Article
Biology
Danni A. Gadd, Robert F. Hillary, Daniel L. McCartney, Shaza B. Zaghlool, Anna J. Stevenson, Yipeng Cheng, Chloe Fawns-Ritchie, Cliff Nangle, Archie Campbell, Robin Flaig, Sarah E. Harris, Rosie M. Walker, Liu Shi, Elliot M. Tucker-Drob, Christian Gieger, Annette Peters, Melanie Waldenberger, Johannes Graumann, Allan F. McRae, Ian J. Deary, David J. Porteous, Caroline Hayward, Peter M. Visscher, Simon R. Cox, Kathryn L. Evans, Andrew M. McIntosh, Karsten Suhre, Riccardo E. Marioni
Summary: This study explores the relationship between DNA methylation and incident diseases using epigenome-wide data. By training and testing epigenetic scores, the researchers identified scores that are associated with various diseases. These scores can serve as valuable resources for disease prediction and risk stratification.
Article
Biochemistry & Molecular Biology
Bradley A. Ruple, Joshua S. Godwin, Paulo H. C. Mesquita, Shelby C. Osburn, Christopher G. Vann, Donald A. Lamb, Casey L. Sexton, Darren G. Candow, Scott C. Forbes, Andrew D. Fruge, Andreas N. Kavazis, Kaelin C. Young, Robert A. Seaborne, Adam P. Sharples, Michael D. Roberts
Summary: Resistance training (RT) has been shown to impact the mitochondrial DNA (mtDNA) methylome in older males, leading to increased lean tissue mass, muscle thickness, and strength. The study observed reduced methylation and more youthful signatures in mtDNA sites of older males post-RT compared to younger males. These findings suggest that RT may enhance mitochondrial transcription levels and induce mitochondrial methylome profiles resembling those of younger men.
Article
Oncology
Ruth Pidsley, Dilys Lam, Wenjia Qu, Timothy J. Peters, Phuc-Loi Luu, Darren Korbie, Clare Stirzaker, Roger J. Daly, Phillip Stricker, James G. Kench, Lisa G. Horvath, Susan J. Clark
Summary: This study used methylome sequencing to investigate the DNA methylation patterns in prostate cancer patients, and identified methylation patterns associated with prostate cancer-specific mortality, as well as prognostic biomarkers. The combination of DNA methylation biomarkers and clinicopathological measures improved the prognostic models for prostate cancer mortality.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Yoon Cho, Mi-Kyung Song, Jae-Chun Ryu
Summary: This study identified dose-dependent methylated genes and anti-correlated target genes of DNA methylation and mRNA in lung tissue of F-344 rats exposed to hexanal. The results revealed potential pulmonary toxicological mechanisms of action of hexanal, involving processes such as neuroactive ligand-receptor interaction and protein kinase cascade. This suggests the potential use of DNA methylation-based epigenetic biomarkers for hexanal exposure.
Article
Genetics & Heredity
Man Li, Litao Bao, Ping Zhu, Shuxia Wang
Summary: This study investigated the impact of metformin on the epigenetic age in subjects with type 2 diabetes mellitus (DM). The results showed an association between metformin intake and slower epigenetic aging.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Olaia Martinez-Iglesias, Vinogran Naidoo, Natalia Cacabelos, Ramon Cacabelos
Summary: This study aimed to identify epigenetic biomarkers for neurodegenerative diseases by analyzing DNA methylation, SIRT activity, and gene expression. The findings suggest that these biomarkers, which showed reduced levels in patients, could be useful for diagnosis, surveillance, and prognosis of neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Jingjin Li, Xiaoping Zhang, Mengxi Yang, Hang Yang, Ning Xu, Xueqiang Fan, Gang Liu, Xintong Jiang, Jiasai Fan, Lifang Zhang, Hu Zhang, Ying Zhou, Rui Li, Si Gao, Jiangli Jin, Zening Jin, Jingang Zheng, Qiang Tu, Jingyi Ren
Summary: Through genome-wide analysis of DNA methylation, it was found that hypomethylation in vulnerable atherosclerotic plaques is associated with genes involved in inflammation, indicating a potential role in driving the progression and destabilization of atherosclerotic cardiovascular disease.
CLINICAL EPIGENETICS
(2021)
Article
Cell Biology
Sarah Voisin, Kirsten Seale, Macsue Jacques, Shanie Landen, Nicholas R. Harvey, Larisa M. Haupt, Lyn R. Griffiths, Kevin J. Ashton, Vernon G. Coffey, Jamie-Lee M. Thompson, Thomas M. Doering, Malene E. Lindholm, Colum Walsh, Gareth Davison, Rachelle Irwin, Catherine McBride, Ola Hansson, Olof Asplund, Aino E. Heikkinen, Paivi Piirila, Kirsi H. Pietilainen, Miina Ollikainen, Sara Blocquiaux, Martine Thomis, Coletta K. Dawn, Adam P. Sharples, Nir Eynon
Summary: Exercise training can prevent age-related decline in muscle function by targeting epigenetic aging. A meta-analysis of human skeletal muscle samples revealed that individuals with higher aerobic fitness have younger epigenetic and transcriptomic profiles. Exercise training can shift these profiles towards a younger state, while muscle disuse leads to aging of the transcriptome. This comprehensive analysis provides valuable insights for future studies on optimizing longevity through the combination of therapeutics and exercise regimes.
Article
Multidisciplinary Sciences
Xiaotong Wu, Hongmei Zhang, Bingjie Zhang, Yu Zhang, Qiuyan Wang, Weimin Shen, Xi Wu, Lijia Li, Weikun Xia, Ryohei Nakamura, Bofeng Liu, Feng Liu, Hiroyuki Takeda, Anming Meng, Wei Xie
Summary: The study examines the distinct epigenetic reprogramming modes in early development between mammals and nonmammals, highlighting the importance of global DNA hypermethylation inheritance and enhancer dememorization in protecting embryonic programs and ensuring gene expression.
Review
Biochemistry & Molecular Biology
Lucia Lopez-Gil, Amparo Pascual-Ahuir, Markus Proft
Summary: This scientific review highlights the central importance of genomic instability in the aging process and explores the cellular and molecular changes associated with aging, as well as the genetic and epigenetic alterations that contribute to genomic instability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Weilin Peng, Guangxu Tu, Zhenyu Zhao, Boxue He, Qidong Cai, Pengfei Zhang, Xiong Peng, Shuai Shi, Xiang Wang
Summary: This study identified a diagnostic model involving methylation of four genes for early diagnosis of EAC by analyzing DNA methylome and gene expression data from EAC tissues. The model was validated in other datasets and may have potential applications in prospective EAC cases.
Article
Oncology
Ching-Chung Chiang, Guan-Ling Lin, Shu-Yi Yang, Chi-Wen Tu, Wen-Long Huang, Chun-Feng Wei, Feng-Chi Wang, Pin-Ju Lin, Wan-Hong Huang, Yu-Ming Chuang, Yu-Ting Lee, Chia-Chou Yeh, Michael W. Y. Chan, Yu-Chen Hsu
Summary: Breast cancer is a common and deadly cancer in women. The methylation level of PCDHB15 promoter is higher in breast cancer samples compared to normal tissues. Lower PCDHB15 expression is associated with shorter relapse-free survival time. Detection of PCDHB15 methylation in cfDNA can serve as a minimally invasive biomarker for breast cancer diagnosis and prognosis.
Article
Multidisciplinary Sciences
Ganesan Arunkumar, Songjoon Baek, David Sturgill, Minh Bui, Yamini Dalal
Summary: This study reveals that transcription of oncogenic lncRNAs derived from 8q24 alters chromatin structure, leading to the deposition of CENP-A-associated complexes at fragile sites in human cancer cells, generating new epigenetic memory.
Review
Veterinary Sciences
Rose Whelan, Sina Toenges, Florian Boehl, Frank Lyko
Summary: Biomarkers for holistic animal welfare monitoring are urgently needed in veterinary medicine. Epigenetic modifications, like DNA methylation, have great potential for biomarker development as they provide valuable information about cellular states and environments. This review discusses animal DNA methylation patterns, the technologies for analyzing them, and key frameworks for developing compound DNA methylation biomarkers, DNA methylation clocks, and environment-specific DNA methylation signatures. Practical examples of applying these biomarkers for health and environmental exposure monitoring are also provided. This article provides an overview of the molecular and biological foundations for developing epigenetic biomarkers in veterinary science and their potential in animal welfare monitoring.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Vadim Fedyuk, Nir Erez, Noa Furth, Olga Beresh, Ekaterina Andreishcheva, Abhijeet Shinde, Daniel Jones, Barak Bar Zakai, Yael Mavor, Tamar Peretz, Ayala Hubert, Jonathan E. Cohen, Azzam Salah, Mark Temper, Albert Grinshpun, Myriam Maoz, Aviad Zick, Guy Ron, Efrat Shema
Summary: This study developed a single-molecule imaging technique that can accurately and sensitively detect colorectal cancer in cell-free nucleosomes. By analyzing the epigenetics, DNA methylation, and cancer-specific protein biomarkers of plasma-isolated nucleosomes, the system allows for high-resolution detection of histone modifications and provides quantitative data on plasma proteins. The analysis showed high accuracy and sensitivity in detecting cancer, even at early stages, and could determine the tissue origin of tumors.
NATURE BIOTECHNOLOGY
(2023)
