期刊
INTERFACE FOCUS
卷 5, 期 4, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rsfs.2015.0035
关键词
bioinspiration; cell compartmentalization; synthetic biology; protein engineering; antibodies; microfluidics; emulsion droplets
类别
资金
- Biological and Biotechnological Research Council (BBSRC)
- Engineering and Physical Sciences Research Council (EPSRC)
- Human Frontier Science Programme
- EU ITN PhosChemRec
- Biotechnology and Biological Sciences Research Council [1102796] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/H046593/1] Funding Source: researchfish
- EPSRC [EP/H046593/1] Funding Source: UKRI
The idea of compartmentalization of genotype and phenotype in cells is key for enabling Darwinian evolution. This contribution describes bioinspired systems that use in vitro compartments-water-in-oil droplets and gel-shell beads-for the directed evolution of functional proteins. Technologies based on these principles promise to provide easier access to protein-based therapeutics, reagents for processes involving enzyme catalysis, parts for synthetic biology and materials with biological components.
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