Article
Multidisciplinary Sciences
Asuka Hirooka, Mayuko Hamada, Daiki Fujiyama, Keiko Takanami, Yasuhisa Kobayashi, Takumi Oti, Yukitoshi Katayama, Tatsuya Sakamoto, Hirotaka Sakamoto
Summary: The research investigates the evolutionary history of "Bombesin" and related peptides in vertebrates. Through gene expression and immunohistochemistry experiments, it is found that these peptides and their receptors are distributed in the brain and stomach of clawed frogs, evolving from ancestors to play multiple roles in the brain and gut.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Hyun-Joo Park, Mi-Kyoung Kim, Yeon Kim, Hyung Joon Kim, Soo-Kyung Bae, Moon-Kyoung Bae
Summary: The study found that in phosphate-induced vascular smooth muscle cell calcification, the expression of neuromedin B and NMB receptor is upregulated, suggesting the potential therapeutic value of the NMB-NMB receptor axis.
Article
Food Science & Technology
Jingyuan Xiong, Ye Tian, Guochen Ma, Xiaoyu Wang, Shufang Shan, Guo Cheng
Summary: The timing of puberty is crucial for adult well-being and can be influenced by factors such as environment, lifestyle, and diet. This study investigates the effects of genistein, a soy isoflavone, at different developmental stages on reproductive development and neuroendocrine regulations in female rats. The results show that genistein exposure during the lactational stage significantly accelerates vaginal opening time and affects the secretion of neuroendocrine factors. However, exposures during neonatal and post-weaning stages do not have significant effects.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Sakura Tanaka, Nilli Zmora, Berta Levavi-Sivan, Yonathan Zohar
Summary: GnRH3 neurons play a crucial role in the reproduction of zebrafish females, independent of GnRH3 peptides. The number of GnRH3 neurons does not directly affect reproductive performance, suggesting that GnRH and its neurons may be dispensable for ovulation in zebrafish.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Haruhiko Kanasaki, Tuvshintugs Tumurbaatar, Zolzaya Tumurgan, Aki Oride, Hiroe Okada, Satoru Kyo
Summary: Kisspeptin and GnRH play roles in regulating gene expression of Kiss-1 and GnRH in hypothalamic cells, leading to an increase in c-Fos protein expression.
REPRODUCTIVE SCIENCES
(2021)
Article
Obstetrics & Gynecology
Andrea Sansone, Maria Schubert, Frank Tuettelmann, Claudia Krallmann, Michael Zitzmann, Sabine Kliesch, Joerg Gromoll
Summary: The FSHB-211 G > T polymorphism affects pituitary response to exogenous GnRH stimulation by reducing FSH and increasing LH outputs. TT carriers displayed significantly higher peak levels of LH compared to GT and GG carriers, with no significant difference in stimulated FSH levels.
HUMAN REPRODUCTION
(2021)
Review
Endocrinology & Metabolism
Miklos Koppan, Zsuzsanna Nagy, Inez Bosnyak, Dora Reglodi
Summary: Pituitary adenylate cyclase activating polypeptide (PACAP) plays important roles in female reproduction, including regulating gonadal hormone production, influencing follicular development, participating in fertilization and embryonic/placental development, affecting hormonal changes during and after birth, and influencing maternal behavior. Increasing evidence suggests similar effects of PACAP in humans.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Amnon Zung, Aviad Nachmany, Ella Burundukov, Tamar Glaser, Sharon Straussman
Summary: FVU-LH testing shows good diagnostic value in distinguishing progressive from nonprogressive puberty, and may serve as a screening method for girls with suspected progressive puberty, reducing the need for GnRH stimulation test.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Shan Liu, Minghui Liu, Lingxiu Li, Huanhuan Li, Danni Qu, Haiying Ren, Hui Su, Yang Zhang, Yuan Li
Summary: A retrospective cohort study on 110 patients with deep ovarian suppression found that a modified GnRH antagonist protocol based on LH levels during the second ovarian stimulation cycle resulted in significantly better reproductive outcomes compared to continuing with GnRH agonist long protocol. The use of modified protocol led to higher ongoing pregnancy and live birth rates, and lower cancellation rate, suggesting that patients may benefit from adjusting their treatment based on LH levels.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Pavlos Fanis, Vassos Neocleous, Irene Papapetrou, Leonidas A. Phylactou, Nicos Skordis
Summary: Human sexual and reproductive development are controlled by the hypothalamic-pituitary-gonadal (HPG) axis, mainly regulated by gonadotropin-releasing hormone (GnRH) and its receptor (GnRHR). Mutations in GnRHR are associated with reproductive disorders. Understanding the genomic and protein structure of GnRHR is crucial for assessing the impact of mutations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Terry W. Moody, Lingaku Lee, Irene Ramos-Alvarez, Tatiana Iordanskaia, Samuel A. Mantey, Robert T. Jensen
Summary: GPCRs are potential therapeutic targets in cancer treatment, especially in CNS/neural tumors. The activation of GPCRs on tumors can stimulate growth effects, making them promising targets for targeted therapy. More effective treatments are needed for CNS/neural tumors like gliomas, neuroblastomas, and medulloblastomas.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Reproductive Biology
Ashley N. Lindo, Jennifer F. Thorson, Michelle N. Bedenbaugh, Richard B. McCosh, Justin A. Lopez, Samantha A. Young, Lanny J. Meadows, Elizabeth C. Bowdridge, Chrysanthi Fergani, Bradley A. Freking, Michael N. Lehman, Stanley M. Hileman, Clay A. Lents
Summary: In pigs, Kisspeptin and NKB neurons are mainly located in the arcuate nucleus, while NK3R cells are distributed in the preoptic area and other hypothalamic regions but not in the arcuate nucleus. Treatment with altrenogest decreases LH secretion without affecting the expression of Kisspeptin and NKB.
BIOLOGY OF REPRODUCTION
(2021)
Review
Endocrinology & Metabolism
Xiaoqun Qin, Xiangping Qu
Summary: This review aims to update important findings about molecular and cellular biology of mammalian bombesin-like peptides (BLPs) and their receptors. Recent studies have provided new insights into the physiological functions of gastrin-releasing peptide (GRP), neuromedin B (NMB), and bombesin in synaptic communication, immune responses, and cancer signaling pathways. Exciting discoveries in the past year have focused on the roles of BLPs and their receptors in the central nervous system, with ongoing research investigating their functions in peripheral tissues and developing new synthetic ligands with high affinity for mammalian bombesin receptors.
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY
(2021)
Article
Endocrinology & Metabolism
Sakura Tanaka, Nilli Zmora, Berta Levavi-Sivan, Yonathan Zohar
Summary: The study found that VipA can both inhibit and induce LH secretion in zebrafish, suggesting the possibility of redundant pathways for LH release. The administration of VipA increased plasma LH levels, indicating that VipA may induce LH release through interaction with non-GnRH factors. These findings provide new insights into the regulation of LH secretion in zebrafish.
Article
Reproductive Biology
Mohammed Saleh, Wolfgang Holtz
Summary: The study aimed to compare the effectiveness of GnRH agonist and hCG as ovulation inducing agents for timed artificial insemination in synchronized superovulated goats. The results showed that both treatments had no significant impact on estrus and ovulation response, but the GnRH analog demonstrated better effects. Additionally, the yield of transferable embryos obtained by non-surgical collection was relatively low.
Article
Urology & Nephrology
Murat Gul, Emre Altintas, Mehmet Serkan Ozkent, Annette Fenner, Ege Can Serefoglu
Summary: The study investigated changes in depicted penis size in nude male paintings from the 15th to 21st centuries. Penile size gradually increased over the centuries, with paintings from the 21st century showing significantly higher penis depiction ratios than earlier centuries. This observation highlights evolving sociocultural influences on male body image and the importance of understanding factors related to the perception of penis size in men.
Review
Endocrinology & Metabolism
Moshe Phillip, Revital Nimri, Richard M. Bergenstal, Katharine Barnard-Kelly, Thomas Danne, Roman Hovorka, Boris P. Kovatchev, Laurel H. Messer, Christopher G. Parkin, Louise Ambler-Osborn, Stephanie A. Amiel, Lia Bally, Roy W. Beck, Sarah Biester, Torben Biester, Julia E. Blanchette, Emanuele Bosi, Charlotte K. Boughton, Marc D. Breton, Sue A. Brown, Bruce A. Buckingham, Albert Cai, Anders L. Carlson, Jessica R. Castle, Pratik Choudhary, Kelly L. Close, Claudio Cobelli, Amy B. Criego, Elizabeth Davis, Carine de Beaufort, Martin de Bock, Daniel J. DeSalvo, J. Hans DeVries, Klemen Dovc, Francis J. Doyle, Laya Ekhlaspour, Naama Fisch Shvalb, Gregory P. Forlenza, Geraldine Gallen, Satish K. Garg, Dana C. Gershenoff, Linda A. Gonder-Frederick, Ahmad Haidar, Sara Hartnell, Lutz Heinemann, Simon Heller, Irl B. Hirsch, Korey K. Hood, Diana Isaacs, David C. Klonoff, Olga Kordonouri, Aaron Kowalski, Lori Laffel, Julia Lawton, Rayhan A. Lal, Lalantha Leelarathna, David M. Maahs, Helen R. Murphy, Kirsten Norgaard, David O'Neal, Sean Oser, Tamara Oser, Eric Renard, Michael C. Riddell, David Rodbard, Steven J. Russell, Desmond A. Schatz, Viral N. Shah, Jennifer L. Sherr, Gregg D. Simonson, R. Paul Wadwa, Candice Ward, Stuart A. Weinzimer, Emma G. Wilmot, Tadej Battelino
Summary: The global prevalence of diabetes continues to be a challenge and the advances in automated insulin delivery (AID) technologies have shown to be safe and effective in helping patients achieve their glycemic goals. However, there is a lack of guidance for clinicians on using AID systems in clinical settings.
Article
Medicine, General & Internal
Charlotte K. Boughton, Janet M. Allen, Julia Ware, Malgorzata E. Wilinska, Sara Hartnell, Ajay Thankamony, Tabitha Randell, Atrayee Ghatak, Rachel E. J. Besser, Daniela Elleri, Nicola Trevelyan, Fiona M. Campbell, Judy Sibayan, Peter Calhoun, Ryan Bailey, Gareth Dunseath, Roman Hovorka
Summary: In youths with new-onset type 1 diabetes, intensive glucose control for 24 months did not appear to prevent the decline in residual C-peptide secretion.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Letter
Endocrinology & Metabolism
Hood Thabit, Charlotte Boughton, Womba Mubita, Jose Rubio, Julia K. Mader, Parth Narendran, Mark Evans, Lalantha Leelarathna, Malgorzata E. Wilinska, Catherine Fullwood, Alice M. Gregory, Roman Hovorka, Martin K. Rutter
DIABETES OBESITY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Aideen B. B. Daly, Charlotte K. K. Boughton, Munachiso Nwokolo, Sara Hartnell, Malgorzata E. E. Wilinska, Alina Cezar, Mark L. L. Evans, Roman Hovorka
Summary: The benefits of fully closed-loop insulin delivery in adults with type 2 diabetes are unclear. A study compared the use of closed-loop therapy with standard insulin therapy and found that closed-loop therapy improved glucose control and reduced mean glucose levels. This suggests that fully closed-loop insulin delivery may be a safe and effective method for improving outcomes in adults with type 2 diabetes.
Article
Endocrinology & Metabolism
Julia Ware, Malgorzata E. Wilinska, Yue Ruan, Janet M. Allen, Charlotte K. Boughton, Sara Hartnell, Lia Bally, Carine de Beaufort, Rachel E. J. Besser, Fiona M. Campbell, Katharine Draxlbauer, Daniela Elleri, Mark L. Evans, Elke Frohlich-Reiterer, Atrayee Ghatak, Sabine E. Hofer, Thomas M. Kapellen, Lalantha Leelarathna, Julia K. Mader, Womba M. Mubita, Parth Narendran, Tina Poettler, Birgit Rami-Merhar, Martin Tauschmann, Tabitha Randell, Hood Thabit, Ajay Thankamony, Nicola Trevelyan, Roman Hovorka
Summary: The safety of the algorithm intensification mode (Boost) in a hybrid closed-loop (HCL) system was evaluated in this study. The results showed that the use of the Boost mode in HCL therapy is safe across all age groups with type 1 diabetes, but it may lead to longer periods of hyperglycemia.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2022)
Article
Endocrinology & Metabolism
Mustafa Fattah, Charlotte K. Boughton, Julia Ware, Janet M. Allen, Sara Hartnell, Malgorzata E. Willinska, Ajay Thankamony, Carine de Beaufort, Fiona M. Campbell, Elke Froehlich-Reiterer, Sabine E. Hofer, Thomas M. Kapellen, Birgit Rami-Merhar, Atrayee Ghatak, Tabitha L. Randell, Rachel E. J. Besser, Daniela Elleri, Nicola Trevelyan, Louise Denvir, Nikki Davis, Lia Bally, Hood Thabit, Lalantha Leelarathna, Mark L. Evans, Julia K. Mader, Roman Hovorka
Summary: Personal glucose targets have an impact on glycemic control, with higher targets leading to poorer control.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2022)
Article
Endocrinology & Metabolism
Julia Ware, Janet M. Allen, Charlotte K. Boughton, Alina Cezar, Sara Hartnell, Malgorzata E. Wilinska, Ajay Thankamony, Mark Deakin, Hannah Leyland, Karen Phelan, Keith Thornborough, Roman Hovorka
Summary: This study evaluated the use of hybrid closed-loop (HCL) insulin delivery with faster insulin aspart (Fiasp) in very young children with type 1 diabetes (T1D). The results showed that there was no significant difference in glycemic control between HCL with Fiasp and standard insulin aspart (IAsp) in children aged 2-6 years with T1D.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Letter
Endocrinology & Metabolism
Rama Lakshman, Aideen B. Daly, Munachiso Nwokolo, Sara Hartnell, Malgorzata E. Wilinska, Alina Cezar, Mark L. Evans, Roman Hovorka, Charlotte K. Boughton
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Heba Alwan, Julia Ware, Charlotte E. Boughton, Malgorzata M. Wilinska, Janet Allen, Rama Lakshman, Munachiso Nwokolo, Sara Hartnell, Lia Bally, Carine de Beaufort, Rachel E. J. Besser, Fiona M. Campbell, Nikki Davis, Louise Denvir, Mark L. Evans, Elke Froehlich-Reiterer, Atrayee Ghatak, Sabine E. Hofer, Thomas M. Kapellen, Lalantha Leelarathna, Julia K. Mader, Parth Narendran, Birgit Rami-Mehrar, Martin Tauschmann, Hood Thabit, Ajay Thankamony, Roman Hovorka
Summary: This study aimed to assess the difference in percentage of time spent in hypoglycemia during closed-loop insulin delivery among different age groups and time of day. The results showed that the median time spent in hypoglycemia over the 24-hour period was highest in children and adolescents, followed by very young children, adults, and older adults. Time spent in hypoglycemia during nighttime was lower than during daytime across all age groups.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Charlotte K. Boughton, Sara Hartnell, Nicola Hobday, Andrea Lake, Katy Davenport, Aideen Daly, Candice Ward, Caroline Taylor, Roman Hovorka, Vishakha Bansiya
Summary: The study investigated the feasibility of implementing a fully closed-loop insulin delivery system in a hospital setting and found that it can be safely and effectively implemented in complex medical and surgical inpatients with challenging glycaemic control.
Article
Endocrinology & Metabolism
A. K. Schneider-Utaka, S. Hanes, C. K. Boughton, S. Hartnell, H. Thabit, W. M. Mubita, K. Draxlbauer, T. Poettler, J. Hayes, M. E. Wilinska, J. K. Mader, P. Narendran, L. Leelarathna, M. L. Evans, R. Hovorka, K. K. Hood
Summary: The use of the CamAPS FX hybrid closed loop system has been found to improve time in range and glycated hemoglobin A1c levels across all age groups. However, there is limited research on its effects on patient-reported outcomes (PROs). This study compared CamAPS FX to sensor-augmented pump in older adults with type 1 diabetes. The results showed that the use of the CL system led to improved PROs and subjective user experience benefits.
Letter
Endocrinology & Metabolism
Rama Lakshman, Aideen B. Daly, Munachiso Nwokolo, Sara Hartnell, Malgorzata E. Wilinska, Alina Cezar, Mark L. Evans, Roman Hovorka, Charlotte K. Boughton
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Letter
Endocrinology & Metabolism
Atrayee K. Ghatak, Charlotte M. Boughton, Janet Allen, Julia E. Ware, Malgorzata Wilinska, Sara Hartnell, Ajay Thankamony, Tabitha Randell, Rachel E. J. Besser, Daniela Elleri, Nicola M. Trevelyan, Fiona Campbell, Roman Hovorka, CLOuD Consortium
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Letter
Endocrinology & Metabolism
Hood Thabit, Charlotte Boughton, Womba Mubita, Jose Rubio, Stuart Allen, Robert Heugh, Julia K. Mader, Parth Narendran, Mark Evans, Lalantha Leelarathna, Malgorzata E. Wilinska, Catherine Fullwood, Clifford Garratt, Roman Hovorka, Martin K. Rutter
DIABETES OBESITY & METABOLISM
(2023)