Article
Chemistry, Analytical
Changgyun Kim, Sekyoung Youm
Summary: This study uses 3D data to determine variables and areas that affect obesity and proposes more detailed guidelines for diagnosing obesity. The accuracy of the model proposed in this study to diagnose obesity is higher than traditional obesity indices.
Letter
Medicine, General & Internal
David A. Gorelick
Summary: This comprehensive review of human adipose tissue fails to mention the role of the endocannabinoid system in fat metabolism. The endogenous cannabinoids and their receptors, found in both white and brown fat, have been recognized as key players in adipose tissue metabolism. Rimonabant, an inverse agonist of cannabinoid receptor type 1, has shown promising effects as a therapeutic target for obesity, dyslipidemia, and insulin resistance, although its clinical use was discontinued due to neuropsychiatric side effects.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Mi Kyoung Son, Dae Sub Song, Kyoungho Lee, Hyun-Young Park
Summary: This study aimed to identify modifiable risk factors for atrial fibrillation (AF) in the midlife general population and estimate their impact. The results showed that high systolic blood pressure, obesity with central obesity, and an inactive lifestyle were significantly associated with incident AF. Maintaining or achieving a lower burden of modifiable risk factors was associated with decreased AF risk.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
William H. H. Dietz
Summary: This study compared the prevalence of pediatric obesity during the COVID-19 lockdown with the annual increases in obesity in NHANES. The changes in prevalence observed in two surveys during the lockdown were 28 to 63 times greater than the annual changes in obesity in NHANES. Increases in obesity were greater in Black and Hispanic youth than in White youth. The COVID-19 lockdown exacerbated the disparities in obesity among this age group.
Article
Cell Biology
Xiang-Wei Ling, Hai-Shuang Wang, Li Wan, Hai-Lei Guo, Zheng-Jun Liu, Cai Lin, Xing-Xing Zhang
Summary: This study revealed a significant relationship between the severity of albuminuria and wound healing in patients with type 2 diabetic foot ulcers, suggesting albuminuria as an independent indicator for healing.
WOUND REPAIR AND REGENERATION
(2021)
Article
Multidisciplinary Sciences
Bedrettin Akar
Summary: This study analysed the safety of simultaneous bilateral total knee arthroplasty (SBTKA) surgery by comparing morbidly obese (MO) patients with obese patients. The results showed that SBTKA surgery is not feasible in morbidly obese patients due to the high complication rate and unsatisfactory clinical outcomes. Staged surgery should be preferred.
Article
Public, Environmental & Occupational Health
Xiaomin Fu, Hongzhou Liu, Jing Liu, Nan Li, Lele Li, Dianshan Ke, Minyan Liu, Yanhui Lu, Lihua Duan, Linlin Ma, Yanfei Huo, Qinghua Lei, Shuangtong Yan
Summary: This study found that the triglyceride-glucose index is independently associated with the risk of incident type 2 diabetes mellitus (T2DM) in Chinese adults aged over 75 years. The index may be useful in monitoring T2DM in older populations.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Clinical Neurology
Jinlei Li, Chunyu Liu, Ting Fang Alvin Ang, Rhoda Au
Summary: This study found that decreasing BMI trends in late life were associated with higher risk of developing dementia. Among them, individuals with an initial increase and subsequent decline in BMI during mid-life had a greater risk of dementia.
ALZHEIMERS & DEMENTIA
(2022)
Article
Multidisciplinary Sciences
Glen E. Duncan, Ally Avery, Jennifer L. M. Thorson, Eric E. Nilsson, Daniel Beck, Michael K. Skinner
Summary: An epigenome-wide association study on monozygotic twins revealed that physical activity can promote systemic epigenetic alterations and impact metabolic risk factors. The study analyzed differences in body mass index, physical activity levels, and neighborhood walkability between twin pairs and identified DNA methylation alterations associated with reduced metabolic parameters. The study also identified genes related to vigorous physical activity, metabolic risk factors, and sex.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Rishi Caleyachetty, Thomas M. Barber, Nuredin Ibrahim Mohammed, Francesco P. Cappuccio, Rebecca Hardy, Rohini Mathur, Amitava Banerjee, Paramjit Gill
Summary: This study aimed to identify ethnicity-specific BMI cutoffs for obesity to prevent type 2 diabetes among non-White populations. The findings suggest that different ethnic populations have different BMI cutoffs equivalent to the risk of type 2 diabetes at a BMI of 30.0 kg/m(2) in White populations, highlighting the need for appropriate clinical surveillance for minority ethnic populations to optimize prevention and management of type 2 diabetes.
LANCET DIABETES & ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Indah Suci Widyahening, Dhanasari Vidiawati, Trevino A. Pakasi, Pradana Soewondo, Abdillah Ahsan
Summary: Noncommunicable diseases (NCDs) pose a significant public health challenge in Indonesia, and their risk factors are associated with COVID-19 severity and mortality. This study investigated the NCD risk profile among university employees in Indonesia and its relationship with contracting COVID-19. The findings revealed a high prevalence of NCD risk factors among university administrative employees, which increased their susceptibility to COVID-19. The study highlights the urgent need for a behavioral intervention program to manage NCD risk factors at the university level.
Article
Multidisciplinary Sciences
Praachi Das, Morganne Igoe, Suzanne Lenhart, Lan Luong, Cristina Lanzas, Alun L. Lloyd, Agricola Odoi
Summary: This study investigates the geographic disparities of COVID-19 risk and the associations between COVID-19 risk and socioeconomic, demographic, movement, and chronic disease factors in the Greater St. Louis Area of Missouri. The results show that there are geographic disparities in COVID-19 risk, and these risks are associated with sociodemographic factors, population movements, and obesity hospitalization risks. The findings highlight the importance of considering these factors in controlling and preventing COVID-19.
Article
Multidisciplinary Sciences
Osama Mahmoud, Frank Dudbridge, George Davey Smith, Marcus Munafo, Kate Tilling
Summary: This article presents a method called 'Slope-Hunter' that corrects conditional bias in genetic associations using model-based clustering. The study found that this method eliminates bias and outperforms alternatives even in the presence of genetic correlation.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Aakash Bavishi, Stephanie A. Kliethermes, Bradley Petek, Nathaniel Moulson, Pranav Mellacheruvu, Timothy W. Churchill, Kimberly Harmon, Manesh R. Patel, Aaron L. Baggish, Jonathan A. Drezner, Raja Kannan Mutharasan
Summary: This study aimed to identify risk factors for hospitalization and severe complications in young adults (18-24 years old) diagnosed with COVID-19. The study found that hospitalized patients were more likely to have pre-existing medical conditions and higher BMI compared to healthy college athletes. Moreover, elevated BMI was associated with increased mortality.
Article
Multidisciplinary Sciences
Ana Babic, Michael H. Rosenthal, Tilak K. K. Sundaresan, Natalia Khalaf, Valerie Lee, Lauren K. K. Brais, Maureen Loftus, Leah Caplan, Sarah Denning, Anamol Gurung, Joanna Harrod, Khoschy Schawkat, Chen Yuan, Qiao-Li Wang, Alice A. A. Lee, Leah H. Biller, Matthew B. B. Yurgelun, Kimmie Ng, Jonathan A. A. Nowak, Andrew J. J. Aguirre, Sangeeta N. N. Bhatia, Matthew G. Vander Heiden, Stephen K. van den Eeden, Bette J. J. Caan, Brian M. M. Wolpin
Summary: The study suggests that skeletal muscle loss can be detected on CT imaging 1-2 years before a clinical diagnosis of pancreatic cancer, indicating its potential utility for earlier detection.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Artur Palasz, Marta Tyszkiewicz-Nwafor, Aleksandra Suszka-Switek, Flora Bacopoulou, Monika Dmitrzak-Weglarz, Agata Dutkiewicz, Agnieszka Slopien, Malgorzata Janas-Kozik, Krzysztof M. Wilczynski, Lukasz Filipczyk, Katarzyna Bogus, Ewa Rojczyk, Elzbieta Paszynska, Ryszard Wiaderkiewicz
Summary: In anorexia nervosa patients, serum levels of neuropeptides phoenixin (PNX) and spexin (SPX) were found to be decreased, with partial weight recovery leading to normalization of PNX concentrations but not SPX levels. These neuropeptides may play a crucial role in the etiology and course of anorexia nervosa.
NUTRITIONAL NEUROSCIENCE
(2021)
Article
Psychiatry
Johannes Thome, Jocelyn Deloyer, Andrew N. Coogan, Deborah Bailey-Rodriguez, Odete A. B. da Cruz e Silva, Frank Faltraco, Cathleen Grima, Snaebjorn Omar Gudjonsson, Cecile Hanon, Martin Holly, Jo Joosten, Ingegerd Karlsson, Gabriela Kelemen, Maria Korman, Krzysztof Krysta, Boleslav Lichterman, Konstantin Loganovsky, Donatella Marazziti, Margarita Maraitou, Serge Mertens deWilmars, Merja Reunamen, Shyhrete Rexhaj, Muhammet Sancaktar, Javier Sempere, Isabelle Tournier, Emilie Weynant, Christiaan Vis, Marie-Clotilde Lebas, Laurence Fond-Harmant
Summary: The current COVID-19 pandemic poses unique and severe challenges for psychiatric patients and mental health services. A survey conducted among 23 experts highlighted important themes and issues related to the impact of COVID-19 on mental health and services, barriers to service provision, and future consequences. Despite being at different stages of their national epidemics, colleagues across several jurisdictions reported key issues that provide valuable insights for mental health services in the current pandemic and future pandemics.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2021)
Review
Environmental Sciences
Krzysztof Krysta, Monika Romanczyk, Albert Diefenbacher, Marek Krzystanek
Summary: Telemedicine has seen rapid development in recent years, with new technologies being utilized in the treatment of various diseases. However, there are limited reports on the use of digital technologies in mental health care for individuals with intellectual disabilities. Overcoming barriers such individuals face in fully utilizing telemedicine requires appropriate support and adaptation.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Chemistry, Medicinal
Marek Krzystanek, Stanislaw Surma, Artur Palasz, Monika Romanczyk, Krzysztof Krysta
Summary: The antidepressant effects of memantine in bipolar depression are promising, with both experimental and clinical evidence supporting its efficacy. The presented case study demonstrates that memantine can be an effective and safe adjunct treatment for mood stabilization in bipolar depression. This suggests that memantine may offer a new approach for patients who do not respond well to traditional medications.
Review
Psychiatry
Shoumitro Deb, Bhathika Perera, Krzysztof Krysta, Mikail Ozer, Marco Bertelli, Ramon Novell, Jannelien Wieland, Tanja Sappok
Summary: This study developed a practice guideline to help clinicians assess and diagnose psychiatric disorders in adults with intellectual disabilities (ID). The study found that adults with ID have a higher prevalence of psychiatric disorders compared to the general population. The guideline provides recommendations on how to address these issues in clinical practice.
EUROPEAN JOURNAL OF PSYCHIATRY
(2022)
Review
Neurosciences
Karolina Kaminska, Michal Ciolek, Krzysztof Krysta, Marek Krzystanek
Summary: This study evaluated the effectiveness of lower extremity exercise interventions, especially treadmill training, in children and adults with Down syndrome. The results showed that combining treadmill training with physiotherapy can improve the mental and physical health of individuals with Down syndrome across different age groups.
Review
Chemistry, Medicinal
Rafal Bies, Joanna Fojcik, Anna Warchala, Beata Tredzbor, Krzysztof Krysta, Katarzyna Piekarska-Bugiel, Marek Krzystanek
Summary: Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, and methylphenidate is the first-line drug for treatment. However, the adverse effects of methylphenidate therapy in adults have not been extensively described. This article reviewed the literature on the risks of methylphenidate therapy for adults with ADHD and found that side effects could include reversible ischemic stroke, myocardial infarction, and psychotic episodes.
Meeting Abstract
Psychiatry
K. Szczurek, N. Furgal, D. Szczepanek, K. Krysta, M. Krzystanek
EUROPEAN PSYCHIATRY
(2022)
Meeting Abstract
Psychiatry
M. Ciolek, K. Kaminskai, M. Nowak, K. Krysta
EUROPEAN PSYCHIATRY
(2022)
Meeting Abstract
Psychiatry
K. Kaminska, M. Ciolek, K. Krysta
EUROPEAN PSYCHIATRY
(2022)
Meeting Abstract
Psychiatry
K. Krysta
EUROPEAN PSYCHIATRY
(2022)
Meeting Abstract
Psychiatry
K. Krysta
EUROPEAN PSYCHIATRY
(2022)
Article
Clinical Neurology
Jade Gourret Baumgart, Helene Kane, Gaetan Absil, Jocelyn Deloyer, Wissam El-Hage, Claudio Fuenzalida, Mihaela Gavrila-Ardelean, Krzysztof Krysta, Laurent Le Saint, Donatella Marazziti, Margarita Moraitou, Merja Reunanen, Shyhrete Rexhaj, Johannes Thome, Laurence Fond-Harmant, Frederic Denis, Shyhrete Rexhaj, Johannes Thome, Laurence Fond-Harmant
Summary: The Covid-19 pandemic has had a significant impact on European mental health and psychiatric services, particularly on the working conditions and mental health of professionals in the field. The extensive use of digital devices has generated stress and tension among these professionals. It is crucial to take action to optimize the occupational health of European mental health professionals, including the development of ad hoc measures and support for the use of digital tools.
CLINICAL NEUROPSYCHIATRY
(2022)
Meeting Abstract
Psychiatry
K. Wilczynski, L. Cichon, A. Augusciak-Duma, A. Sieron, M. Janas-Kozik
EUROPEAN PSYCHIATRY
(2021)
Meeting Abstract
Psychiatry
K. Adamczewska, M. Bien, K. Dudzic, K. Krysta, M. Krzystanek
EUROPEAN PSYCHIATRY
(2021)
