Article
Environmental Sciences
Matthieu Meslin, Claire Beausoleil, Florence Anna Zeman, Jean-Philippe Antignac, Marike Kolossa-Gehring, Christophe Rousselle, Petra Apel
Summary: This paper presents the derivation of Human Biomonitoring Guidance Values (HBM-GVs) for bisphenol S (BPS) for the general population and workers within the European Joint Programme HBM4EU. The study illustrates the usefulness for risk assessment of the HBM-GVs derived for BPS and bisphenol A (BPA) and highlights the difference in risk assessments between the two bisphenols. Results indicate that the risk from occupational exposure to both bisphenols cannot be disregarded.
Article
Medicine, Legal
Sean M. Hays, Christopher R. Kirman, Jennifer Flippin, Theresa Lopez
Summary: This article reviews health risk assessments and biomonitoring data for glyphosate, and derives Biomonitoring Equivalent (BE) values to interpret population biomonitoring data.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Environmental Sciences
Eva Ougier, Florence Zeman, Jean-Philippe Antignac, Christophe Rousselle, Rosa Lange, Marike Kolossa-Gehring, Petra Apel
Summary: The European Human Biomonitoring Initiative (HBM4EU) establishes human biomonitoring guidance values (HBM-GVs) for substances such as BPA, using total BPA in urine as the primary exposure biomarker for BPA. Different HBM-GV(GenPop) values were developed for adults and children based on toxicological data, aiming to reflect a steady-state exposure to the temporary Tolerable Daily Intake (t-TDI) set by the European Food Safety Authority (EFSA).
ENVIRONMENT INTERNATIONAL
(2021)
Article
Public, Environmental & Occupational Health
P. Apel, F. Lamkarkach, R. Lange, F. Sissoko, M. David, C. Rousselle, G. Schoeters, M. Kolossa-Gehring
Summary: The European Initiative HBM4EU aims to establish human biomonitoring as an important tool for determining population exposure to chemicals and giving policy advice. Harmonization and quality assurance of analytical methods, survey design, and evaluation of data are crucial. Health-based human biomonitoring guidance values (HBM-GVs) were developed for various exposure biomarkers, including DINCH, phthalates, bisphenols, pyrethroids, solvents, heavy metal cadmium, and mycotoxin deoxynivalenol (DON).
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Rosa Lange, Petra Apel, Christophe Rousselle, Sandrine Charles, Fatoumata Sissoko, Marike Kolossa-Gehring, Eva Ougier
Summary: The widespread internal exposure of the European population to plasticizers has sparked the urgent need for toxicological interpretation. The European Human Biomonitoring Initiative (HBM4EU) has significantly contributed to understanding actual exposure levels and their impact on health. Human biomonitoring guidance values (HBM-GVs) have been derived for various phthalates and a non-phthalate substitute, aiding in health risk assessment.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2021)
Article
Environmental Sciences
Farida Lamkarkach, Eva Ougier, Robert Garnier, Claude Viau, Marike Kolossa-Gehring, Rosa Lange, Petra Apel
Summary: This study used the methodology agreed upon within the HBM4EU project to derive HBMGVs for the general population and workers exposed to cadmium. Renal effects were selected as the critical effect for both groups based on epidemiological studies, with different key studies chosen for the general population and workers. Results recommended specific HBM-GVs for U-Cd levels in different age groups, with additional recommendations for B-Cd levels for workers.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Farida Lamkarkach, Matthieu Meslin, Marike Kolossa-Gehring, Petra Apel, Robert Garnier
Summary: The methodology to derive human biomonitoring guidance values for dimethylformamide (DMF) within the HBM4EU project was applied in this study. Hepatotoxicity of DMF was found to be the most sensitive effect, with liver enzyme concentrations serving as biomarkers. The biomarkers tNMF and AMCC in urine were selected for biological monitoring of workers exposed to DMF, with different half-lives complementing each other. Medium-high confidence levels were set for tNMF, while further investigations are needed for the consolidation of health-based HBM-GV for AMCC in urine.
Article
Medicine, Legal
Sean M. Hays, Christopher R. Kirman
Summary: This article summarizes the absorption and metabolism of DEET in the human body and evaluates the risk of DEET exposure. Measurement of DEET and its metabolite DBA in urine can be used to monitor the level of DEET exposure and provide guidance for public health officials and regulatory agencies in interpreting DEET biomonitoring data.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Environmental Sciences
Catarina Ferreira, Sofia C. Duarte, Eduardo Costa, Andre M. P. T. Pereira, Liliana J. G. Silva, Anabela Almeida, Celeste Lino, Angelina Pena
Summary: Glyphosate was detected in 95.1% of urine samples from Portuguese children, with some children being exposed to higher concentrations. Glyphosate levels in children's urine were associated with factors such as age, residential proximity to agricultural areas, consumption of homeproduced foods, and parental herbicide application.
ENVIRONMENTAL RESEARCH
(2021)
Article
Environmental Sciences
Ernest-Louli Tewfik, Nolwenn Noisel, Marc-Andre Verner
Summary: This study aims to derive biomonitoring equivalents (BEs) for serum/plasma PFOA and compare them with national biomonitoring data from the US and Canada. The study found that the concentrations of the most recent non-cancer EGVs were higher in Canadian and US national surveys.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Borja Peris-Camarasa, Olga Pardo, Sandra F. Fernandez, Pablo Dualde, Clara Coscolla
Summary: AA is a potentially carcinogenic chemical compound found in processed foods and tobacco smoke. It is primarily eliminated from the body through urine, and its metabolites serve as biomarkers for exposure. The study found that smoking and consumption of fried potato products, biscuits, and pastries were significant predictors of AA exposure.
ENVIRONMENTAL POLLUTION
(2023)
Article
Agriculture, Multidisciplinary
Dawei Chen, Jingguang Li, Yunfeng Zhao, Yongning Wu
Summary: This article summarizes potential human exposures to Fipronil and results of human biomonitoring studies, emphasizing the importance of such studies for assessing Fipronil exposure and human health risks.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Engineering, Environmental
Xianyu Wang, Elvis D. Okoffo, Andrew P. W. Banks, Yan Li, Kevin Thomas, Cassandra Rauert, Lesa L. Aylward, Jochen F. Mueller
Summary: This study evaluated the composition of single-use face mask materials, quantified the concentration of phthalate esters in masks, and found that the inhalation exposure risk of phthalate esters from wearing masks is minimal. The study showed that the intake of individual compounds from masks was significantly lower than tolerable daily intake values, and urine samples collected before and after mask wearing did not show a significant increase in phthalate metabolites, indicating minimal contribution to overall exposure.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Environmental Sciences
Shuixin Yu, Li Kong, Lvfen Gu, Yitian Zhu, Xinji Liu, Yanru Sang, Qunan Wang, Sufang Wang, Dongmei Zhang, Hongjuan Cao, Fangbiao Tao, Kaiyong Liu
Summary: Studies found a connection between antibiotic exposure in urine and dysglycemia risk in the elderly, with sulfaclozine, sulfonamides, and veterinary antibiotics showing increased risk. Additionally, exposure to bacteriostatic antibiotics was associated with a higher dysglycemia risk in females.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Ana Maria Tavares, Susana Viegas, Henriqueta Louro, Thomas Goeen, Tiina Santonen, Mirjam Luijten, Andreas Kortenkamp, Maria Joao Silva
Summary: This study conducted a mixture risk assessment (MRA) based on human biomonitoring (HBM) data in Europe to evaluate the co-exposure of hexavalent chromium, nickel, and polycyclic aromatic hydrocarbons. The results indicate that there is concern regarding the occupational health risk of co-exposure to these substances, particularly in welding activities and waste incineration settings. It highlights the importance of considering exposure to the mixture rather than the individual components to manage workplace risk and protect workers' health.
Article
Toxicology
A. Robert Schnatter, Martijn Rooseboom, Neslihan Aygun Kocabas, Colin M. North, Abigail Dalzell, Johannes Twisk, Frank Faulhammer, Erik Rushton, Peter J. Boogaard, Viktorija Ostapenkaite, Stephen D. Williams
TOXICOLOGY LETTERS
(2020)
Article
Health Care Sciences & Services
Jan L. Brozek, Carlos Canelo-Aybar, Elie A. Akl, James M. Bowen, John Bucher, Weihsueh A. Chiu, Mark Cronin, Benjamin Djulbegovic, Maicon Falavigna, Gordon H. Guyatt, Ami A. Gordon, Michele Hilton Boon, Raymond C. W. Hutubessy, Manuela A. Joore, Vittal Katikireddi, Judy LaKind, Miranda Langendam, Veena Manja, Kristen Magnuson, Alexander G. Mathioudakis, Joerg Meerpohl, Dominik Mertz, Roman Mezencev, Rebecca Morgan, Gian Paolo Morgano, Reem Mustafa, Martin O'Flaherty, Grace Patlewicz, John J. Riva, Margarita Posso, Andrew Rooney, Paul M. Schlosser, Lisa Schwartz, Ian Shemilt, Jean-Eric Tarride, Kristina A. Thayer, Katya Tsaioun, Luke Vale, John Wambaugh, Jessica Wignall, Ashley Williams, Feng Xie, Yuan Zhang, Holger J. Schunemann
Summary: This study presents a conceptual approach for evaluating the certainty of evidence from modeling studies using the GRADE method. The results indicate that the domains determining the certainty of evidence also apply to assessing evidence from models. A framework for selecting the best evidence from models and a summary of preferred terminology are proposed to facilitate communication between modeling and health care disciplines.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2021)
Article
Reproductive Biology
Peter J. Boogaard, Jochen Buschmann, Rainer Fuhst, Katharina Bluemlein, Wolfgang Koch, Dirk Schaudien, Katharina Schwarz, Christine McAlinden, Lize Deferme, Mathieu Vaissiere, Hans B. Ketelslegers, Anna Steneholm
Summary: Rats exposed to fumes of oxidised asphalt did not show prenatal developmental toxicity, however, high-dose exposure resulted in effects on maternal body weight gain, food consumption, lung weights, and histopathological changes in lungs and the upper respiratory tract.
REPRODUCTIVE TOXICOLOGY
(2021)
Article
Medicine, Legal
Yu-Mei Tan, Hugh A. Barton, Alan Boobis, Rachel Brunner, Harvey Clewell, Rhian Cope, Jeffrey Dawson, Jeanne Domoradzki, Peter Egeghy, Pankaj Gulati, Brandall Ingle, Nicole Kleinstreuer, Kelly Lowe, Anna Lowit, Elizabeth Mendez, David Miller, Jeffrey Minucci, James Nguyen, Alicia Paini, Monique Perron, Katherine Phillips, Hua Qian, Tharacad Ramanarayanan, Fiona Sewell, Philip Villanueva, John Wambaugh, Michelle Embry
Summary: In repeated dose animal studies, there are various methods for dose selection, including identification of apical endpoints, use of the limit dose, and determination of a maximum tolerated dose. An alternative approach, the kinetically derived maximum dose, integrates toxicokinetic data into the dose selection process as a mechanism.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Environmental Sciences
Judy S. LaKind, Marc-Andre Verner, Rachel D. Rogers, Helen Goeden, Daniel Q. Naiman, Satori A. Marchitti, Geniece M. Lehmann, Erin P. Hines, Suzanne E. Fenton
Summary: Despite 20 years of biomonitoring studies of PFAS in serum and urine, there is limited understanding of PFAS concentrations in breast milk of women from the United States and Canada. More research is needed to evaluate the potential impact on infant and family health.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2022)
Review
Environmental Sciences
Carol J. Burns, Judy S. LaKind
Summary: This study reviewed the epidemiology literature on pyrethroid insecticides and evaluated the methodological elements for their relevance in risk assessment and decision-making. The results showed that only a small portion of the studies met the requirements for risk assessment, indicating the opportunity for future research to incorporate more translational approaches.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Biochemistry & Molecular Biology
Monica Nordberg, Gunnar F. Nordberg
Summary: This review summarizes the adverse effects of cadmium on human and animal health and emphasizes the importance of preventive measures. It specifically focuses on the role of metallothionein (MT) in cadmium toxicology and highlights the binding of cadmium to MT and the importance of the Cd/Zn ratio in kidney toxicity. The review calls for the application of these findings in risk assessment and preventive measures against cadmium exposures.
Article
Environmental Sciences
Carol J. Burns, Judy S. LaKind, Josh Naiman, Denali Boon, Jane E. Clougherty, Ana M. Rule, Angelika Zidek
Summary: The COVID-19 pandemic has highlighted the need for research on factors that can reduce health risks, especially modifiable factors. Numerous studies have been conducted on the complex relationships between SARS-CoV2 transmission, air pollution, and human health, but they are limited by available data. This project aimed to gather input on improving and funding exposure research on the confluence of air pollution and infectious agents. Experts from various fields provided valuable insights, emphasizing the importance of common definitions, source-specific research, and improved study design. Further discussions are needed to advance our understanding and prepare for future pandemics.
ENVIRONMENTAL RESEARCH
(2022)
Review
Environmental Sciences
Judy S. LaKind, Josh Naiman, Marc-Andre Verner, Laura Leveque, Suzanne Fenton
Summary: This study compares global breast milk and infant formula PFAS measurements with children's drinking water screening values. It finds that concentrations of PFOA and PFOS in breast milk often exceed these values, regardless of geographic location. This highlights the importance of providing pregnant and lactating women, especially those from PFAS-contaminated communities, with the necessary data to make informed decisions on infant nutrition.
ENVIRONMENTAL RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Shoji F. Nakayama, Annie St-Amand, Tyler Pollock, Petra Apel, Yu Ait Bamai, Dana Boyd Barr, Jos Bessems, Antonia M. Calafat, Argelia Castano, Adrian Covaci, Radu Corneliu Duca, Sarah Faure, Karen S. Galea, Sean Hays, Nancy B. Hopf, Yuki Ito, Maryam Zare Jeddi, Marike Kolossa-Gehring, Eva Kumar, Judy S. LaKind, Marta Esteban Lopez, Henriqueta Louro, Kristin Macey, Konstantinos C. Makris, Lisa Melnyk, Aline Murawski, Josh Naiman, Julianne Nassif, Nolwenn Noisel, Devika Poddalgoda, Lesliam Quiros-Alcala, Ata Rafiee, Loic Rambaud, Maria Joao Silva, Jun Ueyama, Marc-Andre Verner, Maisarah Nasution Waras, Kate Werry
Summary: Human biomonitoring (HBM) data can be used to compare population exposures, but finding the relevant health-based biomonitoring guidance values can be time-consuming. To address this issue, an online repository called the Human Biomonitoring Health-Based Guidance Value (HB2GV) Dashboard has been created. This database provides a centralized location for researchers and decision makers to access and interpret HBM data.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Environmental Sciences
Amanda M. Wilson, Irene Mussio, Susan Chilton, Lynn B. Gerald, Rachael M. Jones, Frank A. Drews, Judy S. LaKind, Paloma I. Beamer
Summary: Using an online survey, this study examined nurses' risk preferences and found that most nurses were willing to increase infection risk to maintain baseline occupational asthma (OA) risk, but not willing to accept a larger risk of death to avoid doubling their OA risk. Age, work experience, and previous experience with respiratory viral infections influenced the nurses' choices.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Editorial Material
Environmental Sciences
Judy S. LaKind
Summary: The study by Yao et al. provides valuable insights into infant exposures to per- and polyfluoroalkyl substances (PFAS). They emphasize the importance of establishing a national baseline of PFAS exposure in human milk and assessing the risks of PFAS exposure in exclusively breastfed infants. Despite the existence of national programs for assessing human exposures to environmental chemicals, efforts focused on breast milk monitoring are lacking.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2023)
Review
Toxicology
Peter J. Boogaard
Summary: Benzene is a toxic substance that can cause acute and chronic health effects, including blood disorders and leukemia. Occupational exposure limits (OELs) have been continuously lowered to protect workers from benzene-induced cancer. Human biomonitoring using various potential biomarkers in urine and blood samples is commonly used to assess exposure to benzene.
CRITICAL REVIEWS IN TOXICOLOGY
(2022)
Review
Toxicology
Carol J. Burns, Judy S. LaKind
Summary: The study highlights the importance of the Matrix in facilitating discussions between risk assessment and epidemiology, providing insights on the elements of risk assessment that need to be considered in epidemiology research. Recommendations for improving study design and translation of results are proposed to bridge the gap between epidemiology and risk assessment.
CRITICAL REVIEWS IN TOXICOLOGY
(2021)
Review
Toxicology
Judy S. LaKind, Carol J. Burns, Lynn H. Pottenger, Daniel Q. Naiman, Julie E. Goodman, Satori A. Marchitti
Summary: The study applied a transparent approach to systematically review the evidence on ozone inhalation exposure and adverse metabolic effects. The evidence for the health outcomes assessed was generally weak, with some indications lacking or suggestive details, but overall lacking strong evidence support.
CRITICAL REVIEWS IN TOXICOLOGY
(2021)
Article
Medicine, Legal
Fiona Sewell, Ian Ragan, Graham Horgan, David Andrew, Thomas Holmes, Irene Manou, Boris P. Mueller, Tim Rowan, Barbara G. Schmitt, Marco Corvaro
Summary: There are currently three test guidelines for acute oral toxicity studies, but the subjectivity of one guideline may be hindering its wider use. In order to address this, the NC3Rs and EPAA collaborated to analyze historical data and provide recommendations on the recognition of 'evident toxicity'.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2024)
Article
Medicine, Legal
Michael DeVito, Bas Bokkers, Majorie B. M. van Duursen, Karin van Ede, Mark Feeley, Elsa Antunes Fernandes Gaspar, Laurie Haws, Sean Kennedy, Richard E. Peterson, Ron Hoogenboom, Keiko Nohara, Kim Petersen, Cynthia Rider, Martin Rose, Stephen Safe, Dieter Schrenk, Matthew W. Wheeler, Daniele S. Wikoff, Bin Zhao, Martin van den Berg
Summary: In October 2022, the World Health Organization reevaluated the toxic equivalency factors (TEFs) for chlorinated dioxin-like compounds in a panel convened in Lisbon. This effort utilized an updated database, Bayesian dose response modeling, and meta-analysis to derive Best-Estimate TEFs. Applying these new TEFs may result in lower total toxic equivalents for dioxin-like chemicals.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2024)