Article
Computer Science, Interdisciplinary Applications
Shuai Li, A-Man Zhang, Rui Han
Summary: The study establishes an accurate and inexpensive three-dimensional boundary integral (BI) model for the dynamics of cavitation bubbles in binary immiscible fluid systems. The model is found to be comparable in accuracy to a 3D axisymmetric model and shows good agreement with experimental results. The study also investigates the interactions between two bubbles in different phases, revealing the effects on bubble morphologies, flow patterns, and jet velocities, as well as the differences in fluid mixing mechanisms between multiple bubbles and a single bubble.
JOURNAL OF COMPUTATIONAL PHYSICS
(2023)
Review
Pharmacology & Pharmacy
Jide He, Zenan Liu, Xuehua Zhu, Haizhui Xia, Huile Gao, Jian Lu
Summary: This article reviews the research progress of ultrasound-mediated microbubble cavitation in the treatment of solid tumors, emphasizing its potential to reverse chemoresistance, improve efficacy sensitization response, and reduce adverse side effects.
Article
Engineering, Mechanical
Jianhua Du, Fengjun Chen
Summary: The study reveals that the dynamics and pressure pulsation associated with cavitation erosion are closely related. A numerical model successfully predicts cavity evolution, volume, and pressure pulsation, demonstrating its reliability. The erosion pattern formed by cavitation is attributed to the distribution of pressure.
INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES
(2021)
Article
Materials Science, Multidisciplinary
Jamileh Shojaeiarani, Thomas G. Landry, Jeremy A. Brown, John P. Frampton
Summary: This study demonstrates the formation of microchannels in agarose hydrogels using cavitation-mediated etching. By utilizing an ultrasonic cavitation transducer and a motorized control system, consistent microchannels with ellipsoid cross-sectional areas and uniform widths were achieved. This technique has potential applications in various fields including tissue engineering, drug delivery, and biomimetic lab-on-a-chip systems.
ADVANCED ENGINEERING MATERIALS
(2023)
Article
Engineering, Marine
Rui-Nan Cui, Shuai Li, Shi-Ping Wang, A-Man Zhang
Summary: In this study, the dynamics of high-pressure pulsating bubbles near a concave surface were investigated using experimental and numerical methods. Detailed information on bubble shapes, jet velocity, and wall pressure were obtained, and the validity of the numerical model was confirmed.
Article
Engineering, Marine
Zhen-Yu Hu, Shuai Li, Shi-Ping Wang, A-Man Zhang
Summary: In this study, the nonlinear bubble-plate interaction and the effect of fluid-structure interaction are investigated using boundary integral simulations and experiments. Different bubble collapse patterns and the impact of FSI on jet velocity and pressure are identified. Two scaling laws for plate motion with respect to geometry parameters are proposed.
Article
Mechanics
Qianxi Wang, Wenke Liu, Callan Corbett, Warren R. Smith
Summary: This article presents a grid-free and robust model for simulating the non-spherical oscillation or surface modes of microbubbles under ultrasound. By introducing a viscous pressure correction and using the boundary integral method, the model incorporates compressible and viscous effects and shows good agreement with theoretical and experimental results.
Article
Mechanics
Kawa M. A. Manmi, Imad A. Aziz, Arun Arjunan, Rostam K. Saeed, Abdolrahman Dadvand
Summary: Understanding the acoustic oscillation of microbubbles near boundaries is crucial for designing ultrasonic biomedical devices and surface cleaning technologies effectively. This study investigated microbubble oscillation between two curved rigid plates in a planar acoustic field using the boundary integral method, and evaluated the effects of wave direction and horizontal standoff distance on bubble dynamics. It was discovered that the jet velocity and high-pressure region in acoustic bubbles are significantly larger than those in gas bubbles.
JOURNAL OF HYDRODYNAMICS
(2021)
Article
Acoustics
Jure Zevnik, Matevz Dular
Summary: Hydrodynamic cavitation is a promising method for wastewater treatment due to its ability to eradicate bacteria, inactivate viruses, and destroy biological structures like liposomes. However, the exact damaging mechanisms of hydrodynamic cavitation in different applications remain unknown. This study numerically investigates the interaction between a single cavitation microbubble and a nearby lipid vesicle, identifying three critical modes of vesicle deformation and discussing the critical dimensionless distance for vesicle poration and rupture.
ULTRASONICS SONOCHEMISTRY
(2021)
Article
Acoustics
Hao Wu, Hao Zheng, Yuanyuan Li, Claus-Dieter Ohl, Haixia Yu, Dachao Li
Summary: This study investigates the effect of liquid surface tension on the dynamics of acoustic cavitation bubbles, revealing that low surface tension reduces bubble stability, leading to earlier collapse and farther distance from a rigid wall. Additionally, surface tension influences micro-jet speeds, highlighting the role of surfactants in optimizing acoustic cavitation.
ULTRASONICS SONOCHEMISTRY
(2021)
Article
Mechanics
Dario Abbondanza, Mirko Gallo, Carlo Massimo Casciola
Summary: This study discusses the interaction between the nonlinear fluid motion induced by the collapse of a vapor microbubble and the elastic dynamics of the underlying solid. The collapse of the bubble creates an intense jet that pierces the bubble and impinges the solid, resulting in localized load and the excitation of elastic solid waves. It is speculated that the intense deformation of the solid induced by the liquid jet may lead to plastic deformation and surface damage.
Article
Acoustics
Jinfu Liang, Xueyou Wu, Yupei Qiao
Summary: A theoretical model is proposed to describe the pulsation, translation, and deformation of twin bubbles in an ultrasound field based on potential flow and perturbation theory. The amplitudes of bubbles' oscillations are found to be dependent on initial translation velocities, with the periods of oscillations decreasing as initial translation velocities increase. The interaction between bubbles causes the instable area in the phase space to enlarge.
ULTRASONICS SONOCHEMISTRY
(2021)
Article
Mechanics
Hendrik Reese, Robin Schaedel, Fabian Reuter, Claus-Dieter Ohl
Summary: This study investigates the directed jet flow generated by a cavitation bubble near a rigid boundary, which acts as a pump to transport liquid through a perforated plate. The transport process is complex and dependent on various factors, such as the geometry of the bubble and connecting channel, liquid viscosity, and stand-off distance of the bubble to the plate. The results show that the flow rate and velocity of the jet are influenced by these factors. Additionally, different types of jet flow, such as needle jet and reverse jet, are observed under different conditions.
JOURNAL OF FLUID MECHANICS
(2022)
Article
Computer Science, Interdisciplinary Applications
Mohammadhossein Firouznia, Spencer H. Bryngelson, David Saintillan
Summary: A weakly conducting liquid droplet immersed in another leaky dielectric liquid can exhibit shape deformations and complex dynamics under the effect of an applied electric field. A spectral boundary integral method is used to simulate the droplet electrohydrodynamics, and the method is validated against experimental data and analytical predictions.
JOURNAL OF COMPUTATIONAL PHYSICS
(2023)
Article
Nanoscience & Nanotechnology
Lei Dong, Nana Li, Xixi Wei, Yongling Wang, Liansheng Chang, Hongwei Wu, Liujiang Song, Kang Guo, Yuqiao Chang, Yaling Yin, Min Pan, Yuanyuan Shen, Feng Wang
Summary: A new drug-loaded microbubble complex based on PLGA was developed to target GA to brain tumors through UTMD. The combination of GA/PLGA-CMB with FUS demonstrated a significant inhibitory effect on glioblastoma cell lines and effectively opened the BBB for targeted treatment of glioblastoma in a mouse model.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Acoustics
K. M. A. Manmi, W. B. Wu, N. Vyas, W. R. Smith, Q. X. Wang, A. D. Walmsley
ULTRASONICS SONOCHEMISTRY
(2020)
Article
Mechanics
W. R. Smith, Q. X. Wang
Summary: Numerical simulations of violent bubble dynamics often encounter numerical instabilities due to two time scales associated with the phenomenon, as revealed by the Keller-Miksis equation. The short time scale for significant acoustic radiation emission from the bubble has been determined and validated through comparison with experimental results.
FLUID DYNAMICS RESEARCH
(2021)
Article
Acoustics
N. Vyas, Q. X. Wang, A. D. Walmsley
Summary: This study investigated the use of carbonated water to enhance cavitation generated by ultrasonic scalers for improved biofilm removal from dental implants and other biomaterials. Results showed that cavitation significantly increased and accelerated in carbonated water, leading to more effective biofilm removal. This suggests a potential clinical application for using carbonated water to enhance cavitation and improve biofilm cleaning.
ULTRASONICS SONOCHEMISTRY
(2021)
Article
Cell Biology
Seley Gharanei, Katherine Fishwick, Ruban Peter Durairaj, Tianrong Jin, Eleftherios Siamantouras, Kuo-Kang Liu, Anne Straube, Emma S. Lucas, Christopher J. Weston, Pia Rantakari, Marko Salmi, Sirpa Jalkanen, Jan J. Brosens, Bee Kang Tan
Summary: The study reveals that pericytes in the midluteal human endometrium express VAP-1, and its knockdown affects their biophysical properties and interactions with uterine natural killer cells. This suggests a potential role for VAP-1 as a biomarker for pregnancy pathologies related to compromised perivascular environment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Physical
Lidong Liu, Kuo-Kang Liu
Summary: The paper presents an experimental study on the adhesive contact between liquid-bridged hydrogel microparticles and introduces a novel nanomechanical tester for measuring related parameters. The research findings indicate that the work of adhesion is independent of separation speed and the Young's modulus increases linearly, while JKR theory aligns with the generalized Hertz theory.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Biochemistry & Molecular Biology
Zhuonan Yu, Matthew J. Smith, Richard C. M. Siow, Kuo-Kang Liu
Summary: The study utilized nano-biomechanical technique and mathematical modeling to measure the contractility of dermal fibroblasts from donors of different ages. It was found that fibroblasts from aged donors exhibited greater basal contraction force, while those from young donors showed significantly larger contractile force in response to TGF-beta 1 treatment. These findings provide new insights for regenerative medicine and as a biomarker of dermal ageing processes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Article
Mechanics
Shi-Min Li, Yun-Long Liu, Qianxi Wang, A-Man Zhang
Summary: This study investigates the dynamics of a buoyant pulsating bubble near two crossed perpendicular rigid boundaries, and the numerical results show good agreement with experiments. It is found that an increase in buoyancy leads to a change in jet direction, exhibiting different characteristics at different standoff distances between the walls.
Review
Polymer Science
Zhuonan Yu, Kuo-Kang Liu
Summary: Soft polymers play a crucial role in biomedical engineering for sensing cellular forces and maintaining normal cell functions. Various techniques for soft polymer fabrication have been developed, focusing on quantitativeness and cell-friendliness. Future trends include designing new technologies and processes for cellular force measurement.
Article
Physics, Applied
Kewen Peng, Frank G. F. Qin, Runhua Jiang, Wanjun Qu, Qianxi Wang
Summary: Reactive species (RS) play a critical role in postoperative complications in laser surgery. Through simulation calculations, it has been found that the concentration of RS produced in collapsing bubbles is relatively high, and the generation mechanism mainly involves the decomposition of hydrogen peroxide and reactions between hydrogen, oxygen, and various free radicals. Furthermore, the production of RS increases with pulse energy. These findings can contribute to the development of strategies to mitigate complications or exploit the benefits associated with RS in laser surgery.
JOURNAL OF APPLIED PHYSICS
(2022)
Article
Mechanics
Warren R. Smith, Qianxi Wang
Summary: Small viscous effects in high-Reynolds-number rotational flows accumulate over time to have a leading-order effect, making the high-Reynolds-number limit for the Navier-Stokes equations singular. Investigating whether a solution of the Euler equations can approximate a real flow at large Reynolds number is crucial. The neglect of these facts leads to the use of Euler equations to simulate laminar rotational flows at large Reynolds number.
JOURNAL OF FLUID MECHANICS
(2021)
Article
Chemistry, Multidisciplinary
Lidong Liu, Kai-Tak Wan, Kuo-Kang Liu
Summary: A homemade instrument is used to characterize the adhesion between rigid polymeric microspheres in moist air. The study demonstrates that capillary adhesion force is affected by humidity, especially on rough surfaces. Moisture significantly impacts interparticle adhesion and industrial applications.
Article
Mechanics
Qianxi Wang, Wenke Liu, Callan Corbett, Warren R. Smith
Summary: This article presents a grid-free and robust model for simulating the non-spherical oscillation or surface modes of microbubbles under ultrasound. By introducing a viscous pressure correction and using the boundary integral method, the model incorporates compressible and viscous effects and shows good agreement with theoretical and experimental results.
Article
Chemistry, Analytical
Samuel Husin Surya Mandala, Tai-Jan Liu, Chiung-Mei Chen, Kuo-Kang Liu, Mochamad Januar, Ying-Feng Chang, Chao-Sung Lai, Kuo-Hsuan Chang, Kou-Chen Liu
Summary: A highly sensitive and selective SPR biosensor based on Fe3O4 NPs and paired antibodies was developed for the detection of alpha-syn in serum samples, with a lower detection limit compared to commercial ELISA. The sensor chip can be easily regenerated for repeated measurements, and the SPR sensor demonstrated precise detection of alpha-syn in human biofluids, paving the way for future development in early PD diagnosis.
Article
Nanoscience & Nanotechnology
Mochamad Januar, Suhendro Purbo Prakoso, Chia-Wen Zhong, Horng-Chih Lin, Chuan Li, Jang-Hsing Hsieh, Kuo-Kang Liu, Kou-Chen Liu
Summary: This paper demonstrates a fully room-temperature fabrication of p-type SnOx thin films with high mobility using ion-beam-assisted deposition. The technique allows independent control of ion density and energy, optimizing the optical band gap and hole mobility of the films. The absence of annealing process prevents microcrystal formation and improves the performance of the films.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Correction
Mechanics
Q. X. Wang
