Article
Cell Biology
Ke Peng, Hong Liu, Bin Yan, Xiao-Wen Meng, Shao-Yong Song, Fu-Hai Ji, Zhengyuan Xia
Summary: This study identified and validated key candidate genes related to inflammation and apoptosis pathways underlying myocardial I/R injury. Inhibition of Cathepsin S was shown to alleviate myocardial I/R-induced injury by suppressing inflammation and apoptosis, potentially offering clinical applications in cardioprotection.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Yungang Shan, Deqing Chen, Bo Hu, Guangtao Xu, Wanlu Li, Ye Jin, Xiuhui Jin, Xin Jin, Limin Jin
Summary: The study demonstrated that allicin exerts a protective effect against renal ischemia/reperfusion injury in rats by regulating apoptosis, oxidative stress, and inflammatory response.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Yang Du, Chuan-min Chu, Dong Zhuo, Jin-zhuo Ning
Summary: This study demonstrates that TRIM35 plays a role in renal IRI by inhibiting oxidative stress and enhancing mitochondrial fusion. Additionally, TRIM35 interacts with TIGAR and promotes its degradation, leading to inhibition of mitochondrial fusion. Therefore, TRIM35 may serve as a potential therapeutic target for renal IRI.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Immunology
Lucas Ferreira da Anunciacao, Marcelo Nunes de Sousa, Marina Vidal-dos-Santos, Roberto Armstrong-Jr, Luiz Felipe Pinho Moreira, Cristiano Jesus Correia, Ana Cristina Breithaupt-Faloppa
Summary: Estradiol may have protective effects on lung injury and inflammation caused by ischemia and reperfusion due to aortic occlusion.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Engineering, Biomedical
Jinyan Zhang, Liwei Liu, Zhen Dong, Xicun Lu, Wenxuan Hong, Jin Liu, Xiaoyi Zou, Jinfeng Gao, Hao Jiang, Xiaolei Sun, Kai Hu, Youjun Yang, Junbo Ge, Xiao Luo, Aijun Sun
Summary: This study utilizes a peroxynitrite-triggered carbon monoxide donor to generate a biomimetic carbon monoxide nanogenerator, which is coated with macrophage membrane for targeted delivery to the ischemic area and neutralization of proinflammatory cytokines, effectively improving myocardial ischemia-reperfusion injury. This research provides a new perspective on the safe therapeutic use of carbon monoxide for myocardial ischemia-reperfusion injury by utilizing a novel carbon monoxide donor combined with biomimetic technology. The M/PCOD@PLGA nanogenerator offers targeted delivery of carbon monoxide to the ischemic area, minimizing potential toxicity and enhancing therapeutic efficacy.
BIOACTIVE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Yan Wang, Chun Jie Wu, Yu Du, Yu Qing Liu, Jing Ran Cai, Xue Qing Wu, Shu Qun Hu
Summary: Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are produced during renal ischemia/reperfusion, with peroxynitrite being a major player in renal cell apoptosis. Inhibiting the nitration of SIRT2 tyrosine could be a promising strategy to prevent ischemic renal diseases involving AKI, as it leads to impaired renal function and cell apoptosis.
FREE RADICAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Douglas Ikedo Machado, Eloiza de Oliveira Silva, Sara Ventura, Maria de Fatima Fernandes Vattimo
Summary: Chronic kidney disease (CKD) and acute kidney injury (AKI) are global health problems that affect over 850 million people. Diabetes mellitus (DM) increases the susceptibility to AKI. Curcumin has shown positive effects in diabetic rats with AKI, improving renal function and reducing oxidative stress.
Review
Medicine, Research & Experimental
Komal Thapa, Thakur Gurjeet Singh, Amarjot Kaur
Summary: This study summarizes the importance of PDEs in renal ischemia/reperfusion injury and pharmacological modulation, highlighting that current therapeutic options may not be adequate to treat a group of patients with renal I/R injury.
Article
Immunology
Iman O. Sherif, Nora H. Al-Shaalan
Summary: The study demonstrated that vildagliptin could significantly alleviate lung injury caused by hepatic ischemia/reperfusion by suppressing oxidative stress, inflammation, and related gene expressions.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xiyue Zhang, Yihua Zhang, Qing Miao, Zhiguang Shi, Lulu Hu, Shangmin Liu, Jie Gao, Shuang Zhao, Hongshan Chen, Zhengrong Huang, Yi Han, Yong Ji, Liping Xie
Summary: Inhibition of SNO-HSP90 can alleviate cardiac fibrosis, potentially through blocking the TGF beta/SMAD3 signaling pathway.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Fayez T. Hammad, Suhail Al-Salam, Rahaf Ahmad, Javed Yasin, Awwab F. Hammad, Jasmine Abdul Rasheed, Loay Lubbad
Summary: It has been found that nerolidol has a protective effect on renal ischemia-reperfusion injury, improving renal function and reducing tissue damage.
Article
Nutrition & Dietetics
Byung Hyuk Han, Hyeon Kyoung Lee, Se Hoon Jang, Ai Lin Tai, Youn Jae Jang, Jung Joo Yoon, Hye Yoom Kim, Ho Sub Lee, Yun Jung Lee, Dae Gill Kang
Summary: The study found that GSH significantly improved creatinine clearance, creatinine, and blood urea nitrogen levels, reduced specific renal injury markers such as NGAL and KIM-1, and decreased staining intensity in the kidneys of the I/R group. GSH also inhibited the expression of inflammatory cytokines and inflammasome-related proteins in I/R-induced ARF mice.
Article
Biochemistry & Molecular Biology
Theodoros Eleftheriadis, Georgios Pissas, Spyridon Golfinopoulos, Maria Efthymiadi, Vassilios Liakopoulos, Ioannis Stefanidis
Summary: Inhibition of malate dehydrogenase-2 (MDH-2) protects renal cells from death or senescence caused by ischemia-reperfusion injury. MDH-2 inhibition reduces oxidative stress and inflammation, and maintains cell proliferation capacity.
Article
Biochemistry & Molecular Biology
Rolf Schreckenberg, Annemarie Wolf, Tamara Szabados, Kamilla Gomori, Istvan Adorjan Szabo, Gergely Agoston, Gabor Brenner, Peter Bencsik, Peter Ferdinandy, Rainer Schulz, Klaus-Dieter Schlueter
Summary: Hypoxia upregulates PCSK9 in the heart, which affects myocyte function. Genetic deletion of PCSK9 or antagonism of circulating PCSK9 reduces reperfusion injury. A high-fat diet decreases survival rate during reperfusion, likely due to increased MMP9 activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Bingbing Shen, Mei Mei, Shanmu Ai, Xiaohui Liao, Ning Li, Sha Xiang, Chaolin Wen, Yang Tao, Huanzi Dai
Summary: TRPC6 plays a protective role in renal ischemia/reperfusion injury by promoting zinc ion influx and upregulating A20 expression to inhibit inflammasome activation and attenuate renal damage.
Article
Pediatrics
Erdal Turk, Irfan Karaca, Emine Ozcinar, Aydan Celebiler, Hulya Aybek, Ragip Ortac, Ahmet Guven
JOURNAL OF PEDIATRIC SURGERY
(2015)
Article
Surgery
Huseyin Ozkan, Safak Ekinci, Bulent Uysal, Faruk Akyildiz, Selim Turkkan, Omer Ersen, Kenan Koca, Mehmet Murat Seven
JOURNAL OF SURGICAL RESEARCH
(2015)
Article
Medicine, General & Internal
Melahat Donmez, Bulent Uysal, Yavuz Poyrazoglu, Yesim Er Oztas, Turker Turker, Umit Kaldirim, Ahmet Korkmaz
TURKISH JOURNAL OF MEDICAL SCIENCES
(2015)
Article
Medicine, General & Internal
Hakan Ay, Ramazan Yusksel, Kemal Simsek, Turgut Topal, Ozgur Yesilyurt, Sukru Oter, Ahmet Korkmaz, Mehmet Ozler, Bulent Uysal, Halil Yaman, Orhan Bedir, Hayati Bilgic
TURKISH JOURNAL OF MEDICAL SCIENCES
(2015)
Article
Endocrinology & Metabolism
Erkan Sari, Ediz Yesilkaya, Ahmet Bolat, Turgut Topal, Bilal Altan, Kursat Fidanci, Mehmet Saldir, Galip Erdem, Mustafa Gulgun, Yasemin Gulcan Kurt, Ahmet Guven
JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
(2015)
Article
Medicine, Research & Experimental
Umit Kaldirim, Bulent Uysal, Ramazan Yuksel, Enis Macit, Yusuf E. Eyi, Mehmet Toygar, Salim K. Tuncer, Sukru Ardic, Ibrahim Arziman, Ibrahim Aydin, Yesim Oztas, Yildirim Karslioglu, Turgut Topal
EXPERIMENTAL BIOLOGY AND MEDICINE
(2014)
Article
Toxicology
M. Toygar, I. Aydin, M. Agilli, F. N. Aydin, M. Oztosun, H. Gul, E. Macit, Y. Karslioglu, T. Topal, B. Uysal, M. Honca
HUMAN & EXPERIMENTAL TOXICOLOGY
(2015)
Article
Obstetrics & Gynecology
K. Erkenekli, U. Keskin, B. Uysal, Y. G. Kurt, S. Sadir, T. Cayci, A. Ergun, S. Erkaya, N. Danisman, D. Uygur
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2015)
Article
Pediatrics
Erdal Turk, Mehmet Erdal Memetoglu, Yesim Edirne, Fahri Karaca, Cezmi Saday, Ahmet Guven
JOURNAL OF PEDIATRIC SURGERY
(2014)
Article
Surgery
Sadik Yurttutan, Ramazan Ozdemir, Fuat Emre Canpolat, Mehmet Yekta Oncel, Bulent Uysal, Hatice Germen Unverdi, Omer Erdeve, Ugur Dilmen
JOURNAL OF SURGICAL RESEARCH
(2013)
Article
Pediatrics
Sadik Yurttutan, Ramazan Ozdemir, Fuat Emre Canpolat, Mehmet Yekta Oncel, Hatice Germen Unverdi, Bulent Uysal, Omer Erdeve, Ugur Dilmen
PEDIATRIC SURGERY INTERNATIONAL
(2014)
Article
Urology & Nephrology
Bilal Firat Alp, Ercan Malkoc, Zafer Demirer, Ali Guragac, Turker Turker, Ertan Altayli, Ayhan Ozcan, Bulent Uysal, Turgut Topal, Emin Ozgur Akgul, Ibrahim Yildirim, Ahmet Guven
Article
Urology & Nephrology
Ercan Malkoc, Bilal Firat Alp, Zafer Demirer, Ali Guragac, Furkan Dursun, Ferhat Ates, Ibrahim Yildirim, Ramazan Yuksel, Bulent Uysal, Turgut Topal, Yasemin Gulcan Kurt, Ayhan Ozcan, Ahmet Guven