Article
Pharmacology & Pharmacy
Shuwei Wang, Qi Han, Zhaolan Wei, Yunyi Wang, Lingfu Deng, Mingqing Chen
Summary: The study found that exposure to formaldehyde can cause an increase in blood pressure and damage to the heart, aortic vessels, and kidneys. By blocking the ACE/AT1R axis using an ACE inhibitor, the increase in blood pressure and pathological changes caused by formaldehyde exposure can be alleviated. This result improves our understanding of the impact of formaldehyde exposure on the development of hypertension.
Article
Biochemistry & Molecular Biology
Se Yeong Park, Eun Woo Jeong, Yun Sun Yang, Hyun-Joo Kim, Gwang-woong Go, Hyeon Gyu Lee
Summary: Finger millet ethanol extracts (FEs) exhibit lipid-lowering, antioxidant, renin-angiotensin system-controlling, and vascular remodeling-improving effects in spontaneously hypertensive rats (SHRs), significantly reducing systolic blood pressure.
Article
Clinical Neurology
Malik Nassan, Iyas Daghlas, Ignazio S. Piras, Emily Rogalski, Lianne M. Reus, Yolande Pijnenburg, Leah K. Cuddy, Richa Saxena, M-Marsel Mesulam, Matt Huentelman
Summary: This study used genetic approaches to find that angiotensin-converting enzyme (ACE) inhibition is associated with Alzheimer's disease and frontotemporal dementia, but not with Lewy body dementia or vascular dementia. These results provide evidence for further research on the neurocognitive effects of ACE inhibition.
ALZHEIMERS & DEMENTIA
(2023)
Article
Virology
Anna Papadopoulou, Paraskevi C. Fragkou, Eirini Maratou, Dimitra Dimopoulou, Antonis Kominakis, Ioanna Kokkinopoulou, Christos Kroupis, Athina Nikolaidou, Georgios Antonakos, Vasiliki Papaevangelou, Apostolos Armaganidis, Argirios Tsantes, Eftychia Polyzogopoulou, Sotirios Tsiodras, Anastasia Antoniadou, Paraskevi Moutsatsou
Summary: Accumulated data suggests a role of the renin-angiotensin system in COVID-19 pathogenesis, with the ACE insertion/deletion polymorphism potentially increasing the risk for severe disease. A retrospective study found that COVID-19 patients with the DD genotype and D allele carriers had a higher risk of developing severe disease, associated with lower ACE activity. This highlights the need for further research on ACE genotype-based therapies in COVID-19 patients.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Public, Environmental & Occupational Health
Guillaume Butler-Laporte, Tomoko Nakanishi, Vincent Mooser, Alessandra Renieri, Sara Amitrano, Sirui Zhou, Yiheng Chen, Vincenzo Forgetta, J. Brent Richards
Summary: Mendelian randomization using genetic determinants of serum-ACE levels found no association between genetically decreased ACE levels and susceptibility to, or severity of, COVID-19, suggesting that individuals taking ACE inhibitors should not discontinue therapy during the pandemic.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Food Science & Technology
Jingjing Dong, Shen Wang, Xiaoyao Yin, Min Fang, Zhiyong Gong, Yongning Wu
Summary: This study investigated the antihypertensive effect of rice peptide (RP) and revealed its mechanism of action. The results demonstrated that RP could effectively reduce systolic blood pressure in hypertensive rats, potentially through regulating the renin-angiotensin system and nitric oxide release.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Food Science & Technology
Mingzhe Ma, Yinghui Feng, Yulu Miao, Qiang Shen, Shuting Tang, Juan Dong, John Z. H. Zhang, Lujia Zhang
Summary: Chronic diseases, such as hypertension, have detrimental effects on human health. Conventional drugs for treatment often come with significant side effects. Food-sourced ACE inhibitory peptides provide a safer alternative, with fewer side effects. However, the lack of a systematic and effective screening method and understanding of the sequence characteristics and molecular mechanisms hinder the development of ACE inhibitory peptides.
Article
Biochemistry & Molecular Biology
Ingrid Fricke-Galindo, Ivette Buendia-Roldan, Daniel I. I. Ponce-Aguilar, Gloria Perez-Rubio, Leslie Chavez-Galan, Jesus Alanis-Ponce, Karina Perez-Torres, Daniela Valencia-Perez Rea, Fernanda Tellez-Quijada, Karol J. J. Nava-Quiroz, Rafael de Jesus Hernandez-Zenteno, Angelica Gutierrez-Nava, Ramces Falfan-Valencia
Summary: This paper examines the relationship between the ACE insertion/deletion variant and serum ACE activity with the severity of COVID-19 and its impact on post-COVID-19 patients, comparing it with non-COVID-19 respiratory disorder patients. The DD genotype is associated with an increased risk of invasive mechanical ventilation requirement in COVID-19 patients, and it is more prevalent in COVID-19 and post-COVID-19 groups compared to non-COVID-19 subjects. Serum ACE activity is lower in COVID-19 patients and may be related to disease severity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Fatih Aydin, Vedat Turkoglu, Zehra Bas
Summary: The study successfully purified ACE enzyme from sheep lungs in one step and determined that captopril, a specific ACE inhibitor, has a significant inhibitory effect with a very low IC50 value of 0.51 nM.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Yu-Hang Zhang, Wen-Yu Wang, Xiao-Cong Pang, Zhi Wang, Cheng-Zhuo Wang, Hang Zhou, Bo Zheng, Yi-Min Cui
Summary: The study revealed that thymosin-alpha 1 prevents COVID-19 by binding with ACE and reducing ACE2 expression in human lung epithelial cells, suggesting its potential clinical applications in preventing SARS-CoV-2 infection.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Review
Pharmacology & Pharmacy
Brian M. Egan, Andrea Scharf, Franziska Pohl, Kerry Kornfeld
Summary: The free-living nematode Caenorhabditis elegans is a powerful model organism for studying aging and longevity due to its short lifespan and genetic similarities with mammals. Many genetic pathways have been identified in C. elegans that affect lifespan, and it is also a useful system for drug screens. The renin-angiotensin system (RAS) has been found to influence aging in various species, including C. elegans.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Ioannis Papasavvas, Beatrice Gehrig, Carl P. Herbort
Summary: Lysozyme was found to be much more useful than ACE as a laboratory test to support the diagnosis of ocular sarcoidosis. Polyclonal antibody activation appears to be another useful laboratory test supportive of the diagnosis of ocular sarcoidosis.
Article
Immunology
Duoyao Cao, Suguru Saito, Limin Xu, Wei Fan, Xiaomo Li, Faizan Ahmed, Predrag Jovanovic, Tomohiro Shibata, Mingtian Che, Ellen A. Bernstein, Jorge Gianni, Ajit S. Divakaruni, Derick Okwan-Duodu, Zakir Khan, Celine E. Riera, Fanfan Chen, Kenneth E. Bernstein
Summary: This study reveals the protective effect of ACE overexpression in circulating monocytes against atherosclerosis. ACE overexpression leads to enhanced lipid metabolism, mitochondrial activity, and ATP levels in monocytes. Additionally, increased energy consumption is observed in ACE10/10 mice. These findings highlight the importance of ACE in macrophage metabolism and its role in atherosclerosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Mariana Ferreira-Duarte, Lilian Caroline Goncalves Oliveira, Clara Quintas, Marisa Esteves-Monteiro, Margarida Duarte-Araujo, Teresa Sousa, Dulce Elena Casarini, Manuela Morato
Summary: This study evaluated the catalytic activity of ACE and ACE2 in the intestinal content and corresponding intestinal tissue of Wistar Han rats. The results showed that ACE and ACE2 have catalytic activity in the rat gut, with higher activity of the ACE N-domain compared to the C-domain. Additionally, ACE and ACE2 were more active in the intestinal content than in the corresponding intestinal tissue. In the intestinal tissue, there was a distal-to-proximal prevalence of ACE2 over ACE. This study is the first to report the presence of catalytically active ACE and ACE2 in the rat intestinal content, supporting future research on the regulatory role of the intestinal RAAS on gut function and a putative link to the microbiome.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Medical Laboratory Technology
Akif Bayyigit, Mehmet A. Acar, Pinar Kulahli, Funda Simsek, Mine Adas
Summary: This study found no correlation between serum ACE levels at the time of hospitalization and the prognosis of COVID-19 patients.
CLINICAL LABORATORY
(2022)
Review
Public, Environmental & Occupational Health
Michael D. Wiese, Mary J. Berry, Pravin Hissaria, Jack R. T. Darby, Janna L. Morrison
Summary: Medical care during COVID-19 pandemic is focusing on developing new therapies, but pregnant women, who are at higher risk, often face exclusion from drug trials due to lack of evidence regarding efficacy and safety for both mother and fetus.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2022)
Article
Nutrition & Dietetics
Susan J. Ward, Alison M. Hill, Jonathan D. Buckley, Siobhan Banks, Varinderpal S. Dhillon, Stacey L. Holman, Janna L. Morrison, Alison M. Coates
Summary: The study aimed to investigate the relationship between diet quality and telomere length in Australian adults after a 12-week dietary intervention with an almond-enriched diet. Results showed that although diet quality improved with the almond-enriched diet, it did not significantly affect telomere length. Future studies should explore the impact of more substantial dietary changes over longer periods of time.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Developmental Biology
Ashley S. Meakin, Marzieh Amirmostofian, Jack Rt Darby, Stacey L. Holman, Janna L. Morrison, Michael D. Wiese
Summary: This study validated an assay to quantify the activity of cytochrome P450 (CYP) enzymes in different compartments of the sheep maternal-placental-fetal unit. The results showed that maternal liver had several active CYP enzymes, while placenta and fetal liver had only a few active CYP enzymes. This study provides important insights for studying drug metabolism during pregnancy.
Article
Allergy
J. L. Robinson, K. L. Gatford, C. P. Hurst, V. L. Clifton, J. L. Morrison, M. J. Stark
Summary: Asthma in pregnant women in Australia affects about 17% of pregnancies and is associated with negative perinatal outcomes. Revised guidelines in South Australia aim to improve asthma management during pregnancy based on severity. This study explores whether the revised guidelines have reduced the impact of maternal asthma on adverse perinatal outcomes.
Review
Neurosciences
Catherine G. Dimasi, Jack R. T. Darby, Janna L. Morrison
Summary: Mammalian cardiomyocytes undergo significant maturational changes before and after birth. Immature cardiomyocytes can contribute to cardiac growth through proliferation, allowing the heart to regenerate. However, these changes come at the cost of losing cardiac regenerative capacity, leading to permanent damage in postnatal life. This poses a barrier to developing new treatments for cardiac repair and contributes to heart failure. This review focuses on studying the critical transition period of cardiomyocyte growth, exploring novel factors that may regulate and drive this process, and discussing the potential use of new biomarkers for detecting myocardial infarction and cardiovascular disease.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Biochemical Research Methods
Selvam Paramasivan, Janna L. Morrison, Mitchell C. Lock, Jack R. T. Darby, Roberto A. Barrero, Paul C. Mills, Pawel Sadowski
Summary: Sequential window acquisition of all theoretical mass spectra-mass spectrometry, supported by advanced bioinformatics, provides a comprehensive framework for proteome analysis and biomarker discovery. However, the lack of a generic sample preparation platform for heterogeneous materials from different sources limits its broad application. We developed universal and fully automated workflows using a robotic sample preparation platform, enabling in-depth and reproducible proteome coverage of bovine and ovine specimens. The high correlation between sheep proteomics and transcriptomics datasets validates this development and suggests the potential for various clinical applications across different animal species and disease models.
JOURNAL OF PROTEOME RESEARCH
(2023)
Review
Cardiac & Cardiovascular Systems
Henriette Kuhle, Steven K. S. Cho, Nathaniel Barber, Datta Singh Goolaub, Jack R. T. Darby, Janna L. Morrison, Christoph Haller, Liqun Sun, Mike Seed
Summary: Over the past few decades, advanced imaging techniques have been used to assess cardiovascular physiology and cardiac function in the fetus. Technical development has been necessary to make these assessments feasible in the fetus, while an understanding of the unique physiology of fetal circulation is needed for proper interpretation of the results. This review discusses recent advances in fetal echocardiography and cardiovascular magnetic resonance, providing examples of their application in research and clinical settings, as well as future directions for these technologies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Physiology
Jack R. T. Darby, Georgia K. Williams, Steven K. S. Cho, Ashley S. Meakin, Stacey L. Holman, Megan Quinn, Michael D. Wiese, Christopher K. Macgowan, Mike Seed, Janna L. Morrison
Summary: Babies born with reduced growth face increased risk of poor outcomes. Current interventions are ineffective in improving fetal growth. Resveratrol treatment increases blood flow and oxygenation in the uterus, but high polyphenol diets may negatively affect fetal hemodynamics. This study assessed the safety of resveratrol as an intervention for fetal growth restriction.
PHYSIOLOGICAL REPORTS
(2023)
Review
Health Care Sciences & Services
Joshua L. Robinson, Kathy L. Gatford, Vicki L. Clifton, Janna L. Morrison, Michael J. Stark
Summary: This scoping review aims to describe the methodology, phenotype, and characteristics of maternal asthma models used in preclinical studies, as well as the measured outcomes in the mother and progeny. The review also aims to identify gaps in knowledge regarding maternal and progeny outcomes following maternal asthma in pregnancy.
JBI EVIDENCE SYNTHESIS
(2023)
Article
Neurosciences
Mitchell C. Lock, Kimberley J. Botting, Beth J. Allison, Youguo Niu, Sage G. Ford, Michael P. Murphy, Sandra Orgeig, Dino A. Giussani, Janna L. Morrison
Summary: Chronic fetal hypoxemia increases the risk of respiratory complications at birth. Maternal antioxidant therapy has been shown to be protective for fetal growth and cardiovascular development. This study investigated the effects of maternal antenatal treatment with MitoQ on lung development in hypoxic pregnancy in sheep, and found that it promoted fetal pulmonary surfactant maturation and increased expression of key genes involved in lung development.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Neurosciences
Brahmdeep S. Saini, Robin Ducas, Jack R. T. Darby, Davide Marini, Liqun Sun, Christopher K. Macgowan, Rory Windrim, John C. Kingdom, Rachel M. Wald, Janna L. Morrison, Mike Seed
Summary: Late gestational supine positioning affects maternal cardiac output and oxygen delivery, but not oxygen consumption in the gravid uterus, fetus, placenta, and lower limbs. Supine mothers have lower cardiac output and oxygen delivery compared to lateral positions, but higher collateral venous return.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Multidisciplinary Sciences
Jack R. T. Darby, Song Zhang, Stacey L. Holman, Beverly S. Muhlhausler, Caroline McMillen, Janna L. Morrison
Summary: The effects of fetal glucose infusion on cardiac growth and metabolism signaling molecules were evaluated. Results showed that despite increased fetal plasma glucose and insulin concentrations, there were no significant changes in mRNA expression and protein abundance of these molecules.
Article
Neurosciences
Catherine G. Dimasi, Jack R. T. Darby, Steven K. S. Cho, Brahmdeep S. Saini, Stacey L. Holman, Ashley S. Meakin, Michael D. Wiese, Christopher K. Macgowan, Mike Seed, Janna L. Morrison
Summary: Babies born with fetal growth restriction (FGR) have a higher risk of developing cardiometabolic diseases. FGR reduces substrate supply to the fetus, which affects cardiac growth, metabolism, and function. A study using a sheep model of placental restriction found that FGR decreases glucose and fatty acid transporters, as well as mitochondrial numbers and electron transport chain complexes in the fetal heart.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Meeting Abstract
Developmental Biology
Ashley Meakin, Vicki Clifton, Jack Darby, Stacey Holman, Michael Wiese, Janna Morrison
Meeting Abstract
Developmental Biology
Ashley Meakin, Melanie Smith, Janna Morrison, Claire Roberts, Martha Lappas, Stacey Ellery, Olivia Holland, Tony Perkins, Sharon McCracken, Vicki Flenady, Vicki Clifton