Article
Medicine, Legal
Sean M. Hays, Christopher R. Kirman, Jennifer Flippin, Theresa Lopez
Summary: This article reviews health risk assessments and biomonitoring data for glyphosate, and derives Biomonitoring Equivalent (BE) values to interpret population biomonitoring data.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Medicine, Legal
Sean M. Hays, Christopher R. Kirman
Summary: This article summarizes the absorption and metabolism of DEET in the human body and evaluates the risk of DEET exposure. Measurement of DEET and its metabolite DBA in urine can be used to monitor the level of DEET exposure and provide guidance for public health officials and regulatory agencies in interpreting DEET biomonitoring data.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Environmental Sciences
Ernest-Louli Tewfik, Nolwenn Noisel, Marc-Andre Verner
Summary: This study aims to derive biomonitoring equivalents (BEs) for serum/plasma PFOA and compare them with national biomonitoring data from the US and Canada. The study found that the concentrations of the most recent non-cancer EGVs were higher in Canadian and US national surveys.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Sandra Perez, Catherine German-Labaume, Sebastien Mathiot, Sylvaine Goix, Philippe Chamaret
Summary: The study investigated the potential relationships between air pollution, socio-economy, and proven pathologies within an industrial area in Southern France, highlighting correlations between population exposure to air pollutants and some pathologies. Specific health effects were observed for different pollutants at different concentration levels, while the influence of socio-economic factors on diseases was also revealed. Additionally, a diffuse PCB pollution was observed in the study area which may potentially cause lung cancers.
ENVIRONMENTAL RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Tiina Santonen, Selma Mahiout, Paula Alvito, Petra Apel, Jos Bessems, Wieneke Bil, Teresa Borges, Stephan Bose-O'Reilly, Jurgen Buekers, Ana Isabel Canas Portilla, Argelia Castano Calvo, Mercedes de Alba Gonzalez, Noelia Dominguez-Morueco, Marta Esteban Lopez, Ingrid Falnoga, Antje Gerofke, Maria del Carmen Gonzalez Caballero, Milena Horvat, Pasi Huuskonen, Normunds Kadikis, Marike Kolossa-Gehring, Rosa Lange, Henriqueta Louro, Carla Martins, Matthieu Meslin, Lars Niemann, Susana Pedraza Diaz, Veronika Plichta, Simo P. Porras, Christophe Rousselle, Bernice Scholten, Maria Joao Silva, Zdenka Slejkovec, Janja Snoj Tratnik, Agnes Somen Joksic, Jose Tarazona, Maria Uhl, An Van Nieuwenhuyse, Susana Viegas, Anne Marie Vinggaard, Marjolijn Woutersen, Greet Schoeters
Summary: The European Human Biomonitoring Initiative, HBM4EU, aimed to provide examples and good practices for the effective use of human biomonitoring data in human health risk assessment.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Environmental Sciences
Catarina Ferreira, Sofia C. Duarte, Eduardo Costa, Andre M. P. T. Pereira, Liliana J. G. Silva, Anabela Almeida, Celeste Lino, Angelina Pena
Summary: Glyphosate was detected in 95.1% of urine samples from Portuguese children, with some children being exposed to higher concentrations. Glyphosate levels in children's urine were associated with factors such as age, residential proximity to agricultural areas, consumption of homeproduced foods, and parental herbicide application.
ENVIRONMENTAL RESEARCH
(2021)
Article
Environmental Sciences
Noelia Dominguez-Morueco, Susana Pedraza-Diaz, Maria del Carmen Gonzalez-Caballero, Marta Esteban-Lopez, Mercedes de Alba-Gonzalez, Andromachi Katsonouri, Tiina Santonen, Ana Canas-Portilla, Argelia Castano
Summary: A risk assessment was conducted to estimate the risk associated with methylmercury exposure of vulnerable European populations using Human Biomonitoring data. The assessment showed that in certain European regions, the risk of exposure to methylmercury for children/adolescents and women of childbearing age is close to or exceeds the exposure guidance values.
Article
Environmental Sciences
Sandra F. Fernandez, Olga Pardo, Clara Coscolla, Vicent Yusa, B. I. O. V. A. L. task force BIOVAL task force
Summary: The study evaluated the exposure of Spanish children to acrylamide (AA) and found that their intake levels were relatively high, with fried potato products and biscuits contributing to the higher levels of AA metabolites in urine. This suggests a potential health risk of AA exposure in children, highlighting the importance of close monitoring.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Anna Pouch, Agata Zaborska, Mikolaj Mazurkiewicz, Aleksandra Winogradow, Ksenia Pazdro
Summary: This study examined contamination levels of PCBs, HCB, and PAHs in Arctic fjords, and found that the concentrations of contaminants in seawater depend on the physicochemical properties of the compounds, local human activities, and occurrence of glacier meltwaters. While most seawater samples had harmless levels of HCB and PAHs, some suspended particulate matter samples showed toxic levels of these compounds.
MARINE POLLUTION BULLETIN
(2021)
Article
Environmental Sciences
Aldwin Ndhlovu, Lucienne R. D. Human, Janine B. Adams, Gavin M. Rishworth, Chijioke Olisah, Thomas G. Bornman
Summary: A focused diagnosis of ecosystem health was conducted in two South African estuaries (Kromme and Gamtoos) using four pollution indices to assess metal contaminant toxicity levels. The results showed high Cd levels and elevated concentrations of Mn and Fe in both estuaries. Although the results indicate low metal contamination, continuous monitoring is necessary to manage these estuarine systems that support a wide range of socio-economic and ecosystem services.
MARINE POLLUTION BULLETIN
(2023)
Article
Environmental Sciences
Larissa Souza Passos, Eryka Costa de Almeida, Alexandre Villela, Adilson Nunes Fernandes, Marcelo Manzi Marinho, Levy Carvalho Gomes, Ernani Pinto
Summary: This study assessed the pollution extent of a crucial public water supply reservoir in southeastern Brazil. The findings revealed high concentrations of cyanobacteria and cyanotoxins in the reservoir, posing a significant ecological risk to aquatic life. Additionally, the analysis showed that levels of metals, metalloids, and fecal bacteria were below the maximum permitted limit according to Brazilian legislation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Borja Peris-Camarasa, Olga Pardo, Sandra F. Fernandez, Pablo Dualde, Clara Coscolla
Summary: AA is a potentially carcinogenic chemical compound found in processed foods and tobacco smoke. It is primarily eliminated from the body through urine, and its metabolites serve as biomarkers for exposure. The study found that smoking and consumption of fried potato products, biscuits, and pastries were significant predictors of AA exposure.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Jiho Lee, JiWoo Kim, Yongho Shin, Eunyoung Park, Junghak Lee, Young-Soo Keum, Jeong-Han Kim
Summary: This study assessed the risk of agricultural workers to thiamethoxam during pesticide mixing/loading and hand-held sprayer application in vineyards. The results showed low levels of dermal and inhalation exposure to thiamethoxam, with a risk index much lower than 1. The validity of risk assessment using whole-body dosimetry (WBD) method was confirmed through the analysis of urinary metabolites.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Food Science & Technology
Ilker Ugulu, Pervaiz Akhter, Zafar Iqbal Khan, Mubeen Akhtar, Kafeel Ahmad
Summary: This study aimed to observe the effect of different organic fertilizers on metal accumulation in pepper plants, to determine soil pollution severity, and to examine the health risks associated with consuming peppers grown with organic fertilizers. Results showed that trace metal concentrations in both soil and pepper samples exceeded the acceptable health risk levels, especially for cadmium and lead.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Environmental Sciences
Cibele Aparecida Cesila, Marilia Cristina Oliveira Souza, Jonas Carneiro Cruz, Mariana Zuccherato Bocato, Andres Dobal Campiglia, Fernando Barbosa
Summary: Over the years, humans have been continuously exposed to Polycyclic aromatic hydrocarbons (PAHs), which are legacy pollutants ubiquitous in the environment and represent the main chemical pollutants in urban areas. Studies on the impacts of exposure to these chemicals have gained increasing prominence worldwide due to their potential toxicity profile. Human biomonitoring (HB) studies to evaluate the exposure of Brazilian pregnant women to PAHs revealed high levels of PAH metabolites in urine samples, indicating a potential health risk and a high probability of carcinogenic risk. This highlights the need for further research and health protection measures for the Brazilian population.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Lesa Aylward, Giulia Vilone, Christina Cowan-Ellsberry, Jon A. Arnot, John N. Westgate, Cian O'Mahony, Sean M. Hays
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2020)
Article
Public, Environmental & Occupational Health
L. M. L. Toms, J. Braunig, S. Vijayasarathy, S. Phillips, P. Hobson, L. L. Aylward, M. D. Kirk, J. F. Mueller
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2019)
Article
Environmental Sciences
Yan Li, Xianyu Wang, Leisa-Maree L. Toms, Chang He, Peter Hobson, Peter D. Sly, Lesa L. Aylward, Jochen F. Mueller
ENVIRONMENTAL RESEARCH
(2019)
Article
Public, Environmental & Occupational Health
Sarah Faure, Nolwenn Noisel, Kate Werry, Subramanian Karthikeyan, Lesa L. Aylward, Annie St-Amand
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2020)
Article
Environmental Sciences
Daniel S. Drage, Amy L. Heffernan, Thomas K. Cunningham, Lesa L. Aylward, Jochen F. Mueller, Thozhukat Sathyapalan, Stephen L. Atkin
ENVIRONMENTAL RESEARCH
(2019)
Article
Medicine, Legal
S. Ramoju, M. Andersen, D. Poddalgoda, A. Nong, N. Karyakina, N. Shilnikova, K. Krishnan, D. Krewski
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2020)
Article
Endocrinology & Metabolism
Harshal Deshmukh, Lesa L. Aylward, Martin Rose, Alwyn Fernandes, Peter Sedman, Natalie J. Thatcher, Stephen L. Atkin, Thozhukat Sathyapalan
CLINICAL ENDOCRINOLOGY
(2020)
Article
Medicine, Legal
S. Ramoju, M. E. Andersen, A. Nong, N. Karyakina, N. Shilnikova, K. Krishnan, D. Krewski
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2020)
Article
Medicine, Legal
Devika Poddalgoda, Sean M. Hays, Andy Nong
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2020)
Article
Environmental Sciences
Marc-Andre Verner, Hassan Salame, Conrad Housand, Linda S. Birnbaum, Maryse F. Bouchard, Jonathan Chevrier, Lesa L. Aylward, Daniel Q. Naiman, Judy S. LaKind
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Medicine, Legal
Honesty Tohon, Mathieu Valcke, Rocio Aranda-Rodriguez, Andy Nong, Sami Haddad
Summary: This study used a reverse dosimetry PBPK modeling approach to estimate toluene atmospheric exposure from urinary measurements of S-benzylmercapturic acid. Results showed that estimating toluene exposure based on spot measurements generated more variability and uncertainty compared to 24-h urine samples. Toluene levels estimated were well below Health Canada's maximum chronic air guidelines, suggesting low health risks.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Toxicology
Andrea Rowan-Carroll, Anthony Reardon, Karen Leingartner, Remi Gagne, Andrew Williams, Matthew J. Meier, Byron Kuo, Julie Bourdon-Lacombe, Ivy Moffat, Richard Carrier, Andy Nong, Luigi Lorusso, Stephen S. Ferguson, Ella Atlas, Carole Yauk
Summary: This study focused on four model PFAS and found that they may have common molecular targets and toxicities, with PFOS and PFDS being the most similar. The data from the study provide baseline toxicity levels for comparison with other known PFAS.
TOXICOLOGICAL SCIENCES
(2021)
Article
Medicine, Legal
Devika Poddalgoda, Sean M. Hays, Chris Kirman, Natasha Chander, Andy Nong
Summary: Aluminium is commonly found in consumer products, with food being the main source of exposure for the Canadian population. Monitoring aluminium concentration in blood and urine can help assess exposure levels. Derived biomonitoring equivalents for blood and urine can assist in health risk assessment and management.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Toxicology
Byron Kuo, Marc A. Beal, John W. Wills, Paul A. White, Francesco Marchetti, Andy Nong, Tara S. Barton-Maclaren, Keith Houck, Carole L. Yauk
Summary: Risk assessments are increasingly relying on in vitro assays for genotoxicity testing. This study evaluated 292 chemical datasets using the in vitro micronucleus test (MNvit) for hazard identification. The results identified 157 clastogenic chemicals, 25 negatives, and 110 inconclusive substances. In vitro to in vivo extrapolation (IVIVE) was used to convert concentrations into administered equivalent doses (AEDs), which were generally lower than points of departure (PODs) based on in vivo endpoints. Exposure estimates were utilized to calculate bioactivity exposure ratio (BER) values, identifying chemicals that may require additional testing.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Toxicology
Malek Jomaa, Guillaume Pelletier, Denis Dieme, Jonathan Cote, Hamadi Fetoui, Andy Nong, Michele Bouchard
Summary: We conducted a study on rats to assess the effects of dose and co-exposure with other rare earth elements (REEs) on the toxicokinetics of praseodymium (Pr) and cerium (Ce). The study showed that dose and mixture exposure are important factors determining the toxicokinetics of REEs.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Medicine, Legal
Fiona Sewell, Ian Ragan, Graham Horgan, David Andrew, Thomas Holmes, Irene Manou, Boris P. Mueller, Tim Rowan, Barbara G. Schmitt, Marco Corvaro
Summary: There are currently three test guidelines for acute oral toxicity studies, but the subjectivity of one guideline may be hindering its wider use. In order to address this, the NC3Rs and EPAA collaborated to analyze historical data and provide recommendations on the recognition of 'evident toxicity'.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2024)
Article
Medicine, Legal
Michael DeVito, Bas Bokkers, Majorie B. M. van Duursen, Karin van Ede, Mark Feeley, Elsa Antunes Fernandes Gaspar, Laurie Haws, Sean Kennedy, Richard E. Peterson, Ron Hoogenboom, Keiko Nohara, Kim Petersen, Cynthia Rider, Martin Rose, Stephen Safe, Dieter Schrenk, Matthew W. Wheeler, Daniele S. Wikoff, Bin Zhao, Martin van den Berg
Summary: In October 2022, the World Health Organization reevaluated the toxic equivalency factors (TEFs) for chlorinated dioxin-like compounds in a panel convened in Lisbon. This effort utilized an updated database, Bayesian dose response modeling, and meta-analysis to derive Best-Estimate TEFs. Applying these new TEFs may result in lower total toxic equivalents for dioxin-like chemicals.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2024)