Article
Neurosciences
Mriga Das, Duo Cheng, Till Matzat, Vanessa J. Auld
Summary: Glia are crucial for protecting and enabling nervous system function, and the formation of the glial sheath around peripheral axons plays a key role. In this study, the role of Innexins in mediating glial function in the Drosophila periphery was investigated. It was found that Inx1 and Inx2 are important for peripheral glia development, and their loss led to defects in wrapping glia and disruption of the glia wrap. Inx2 was also found to play a role in linking subperineurial glia and wrapping glia, ensuring the integrity of the glial wrap.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Cell Biology
Bin Yuan, Jing Yang, Louis Dubeau, Yanfen Hu, Rong Li
Summary: The study identified the crucial role of an ER beta-specific phosphotyrosine residue in mouse ovarian development and function, with mutant mice showing reduced fertility and decreased ovarian cell proliferation. These findings provide strong genetic and molecular evidence for the impact of isotype-specific ER beta phosphorylation in ovarian tissues.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Obstetrics & Gynecology
L. M. Del Castillo, A. Buigues, V Rossi, M. J. Soriano, J. Martinez, M. De Felici, H. K. Lamsira, F. Di Rella, F. G. Klinger, A. Pellicer, S. Herraiz
Summary: LH treatment before and during chemotherapy can prevent detrimental effects on follicles and reproductive lifespan in mice, potentially mediated by enhanced DNA repair response and anti-apoptotic signals.
HUMAN REPRODUCTION
(2021)
Article
Cell Biology
Simin Younesi, Sarah J. Spencer, Luba Sominsky
Summary: Acute depletion of monocytes does not have sustained effects on ovarian follicle health, but it may exacerbate the impact of lipopolysaccharide (LPS) and transiently suppress ovulatory capacity, which is likely to be restored with resolution of the inflammatory environment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Jeremy Gingrich, Yong Pu, Brad L. Upham, Madeline Hulse, Sarah Pearl, Denny Martin, Anita Avery, Almudena Veiga-Lopez
Summary: Gap junction intercellular communication (GJIC) is crucial for ovarian function and can be modulated by chemicals like bisphenol S, which may enhance GJIC in ovine and human theca cells through signal pathway regulation. Upregulation of GJIC could lead to the hyperplasia of the theca cell layer or hinder ovulation by maintaining the oocyte in meiotic arrest.
Article
Cell Biology
Oindrila De, Clinton Rice, Teresa Zulueta-Coarasa, Rodrigo Fernandez-Gonzalez, Robert E. Ward
Summary: In Drosophila, mutations in core SJ proteins not only affect the occluding function of SJs, but also disrupt developmental events such as cell shape changes and adhesion in the process of dorsal closure. These mutations result in defects in DC and reduced levels of E-cadherin.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Mathieu Pernot, Beatrice Jaspard-vinassa, Alice Abelanet, Sebastien Rubin, Isabelle Forfar, Sylvie Jeanningros, Laura Cetran, Murielle Han-Yee Yu, Elise Bake, Stephane Hatem, Pascale Dufourcq, Thierry Couffinhal, Cecile Duplaa
Summary: Heart failure is a common stage of most cardiopathies, and the polarization of cardiomyocytes is crucial for heart function. PDZRN3 is a novel signaling pathway that controls heart development and maintenance, and may serve as a potential therapeutic target for preventing heart failure.
SCIENTIFIC REPORTS
(2022)
Article
Obstetrics & Gynecology
Ernesto Bosch, Pilar Alama, Josep Lluis Romero, Marta Mari, Elena Labarta, Antonio Pellicer
Summary: Ovarian stimulation with highly purified (hp)-HMG can prevent elevated progesterone in the follicular phase compared to recombinant FSH (r-FSH) by enhancing the Delta 4 pathway, leading to lower progesterone levels at the end of the cycle.
HUMAN REPRODUCTION
(2023)
Review
Endocrinology & Metabolism
Kana Ikegami, Youki Watanabe, Sho Nakamura, Teppei Goto, Naoko Inoue, Yoshihisa Uenoyama, Hiroko Tsukamura
Summary: Research has shown that hypothalamic arcuate kisspeptin neurons play a crucial role in regulating gametogenesis and steroidogenesis in mammals by overseeing the pulsatile release of GnRH. These neurons, also known as KNDy neurons, express NKB and Dyn. The article focuses on the cellular and molecular mechanisms underlying GnRH pulse generation, as well as the factors that modulate the activity of KNDy neurons and consequent pulsatile GnRH/LH release in mammals.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Genetics & Heredity
Aditi H. Chaubey, Savannah E. Sojka, John O. Onukwufor, Meredith J. Ezak, Matthew D. Vandermeulen, Alexander Bowitch, Anezka Vodickova, Andrew P. Wojtovich, Denise M. Ferkey
Summary: Organisms rely on chemical cues to detect food, reproductive partners, predators, and harmful stimuli. The nematode Caenorhabditis elegans has primary nociceptors called ASH sensory neurons, which are activated by aversive stimuli and lead to backward locomotion and stimulus avoidance. This study reveals that animals lacking the gap junction component INX-20 show hypersensitivity to chemical stimuli that signal through G protein-coupled receptor pathways in ASH, suggesting a role for INX-20 in dampening ASH sensitivity.
Article
Multidisciplinary Sciences
Caterina Sellitto, Leping Li, Thomas W. White
Summary: Mutations in connexin channels genes cause various human skin diseases, including KID syndrome. In a transgenic mouse model of KID syndrome, topical application of a hemichannel inhibitor reduced skin pathology associated with the syndrome. However, discontinuation of the inhibitor allowed disease progression, suggesting potential for therapeutic intervention targeting aberrant hemichannel activity in KID syndrome.
SCIENTIFIC REPORTS
(2021)
Article
Agriculture, Dairy & Animal Science
Valentina Lodde, Alberto Maria Luciano, Giulia Musmeci, Ileana Miclea, Irene Tessaro, Mariella Aru, David F. Albertini, Federica Franciosi
Summary: Women's reproductive performance declines starting in midlife, with a very low possibility of pregnancy by age 40-45. Premature ovarian failure and early ovarian aging can lead to low-quality eggs, impacting fertility. Understanding cellular mechanisms is essential for finding solutions to reproductive aging issues.
Article
Genetics & Heredity
Chang-Ru Tsai, Yan Wang, Alec Jacobson, Niki Sankoorikkal, Josue D. Chirinos, Sirisha Burra, Nishanth Makthal, Muthiah Kumaraswami, Michael J. Galko
Summary: This research investigates the wound-induced inflammation in Drosophila melanogaster larvae and identifies the important role of the platelet-derived growth factor/vascular endothelial growth factor-related receptor (Pvr) and its ligand Pvf1 in blood cell spreading at the wound site. The study also defines distinct downstream signaling factors required for epidermal wound closure or hemocyte spreading, shedding light on the molecular mechanisms involved in these processes.
G3-GENES GENOMES GENETICS
(2022)
Article
Public, Environmental & Occupational Health
Mandy L. L. Tan, Hui L. Kwong, Chia C. Ang, Hong L. Tey, Joyce S. S. Lee, David L. Becker
Summary: The study found that the expression patterns of Cx43 in inflammatory skin diseases such as eczema and psoriasis show dynamic changes, which may represent potential therapeutic targets in the future.
HEALTH SCIENCE REPORTS
(2021)
Article
Medicine, General & Internal
Hira Ayaz, Aiman Farogh Anjum, Nasar Abbas Shamsi, Abdul Samad, Sidra Arshad, Aamna Khokhar, Talha Laique
Summary: The aqueous extract of Withania coagulans had a significant influence on serum follicle stimulating hormone and luteinizing hormone levels in rats with polycystic ovarian disease, leading to a return to normalcy in ovarian weight. This study concluded that Withania coagulans can be a substitute for ameliorating deranged gonadotropin levels in polycystic ovary disease.
PAKISTAN JOURNAL OF MEDICAL & HEALTH SCIENCES
(2021)