nogueres Simas, Marina Nunes, Samara Urban de Oliva, Sandra Maria Miraglia
Summary: This study evaluated the sperm parameters of adult rats exposed to chronic mild stress (CMS) from peripuberty to adulthood, treated or not with escitalopram. The results showed that exposure to stress and/or treatment with escitalopram reduced sperm quality and may compromise male fertility.
Article
Reproductive Biology
Fatima Kazue Okada, Rhayza Roberta Andretta, Deborah Montagnini Spaine
REPRODUCTION AND FERTILITY
(2020)