Article
Endocrinology & Metabolism
Suman Baral, Satyan Rajbhandari
Summary: Nepal, a developing country, is facing a major health challenge with a high prevalence of diabetes (8.5%) affecting around 2 million people. Limited resources pose barriers to providing affordable and convenient diabetes care or regular screening for complications. There is no reliable data on the incidence, prevalence, and complications of diabetic foot problems in Nepal.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Hongping Gong, Yan Ren, Zhenyi Li, Panpan Zha, Raju Bista, Yan Li, Dawei Chen, Yun Gao, Lihong Chen, Xingwu Ran, Chun Wang
Summary: This study analyzed the clinical characteristics of diabetic inpatients with foot ulcers and explored the risk factors for lower extremity amputation. The study found that diabetic patients with amputation were older, had longer duration of diabetes, poor glycemic control, malnutrition, peripheral arterial disease, and severe foot ulcers with infection. A history of prior amputation, foot gangrene, and low ankle brachial index were independent predictors of lower extremity amputation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, Research & Experimental
Yuxia Cheng, Ping Zu, Jie Zhao, Lintao Shi, Hongyan Shi, Mei Zhang, Aihong Wang
Summary: The study found that diabetes duration, callus, history of vascular intervention, and amputation were independent risk factors for recurrent DFUs in a cohort of Chinese patients with active DFU.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Denisa Tanasescu, Dan Sabau, Andrei Moisin, Claudia Gherman, Radu Fleaca, Ciprian Bacila, Calin Mohor, Ciprian Tanasescu
Summary: The prevalence of diabetes has increased dramatically in the past decade, particularly in developing countries. This study developed a risk score system for diabetic foot ulcer patients based on clinical and statistical data to assess the risk of amputation. Factors such as smoking, obesity, dyslipidemia, unbalanced diabetes, long duration of diabetes, hepatic steatosis, and co-existing heart diseases were found to aggravate diabetic foot injuries.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Endocrinology & Metabolism
Qingwei Lu, Jun Wang, Xiaolu Wei, Gang Wang, Yang Xu
Summary: Through logistic regression analysis, independent factors associated with major amputation included previous amputation history, smoking, coronary artery disease, ankle brachial index <0.4, Wagner 5, activated partial thromboplastin time, glycosylated hemoglobin A1c, hemoglobin, plasma albumin, and white blood cell count.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Endocrinology & Metabolism
Taavy A. Miller, James H. Campbell, Nick Bloom, Shane R. Wurdeman
Summary: This study examined the timing variations of lower-limb amputation (LLA) among diabetic foot ulcer (DFU) patients by race/ethnicity and sex, finding that Black/African Americans were more likely to have earlier LLA after DFU compared to non-Hispanic/Whites, and more men received earlier LLA than women.
Article
Dermatology
Xiaofeng Peng, Dengqun Gou, Lu Zhang, Hemei Wu, Yu Chen, Xing Shao, Li Li, Ming Tao
Summary: This study aimed to investigate the influencing factors of lower limb amputation in patients with diabetic foot ulcers. Retrospective data of patients with diabetic foot ulcers hospitalized in a tertiary general hospital in Guizhou Province from January 2019 to March 2022 were collected and analyzed. The results showed that decreased levels of HDL cholesterol were associated with a higher risk of lower limb amputation in patients with diabetic foot ulcers. The findings suggest that decreased HDL cholesterol levels can serve as an independent predictor of amputation in this patient population.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Medicine, General & Internal
Omer M. Abdelbagi, Imad R. Musa, Salim A. Altigani, Abdelrhaman Osman, Ishag Adam
Summary: This study revealed a high prevalence of diabetic foot among patients with diabetes in Nahr an Nil State, Sudan. Factors such as older age, type 2 diabetes, duration of diabetes, family history of diabetes, hypertension, and obesity were associated with diabetic foot.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Review
Chemistry, Multidisciplinary
Mayland Chang, Trung T. Nguyen
Summary: Diabetic foot ulcers (DFUs) are chronic wounds that affect 30% of diabetic patients, with dysregulation of the normal wound healing process. Infection in DFUs increases inflammation and delays wound healing. Selective inhibition of MMP-9 may be a promising strategy for treatment of DFUs.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Michael Fang, Jiaqi Hu, Yein Jeon, Kunihiro Matsushita, Elizabeth Selvin, Caitlin W. Hicks
Summary: Data on the long-term consequences of diabetic foot disease (DFD) are limited. This study examined the association between DFD and major clinical outcomes in patients with diabetes. The results showed that DFD was associated with cardiovascular disease, nontraumatic lower-extremity amputation, major fall, and death.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Dermatology
Yu-Yu Chou, Chin-Chun Hou, Chien-Wei Wu, Dun-Wei Huang, Sheng-Lin Tsai, Ting-Hsuan Liu, Lu-Ming Ding, Chun-Kai Chang, Kuang-Ling Ou, Yu-Lung Chiu, Yuan-Sheng Tzeng
Summary: This research aimed to determine risk factors predicting major amputation in diabetic patients with foot ulcers. Invasive ulcer depth and C-reactive protein levels were found to be significant predictors. The median time from hospitalisation to lower extremity amputation was approximately 35 days, with most at-risk patients falling within that timeline.
INTERNATIONAL WOUND JOURNAL
(2022)
Review
Endocrinology & Metabolism
Katherine McDermott, Michael Fang, Andrew J. M. Boulton, Elizabeth Selvin, Caitlin W. Hicks
Summary: Diabetic foot ulcers are a preventable cause of morbidity in adults with diabetes, leading to functional decline, infection, hospitalization, amputation, and death. The lifetime risk of foot ulcer is increasing and recurrent ulcers are common. Amputation and mortality rates are high and linked to poor diabetes management. Prevention and early detection through multidisciplinary care are crucial to reduce morbidity and disparities associated with diabetic foot ulcers.
Article
Medicine, General & Internal
Joon Myeong So, Ji Ho Park, Jin Gyeong Kim, Il Rae Park, Eun Yeong Ha, Seung Min Chung, Jun Sung Moon, Chul Hyun Park, Woo-Sung Yun, Tae-Gon Kim, Woong Kim, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee
Summary: The study assessed the risk factors for major amputation of diabetic foot ulcers (DFUs) in patients with diabetic kidney disease (DKD) stages 3b-5. The location and extension of DFU, as well as severe medial arterial calcification (MAC), were identified as independent risk factors for major amputation in patients with DFUs. The current use of antiplatelets was a possible protective factor for major amputations.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Dermatology
Huiling Zhang, Chuanwang Huang, Jie Bai, Jing Wang
Summary: A meta-analysis study found that male gender, smoking, previous foot ulcer, osteomyelitis, gangrene, hypertension, and white blood cell count were risk factors for lower extremity amputation in patients with diabetic foot ulcers. However, caution should be exercised when using these results due to the small sample sizes of several selected studies.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
Ka-Huen Yip, Yuk-Chiu Yip, Wai-King Tsui
Summary: This study explored the thoughts and experiences of patients with diabetic foot ulcers in Hong Kong regarding lower-limb amputation. It found that lower-limb amputation is considered a forbidden topic, making it culturally difficult for Chinese patients to discuss the matter with healthcare authorities and family members. Healthcare workers should be aware of how they communicate regarding lower-limb amputation.
INTERNATIONAL WOUND JOURNAL
(2023)