Article
Quantum Science & Technology
Mischa P. Woods, Ralph Silva, Gilles Putz, Sandra Stupar, Renato Renner
Summary: This article explores the information theory of clocks and constraints on the precision of clocks imposed by information. Using information-theoretic considerations, the authors analyze the relationship between the accuracy of a clock and its size, finding that a quantum clock can achieve higher accuracy compared to a purely classical clock of the same size.
Article
Oncology
Yanlin Gao, Qi Zhao, Haoqing Li, Jingmin Li, Peiyu Li
Summary: The efficacy of peripheral iridectomy was found to be better than that of compound trabeculectomy for glaucoma. Monitoring the levels of Hcy and hs-CRP in patients before and after surgery can effectively assess clinical outcomes and the safety of the procedure.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Jocelyn M. Wessels, Miguel A. Dominguez, Nicholas A. Leyland, Sanjay K. Agarwal, Warren G. Foster
Summary: Endometriosis is a chronic gynecological condition affecting approximately 10% of reproductive age women, with potential causes related to retrograde menstruation and bacteria present in the uterus. The study found that the endometrial microbiota of people with endometriosis was more diverse, while those with pelvic pain but surgically confirmed absence of endometriosis and diagnosed with other benign gynecological conditions had less diverse endometrial microbiota.
SCIENTIFIC REPORTS
(2021)
Article
Computer Science, Interdisciplinary Applications
Arnald Puy, Samuele Lo Piano, Andrea Saltelli
Summary: VARS is a new comprehensive framework proposed for sensitivity analysis, offering a more intuitive notion of sensitivity. However, it lacks a clear definition of what an "important" factor is compared to classic methods. While enriching the existing methods, VARS is more suitable as a complement rather than a replacement for variance-based sensitivity analysis methods.
ENVIRONMENTAL MODELLING & SOFTWARE
(2021)
Article
Multidisciplinary Sciences
Ryan Babbush, William J. Huggins, Dominic W. Berry, Shu Fay Ung, Andrew Zhao, David R. Reichman, Hartmut Neven, Andrew D. Baczewski, Joonho Lee
Summary: Quantum algorithms for simulating electronic ground states offer higher accuracy but are slower than classical mean-field algorithms. However, certain first-quantized quantum algorithms enable exact time evolution of electronic systems with significantly less space and operations compared to conventional real-time Hartree-Fock and density functional theory. The authors also introduce a more efficient quantum algorithm for mean-field state preparation. Quantum speedup is most pronounced for finite-temperature simulations.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Sarah A. Neely, Jill M. Williamson, Anna Klingseisen, Lida Zoupi, Jason J. Early, Anna Williams, David A. Lyons
Summary: Through research on zebrafish, it was found that surviving oligodendrocytes are less efficient in generating new myelin sheaths and frequently misdirect the myelin to neuronal cell bodies, which is similar to the pathology seen in multiple sclerosis (MS). Conversely, oligodendrocytes generated after demyelination produce abundant and correctly targeted myelin sheaths, suggesting that they may also have a better regenerative potential in MS.
NATURE NEUROSCIENCE
(2022)
Review
Medicine, Research & Experimental
Christophe Bounaix Morand du Puch, Mathieu Vanderstraete, Stephanie Giraud, Christophe Lautrette, Niki Christou, Muriel Mathonnet
Summary: Cancer is a complex and heterogeneous disease, leading to the development of personalized medicine concepts and various diagnostic tools to adapt treatments to individual patients. Functional assays represent valuable in vitro diagnostic tools that play a major role in cancer treatment alongside molecular diagnostics. Further advancements are needed to fully integrate functional assays into routine clinical practice.
Article
Chemistry, Analytical
Birui Jin, Zhiguo Du, Jingcheng Ji, Yuemeng Bai, Deding Tang, Lihua Qiao, Jiatao Lou, Jie Hu, Zedong Li
Summary: Upconversion nanoparticles (UCNPs)-based fluorescence probes have great potential in point-of-care testing (POCT) due to their high photostability and background-free fluorescence. This paper optimized UCNPs-probes by regulating probe density and demonstrated their effectiveness in detecting C-reactive protein (CRP) using a traditional lateral flow assay (LFA) platform. The optimized UCNPs-LFA, combined with a home-made benchtop fluorescence analyzer, achieved high-performance POCT with significantly enhanced sensitivity and a broad detection range for CRP.
Article
Biology
R. P. Guralnick, L. P. Campbell, M. W. Belitz
Summary: Butterfly phenology is more affected by extreme weather events than by annual mean temperatures. Previous phenology studies have focused on climatic averages and heat accumulation, neglecting climate variability. This study used long-term data from natural history collections to estimate Lepidoptera phenology in the Eastern USA over a 70-year period. Unusually warm and cold days were found to have strong effects on flight duration, with increasing numbers of such days leading to longer flights. These findings highlight the importance of considering unusual weather events in understanding phenological responses to global change.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biology
Amy Streets, Hayley England, Justin Marshall
Summary: Stomatopod crustaceans, or mantis shrimps, have a wide range of spectral sensitivity but poor spectral discrimination. They may utilize a different method of color processing, interpreting color as a parallel pattern of photoreceptor activation.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
Review
Orthopedics
B. R. da Costa, P. Saadat, R. M. Basciani, A. Agarwal, B. C. Johnston, P. Juni
Summary: Study findings suggest that the Visual Analogue Scale (VAS) for global osteoarthritis pain has slightly higher assay sensitivity compared to the Western Ontario and McMaster University (WOMAC) pain subscale, without a significant increase in between-trial heterogeneity.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Computer Science, Interdisciplinary Applications
Saima Rathore, Muhammad A. Iftikhar, Ahmad Chaddad, Ashish Singh, Zeeshan Gillani, Ahmed Abdulkadir
Summary: This study evaluated the OS prediction accuracy of combinations of prognostic markers in glioma patients by quantifying features in multi-contrast MRI and digital pathology images, along with IDH mutation status and basic demographic variables. The results showed that adding MRI or pathology features improved the prediction of OS compared to models based on age, sex, and mutation status alone. The full multi-omics model, which integrated MRI, pathology, clinical, and genetic profiles, exhibited the best prediction of OS.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Biodiversity Conservation
S. Nolan, A. A. Frazao, J. D. Hosen, C. M. Febria
Summary: In the era of the Anthropocene, streams and rivers are heavily impacted by catchment land use, affecting stream water quality and ecological condition. However, biomonitoring programs underuse structural and functional indicators, limiting their ability to provide practical insight into functional-based restoration approaches.
ECOLOGICAL INDICATORS
(2023)
Article
Engineering, Electrical & Electronic
Sang-Mi Jeong, Minkyun Son, Youngsoo Kang, Jonguk Yang, Taekyung Lim, Sanghyun Ju
Summary: The proposed method uses highly stretchable and conductive fiber-based multi-angle fiber array to precisely measure human joint motion in real time. By embedding conductive carbon nanotubes (CNTs) within spandex fibers, joint motion can be monitored stably without degrading conductivity even during repeated stretching and contraction. The technology is high-precision and applicable for use in wearable healthcare devices that require precise measurements.
NPJ FLEXIBLE ELECTRONICS
(2021)
Article
Environmental Sciences
Shuzhen Li, Jialiang Zhou, Qiang Liu, Liqiao Liang, Tao Sun, Xiaofeng Xu, Miao Li, Xuan Wang, Xiaomin Yuan
Summary: This article uses meta-analysis to synthesize data from Chinese coastal salt marshes and analyze the sensitivity of CO2 emissions to climate changes. The study finds that warming has a greater impact on CO2 emissions compared to changes in precipitation. The results also show that changes in precipitation can either suppress or enhance CO2 emissions from coastal wetlands.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Charlotte Van den Eynde, Katrien De Clercq, Rieta Van Bree, Katrien Luyten, Daniela Annibali, Frederic Amant, Sileny Han, Els Van Nieuwenhuysen, Thais Baert, Karen Peeraer, Thomas Voets, Toon Van Gorp, Joris Vriens
Summary: The study revealed a strong association between TRP channel mRNA expression and cellular phenotypes in the endometrium. Specifically, TRPV2 and TRPC1 mRNA expression correlated with the mesenchymal phenotype, while TRPM4 mRNA expression was associated with the epithelial phenotype. These findings suggest that TRP channels could serve as biomarkers for high-risk endometrial cancer and potential targets for treatment.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Editorial Material
Obstetrics & Gynecology
C. Tomassetti, T. Beukeleirs, A. Conforti, S. Debrock, K. Peeraer, C. Meuleman, T. D'Hooghe
OBSTETRICAL & GYNECOLOGICAL SURVEY
(2022)
Article
Obstetrics & Gynecology
Brecht Geysenbergh, Anne-Sophie Boes, Celine Bafort, Anne-Sophie van Rompuy, Sara Neyens, Sharon Lie Fong, Sophie Debrock, Joris Vriens, Peter De Loecker, Eline Dancet, Thomas D'Hooghe, Karen Peeraer
Summary: This study aimed to investigate the prevalence of chronic endometritis (CE) in infertile women, its impact on reproductive outcomes, and the accuracy of hysteroscopy as a screening tool for CE. The study included 514 asymptomatic patients with infertility who underwent hysteroscopy and endometrial biopsy (EMB). CE was identified in 2.8% of patients starting assisted reproductive technologies (ART). The clinical pregnancy rate (CPR) did not differ significantly between patients with CE and the entire cohort of patients without CE, but was significantly lower in the 2 years after EMB in patients with CE compared to matched controls. Hysteroscopy had low sensitivity and high specificity in diagnosing CE.
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
(2023)
Article
Obstetrics & Gynecology
Olga Tsuiko, Yasmine El Ayeb, Tatjana Jatsenko, Joke Allemeersch, Cindy Melotte, Jia Ding, Sophie Debrock, Karen Peeraer, Arne Vanhie, Anne De Leener, Celine Pirard, Candice Kluyskens, Ellen Denayer, Eric Legius, Joris Robert Vermeesch, Hilde Brems, Eftychia Dimitriadou
Summary: Long-read amplicon sequencing is a simple and cost-effective strategy for preclinical preimplantation genetic testing in couples with a de novo pathogenic variant. This approach allows for the identification of the parental origin of the mutant allele and provides access to universal genome-wide haplotyping-based PGT programs. The success rate of this method is 75%.
HUMAN REPRODUCTION
(2023)
Review
Obstetrics & Gynecology
L. Dias, S. G. Willems, J. Luyten, P. De Loecker, T. M. D'Hooghe, K. Peeraer, E. A. . F. Dancet
Summary: Infertility can have a negative impact on the life goal of parenthood and the quality of life of individuals, and the process of fertility clinics can be burdensome. This review and pilot study aimed to explore the effects of the pre-IVF fertility clinic trajectory on patient-reported outcomes measures (PROMs) for emotional well-being and quality of life. Findings showed that the diagnostic workup reduced infertility-specific distress in men, but there were conflicting results regarding its effects on the anxious and depressive reactions of (wo)men. Intrauterine insemination (IUI) was found to increase depressive reactions in (wo)men. However, more research is needed on infertility-specific, health-related, and overall quality of life. The pilot study also indicated that the overall quality of life of (wo)men was not affected by the diagnostic workup but decreased by the time of the third IUI. Longitudinal studies on the impact of starting the fertility clinic trajectory on PROMs are crucial for patient-centered clinical and policy decision-making.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Eva Van Steijvoort, Hilde Peeters, Hilde Vandecruys, Jasper Verguts, Karen Peeraer, Gert Matthijs, Pascal Borry
Summary: The aim of this study was to assess the satisfaction, anxiety, knowledge retention, psychosocial and counseling-related aspects among couples who chose reproductive genetic carrier screening (RGCS). The findings showed that all participants felt they had enough information to make an informed choice and none of them regretted their decision to have RGCS. The study demonstrated that the information/counseling and reporting strategy used in this context led to high participant satisfaction, increased knowledge, and positive psychosocial and counseling-related outcomes.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Obstetrics & Gynecology
Matthias Boogaerts, Annemie Mengels, Sharon Lie Fong, Karen Peeraer, Carla Tomasseti, Arne Vanhie
Summary: This study aimed to assess the impact of the indication for oocyte reception (OR) or embryo reception (ER) on reproductive and obstetric outcomes. The results showed that the indication for OR/ER seems to have little impact on the outcomes, except for patients with premature ovarian insufficiency (POI) due to Turner syndrome or treatment with chemotherapy/radiotherapy.
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
(2023)
Article
Genetics & Heredity
Nilufer Rahmioglu, Sally Mortlock, Marzieh Ghiasi, Peter L. Moller, Lilja Stefansdottir, Genevieve Galarneau, Constance Turman, Rebecca Danning, Matthew H. Law, Yadav Sapkota, Paraskevi Christofidou, Sini Skarp, Ayush Giri, Karina Banasik, Michal Krassowski, Maarja Lepamets, Blazej Marciniak, Margit Noukas, Danielle Perro, Eeva Sliz, Marta Sobalska-Kwapis, Gudmar Thorleifsson, Nura F. Topbas-Selcuki, Allison Vitonis, David Westergaard, Ragnheidur Arnadottir, Kristoffer S. Burgdorf, Archie Campbell, Cecilia S. K. Cheuk, Caterina Clementi, James Cook, Immaculata De Vivo, Amy DiVasta, O. Dorien, Jacqueline F. Donoghue, Todd Edwards, Pierre Fontanillas, Jenny N. Fung, Reynir T. Geirsson, Jane E. Girling, Paivi Harkki, Holly R. Harris, Martin Healey, Oskari Heikinheimo, Sarah Holdsworth-Carson, Isabel C. Hostettler, Henry Houlden, Sahar Houshdaran, Juan C. Irwin, Marjo-Riitta Jarvelin, Yoichiro Kamatani, Stephen H. Kennedy, Ewa Kepka, Johannes Kettunen, Michiaki Kubo, Bartosz Kulig, Venla Kurra, Hannele Laivuori, Marc R. Laufer, Cecilia M. Lindgren, Stuart MacGregor, Massimo Mangino, Nicholas G. Martin, Charoula Matalliotaki, Michail Matalliotakis, Alison D. Murray, Anne Ndungu, Camran Nezhat, Catherine M. Olsen, Jessica Opoku-Anane, Sandosh Padmanabhan, Manish Paranjpe, Maire Peters, Grzegorz Polak, David J. Porteous, Joseph Rabban, Kathyrn M. Rexrode, Hanna Romanowicz, Merli Saare, Liisu Saavalainen, Andrew J. Schork, Sushmita Sen, Amy L. Shafrir, Anna Siewierska-Gorska, Marcin Slomka, Blair H. Smith, Beata Smolarz, Tomasz Szaflik, Krzysztof Szyllo, Atsushi Takahashi, Kathryn L. Terry, Carla Tomassetti, Susan A. Treloar, Arne Vanhie, Katy Vincent, Kim C. Vo, David J. Werring, Eleftheria Zeggini, Maria Zervou, Kari Stefansson, Mette Nyegaard, Outi Uimari, Piraye Yurttas-Beim, Joyce Y. Tung, Sosuke Adachi, Julie E. Buring, Paul M. Ridker, Thomas D'Hooghe, George N. Goulielmos, Dharani K. Hapangama, Caroline Hayward, Andrew W. Horne, Siew-Kee Low, Hannu Martikainen, Daniel Chasman, Peter A. W. Rogers, Philippa T. Saunders, Marina Sirota, Tim Spector, Dominik Strapagiel, David C. Whiteman, Linda C. Giudice, Digna R. Velez-Edwards, Peter Kraft, Andres Salumets, Dale R. Nyholt, Reedik Magi, Christian M. Becker, Valgerdur Steinthorsdottir, Stacey A. Missmer, Grant W. Montgomery, Andrew P. Morris, Krina T. Zondervan
Summary: Endometriosis is a common condition associated with pelvic pain and infertility. A genome-wide association study identified 42 significant loci and found genetic correlations between endometriosis and other pain conditions. Targeted investigations are needed to understand the shared genetic mechanisms and develop new treatments.
Article
Endocrinology & Metabolism
Aurelie Hennes, Johanna Devroe, Katrien De Clercq, Martina Ciprietti, Katharina Held, Katrien Luyten, Nele Van Ranst, Nina Maenhoudt, Karen Peeraer, Hugo Vankelecom, Thomas Voets, Joris Vriens
Summary: Early embryo implantation involves a complex process of communication between the blastocyst and the endometrium. Proteases secreted by the blastocyst stimulate calcium signaling pathways in endometrial epithelial cells. This study identified protease-activated receptor 2 (PAR2) as the molecular initiator of calcium responses in endometrial epithelial cells and revealed the downstream signaling pathways involved.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
A. Mengels, A. Van Muylder, K. Peeraer, J. Luyten, A. Laenen, C. Spiessens, S. Debrock
Summary: This study compared the cumulative pregnancy rates of supernumerary embryos vitrified on Day 3 and Day 5/6. The results showed no significant difference between the two groups. It is known that extended embryo culture and blastocyst transfer on Day 5/6 yield higher pregnancy and live birth rates in IVF or ICSI treatment. However, this study focused on vitrification for cryopreservation of supernumerary embryos, rather than the traditional slow freezing protocol.
HUMAN REPRODUCTION
(2023)
Meeting Abstract
Obstetrics & Gynecology
O. Tsuiko, C. Melotte, K. Peeraer, A. Vanhie, E. Denayer, J. Vermeesch, E. Dimitriadou, S. Debrock
HUMAN REPRODUCTION
(2023)
Meeting Abstract
Obstetrics & Gynecology
L. Dias, P. De Loecker, I. Custers, K. Peeraer, E. Dancet
HUMAN REPRODUCTION
(2023)
Meeting Abstract
Obstetrics & Gynecology
Eleonora Persoons, Marie Mulier, Catherine Luyten, Carla Tomassetti, Thomas Voets, Joris Vriens
REPRODUCTIVE SCIENCES
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Eva Van Steijvoort, Hilde Peeters, Hilde Vandecruys, Jasper Verguts, Karen Peeraer, Gert Matthijs, Pascal Borry
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Eftychia Dimitriadou, Yassmine Ayeb, Tatjana Jatsenko, Cindy Melotte, Olga Tsuiko, Hilde Brems, Joke Allemeersch, Silke Hollants, Silke Hollants, Sophie Debrock, Karen Peeraer, Ellen Denayer, Eric Legius, Joris Robert Vermeesch
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)