Article
Reproductive Biology
Ilaria Colombo, Beatrice Mislei, Gaetano Mari, Eleonora Iacono, Barbara Merlo
Summary: This study aimed to test the effect of platelet lysate (PL) on the inflammatory uterine response in mares susceptible to persistent mating-induced endometritis (PMIE). The results showed that PL treatment could reduce the inflammatory response in mares susceptible to PMIE, relieving uterine edema and migration of inflammatory cells.
Article
Reproductive Biology
Eriky Akio de Oliveira Tongu, Lorenzo G. T. M. Segabinazzi, Marina Landim Alvarenga, Aldine Monteiro, Frederico Ozanam Papa, Marco Antonio Alvarenga
Summary: The study evaluated the effects of mesenchymal stem cell-conditioned medium (MSC-CM) on sperm parameters, intrauterine inflammation, intrauterine fluid accumulation, and fertility in mares. MSC-CM did not affect sperm parameters when mixed with diluted semen, and reduced post-insemination inflammatory responses in mares with different susceptibilities to endometritis. Fertility rates did not differ significantly among groups.
Article
Chemistry, Medicinal
Sofia Martins Sousa, Cristina Pinto Ribeiro Xavier, Maria Helena Vasconcelos, Andreia Palmeira
Summary: Drug repurposing is a time-saving and cost-effective strategy that develops new treatments using approved or investigational drugs. Non-steroidal anti-inflammatory drugs (NSAIDs) have been identified as potential anticancer agents due to their anti-inflammatory properties. Several commercial NSAIDs, including aspirin and ibuprofen, have shown antitumor activity and are being evaluated in clinical trials for cancer treatment. However, the benefits and complications of using NSAIDs for cancer therapy need to be carefully evaluated, especially for patients with limited treatment options.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2023)
Article
Immunology
Lu Cao, Rui Qin, Junbao Liu
Summary: This study investigated the protective effects of FXR on LPS-induced endometritis and the underlying mechanisms. The results showed that FXR agonists alleviated endometritis, while FXR knockout mice had more severe inflammatory responses. Ferroptosis was increased during endometritis, and its inhibition alleviated the condition. Activation of FXR by OCA decreased ferroptosis and inhibited endometritis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Green & Sustainable Science & Technology
Thiago Lopes da Silva, Camila Stefanne Dias Costa, Meuris Gurgel Carlos da Silva, Melissa Gurgel Adeodato Vieira
Summary: This article provides detailed information about the properties of anti-inflammatory drugs found in water and effluents, the latest results on the concentration of these compounds in different aquatic environments, the main characteristics of AOP, and the recent achievements in oxidation processes aimed at degrading NSAIDs.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Biochemistry & Molecular Biology
Yuki Kikuchi, Eriko Sugano, Shiori Yuki, Kitako Tabata, Yuka Endo, Yuya Takita, Reina Onoguchi, Taku Ozaki, Tomokazu Fukuda, Yoshihiro Takai, Takahiro Kurose, Koichi Tanaka, Yoichi Honma, Eduardo Perez, Maxwell Stock, Jose R. Fernandez, Masanori Tamura, Michael Voronkov, Jeffry B. Stock, Hiroshi Tomita
Summary: SIG-1451 partially protects against light-induced photoreceptor degeneration by inhibiting inflammatory responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Hongchu Bao, Qinglan Qu, Wei Zhang, Xinrong Wang, Jianye Fang, Jinwen Xue, Zhenteng Liu, Shunzhi He
Summary: The study found that proinflammatory cytokines induced by LPS through the TLR4/NF-kappa B pathway promote the expression of NRF2 and its translocation into the nucleus. Additionally, NRF2 inhibits the expression of proinflammatory cytokines by directly binding to p65.
MEDIATORS OF INFLAMMATION
(2021)
Review
Genetics & Heredity
Hoang Kim Tu Trinh, Le Duy Pham, Kieu Minh Le, Hae-Sim Park
Summary: Non-steroidal anti-inflammatory drugs (NSAIDs) are the main cause of drug hypersensitivity reactions worldwide, with diverse clinical phenotypes that can be classified into cross-reactive or selective responses. Genetic and epigenetic backgrounds play important roles in NSAID-induced hypersensitivity reactions.
FRONTIERS IN GENETICS
(2021)
Article
Chemistry, Physical
Abdessamad Y. A. Kaassis, Wafa T. Al-Jamal, Margarita Strimaite, Maja Severic, Gareth R. Williams
Summary: Two novel biocompatible hydroxy double salts (HDS), MgZn-Cl and FeZn-Cl, were found to successfully intercalate diclofenac, ibuprofen, and valproate. Drug release studies showed that the solubility of the drug ions controls the fate of the HDS in an acidic environment, with valproate intercalates dissolving completely at pH 1.0 within two hours. The HDS were also found to be biocompatible and stable upon storage for 5 years in vitro.
APPLIED CLAY SCIENCE
(2022)
Article
Immunology
Margo L. Macpherson, Steeve Giguere, Malgorzata A. Pozor, Chelsie A. Burden, Londa J. Berghaus, Roy D. Berghaus, Jennifer C. Varner, Justin T. Hayna, Susanne M. Benson, Sarah A. Randell, Sara K. Lyle, Audrey A. Kelleman, Kelsey A. Hart, Martha F. Mallicote, David W. Horohov
Summary: The study suggests that administration of firocoxib has a suppressive effect on cytokine and prostaglandin production in mares with placentitis.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Tina Helmecke, Dominik Hahn, Nadine Matzke, Lisa Ferdinand, Lars Franke, Sebastian Kuehn, Gunter Fischer, Carsten Werner, Manfred F. Maitz
Summary: This paper introduces a new polymer hydrogel platform that releases anti-inflammatory molecules in response to the inflammatory activation of human blood. The hydrogel is conjugated with anti-inflammatory peptide drugs through a peptide sequence cleaved by elastase released from activated granulocytes. The adaptive drug delivery triggered by activated granulocytes and the effect of the released drug on the respective inflammatory pathways are demonstrated.
Article
Crystallography
Francisco Javier Acebedo-Martinez, Carolina Alarcon-Payer, Lucia Rodriguez-Domingo, Alicia Dominguez-Martin, Jaime Gomez-Morales, Duane Choquesillo-Lazarte
Summary: The design of drug-drug multicomponent pharmaceutical solids is a novel drug development approach in the pharmaceutical industry, aiming to improve the bioavailability of oral administration drugs. The new formulation showed improved solubility for NSAIDs but not for furosemide. Further studies are needed to evaluate the drug-drug interaction in the novel multicomponent solids for potential therapeutic alternatives.
Article
Biochemistry & Molecular Biology
Takeshi Tenno, Kohki Kataoka, Natsuko Goda, Hidekazu Hiroaki
Summary: The article discusses the potential application of select non-steroidal anti-inflammatory drugs as tight junction modulators by regulating the PDZ domain of zonula occludens-1. This can lead to decreased epithelial barrier function and improved paracellular absorption of drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Kevin Le Duc, Sixtine Gilliot, Jean Benoit Baudelet, Sebastien Mur, Mohamed Riadh Boukhris, Olivia Domanski, Pascal Odou, Laurent Storme
Summary: This case highlights the potential fetal and neonatal complications associated with maternal use of topical Diclofenac medication during pregnancy, resulting in antenatal closure of the ductus arteriosus.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Maria Jose Martinez Monteros, Carolina Maldonado Galdeano, Maria Florencia Balcells, Ricardo Weill, Juan Andres De Paula, Gabriela Perdigon, Silvia Ines Cazorla
Summary: Probiotic supplementation can reduce symptoms of NSAID-induced inflammation in the small intestine, increase antimicrobial activity in the intestines, and promote changes in the gut microbiota to maintain intestinal homeostasis.
SCIENTIFIC REPORTS
(2021)
Article
Agriculture, Dairy & Animal Science
Dominik Lechner, Jorg Aurich, Sabine Schafer-Somi, Christine Aurich
Summary: In a retrospective analysis of 508 ejaculates from 297 dogs, the efficiency of semen cryopreservation and the effects of age, season, and dog size on the characteristics of fresh and cryopreserved semen were evaluated. The study found that sperm cryotolerance is consistent for much of a dog's lifespan but decreases after a certain age. Dog semen can be cryopreserved successfully throughout the year and is not affected by dog body weight.
ANIMAL REPRODUCTION SCIENCE
(2022)
Letter
Agriculture, Dairy & Animal Science
Christine Aurich, Robert Cushman, Marc Yeste
ANIMAL REPRODUCTION SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Camille Gautier, Christine Aurich
Summary: The lipid composition of the sperm plasma membrane plays a crucial role in sperm function, with changes in cholesterol and PUFA levels affecting sperm motility and fertilization ability. Adding PUFA and antioxidants can improve the integrity of the sperm membrane.
ANIMAL REPRODUCTION SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
C. Nagel, C. Aurich
Summary: Induction of foaling in mares can lead to the birth of dysmature foals due to the variability in physiological equine gestation length. The effectiveness of treatments such as glucocorticoids and progestogens in preparing mares for foaling varies, with some methods advancing and others delaying the onset of labor. Despite different treatments available, foal health remains somewhat unpredictable, requiring further research to improve induction methods.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
A. Lutzer, C. Nagel, B. A. Murphy, J. Aurich, M. Wulf, C. Gautier, Christine Aurich
Summary: The study found that blue LED light directed at one eye of pregnant mares shortened gestation, influenced foal height and hair coat, but had no significant effect on weight.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
M. Kaps, Anne Lutzer, C. Gautier, C. Nagel, J. Aurich, C. Aurich
Summary: The study investigates the effect of altrenogest on the stress response of female horses during initial equestrian training. The results show that altrenogest reduced the stress response of the mares to equestrian training and also affected their body weight and body condition scores.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2022)
Meeting Abstract
Agriculture, Dairy & Animal Science
Veronica Vigolo, Camille Gautier, Christine Aurich, Maria Elena Falomo
ANIMAL REPRODUCTION SCIENCE
(2022)
Meeting Abstract
Agriculture, Dairy & Animal Science
Camille Gautier, Martim Kaps, Joerg Aurich, Christine Aurich
ANIMAL REPRODUCTION SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Veronica Vigolo, Camille Gautier, Maria Elena Falomo, Christine Aurich
Summary: The use of microfluidic technology is increasing in artificial reproduction technologies. ZyMot Multi is a popular device for sperm selection in vitro fertilization and intracytoplasmic sperm injection. This study aims to test the efficacy of the ZyMot Multi for stallion semen. Results suggest that the ZyMot Multi device selects a specific sperm population from any stallion ejaculate with motile sperm and could be a valid tool to predict the fertility of frozen-thawed stallion semen.
REPRODUCTION IN DOMESTIC ANIMALS
(2023)
Article
Reproductive Biology
Camille Gautier, Jorg Aurich, Martim Kaps, Carolina T. C. Okada, Lisa-Helene Wagner, Maria Melchert, Christine Aurich
Summary: This study investigates the effects of GnRH agonist treatment on the resumption of testicular function after GnRH vaccination in stallions. It found that the downregulation of testicular function by GnRH vaccination can be counteracted with buserelin, a GnRH agonist.
Review
Agriculture, Dairy & Animal Science
O. Bogado Pascottini, C. Aurich, G. England, A. Grahofer
Summary: Endometritis is a common cause of sub- and infertility in domestic animals. It is triggered by a shift in the microbiota of the uterus and associated immune dysfunction. Both postpartum and postmating endometritis can have detrimental effects on fertility.
REPRODUCTION IN DOMESTIC ANIMALS
(2023)
Article
Agriculture, Dairy & Animal Science
Amr El-Shalofy, Camille Gautier, Younis Khan, Jorg Aurich, Christine Aurich
Summary: This study aimed to investigate the effects of storing horse semen either in a dry shipper (< -150 C) or on dry ice (< -78 C) for up to 14 days. The results showed that changes in semen occurred on dry ice after seven days, while no changes were observed in semen stored in a dry shipper. However, after 14 days, both shipping devices had adverse effects on sperm DNA integrity and high mitochondrial membrane potential.
ANIMAL REPRODUCTION SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Lisa-Helene Wagner, Joerg Aurich, Maria Melchert, Carolina T. C. Okada, Camille Gautier, Martim Kaps, Svenja Claassen, Christine Aurich
Summary: Low progesterone concentration in the early luteal phase delays conceptus growth and increases the risk of pregnancy loss.
ANIMAL REPRODUCTION SCIENCE
(2023)
Article
Reproductive Biology
Dominik Lechner, Jorg Aurich, Joachim Spergser, Christine Aurich
Summary: This study aimed to investigate bacterial contamination of canine semen and the effect of dual semen collection on contamination. The results showed limited microbial contamination in dog semen, and the second collection had less bacterial contamination compared to the first. Therefore, the use of antibiotics in canine semen should be questioned.
Article
Reproductive Biology
Svenja Claassen, Joerg Aurich, Ingrid Walter, Camille Gautier, Christine Aurich
Summary: This study analyzed the relationship between anti-Mullerian hormone (AMH) concentration in blood and ovarian tissue in female cats. The results showed that AMH protein was expressed in all endocrine structures of the cat ovary, but its usefulness for assessing individual cat ovarian function is limited.