期刊
REGULATORY PEPTIDES
卷 150, 期 1-3, 页码 88-94出版社
ELSEVIER
DOI: 10.1016/j.regpep.2008.06.002
关键词
G-protein coupled receptor; Receptor dimer; Receptor monomer; Gi subunit
The neuropeptide Y (NPY) Y2 receptors and the pancreatic polypeptide Y4 receptors from rabbit kidney cortex are isolated largely as similar to 180 kDa complexes constituted of one receptor dimer and one G-protein heterotrimer, similar to NPY receptors expressed in the Chinese hamster ovary (CHO) cells. As expected, kidney and CHO cell Y2 dimers are converted into monomers by increasing concentrations of a selective agonist. Prevalence of dimeric Y2 receptors in the kidney could be related to low plasma levels of Y2 agonists, and possibly also to a relatively low concentration of Gi alpha subunits. (C) 2008 Elsevier B.V. All rights reserved.
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