Article
Agronomy
L. Chet Loveland, Steve B. B. Orloff, Matt A. A. Yost, Mylen Bohle, Giuliano C. C. Galdi, Thomas Getts, Daniel H. H. Putnam, Corey V. V. Ransom, Deborah A. A. Samac, Rob Wilson, J. Earl Creech
Summary: Glyphosate-resistant alfalfa has been widely adopted in the US, but there is a potential for crop injury under specific environmental conditions. Research on best management practices suggests that spring applications of low glyphosate rates can reduce the risk of height and biomass yield reduction in alfalfa.
Article
Microbiology
Marjo Helander, Aditya Jeevannavar, Kimmo Kaakinen, Suni A. Mathew, Kari Saikkonen, Benjamin Fuchs, Pere Puigbo, Olli J. Loukola, Manu Tamminen
Summary: Pollinator decline is a serious issue, with the overuse of pesticides, particularly glyphosate, being a potential cause. This study found that glyphosate negatively affects the gut microbiota of bumblebees, reducing diversity and decreasing the abundance of sensitive bacterial species. These findings suggest that the heavy use of glyphosate-based herbicides may have implications for bees and ecosystems.
FEMS MICROBIOLOGY ECOLOGY
(2023)
Article
Environmental Sciences
Lisa Buchenauer, Kristin M. Junge, Sven-Bastiaan Haange, Jan C. Simon, Martin von Bergen, Anna-Lena Hoh, Gabriela Aust, Ana C. Zenclussen, Gabriele I. Stangl, Tobias Polte
Summary: Exposure to low-dose glyphosate in mothers has an immunosuppressive effect on their female offspring, which is not observed in the second generation. The altered microbiota composition might mediate this immune response modulation.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Agronomy
Rui Liu, Vipan Kumar, Amit Jhala, Prashant Jha, Phillip W. Stahlman
Summary: Various herbicide programs were evaluated for controlling glyphosate- and mesotrione-resistant Palmer amaranth in glyphosate- and glufosinate-resistant corn. Results showed that effective PRE fb EPOST herbicide programs can provide efficient control of resistant Palmer amaranth and increase corn grain yield and net economic return.
Article
Chemistry, Multidisciplinary
Jana Niedobova, Jana Ourednickova, Radek Michalko, Michal Skalsky
Summary: Glyphosate-based herbicides, commonly used worldwide, may have different effects on predatory activity of spiders, indicating the importance of considering formulation toxicity in pesticide evaluations.
ENVIRONMENTAL CHEMISTRY LETTERS
(2022)
Article
Environmental Sciences
Doris Klingelhofer, Markus Braun, Dorthe Bruggmann, David A. Groneberg
Summary: Glyphosate, the most widely used herbicide globally, has sparked controversy over its effects on human health and the environment. Research output has grown in line with consumption, with different countries showing varying levels of interest and investment in glyphosate studies. Market and agricultural interests drive research incentives, with the need to expand the international research network to include developing economies for a more comprehensive understanding of glyphosate use.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Plant Sciences
Renan Zampiroli, Joao Paulo Arantes Rodrigues da Cunha, Cleyton Batista de Alvarenga
Summary: This study evaluated the phytotoxic effects of the herbicide dicamba alone and mixed with glyphosate as a result of simulated drift in a coffee-producing area. Low doses of the herbicides caused leaf epinasty, changes in internodal distance, and branch curvature in coffee plants, but did not affect productivity and performance, only altering the physical classifications of the grains.
Article
Environmental Sciences
Harald Cederlund
Summary: Glyphosate and AMPA concentrations in groundwater near Swedish railways were generally low, with higher levels detected directly beneath the track. Limited horizontal spread was observed outside the track area, indicating minimal impact on groundwater quality in the surrounding environment. Higher concentrations detected in 2018 were possibly due to decreased degradation during an unusually hot and dry summer. Soil samples showed varied levels of glyphosate and AMPA, with some within expected ranges based on application doses and predicted half-lives. No accumulation of glyphosate in railway ballast was observed over time.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Fiorella Masotti, Betiana S. Garavaglia, Ainelen Piazza, Paula Burdisso, Silvia Altabe, Natalia Gottig, Jorgelina Ottado
Summary: Thirteen bacterial strains capable of degrading glyphosate were isolated from environmental samples in Argentine soybean crop areas, with Achromobacter, Agrobacterium, and Ochrobactrum showing the best degradation performance. The genome of the highly efficient GBH degrader Agrobacterium tumefaciens CHLDO was sequenced, revealing the presence of a phn cluster responsible for phosphonate metabolization. Expression analysis of the phn genes in A. tumefaciens CHLDO suggests their strong participation in GBH degradation, highlighting the potential for bioremediation techniques in glyphosate-contaminated environments.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Erick V. S. Motta, Nancy A. Moran
Summary: This study investigated the effects of herbicide on the gut microbiota and survival rates of the eastern bumble bee. The results showed that herbicide exposure had a temporary impact on the gut microbiota but did not cause long-lasting damage. It also suggested a potential negative effect on the survival rates of bumble bees at high concentrations.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Pharmacology & Pharmacy
Ambra Maddalon, Valentina Galbiati, Claudio Colosio, Stefan Mandic-Rajcevic, Emanuela Corsini
Summary: Glyphosate, the active ingredient of widely used herbicides, is being debated due to emerging studies indicating its potential hazard and toxicity on non-target organisms. While evidence suggests potential endocrine disruption by Glyphosate-based herbicides targeting sex and thyroid hormones, studies on immunotoxicity are limited but highlight possible harmful effects. Further research is needed to investigate the safety profile of Glyphosate-based herbicides and their potential impact on human exposure.
Review
Environmental Sciences
Germano A. B. Lanzarin, Luis M. Felix, Antonio Fontainhas-Fernandes, Sandra Mariza Monteiro, Carlos Venancio
Summary: A critical review was conducted to investigate the toxicity of glyphosate and glyphosate-based herbicides on zebrafish. The results showed that both substances can cause damage to zebrafish, compromising their survival, reproduction, and maintenance. These findings may be applicable to other fish species and aquatic ecosystems.
Article
Environmental Sciences
Jennifer Clapp
Summary: The growing use of chemical herbicides in modern industrial agriculture has significant environmental and health impacts on global agricultural systems, mainly due to the complex interplay among technological, market, and regulatory developments.
GLOBAL ENVIRONMENTAL CHANGE-HUMAN AND POLICY DIMENSIONS
(2021)
Article
Environmental Sciences
Nicoleta Suciu, Elisabetta Russo, Maura Calliera, Gian Piero Luciani, Marco Trevisan, Ettore Capri
Summary: Monitoring and modeling results indicate the high concentrations of glyphosate and its degradation product AMPA in groundwater in Italian vineyards, possibly due to agricultural practices and water source contamination. This study highlights the importance of groundwater monitoring and suggests strategies to mitigate contamination drivers.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
B. Strandberg, P. B. Sorensen, M. Bruus, R. Bossi, Y. L. Dupont, M. Link, C. F. Damgaard
Summary: The study investigated the impact of herbicide spray drift on non-target plant flowering, revealing that glyphosate deposition negatively affected flower numbers on certain plants but did not significantly affect flowering time. This suggests that pesticide use may have implications for pollinator populations.
ENVIRONMENTAL POLLUTION
(2021)
Article
Ophthalmology
Gabrielle D. Lacy, Maria Fernanda Abalem, Chris A. Andrews, Lilia T. Popova, Erin P. Santos, Gina Yu, Hanan Y. Rakine, Natasha Baig, Joshua R. Ehrlich, Abigail T. Fahim, Kari H. Branham, Joan A. Stelmack, Bonnielin K. Swenor, Gislin Dagnelie, David C. Musch, K. Thiran Jayasundera
Summary: A validated patient-reported outcome measure for inherited retinal degenerations was developed through qualitative and quantitative questionnaire development. The final 59-item questionnaire measures 7 unidimensional domains and shows stable test-retest variability. Known as the Michigan Retinal Degeneration Questionnaire, it can be used in clinical evaluation of patients with inherited retinal degenerations.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Gabrielle D. Lacy, Maria Fernanda Abalem, Chris A. Andrews, Rebhi Abuzaitoun, Lilia T. Popova, Erin P. Santos, Gina Yu, Hanan Y. Rakine, Natasha Baig, Joshua R. Ehrlich, Abigail T. Fahim, Kari H. Branham, Bonnielin K. Swenor, Paul R. Lichter, Gislin Dagnelie, Joan A. Stelmack, David C. Musch, K. Thiran Jayasundera
Summary: This study developed a patient-reported outcome measure for screening and monitoring vision-related anxiety in patients with inherited retinal degenerations. The questionnaire, initially consisting of 166 items, was validated and reduced to 14 items divided into two dimensions: rod function anxiety and cone function anxiety. The questionnaire showed high marginal reliability and exhibited convergence validity with symptoms of depression and anxiety.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Review
Ophthalmology
Tai Anh Vu, Eva K. Fenwick, Alfred T. L. Gan, Ryan E. K. Man, Benjamin K. J. Tan, Preeti Gupta, Kam Chun Ho, Carlos A. Reyes-Ortiz, Stella Trompet, Jacobijn Gussekloo, Joan M. O'Brien, Sigrid Mueller-Schotte, Tien Yin Wong, Yih Chung Tham, Ching-Yu Cheng, Allen T. C. Lee, Greta Rait, Bonnielin K. Swenor, Varshini Varadaraj, Willa D. Brenowitz, Felipe A. Medeiros, Virginie Nael, Kaavya Narasimhalu, Christopher L. H. Chen, Ecosse L. Lamoureux
Summary: The results of the systematic review and meta-analysis confirmed that individuals with visual impairment were more likely to have cognitive impairment, while those with cognitive impairment were more likely to have visual impairment. Factors such as age, sex, and follow-up duration partially explained the significant heterogeneity in the associations between visual impairment and cognitive impairment.
Article
Ophthalmology
Kanza Aziz, Bonnielin K. Swenor, Joseph K. Canner, Mandeep S. Singh
Summary: Stargardt disease (SD) is associated with significant direct healthcare costs, with the annual per-patient cost higher than that of sensory neural hearing loss (SHL) and age-related macular degeneration (AMD). Adjusted for age, sex, year of first service, and type of benefit plan, the annual payment for SD was found to be higher than SHL and AMD.
OPHTHALMIC EPIDEMIOLOGY
(2021)
Review
Ophthalmology
Lama Assi, Fatimah Chamseddine, Perla Ibrahim, Hadi Sabbagh, Lori Rosman, Nathan Congdon, Jennifer Evans, Jacqueline Ramke, Hannah Kuper, Matthew J. Burton, Joshua R. Ehrlich, Bonnielin K. Swenor
Summary: There is a significant association between vision impairment or eye diseases and reduced quality of life, and ophthalmic interventions have been shown to improve quality of life.
JAMA OPHTHALMOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Matthew J. Burton, Jacqueline Ramke, Ana Patricia Marques, Rupert R. A. Bourne, Nathan Congdon, Iain Jones, Brandon A. M. Ah Tong, Simon Arunga, Damodar Bachani, Covadonga Bascaran, Andrew Bastawrous, Karl Blanchet, Tasanee Braithwaite, John C. Buchan, John Cairns, Anasaini Cama, Margarida Chagunda, Chimgee Chuluunkhuu, Andrew Cooper, Jessica Crofts-Lawrence, William H. Dean, Alastair K. Denniston, Joshua R. Ehrlich, Paul M. Emerson, Jennifer R. Evans, Kevin D. Frick, David S. Friedman, Joao M. Furtado, Michael M. Gichangi, Stephen Gichuhi, Suzanne S. Gilbert, Reeta Gurung, Esmael Habtamu, Peter Holland, Jost B. Jonas, Pearse A. Keane, Lisa Keay, Rohit C. Khanna, Peng Tee Khaw, Hannah Kuper, Fatima Kyari, Van C. Lansingh, Islay Mactaggart, Milka M. Mafwiri, Wanjiku Mathenge, Ian McCormick, Priya Morjaria, Lizette Mowatt, Debbie Muirhead, Gudlavalleti V. S. Murthy, Nyawira Mwangi, Daksha B. Patel, Tunde Peto, Babar M. Qureshi, Solange R. Salomao, Virginia Sarah, Bernadetha R. Shilio, Anthony W. Solomon, Bonnielin K. Swenor, Hugh R. Taylor, Ningli Wang, Aubrey Webson, Sheila K. West, Tien Yin Wong, Richard Wormald, Sumrana Yasmin, Mayinuer Yusufu, Juan Carlos Silva, Serge Resnikoff, Thulasiraj Ravilla, Clare E. Gilbert, Allen Foster, Hannah B. Faal
LANCET GLOBAL HEALTH
(2021)
Review
Public, Environmental & Occupational Health
Joshua R. Ehrlich, Jacqueline Ramke, David Macleod, Helen Burn, Chan Ning Lee, Justine H. Zhang, William Waldock, Bonnielin K. Swenor, Iris Gordon, Nathan Congdon, Matthew Burton, Jennifer R. Evans
Summary: This study found an association between vision impairment and all-cause mortality, with an increase in mortality rate as vision impairment worsens.
LANCET GLOBAL HEALTH
(2021)
Article
Ophthalmology
Wesam S. Shalaby, Annamalai Odayappan, Rengaraj Venkatesh, Bonnielin K. Swenor, Pradeep Y. Ramulu, Alan L. Robin, Kavitha Srinivasan, Aakriti Garg Shukla
Summary: This study assessed perceptions and implications of COVID-19 infection among individuals with visually impairment and those with normal sight, revealing that visually impaired individuals are more concerned about their health, rely more on word of mouth for news, while individuals with normal sight focus more on frequent handwashing and have better awareness of telemedicine.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Geriatrics & Gerontology
Lama Assi, Joshua R. Ehrlich, Yunshu Zhou, Alison Huang, Judith Kasper, Frank R. Lin, Michael M. McKee, Nicholas S. Reed, Bonnielin K. Swenor, Jennifer A. Deal
Summary: The study revealed that dual sensory impairment in older adults is associated with functional limitations, and the combined effect of dual sensory impairment and dementia leads to even greater functional limitations.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Editorial Material
Ophthalmology
Jacqueline Ramke, Brandon A. M. Ah Tong, Judith Stern, Bonnielin K. Swenor, Hannah B. Faal, Matthew J. Burton
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2022)
Editorial Material
Ophthalmology
Jacqueline Ramke, Brandon A. M. Ah Tong, Bonnielin K. Swenor
JAMA OPHTHALMOLOGY
(2022)
Meeting Abstract
Ophthalmology
Varshini Varadaraj, Shang-En Chung, Orla Sheehan, David Roth, Oliver Schein, Karen Bandeen-Roche, Bonnielin Swenor
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Meeting Abstract
Ophthalmology
Lubaina Tayeb Arsiwala, Xinxing Guo, Richey A. Sharrett, Pradeep Y. Ramulu, Aleksandra Mihailovic, Bonnielin K. Swenor, Yanan Dong, Alison Abraham
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Meeting Abstract
Ophthalmology
Kanza Aziz, Joseph K. Canner, Tapan Patel, Bonnielin K. Swenor, Mandeep S. Singh
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Meeting Abstract
Ophthalmology
Niranjani Nagarajan, Varshini Varadaraj, Penny L. Rosenblum, Bonnielin K. Swenor
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Medicine, Legal
Fiona Sewell, Ian Ragan, Graham Horgan, David Andrew, Thomas Holmes, Irene Manou, Boris P. Mueller, Tim Rowan, Barbara G. Schmitt, Marco Corvaro
Summary: There are currently three test guidelines for acute oral toxicity studies, but the subjectivity of one guideline may be hindering its wider use. In order to address this, the NC3Rs and EPAA collaborated to analyze historical data and provide recommendations on the recognition of 'evident toxicity'.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2024)
Article
Medicine, Legal
Michael DeVito, Bas Bokkers, Majorie B. M. van Duursen, Karin van Ede, Mark Feeley, Elsa Antunes Fernandes Gaspar, Laurie Haws, Sean Kennedy, Richard E. Peterson, Ron Hoogenboom, Keiko Nohara, Kim Petersen, Cynthia Rider, Martin Rose, Stephen Safe, Dieter Schrenk, Matthew W. Wheeler, Daniele S. Wikoff, Bin Zhao, Martin van den Berg
Summary: In October 2022, the World Health Organization reevaluated the toxic equivalency factors (TEFs) for chlorinated dioxin-like compounds in a panel convened in Lisbon. This effort utilized an updated database, Bayesian dose response modeling, and meta-analysis to derive Best-Estimate TEFs. Applying these new TEFs may result in lower total toxic equivalents for dioxin-like chemicals.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2024)