期刊
REPRODUCTION
卷 156, 期 6, 页码 559-567出版社
BIOSCIENTIFICA LTD
DOI: 10.1530/REP-18-0041
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资金
- Eunice Kennedy Shriver National Institute of Child Health and Human Development [K12 HD000849]
- Burroughs Wellcome Fund, as part of the Reproductive Scientist Development Program
MicroRNAs (miRs) are small molecules important for regulation of transcription and translation. The objective was to identify hormonally regulated miRs in human endometrial stromal cells and to determine the impact of the endocrine disruptor, bisphenol A (BPA), on those miRs. miR microarray analysis and multiple confirmatory cell preparations treated with 17 beta-estradiol (E2) and BPA altered miR-27b, let-7c, let-7e and miR-181b. Further, decidualization downregulated miR-27b. VEGFB and VEGFC were validated as targets of miR-27b. Identification of miR-27b target genes suggests that BPA and E2 downregulate miR-27b thereby leading to upregulation of genes important for vascularization and angiogenesis of the endometrium during the menstrual cycle and decidualization.
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