Thrombin stimulates insulin secretion via protease-activated receptor-3

Zucker Diabetic Fatty rats exhibit hypercoagulability and accelerated thrombus formation in the Arterio-Venous shunt model of thrombosis

(2014) Jin Shang et al.   THROMBOSIS RESEARCH

Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3

(2013) L. Burnier et al.   BLOOD

An atlas and functional analysis of G-protein coupled receptors in human islets of Langerhans

(2013) Stefan Amisten et al.   PHARMACOLOGY & THERAPEUTICS

Diabetes Mellitus and the β Cell: The Last Ten Years

(2012) Frances M. Ashcroft et al.   CELL

Secreted Frizzled-Related Protein 4 Reduces Insulin Secretion and Is Overexpressed in Type 2 Diabetes

(2012) Taman Mahdi et al.   Cell Metabolism

IUPHAR-DB: updated database content and new features

(2012) J. L. Sharman et al.   NUCLEIC ACIDS RESEARCH

Exploiting Protein-Protein Interaction Networks for Genome-Wide Disease-Gene Prioritization

(2012) Emre Guney et al.   PLoS One

Incretin-based therapies for type 2 diabetes mellitus: a review of direct comparisons of efficacy, safety and patient satisfaction

(2012) Sheldon Russell   International Journal of Clinical Pharmacy

Mitochondrial signals drive insulin secretion in the pancreatic β-cell

(2011) Andreas Wiederkehr et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Activation of Protease-Activated Receptors 3 and 4 Accelerates Tissue Factor–Induced Thrombin Generation on the Surface of Vascular Smooth Muscle Cells

(2010) Param Vidwan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Evidence that low-grade systemic inflammation can induce islet dysfunction as measured by impaired calcium handling

(2010) Stacey B. Dula et al.   CELL CALCIUM

From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus

(2009) R. A. DeFronzo   DIABETES

Reverse Engineering Molecular Regulatory Networks from Microarray Data with qp-Graphs

(2009) Robert Castelo et al.   JOURNAL OF COMPUTATIONAL BIOLOGY

A network view of disease and compound screening

(2009) Eric E. Schadt et al.   NATURE REVIEWS DRUG DISCOVERY

Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes

(2009) Bo Ahrén   NATURE REVIEWS DRUG DISCOVERY